SAGE Open Medical Case Reports最新文献

{"title":"Drug-induced subacute cutaneous lupus erythematosus secondary to Dupilumab: A case report.","authors":"Miranda Waugh, Geneviève Gavigan","doi":"10.1177/2050313X241284049","DOIUrl":"https://doi.org/10.1177/2050313X241284049","url":null,"abstract":"<p><p>We present the case of a 63-year-old male with known rheumatoid arthritis, diabetes, hypertension, and peripheral neuropathy who developed drug-induced subacute cutaneous lupus erythematosus secondary to Dupilumab for his chronic hand dermatitis.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241284049"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodeno-duodenal intussusception due to gastrointestinal stromal tumor: A case report.","authors":"Boumeriem Khaoula, Bourekba Iliass, Paulino Insumbo, Nassar Ittimade, Imrani Kaoutar, Moatassim Billah Nabil","doi":"10.1177/2050313X241285576","DOIUrl":"https://doi.org/10.1177/2050313X241285576","url":null,"abstract":"<p><p>Gastrointestinal stromal tumors, previously referred to as leiomyomas and leiomyosarcomas, are one of the most common mesenchymal tumors of the gastrointestinal tract, predominantly located in the stomach (60%-70%), followed by the small intestine (20%-30%). They manifest at any age but more commonly in patients older than 50 years. Patients with gastrointestinal stromal tumors usually have vague and nonspecific symptoms. The diagnosis is sometimes challenging requiring multiple imaging modalities, including computed tomography and magnetic resonance imaging, used for diagnosis, staging, and surveillance. Treatment involves surgery and targeted therapy. Serious complications have been reported such as intussusception which is exceptionally rare due to the extraluminal growth pattern tendency of gastrointestinal stromal tumors. We present the case of a 77-year-old female with duodeno-duodenal intussusception secondary to a gastrointestinal stromal tumor. This case report contributes valuable insight into the diverse presentation and complications of gastrointestinal stromal tumors.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241285576"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"40-Gene expression profile test predicting metastatic risk in localized, high-risk cutaneous squamous cell carcinoma for peer review.","authors":"Luna Samman, Chloe Fernandez, Carlos Gomez-Meade","doi":"10.1177/2050313X241284141","DOIUrl":"https://doi.org/10.1177/2050313X241284141","url":null,"abstract":"<p><p>This case study investigates the use of a 40-gene expression profile to independently predict the risk of metastasis in an immunocompromised 75-year-old male patient with cutaneous squamous cell carcinoma of his left cheek. The patient's previous medical history included non-melanoma skin cancer. Traditional staging methods, such as those from the American Joint Committee on Cancer 8th edition and Brigham and Women's Hospital, suggested a high risk of metastasis for this patient. However, the 40-gene expression profile test identified the patient as having a low risk (Class 1 result) of metastasis within 3 years. The patient successfully underwent Mohs surgery, and pathology was notable for positive perineural invasion of large caliber nerves. This case highlights the potential of the 40-gene expression profile as an independent predictor in assessing metastatic risk compared to traditional staging methods.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241284141"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilomatricoma presenting as a giant cutaneous horn in an 8-year-old child: A case report and literature review.","authors":"Madeleine Crawford, Jincheng Shi, Archan Kakadekar, Ashley Sutherland","doi":"10.1177/2050313X241284119","DOIUrl":"https://doi.org/10.1177/2050313X241284119","url":null,"abstract":"<p><p>Pilomatricoma is an uncommon benign adnexal tumor of childhood. We report a case of pilomatricoma presenting as a large, recurrent painful cutaneous horn on the neck of an 8-year-old boy treated with surgical excision. On histopathology, classical features of pilomatricoma along with transepidermal elimination and perforation were shown. We propose that perforating pilomatricoma and pilomatrical horn represent equivalent clinical and pathological entities. The diagnosis of perforating pilomatricoma should be considered in pediatric patients presenting with a cutaneous horn.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241284119"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and management challenges of a rare case of caesarean scar pregnancy in a low-resource setting: a case report.","authors":"Malarchy E Nwankwo, Richard O Egeonu, Arinze C Ikeotuonye, George U Eleje, Chisolum O Okafor, Golibe C Ikpeze, Samuel N Ugadu, Chimezie M Agbanu, Adamalarchy F Nwankwo, Chigozie G Okafor","doi":"10.1177/2050313X241286670","DOIUrl":"10.1177/2050313X241286670","url":null,"abstract":"<p><p>Caesarean scar pregnancy is a rare type of ectopic pregnancy with the potential for catastrophic outcomes. A high index of suspicion is required for prompt diagnosis and intervention to improve outcomes. This report describes a rare case of Caesarean scar pregnancy, which was initially misdiagnosed as a threatened miscarriage and cervical ectopic pregnancy. A 35-year-old multiparous lady with two previous caesarean sections presented to the Gynaecology Unit of the Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nigeria, at an estimated gestational age of 10 weeks, with recurrent vaginal bleeding of eight weeks' duration. She was referred to our facility from a private hospital, where she had first been managed as a case of threatened miscarriage and later as a cervical ectopic pregnancy. The transvaginal ultrasound in our facility was in keeping with a viable Caesarean scar pregnancy. The urine pregnancy test was positive, and the quantitative serum beta human chorionic gonadotropin was 75.6 mIU/ml. She had initial medical treatment with a combination of systemic multidose and intrauterine sac methotrexate and, subsequently, hysterotomy. Following systemic and local methotrexate, there was the demise of the foetus, which was evacuated at hysterotomy, and the uterine scar defect was repaired. She was discharged home in stable clinical condition one week after surgery. Her serum beta human chorionic gonadotropin dropped to 51.6 mIU/mL two weeks post-hysterotomy, and her urine pregnancy test became negative three weeks later. Though rare, caesarean scar pregnancy should be considered a differential diagnosis in reproductive-aged women with a previous caesarean section who present with vaginal bleeding in the first trimester.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241286670"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myxedema ascites? A rare presentation of ascites in severe hypothyroidism: A case report and review.","authors":"Kylie Divashnee Konar, Somasundram Pillay, Nishan Sookdev","doi":"10.1177/2050313X241282218","DOIUrl":"https://doi.org/10.1177/2050313X241282218","url":null,"abstract":"<p><p>Ascites represents an infrequent sequela of hypothyroidism, manifesting in fewer than 4% of affected individuals. Herein, we delineate a case characterized by profound hypothyroidism accompanied by substantial ascites, further complicated by cardiac insufficiency. A 29-year-old female, previously diagnosed with postradiation hypothyroidism subsequent to a diagnosis of Grave's disease 11 years prior, presented with exacerbating dyspnoea, abdominal distension, and orthopnea. In January 2024, she was admitted with massive ascites, exhibiting clinical manifestations of both hypothyroidism and cardiac failure. Thyroid function tests were markedly abnormal, with a thyroid-stimulating hormone level of 77.65 mIU/L, triiodothyronine at 2.2 nmol/L, and thyroxine levels below 3.2 pmol/L. Echocardiographic evaluation revealed dilated cardiomyopathy with a significantly reduced systolic (ejection fraction of 25.9%) and diastolic function (E/A ratio of 0.87). Analysis of the ascitic fluid demonstrated a serum-ascites albumin gradient exceeding 1.1 g/L (3 g/L). Ultrasonography of the abdomen ruled out portal hypertension, while computed tomography of the abdomen confirmed extensive ascites without evidence of malignancy. Under the supervision of a specialist, the patient was administered a high dosage of levothyroxine (300 mcg), leading to a significant amelioration in both thyroid function parameters and her ascites. Subsequent thyroid function tests demonstrated a decrease in thyroid-stimulating hormone levels to 11.7 mIU/L and an increase in thyroxine levels to 15.6 pmol/L, indicating a positive response to the thyroid hormone replacement therapy. Subsequent echocardiographic assessment showed improvement in the ejection fraction to 26.9% and diastolic function (E/A ratio of 1.27). Myxedema ascites, though infrequent, is readily amenable to treatment. The serum-ascites albumin gradient exceeding 1.1 g/L may be indicative of hypothyroidism-associated ascites, although the paucity of studies renders it uncertain whether this is a characteristic feature. Further investigation into the etiology, diagnostic criteria, and management strategies for ascites in the context of hypothyroidism is warranted.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241282218"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed epithelial and stromal tumor of the seminal vesicle: A case report and literature review.","authors":"Changrong Wang, Jingjing Xiang, Yuyong Wang","doi":"10.1177/2050313X241277674","DOIUrl":"https://doi.org/10.1177/2050313X241277674","url":null,"abstract":"<p><p>A mixed epithelial and stromal tumor of the seminal vesicle gland is an uncommon neoplasm characterized by a dual population of epithelial and stromal cells. In this case report, we present a 59-year-old male patient who presented with a large, 10 cm mass in the left seminal vesicle, which was preliminarily suspected to be a malignant tumor of the seminal vesicle based on magnetic resonance imaging findings. Histopathological evaluation, however, revealed a tumor with biphasic epithelial-mesenchymal differentiation, predominantly displaying mesenchymal characteristics. The epithelium and stroma displayed papillary and foliar structures, respectively. The epithelial cells were bland, arranged in either single or multi-layered cuboidal patterns, and the stromal cells were spindle shaped with a sparse distribution. The patient experienced a favorable postoperative outcome. The diagnosis of mixed epithelial and stromal tumor is challenging based on clinical and imaging findings alone, and definitive diagnosis relies on pathological examination. This case report addresses a rare presentation of low-grade mixed epithelial and stromal tumor in the seminal vesicle gland and aims to expand the understanding of this entity by reviewing the relevant literature.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241277674"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Destructive foreign body granuloma: A case report.","authors":"Pithiwat Wongwan, Sarun Prakairungthong, Suvajana Atipas, Kanthong Thongyai, Siriporn Limviriyakul, Kanokrat Suvarnsit","doi":"10.1177/2050313X241286689","DOIUrl":"10.1177/2050313X241286689","url":null,"abstract":"<p><p>External auditory canal polyps are predominantly inflammatory processes but occasionally indicate more severe pathology. Prolonged conservative management may postpone accurate diagnosis and appropriate therapeutic intervention. This case report presents a 37-year-old woman, previously healthy with a normal ear, who underwent a right myringotomy with the insertion of a pressure-equalizing tube in one hospital after an upper respiratory tract infection. However, due to the pandemic era, she lost follow-up for 2 years and subsequently presented to another hospital with worsening hearing and persistent otorrhea. The attending physician found a large polypoid lesion occupying her right external ear canal. A computerized tomography scan revealed an irregular enhancement mass involving the right ear canal, the middle ear cavity, and mastoid air cells with multiple destruction of the skull base and intracranial involvement in the right middle cranial fossa. The possibility of malignancy was raised, prompting the patient to seek evaluation in a third hospital. A right tympanomastoidectomy was performed, and during a posterior tympanotomy, a pressure-equalizing tube was discovered in her middle ear. The pathological results confirmed the presence of foreign body granuloma. Following surgery, the patient's otorrhea improved.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241286689"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Autoimmune progesterone dermatitis post-intrauterine device placement in rural occupied Palestine.","authors":"Ibrahim Alheeh, Neveen Shalalfeh, Shatha Wajeeh, Rou'a Farah, Rahaf Farah","doi":"10.1177/2050313X241283601","DOIUrl":"https://doi.org/10.1177/2050313X241283601","url":null,"abstract":"<p><p>Autoimmune progesterone dermatitis is considered a rare cyclical autoimmune reaction to endogenous progesterone in fertile females that is characterized by skin lesions ranging from mild urticaria to anaphylaxis. A 30-year-old woman who had an intrauterine device placed, presented to her family medicine clinic with erythema and some edematous lesions, and pruritus. The skin biopsy showed perivascular infiltrate with neutrophils and was diagnosed as autoimmune progesterone dermatitis. Treatment included intrauterine device removal and treatment with tamoxifen. This is the first documented case of autoimmune progesterone dermatitis in occupied Palestine.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241283601"},"PeriodicalIF":0.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute extreme hypocapnia and diabetic coma in an elderly patient after surgery: A case report.","authors":"Thomas Strecker, Michaela Siegle, Frank Bremer","doi":"10.1177/2050313X241282761","DOIUrl":"10.1177/2050313X241282761","url":null,"abstract":"<p><p>Hyperglycemia and diabetic ketoacidosis are serious and life-threatening emergencies in diabetes patients. Early recognition of the symptoms of these disorders and their management are essential. Therapy is adequate rehydration, insulin treatment, electrolyte replacement, and handling of the underlying causative disease. Herein, we present an 83-year-old male with an extremely altered blood gas analysis after a surgical procedure of his left hand due to a phlegmon and describe the successful treatment through intensive care.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"12 ","pages":"2050313X241282761"},"PeriodicalIF":0.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}