上唇肌上皮瘤:一例罕见病例报告及诊断方法的文献回顾。

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
SAGE Open Medical Case Reports Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI:10.1177/2050313X241305185
Farid Ghadyani, Samira Behrad
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引用次数: 0

摘要

肌上皮瘤是一种极为罕见的涎腺肿瘤,具有多种组织学变异。了解肌上皮瘤的临床、影像学和分子特征对准确诊断和治疗至关重要。我们提出一个病例40岁的伊朗男性无痛,坚定,孤立的外生肿块上唇。手术切除治愈,36个月无复发。组织病理学分析证实肌上皮瘤伴梭形和浆细胞样细胞变异。肌上皮瘤的罕见性反映在流行病学研究中,其特征主要通过病例报告中的信息来认识。它主要出现在大唾液腺的部位,偶尔也出现在上颚。发生在上唇部位是极为罕见的,只出现在少数病例报告。寻找以前可能的病因暴露史可能不是一个促进因素。鉴别诊断包括多形性腺瘤、肌上皮癌和基底细胞腺瘤。主要的诊断方法是组织病理学分析。随后,可以评估肿瘤的性质、细胞变异和可能的转化。而分子研究补充诊断,他们的常规临床应用是有限的,他们的必要性是有争议的。当不确定性出现时,人工智能的应用可能会有所帮助,或者用于分析微观图像。手术切除与健康的边缘是治愈的,随访是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Myoepithelioma of the upper lip: A rare case report with a literature review of diagnostic approaches.

Myoepithelioma is an extremely rare salivary gland neoplasm with diverse histological variants. Understanding myoepithelioma's clinical, radiological, and molecular features is crucial for accurate diagnosis and management. We present a case of a 40-year-old Iranian male with a painless, firm, solitary exophytic mass on the upper lip. Surgical excision was curative, with no recurrence at 36 months. Histopathological analysis confirmed myoepithelioma with spindle and plasmacytoid cell variants. Myoepithelioma's rarity is reflected in epidemiologic studies and its features are mainly recognized by the information in the case reports. Majorly it appears at the site of major salivary glands and occasionally the palate. The occurrence at the site of the upper lip is extremely rare and only appeared in a few case reports. Seeking the history of previous exposures to possible etiologic factors might not be a facilitator. Differential diagnosis includes pleomorphic adenoma, myoepithelial carcinoma, and basal cell adenoma. The main diagnostic approach is histopathological analysis. Following that, the tumor's nature, cell variants, and possible transformation could be evaluated. While molecular studies supplement diagnosis, their routine clinical use is limited and their necessity is debated. The application of artificial intelligence could be helpful when uncertainty arises, or for analyzing microscopic images. Surgical excision with healthy margins is curative, and follow-up is essential.

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来源期刊
SAGE Open Medical Case Reports
SAGE Open Medical Case Reports MEDICINE, GENERAL & INTERNAL-
CiteScore
0.60
自引率
0.00%
发文量
320
审稿时长
8 weeks
期刊介绍: SAGE Open Medical Case Reports (indexed in PubMed Central) is a peer reviewed, open access journal. It aims to provide a publication home for short case reports and case series, which often do not find a place in traditional primary research journals, but provide key insights into real medical cases that are essential for physicians, and may ultimately help to improve patient outcomes. SAGE Open Medical Case Reports does not limit content due to page budgets or thematic significance. Papers are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, SAGE Open Medical Case Reports facilitates the discovery of the connections between papers, whether within or between disciplines. Case reports can span the full spectrum of medicine across the health sciences in the broadest sense, including: Allergy/Immunology Anaesthesia/Pain Cardiovascular Critical Care/ Emergency Medicine Dentistry Dermatology Diabetes/Endocrinology Epidemiology/Public Health Gastroenterology/Hepatology Geriatrics/Gerontology Haematology Infectious Diseases Mental Health/Psychiatry Nephrology Neurology Nursing Obstetrics/Gynaecology Oncology Ophthalmology Orthopaedics/Rehabilitation/Occupational Therapy Otolaryngology Palliative Medicine Pathology Pharmacoeconomics/health economics Pharmacoepidemiology/Drug safety Psychopharmacology Radiology Respiratory Medicine Rheumatology/ Clinical Immunology Sports Medicine Surgery Toxicology Urology Women''s Health.
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