Movement Disorders最新文献

{"title":"Melanopsin-Mediated Post-Illumination Pupillary Response in Idiopathic Rapid Eye Movement (REM) Sleep Behavior Disorder and Parkinson's Disease.","authors":"Joey W Y Chan,Bei Huang,Siyi Gong,Yuhua Yang,Shi Tang,Steven Wai-Ho Chau,Ngan Yin Chan,Tim Man-Ho Li,Yaping Liu,Anne Y Y Chan,Karen K Y Ma,Shirley X Li,Joshua Tsoh,Kelvin K L Chong,Kathryn A Roecklein,Vincent C T Mok,Yun Kwok Wing","doi":"10.1002/mds.70412","DOIUrl":"https://doi.org/10.1002/mds.70412","url":null,"abstract":"AIMSTo conduct a case-control study to investigate melanopsin-mediated post-illumination pupillary response (PIPR) in patients with Parkinson's disease (PD), video-polysomnography-confirmed isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD), and age-matched healthy controls (HC).METHODSPIPR was measured at 6 s after light offset (PIPR-6s). Net PIPR-6s was calculated by subtracting the red-light response from the blue-light response. Participants also underwent 1-week actigraphy, overnight urinary 6-sulfatoxymelatonin assessment, and cognitive testing using the Hong Kong Montreal Cognitive Assessment (HK-MoCA).RESULTSWe recruited 135 participants (mean age 64.4 ± 5.7 years; 56% male), with 45 in each group. Net PIPR-6s was 23.8 ± 9.4% in HC, 18.6 ± 10.8% in iRBD, and 13.3 ± 9.6% in PD (P < 0.001; HC > iRBD > PD). Net PIPR-6s was positively associated with circadian rest-activity rhythm amplitude, mesor, and HK-MoCA score.CONCLUSIONAttenuated PIPR may reflect early dysfunction in melanopsin-mediated phototransduction in the prodromal stage of synucleinopathy. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148348913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Depression in Persons with Parkinson's Disease","authors":"Albert F.G. Leentjens MD, PhD,&nbsp;Gregory M. Pontone MD, MHS","doi":"10.1002/mds.70285","DOIUrl":"10.1002/mds.70285","url":null,"abstract":"<p>Depression is a prevalent and disabling syndrome characterized by sustained sadness and/or anhedonia, as well as cognitive and physical symptoms. In Parkinson's disease (PD), depression is both common and clinically challenging due to overlapping symptoms and complex etiologic interactions. Major depressive disorder occurs in approximately 17% of PD patients, while clinically significant depressive symptoms affect over one-third. Both PD-specific and general risk factors contribute to this burden, with the latter playing a greater role. Diagnosis is complicated by symptom overlap, prompting recommendations for an inclusive diagnostic approach and use of rating scales specifically validated in PD. Differentiation from related syndromes such as apathy, demoralization and anxiety disorders is essential for appropriate management. Treatment follows general population algorithms, incorporating pharmacotherapy—particularly selective serotonergic reuptake inhibitors, serotonin and noradrenalin reuptake inhibitors, and tricyclic antidepressants—and psychotherapy such as cognitive behavioral or interpersonal therapy, though adjustments are needed to account for PD-related vulnerabilities. Access to adequate care is often hampered by the lack of mental health specialists with specific expertise in PD. From a research standpoint, PD provides a unique model for studying the neurobiology of mood regulation, implicating dopaminergic, serotonergic, and noradrenergic systems, as well as hypothalamic–pituitary–adrenal axis dysfunction. Emerging methods, including deep brain stimulation, ecological momentary assessment, neuroimaging, and machine learning, are expanding insights into emotional processing and its neurophysiological underpinnings. Clinically, routine screening and evidence-based treatment have improved care. Future research promises to refine diagnostic criteria, optimize therapies, and deepen understanding of affective dysregulation in Parkinson's disease. © 2026 The Author(s). <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":"1355-1361"},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation","authors":"Thomas Koeglsperger MD,&nbsp;Maximilian Scherer PhD,&nbsp;Andrea A. Kühn MD,&nbsp;Alexandre Eusebio MD,&nbsp;Alfonso Fasano MD,&nbsp;Joachim K. Krauss MD","doi":"10.1002/mds.70284","DOIUrl":"10.1002/mds.70284","url":null,"abstract":"<p>Adaptive deep brain stimulation (aDBS) represents an important evolution in the treatment of Parkinson's disease (PD), building on conventional DBS (cDBS) by adjusting stimulation in response to real-time physiological signals. By enabling dynamic targeting of disease-related neural activity, aDBS offers the potential for more precise modulation of motor symptoms. Additional anticipated advantages include reduced stimulation-related side effects and improved energy efficiency, supporting long-term device performance. Although clinical uptake is still at an early stage, growing experience has highlighted both opportunities and areas requiring further refinement. Key challenges include inter-individual variability in biomarker expression, diversity in programming approaches, and ongoing debate regarding optimal thresholds and response latencies. The clinical significance of short-term local field potential (LFP) recordings continues to be actively investigated, particularly in the context of signal artifacts, physiological variability, and current hardware limitations. Beyond technical considerations, factors such as patient selection, ethical frameworks, and cost-effectiveness remain important determinants of broader implementation. Continued progress will depend on the development of robust and flexible control strategies that incorporate multimodal biomarkers, including wearable-derived motor metrics and patient-reported outcomes, to support personalized therapy. With an expanding evidence base and recent regulatory approvals, aDBS is increasingly transitioning from an experimental concept to a viable clinical tool. Future efforts should prioritize the translation of research paradigms into scalable clinical workflows that effectively balance automation with individualized patient care. © 2026 The Author(s). <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":"1370-1383"},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macroscale Gradient-Informed Neural Oscillation Topography in Parkinson's Disease","authors":"Hao Ding PhD,&nbsp;Ke Xie PhD,&nbsp;Manuel Bange PhD,&nbsp;Hannah Kühne MD,&nbsp;Jenny Blech MSc,&nbsp;Bahman Nasseroleslami PhD,&nbsp;Jens Volkmann MD, PhD,&nbsp;Sergiu Groppa MD, PhD,&nbsp;Muthuraman Muthuraman PhD","doi":"10.1002/mds.70277","DOIUrl":"10.1002/mds.70277","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Parkinson's disease (PD) is characterized by large-scale disruptions in beta and gamma oscillations. Although subcortical beta power is an established biomarker for current adaptive deep brain stimulation (aDBS), it may not fully capture the global pathophysiological burden and the macroscale hierarchical reorganization of the cortex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We characterize the frequency-specific reorganization of the cortical hierarchy across resting and motor states using functional gradients. We sought to identify topographic biomarkers that emerge across different behavioral states and determine whether these hierarchical features provide predictive power for global motor severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>High-density electroencephalography and magnetic resonance imaging–based source reconstruction were employed in patients with PD (n = 35) and healthy control subjects (n = 34). To characterize cortical connectivity transitions, we applied a manifold learning framework to derive frequency-specific functional gradients. We quantified the diagnostic and predictive utility of these hierarchical features and performed transcriptomic enrichment analysis to validate the biological relevance of the alterations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with PD exhibited a macroscale reorganization of the cortical hierarchy that was both frequency specific and state dependent. These gradient-based biomarkers effectively differentiated patient groups and significantly predicted global Unified Parkinson's Disease Rating Scale Part III severity. Findings showed a robust framework with distinct topographical signatures, manifesting as a redistribution of informative signals across cortical regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This work demonstrates that PD induces a macroscale reorganization of the cortical hierarchy. State-dependent topographical biomarkers effectively predict clinical severity and align with the disease pathological landscape. By identifying optimal sensing sites across distributed networks, our findings provide a principled reference to support next-generation, cortical-guided aDBS. © 2026 The Author(s). <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":"1434-1444"},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pioneering 1915 Film on Movement Disorders in Spain: Parkinsonism, Huntington's Disease, and Paradoxical Kinesia","authors":"Íñigo Corral MD, PhD,&nbsp;Juan Carlos Martínez Castrillo MD, PhD,&nbsp;Kailash P. Bhatia MD, PhD,&nbsp;Pedro J. García Ruiz MD, PhD,&nbsp;Andrew Lees MD, PhD","doi":"10.1002/mds.70257","DOIUrl":"10.1002/mds.70257","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Soon after the advent of cinematography in 1895, neurologists began exploring its use as a permanent record of physical signs and as a teaching aid. We present the first known Spanish film on movement disorders, recorded in 1915.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We describe and analyze the patients shown in the film within its historical context.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The first section of the film is a teaching session in which a fixed camera records the patients and the professor, surrounded by students. It presents 10 patients, including parkinsonian and catatonic patients. In the second section, a mobile camera follows two cases in more detail: a patient with probable Huntington's disease (HD), and an impressive case of paradoxical kinesia in Parkinson's disease (PD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The didactic value of the film is exceptional. It presents the first reported Spanish case of HD, and the first documented case of paradoxical kinesia in PD, 6 years before its written description in 1921. © 2026 International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":"1387-1390"},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147371024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Motor Effectors to Action Networks: SCAN Reshapes Parkinson's Disease Pathophysiology","authors":"Rubens Gisbert Cury MD, PhD,&nbsp;Nicola Pavese MD, PhD, FEAN","doi":"10.1002/mds.70347","DOIUrl":"10.1002/mds.70347","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":"1385-1386"},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Unusual Suspects: Macrophages in Parkinson's Disease?","authors":"Sujas Bhardwaj MTech, PhD,&nbsp;Albert Stezin MBBS, DGM, PhD","doi":"10.1002/mds.70339","DOIUrl":"10.1002/mds.70339","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurology Under Fire: What About Parkinson's Disease in Wartime?","authors":"Margherita Fabbri MD, PhD,&nbsp;Olivier Rascol MD, PhD","doi":"10.1002/mds.70350","DOIUrl":"10.1002/mds.70350","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":"1333-1336"},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"June Infographic","authors":"","doi":"10.1002/mds.70384","DOIUrl":"https://doi.org/10.1002/mds.70384","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 Macroscale Gradient-Informed Neural Oscillation Topography in Parkinson's Disease\u0000\u0000 </p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148322469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reorganization of Directed Corticomuscular Network via Median Nerve Stimulation in Cervical Dystonia","authors":"Ru-Kai Chen MMed,&nbsp;Wu-Xiang Shi PhD,&nbsp;Yun-Fang He BMed,&nbsp;Jie Lin MD,&nbsp;Jun-Mei Wang MMed,&nbsp;Yan-Yu Shi BMed,&nbsp;Yu-Rong Li PhD,&nbsp;Nai-Qing Cai MD","doi":"10.1002/mds.70260","DOIUrl":"10.1002/mds.70260","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cervical dystonia (CD) originates in dysfunctional sensorimotor integration, creating an urgent need for neuromodulatory interventions that recalibrate pathological corticomuscular circuits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to investigate whether median nerve electrical stimulation (MNES) can serve as a novel, noninvasive therapy that specifically targets the abnormal corticomuscular network.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We investigated high-density electroencephalography combined with synchronized electromyography (EMG) recordings from 17 patients and 17 healthy control subjects during MNES and sensory trick (ST) tasks. Source-localized cortical activity and muscle signals were integrated into a directional corticomuscular network, with connectivity quantified by phase transfer entropy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MNES selectively suppressed pathological 4 to 8 Hz intermuscular coupling in patients, reorganized aberrant muscle synergy, and drove frequency-specific network reorganization: reduced beta-band outflow, decreased clustering coefficients, and prolonged the shortest path lengths across multiple frequency bands. Crucially, MNES enhanced hemispheric asymmetry in primary sensory cortex, supplementary motor area, and cerebellum. Operating predominantly in theta/alpha bands, MNES contrasted sharply with ST's gamma-band modulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings demonstrate that MNES restores corticomuscular network dynamics through multilever reconfiguration, attenuating pathological synchrony while facilitating adaptive circuit plasticity, thereby validating directed network analysis as a framework for circuit-targeted neuromodulation in movement disorders. © 2026 International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 6","pages":"1391-1401"},"PeriodicalIF":7.7,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}