Movement Disorders最新文献

{"title":"Asymmetry of the Dentato-Rubro-Thalamic Tracts in Cervical Dystonia","authors":"Rachel E. Sondergaard PhD, Conrad P. Rockel PhD, Filomeno Cortese PhD, G. Bruce Pike PhD, Zelma H.T. Kiss MD, PhD, Davide Martino MD, PhD","doi":"10.1002/mds.29594","DOIUrl":"10.1002/mds.29594","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 10","pages":"1970-1972"},"PeriodicalIF":8.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Sex-Specific Survival on the Incidence of Dementia in Parkinson's Disease","authors":"Anne Fink PhD,&nbsp;Richard Dodel MD, PhD,&nbsp;Daniela Georges PhD,&nbsp;Gabriele Doblhammer PhD","doi":"10.1002/mds.29596","DOIUrl":"10.1002/mds.29596","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of our study is to analyze sex-specific patterns of Parkinson's disease dementia (PDD) incidence. We are investigating the extent to which sex differences in survival after initial Parkinson's disease (PD) diagnosis influence differences in PDD risk among PD patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used a random sample of German longitudinal health claims data of persons ages 50+ (2004–2019; n = 250,000) and identified new PD cases ages 65+ who were followed-up for a PDD diagnosis or death between 2006 and 2017. We performed Cox and competing-risk regression models, with death as competing event, to calculate PDD hazard ratios (HR) adjusted for age at PD onset, PD severity as measured by the modified Hoehn and Yahr (HY) scale, comorbidities, and medications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 2195 new PD cases, 602 people died before PDD and 750 people developed PDD by the end of 2017. The adjusted risk of PDD differs by sex, with men having a higher PDD risk than women. When accounting for death, men and women do not differ in their PDD risk (HR = 1.02, <i>P</i> = 0.770). Sex-specific analyses showed significant age and severity effects in women (age: HR = 1.05, <i>P</i> &lt; 0.001; HY 3–5 vs. 0–2.5: HR = 1.46, <i>P</i> = 0.011), but not in men.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Older age at first PD diagnosis and higher disease severity increase PDD risk, but this association is attenuated for PD men when controlling for death. This implies that the most frail PD men die rapidly before receiving a dementia diagnosis, whereas women with PD survive at higher rates, regardless of their age at onset and disease severity. © 2023 The Authors. <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 11","pages":"2041-2052"},"PeriodicalIF":8.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic covariance pattern analysis outperforms visual reading of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy","authors":"Ralph Buchert PhD,&nbsp;Florian Wegner MD,&nbsp;Hans-Jürgen Huppertz MD,&nbsp;Georg Berding MD,&nbsp;Matthias Brendel MD,&nbsp;Ivayla Apostolova MD,&nbsp;Carsten Buhmann MD,&nbsp;Alexander Dierks MD,&nbsp;Sabrina Katzdobler MD,&nbsp;Martin Klietz MD,&nbsp;Johannes Levin MD,&nbsp;Nima Mahmoudi MD,&nbsp;Andreas Rinscheid PhD,&nbsp;Sophia Rogozinski MD,&nbsp;Jost-Julian Rumpf MD,&nbsp;Christine Schneider MD,&nbsp;Sophia Stöcklein MD,&nbsp;Phoebe G. Spetsieris PhD,&nbsp;David Eidelberg MD,&nbsp;Mike P. Wattjes MD, PhD,&nbsp;Osama Sabri MD,&nbsp;Henryk Barthel MD,&nbsp;Günter Höglinger MD,&nbsp;for the Alzheimer's Disease Neuroimaging Initiative","doi":"10.1002/mds.29581","DOIUrl":"https://doi.org/10.1002/mds.29581","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To date, studies on positron emission tomography (PET) with ¹⁸F-fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP-RS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate FDG-PET in a patient sample representing the broad phenotypic PSP spectrum typically encountered in routine clinical practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective, multicenter study included 41 PSP patients, 21 (51%) with RS and 20 (49%) with non-RS variants of PSP (vPSP), and 46 age-matched healthy controls. Two state-of-the art methods for the interpretation of FDG-PET were compared: visual analysis supported by voxel-based statistical testing (five readers) and automatic covariance pattern analysis using a predefined PSP-related pattern.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sensitivity and specificity of the majority visual read for the detection of PSP in the whole cohort were 74% and 72%, respectively. The percentage of false-negative cases was 10% in the PSP-RS subsample and 43% in the vPSP subsample. Automatic covariance pattern analysis provided sensitivity and specificity of 93% and 83% in the whole cohort. The percentage of false-negative cases was 0% in the PSP-RS subsample and 15% in the vPSP subsample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Visual interpretation of FDG-PET supported by voxel-based testing provides good accuracy for the detection of PSP-RS, but only fair sensitivity for vPSP. Automatic covariance pattern analysis outperforms visual interpretation in the detection of PSP-RS, provides clinically useful sensitivity for vPSP, and reduces the rate of false-positive findings. Thus, pattern expression analysis is clinically useful to complement visual reading and voxel-based testing of FDG-PET in suspected PSP. © 2023 The Authors. <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 10","pages":"1901-1913"},"PeriodicalIF":8.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29581","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68179261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Disinhibition Drives Freezing of Gait in Parkinson's Disease and an Exploratory Repetitive Transcranial Magnetic Stimulation Study","authors":"Huimin Sun MD,&nbsp;Caiting Gan MD,&nbsp;Lina Wang MD,&nbsp;Min Ji MSc,&nbsp;Xingyue Cao MSc,&nbsp;Yongsheng Yuan MD,&nbsp;Heng Zhang MSc,&nbsp;Aidi Shan MSc,&nbsp;Mengxi Gao MSc,&nbsp;Kezhong Zhang MD, PhD","doi":"10.1002/mds.29595","DOIUrl":"10.1002/mds.29595","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dysfunction of the primary motor cortex, participating in regulation of posture and gait, is implicated in freezing of gait (FOG) in Parkinson's disease (PD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim was to reveal the mechanisms of “OFF-period” FOG (OFF-FOG) and “levodopa-unresponsive” FOG (ONOFF-FOG) in PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We measured the transcranial magnetic stimulation (TMS) indicators and gait parameters in 21 healthy controls (HCs), 15 PD patients with ONOFF-FOG, 15 PD patients with OFF-FOG, and 15 PD patients without FOG (Non-FOG) in “ON” and “OFF” medication conditions. Difference of TMS indicators in the four groups and two conditions and its correlations with gait parameters were explored. Additionally, we explored the effect of 10 Hz repetitive TMS on gait and TMS indicators in ONOFF-FOG patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In “OFF” condition, short interval intracortical inhibition (SICI) exhibited remarkable attenuation in FOG patients (both ONOFF-FOG and OFF-FOG) compared to Non-FOG patients and HCs. The weakening of SICI correlated with impaired gait characteristics in FOG. However, in “ON” condition, SICI in ONOFF-FOG patients reduced compared to OFF-FOG patients. Pharmacological treatment significantly improved SICI and gait in OFF-FOG patients, and high-frequency repetitive TMS distinctly improved gait in ONOFF-FOG patients, accompanied by enhanced SICI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Motor cortex disinhibition, represented by decreased SICI, is related to FOG in PD. Refractory freezing in ONOFF-FOG patients correlated with the their reduced SICI insensitive to dopaminergic medication. SICI can serve as an indicator of the severity of impaired gait characteristics in FOG and reflect treatments efficacy for FOG in PD patients. © 2023 The Authors. <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 11","pages":"2072-2083"},"PeriodicalIF":8.6,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10115733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar Modulation of Sensorimotor Associative Plasticity Is Impaired in Cervical Dystonia","authors":"Kai Grimm MD,&nbsp;Lisa Prilop MD,&nbsp;Gerhard Schön MSc,&nbsp;Mathias Gelderblom MD,&nbsp;Jonas Misselhorn PhD,&nbsp;Christian Gerloff MD,&nbsp;Simone Zittel MD","doi":"10.1002/mds.29586","DOIUrl":"10.1002/mds.29586","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In recent years, cervical dystonia (CD) has been recognized as a network disorder that involves not only the basal ganglia but other brain regions, such as the primary motor and somatosensory cortex, brainstem, and cerebellum. So far, the role of the cerebellum in the pathophysiology of dystonia is only poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to investigate the role of the cerebellum on sensorimotor associative plasticity in patients with CD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixteen patients with CD and 13 healthy subjects received cerebellar transcranial direct current stimulation (ctDCS) followed by a paired associative stimulation (PAS) protocol based on transcranial magnetic stimulation that induces sensorimotor associative plasticity. Across three sessions the participants received excitatory anodal, inhibitory cathodal, and sham ctDCS in a double-blind crossover design. Before and after the intervention, motor cortical excitability and motor symptom severity were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PAS induced an increase in motor cortical excitability in both healthy control subjects and patients with CD. In healthy subjects this effect was attenuated by both anodal and cathodal ctDCS with a stronger effect of cathodal stimulation. In patients with CD, anodal stimulation suppressed the PAS effect, whereas cathodal stimulation had no influence on PAS. Motor symptom severity was unchanged after the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cerebellar modulation with cathodal ctDCS had no effect on sensorimotor associative plasticity in patients with CD, in contrast with the net inhibitory effect in healthy subjects. This is further evidence that the cerebello-thalamo-cortical network plays a role in the pathophysiology of dystonia. © 2023 The Authors. <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 11","pages":"2084-2093"},"PeriodicalIF":8.6,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10466729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear Imaging Data-Driven Classification of Parkinson's Disease","authors":"Tomoko Totsune MD, PhD,&nbsp;Toru Baba MD, PhD,&nbsp;Yoko Sugimura MD,&nbsp;Hideki Oizumi MD, PhD,&nbsp;Hiroyasu Tanaka MD, PhD,&nbsp;Toshiaki Takahashi MD, PhD,&nbsp;Masaru Yoshioka MD, PhD,&nbsp;Ken-ichi Nagamatsu MD, PhD,&nbsp;Atsushi Takeda MD, PhD","doi":"10.1002/mds.29582","DOIUrl":"10.1002/mds.29582","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder characterized by motor and nonmotor symptoms. Several features have prognostic importance and have been used as key indicators for identifying clinical subtypes. However, the symptom-based classification approach has limitations with respect to the stability of the obtained subtypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> OBJECTIVES</h3>\u0000 \u0000 <p>The purpose of this study was to identify subtypes of PD using nuclear imaging biomarkers targeting the cardiac sympathetic nervous and nigro-striatal systems and to compare patterns of cortical morphological change among obtained subtypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We performed unbiased hierarchical cluster analysis using ¹²³I-metaiodobenzylguanidine cardiac scintigraphy and ¹²³I-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane single photon emission computed tomography data for 56 patients with PD. We compared clinical characteristics and the patterns of cortical atrophy in the obtained clusters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Three clusters were identified and showed distinct characteristics in onset ages and dopamine-replacement therapy and deep brain stimulation requirements. According to the characteristics, clusters were classified into two subtypes, namely, “cardio-cortical impairment (CC)” and “dopaminergic-dominant dysfunction (DD)” subtype. The three clusters were named according to subtype and time since onset in which 14 patients were classified as “early DD,” 25 as “advanced DD,” and 17 as “early CC.” Compared with the early DD subtype, the early CC subtype showed parietal-dominant diffuse cortical atrophy and the advanced DD subtype showed left-side predominant mild cortical atrophy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSIONS</h3>\u0000 \u0000 <p>Nuclear imaging biomarker–based classification can be used to identify clinically and pathologically relevant PD subtypes with distinct disease trajectories. © 2023 International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 11","pages":"2053-2063"},"PeriodicalIF":8.6,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GNAO1 Haploinsufficiency: The Milder End of the GNAO1 Phenotypic Spectrum","authors":"Serena Galosi MD, PhD,&nbsp;Maria Novelli MD,&nbsp;Martina Di Rocco PhD,&nbsp;Elisabetta Flex PhD,&nbsp;Elena Messina PhD,&nbsp;Luca Pollini MD,&nbsp;Elena Parrini PhD,&nbsp;Francesco Pisani MD,&nbsp;Renzo Guerrini MD, FRCP,&nbsp;Vincenzo Leuzzi MD,&nbsp;Simone Martinelli PhD","doi":"10.1002/mds.29585","DOIUrl":"10.1002/mds.29585","url":null,"abstract":"&lt;p&gt;\u0000 &lt;i&gt;GNAO1&lt;/i&gt; variants are typically associated with severe, early-onset movement disorders (MDs) with life-threatening and drug-resistant paroxysmal exacerbations, neurodevelopmental disorders, and epilepsy. Recently, the phenotypic spectrum has broadened to include milder phenotypes with late-onset dystonia, minor cognitive impairment, and other neurological signs, including parkinsonism and myoclonus. &lt;i&gt;GNAO1&lt;/i&gt; haploinsufficiency has been evoked as a putative mechanism underlying milder clinical presentations.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; To date, however, the functional consequences of this class of variants have not yet been evaluated.&lt;/p&gt;&lt;p&gt;We report on an 8-year-old boy with subtle neurological signs, including generalized tonic–clonic seizures during fever, mild language impairment, dystonic postures of lower limbs during walking, and occasional tongue dyskinetic movements (see Data S1 for more details and Video 1). A next generation sequencing–based epilepsy panel revealed a de novo NM_020988.3:c.163_164del variant in &lt;i&gt;GNAO1&lt;/i&gt;. No additional candidate variants were identified. Reverse transcription polymerase chain reaction showed an approximately 50% decrease in the expression of the endogenous &lt;i&gt;GNAO1&lt;/i&gt; gene in cells from the affected child compared with cells from the unaffected father (Figs. 1A and S2), suggesting nonsense-mediated mRNA decay (NMD). If translated, the c.163_164delAT allele was predicted to generate a truncated protein (p.Ile55Hisfs*3). As expected, Western blotting performed in transiently transfected HEK293T cells revealed the lack of the truncated form of Gαo (Fig. 1B), which was not restored by MG132 or bafilomycin treatments, inhibitors of the ubiquitin/proteasome and autophagy pathways, respectively. These findings demonstrate that the c.163_164delAT transcript undergoes NMD, leading to &lt;i&gt;GNAO1&lt;/i&gt; haploinsufficiency.&lt;/p&gt;&lt;p&gt;Genotype/phenotype correlations in &lt;i&gt;GNAO1&lt;/i&gt; encephalopathy are still far from being elucidated. Recent studies suggest that pathogenic variants have a loss-of-function effect on Gαo-mediated signaling,&lt;span&gt;&lt;sup&gt;3-7&lt;/sup&gt;&lt;/span&gt; but the consequences on G-beta-gamma subunit (Gβγ) signaling that regulates cyclic adenosine monophosphate production remain unclear. Emerging data show that haploinsufficiency is associated with milder clinical features and later onset than missense changes underlying developmental and epileptic encephalopathy type 17 (Mendelian inheritance in man [MIM]#615473) or neurodevelopmental disorder with involuntary movements (MIM#617493). This finding has important implications. First, given the different phenotypic output, variants associated with the canonical form of &lt;i&gt;GNAO1&lt;/i&gt; encephalopathy cannot have a simple loss-of-function effect; rather, they behave as dominant-negative alleles or alter Gα/Gβγ association, as recently shown for a subset of changes.&lt;span&gt;&lt;sup&gt;3-7&lt;/sup&gt;&lt;/span&gt; Second, the phenotype associated with &lt;i&gt;GNAO1&lt;/i&gt; haploin","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 12","pages":"2313-2314"},"PeriodicalIF":8.6,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10428473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinsonisms","authors":"","doi":"10.1002/mds.29538","DOIUrl":"https://doi.org/10.1002/mds.29538","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 S1","pages":"S63-S139"},"PeriodicalIF":8.6,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6032666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Movement Disorders and Drug-Induced Movement Disorders","authors":"","doi":"10.1002/mds.29540","DOIUrl":"https://doi.org/10.1002/mds.29540","url":null,"abstract":".","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 S1","pages":"S241-S253"},"PeriodicalIF":8.6,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5803411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology","authors":"","doi":"10.1002/mds.29544","DOIUrl":"https://doi.org/10.1002/mds.29544","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"38 S1","pages":"S522-S586"},"PeriodicalIF":8.6,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6047489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}