Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2025-07-31 DOI:10.1002/mds.30310

Asha Kishore, Rupam Borgohain, Divya Kalikavil Puthenveedu, Roopa Rajan, Pramod Kumar Pal, Rukmini‐Mridula Kandadai, Ravi Yadav, Sahil Mehta, Hrishikesh Kumar, Niraj Kumar, Prashanth Lingappa Kukkle, Soaham Desai, Kuldeep Shetty, Pettarusp Wadia, Annu Aggarwal, Pankaj Ashok Agarwal, Mirza Masoom Abbas, Syam Krishnan, Divya Madathiparambil Radhakrishnan, Gurusidheswar Mahadevappa Wali, Achal Srivastava, Nitish Kamble, Teresa Maria D′ Costa Ferreira, Vivek Lal, Ashwin Ashok Kumar Sreelatha, Luis‐Giraldo Gonzalez‐Ricardo, Manas Chacko, Manu Sharma

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引用次数: 0

Abstract

BackgroundParkinson's disease (PD) phenotype may vary with genetic, ethno‐geographic, cultural, and environmental factors.ObjectivesThe aim was to develop a clinical database of PD in India and assess the influence of age‐at‐onset (AAO), gender, and motor subtype on the clinical profile of PD.MethodsA cross‐sectional study of PD was conducted across 18 Indian hospitals. Standardized assessments were performed by movement disorder specialists. Data were collected using uniform questionnaires during the recruitment visit. A total of 3300 age‐ and gender‐matched case–control pairs were analyzed for environmental exposures, habits, and co‐morbidities.ResultsWe recruited 7918 PD cases with a mean AAO of 54.2 ± 11.8 years and a median disease duration of 5 years (interquartile range: 2–9). Subgroup analyses based on AAO, gender, and motor phenotype revealed significant differences in motor and non‐motor symptoms, exposures, habits, and co‐morbidities. Except coffee consumption, previously known associations were observed for exposure to insecticides/pesticides/fungicides (odds ratio [OR]: 1.67), head injury (OR: 3.11), coffee consumption (OR: 1.73), diabetes (OR: 1.48), hypertension (OR: 1.73), and smoking (OR: 0.74) in the Indian population.ConclusionsThis large pan‐Indian study highlights the clinical characteristics, environmental exposures, habits, and comorbid diseases associated with PD, which were broadly similar to those observed in European populations. The earlier AAO in Indian PD patients suggests a potentially higher genetic risk, warranting further investigation. A nationwide, community‐based, epidemiological study is needed to achieve a comprehensive understanding of all risk factors for PD in India and to validate the risk factors identified in this hospital‐based study. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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印度帕金森病的人口统计学和临床概况：来自全国多中心研究的观察

帕金森病（PD）的表型可能随遗传、民族地理、文化和环境因素而变化。目的：建立印度PD临床数据库，评估发病年龄（AAO）、性别和运动亚型对PD临床特征的影响。方法对印度18家医院进行PD横断面研究。由运动障碍专家进行标准化评估。在招募访问期间使用统一的问卷收集数据。对3300对年龄和性别匹配的病例对照进行了环境暴露、习惯和合并症分析。结果我们招募了7918例PD患者，平均AAO为54.2±11.8年，中位病程为5年（四分位数间距：2-9）。基于AAO、性别和运动表型的亚组分析显示，运动和非运动症状、暴露、习惯和合并症存在显著差异。除咖啡摄入外，先前已知的与杀虫剂/农药/杀菌剂暴露（比值比[OR]: 1.67）、头部损伤（OR: 3.11）、咖啡摄入（OR: 1.73）、糖尿病（OR: 1.48）、高血压（OR: 1.73）和吸烟（OR: 0.74）有关。结论：这项大规模的泛印度研究强调了PD的临床特征、环境暴露、习惯和共病，这些与欧洲人群的观察结果大致相似。印度PD患者早期的AAO提示潜在较高的遗传风险，值得进一步研究。需要开展一项全国性的、以社区为基础的流行病学研究，以全面了解印度PD的所有危险因素，并验证这项以医院为基础的研究中确定的危险因素。©2025作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.