Movement Disorders最新文献

{"title":"Substantiating the Short Burst Duration in Cortical Myoclonus.","authors":"Sterre van der Veen, Amber Maliepaard, Madelein van der Stouwe, Jelle Dalenberg, Inge Tuitert, Jan Willem J Elting, Marina A J Tijssen","doi":"10.1002/mds.29990","DOIUrl":"https://doi.org/10.1002/mds.29990","url":null,"abstract":"<p><strong>Background: </strong>Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown.</p><p><strong>Objective: </strong>This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.</p><p><strong>Methods: </strong>We manually identified the burst duration of 8 patients with CM, confirmed by electromyography-electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-SGCE positive and negative).</p><p><strong>Results: </strong>The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.</p><p><strong>Conclusion: </strong>The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142306806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacsin levels in PBMCs: A diagnostic assay for SACS variants in peripheral blood cells - A PROSPAX study.","authors":"Ceren Tunca, Eylül Ece İşlek Camadan, Natalia Smolina, Robin J Palvadeau, Özgür Öztop Çakmak, Atay Vural, Andreas Traschütz, Filippo M Santorelli, Bernard Brais, Rebecca Schüle, Matthis Synofzik, A Nazlı Başak","doi":"10.1002/mds.30012","DOIUrl":"https://doi.org/10.1002/mds.30012","url":null,"abstract":"<p><strong>Background: </strong>Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a common recessive ataxia that is still underdiagnosed worldwide. An easily accessible diagnostic biomarker might help to diagnostically confirm patients presenting SACS variants of unknown significance (VUS) or atypical phenotypes.</p><p><strong>Objectives: </strong>To detect sacsin in peripheral blood mononuclear cells (PBMCs) and to validate its diagnostic biomarker quality to discriminate biallelic SACS patients (including patients with VUS and/or atypical phenotypes) against healthy controls, non-ARSACS spastic ataxia patients, and heterozygous SACS carriers.</p><p><strong>Methods: </strong>Sacsin protein levels in PBMCs were assessed in patients versus controls and validated in skin-derived fibroblasts.</p><p><strong>Results: </strong>Patients with biallelic SACS variants - including patients with VUS and/or atypical phenotypes - showed loss of sacsin in PBMCs, with discriminative performance against healthy, heterozygous, and non-ARSACS controls. This included all investigated SACS missense variants. Also, C-terminal variants escaping nonsense-mediated decay, while not differing from controls in expression level, showed lower molecular weight in this assay.</p><p><strong>Conclusions: </strong>Assessing sacsin levels using PBMCs offers an easy, peripherally accessible diagnostic biomarker for ARSACS, with PBMCs being much less invasive and easier to handle than fibroblasts. Additionally, this might be a potential target-engagement blood biomarker for sacsin-increasing therapies. © 2024 International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142306805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confirmation of RAB32 Ser71Arg Involvement in Parkinson's Disease.","authors":"Guillaume Cogan, Christelle Tesson, Christine Brefel-Courbon, Aymeric Lanore, Gatepe Cedoine Kodjovi, Lisa Welment, Fabienne Clot, Suzanne Lesage, Alexis Brice","doi":"10.1002/mds.30024","DOIUrl":"https://doi.org/10.1002/mds.30024","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142277685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome.","authors":"David P Vaughan,Riona Fumi,Marte Theilmann Jensen,Megan Hodgson,Tatiana Georgiades,Lesley Wu,Danielle Lux,Ruth Obrocki,Jennifer Lamoureux,Olaf Ansorge,Kieren S J Allinson,Thomas T Warner,Zane Jaunmuktane,Anjum Misbahuddin,P Nigel Leigh,Boyd C P Ghosh,Kailash P Bhatia,Alistair Church,Christopher Kobylecki,Michele T M Hu,James B Rowe,Cornelis Blauwendraat,Huw R Morris,Edwin Jabbari","doi":"10.1002/mds.30019","DOIUrl":"https://doi.org/10.1002/mds.30019","url":null,"abstract":"BACKGROUNDSeed amplification assay (SAA) testing has been developed as a biomarker for the diagnosis of α-synuclein-related neurodegenerative disorders.OBJECTIVEThe objective of this study was to assess the rate of α-synuclein SAA positivity in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) and to analyze clinical and pathological features of SAA-positive and -negative cases.METHODSA total of 96 cerebrospinal fluid samples from clinically diagnosed PSP (n = 59) and CBS (n = 37) cases were analyzed using α-synuclein SAA.RESULTSSix of 59 (10.2%) PSP cases were α-synuclein SAA positive, including one case who was MSA-type positive. An exploratory analysis showed that PSP cases who were Parkinson's disease-type positive were older and had a shorter disease duration compared with SAA-negative cases. In contrast, 11 of 37 (29.7%) CBS cases were α-synuclein SAA positive, including two cases who were MSA-type positive.CONCLUSIONSOur results suggest that α-synuclein seeds can be detected in PSP and CBS using a cerebrospinal fluid α-synuclein SAA, and in PSP this may impact on clinical course. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"213 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAB32 Variants in a German Parkinson's Disease Cohort","authors":"Carolin Gabbert MSc,&nbsp;Cholpon Shambetova MD,&nbsp;Christoph Much,&nbsp;Joanne Trinh PhD,&nbsp;Christine Klein MD","doi":"10.1002/mds.30005","DOIUrl":"10.1002/mds.30005","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"39 11","pages":"2121-2123"},"PeriodicalIF":7.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.30005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Group Cognitive Behavioral Therapy Telehealth Intervention for Functional Movement Disorder.","authors":"Vera N Kulikov,Dodie A Gillett,Carine W Maurer","doi":"10.1002/mds.30021","DOIUrl":"https://doi.org/10.1002/mds.30021","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"197 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights into Freezing of Gait in Parkinson's Disease from Spectral Dynamic Causal Modeling","authors":"Seira Taniguchi PhD,&nbsp;Yuta Kajiyama MD, PhD,&nbsp;Takanori Kochiyama PhD,&nbsp;Gajanan Revankar MBBS, PhD,&nbsp;Kotaro Ogawa MD, PhD,&nbsp;Emi Shirahata MD,&nbsp;Kana Asai MD,&nbsp;Chizu Saeki MD,&nbsp;Tatsuhiko Ozono MD, PhD,&nbsp;Yasuyoshi Kimura MD, PhD,&nbsp;Kensuke Ikenaka MD, PhD,&nbsp;Nicholas D'Cruz PhD,&nbsp;Moran Gilat PhD,&nbsp;Alice Nieuwboer PhD,&nbsp;Hideki Mochizuki MD, PhD","doi":"10.1002/mds.29988","DOIUrl":"10.1002/mds.29988","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Freezing of gait is one of the most disturbing motor symptoms of Parkinson's disease (PD). However, the effective connectivity between key brain hubs that are associated with the pathophysiological mechanism of freezing of gait remains elusive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to identify effective connectivity underlying freezing of gait.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study applied spectral dynamic causal modeling (DCM) of resting-state functional magnetic resonance imaging in dedicated regions of interest determined using a data-driven approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Abnormally increased functional connectivity between the bilateral dorsolateral prefrontal cortex (DLPFC) and the bilateral mesencephalic locomotor region (MLR) was identified in freezers compared with nonfreezers. Subsequently, spectral DCM analysis revealed that increased top-down excitatory effective connectivity from the left DLPFC to bilateral MLR and an independent self-inhibitory connectivity within the left DLPFC in freezers versus nonfreezers (&gt;99% posterior probability) were inversely associated with the severity of freezing of gait. The lateralization of these effective connectivity patterns was not attributable to the initial dopaminergic deficit nor to structural changes in these regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We have identified novel effective connectivity and an independent self-inhibitory connectivity underlying freezing of gait. Our findings imply that modulating the effective connectivity between the left DLPFC and MLR through neurostimulation or other interventions could be a target for reducing freezing of gait in PD. © 2024 The Author(s). <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"39 11","pages":"1982-1992"},"PeriodicalIF":7.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29988","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Magnetic Resonance-Guided Focused Ultrasound Lesion of the Subthalamic Nucleus in Parkinson's Disease: A Prospective Study.","authors":"Laura Armengou-Garcia,Carlos A Sanchez-Catasus,Iciar Aviles-Olmos,Adolfo Jiménez-Huete,Genoveva Montoya-Murillo,Arantza Gorospe,Antonio Martin-Bastida,Lain Hermes Gonzalez-Quarante,Jorge Guridi,Maria C Rodriguez-Oroz","doi":"10.1002/mds.30020","DOIUrl":"https://doi.org/10.1002/mds.30020","url":null,"abstract":"BACKGROUNDUnilateral subthalamic nucleus (STN) ablation using magnetic resonance-guided focused ultrasound (MRgFUS) is being explored as a new treatment for asymmetric Parkinson's disease (PD).OBJECTIVESThe aims were to study the efficacy and safety of this treatment in asymmetric PD patients and to characterize the lesions.METHODSThis prospective, single-center, open-label study evaluated asymmetric PD patients at 6 (n = 20) and 12 months (n = 12) after MRgFUS lesion of the STN. The primary outcome was the change in the Movement Disorders Society-Unified Parkinson's Disease Rating Scale, Part III (MDS-UPDRS III), score in off medication on the treated side and the adverse events (AEs) at 6-month follow-up. We also evaluated cognitive-neuropsychological changes, self-assessment of clinical improvement, and the correlation of the lesion volume with the motor outcomes.RESULTSOn the treated side, the MDS-UPDRS III score (mean difference = 13.8) and the scores in rigidity, bradykinesia, and tremor improved (P < 0.001) throughout the follow-up compared to baseline (at 6 months: rigidity mean difference = 2.8, improvement: 83.5%; bradykinesia mean difference = 6.0, improvement: 69.4%; tremor mean difference = 4.7, improvement: 91.5%). One patient had severe weakness in the treated hemibody, 1 had moderate dyskinesia, and 1 was in moderate confusional state that became mild (weakness) or completely resolved (dyskinesia and confusional state) at 6 months. The rest of the AEs were mild. We observed no clinically relevant changes in cognitive-neuropsychological tests. The percentage of ablation of the STN correlated with the improvement in the total MDS-UPDRS III and contralateral tremor scores (P < 0.05).CONCLUSIONUnilateral MRgFUS lesion of the STN resulted in a significant motor improvement. We observed no persistent severe AEs, although mild, mostly transient AEs were frequent. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"13 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies","authors":"Björn-Hergen Laabs PhD,&nbsp;Katja Lohmann PhD,&nbsp;Eva-Juliane Vollstedt MD,&nbsp;Tobias Reinberger PhD,&nbsp;Lisa-Marie Nuxoll MSc,&nbsp;Gamze Kilic-Berkmen PhD,&nbsp;Joel S. Perlmutter MD,&nbsp;Sebastian Loens MD,&nbsp;Carlos Cruchaga PhD,&nbsp;Andre Franke PhD,&nbsp;Valerija Dobricic PhD,&nbsp;Frauke Hinrichs,&nbsp;Anne Grözinger BSc,&nbsp;Eckart Altenmüller MD,&nbsp;Steven Bellows MD,&nbsp;Sylvia Boesch MD, MSc,&nbsp;Susan B. Bressman MD,&nbsp;Kevin R. Duque MD,&nbsp;Alberto J. Espay MD,&nbsp;Andreas Ferbert MD,&nbsp;Jeanne S. Feuerstein MD,&nbsp;Samuel Frank MD,&nbsp;Thomas Gasser MD,&nbsp;Bernhard Haslinger MD,&nbsp;Robert Jech MD, PhD,&nbsp;Frank Kaiser PhD,&nbsp;Christoph Kamm MD,&nbsp;Katja Kollewe MD,&nbsp;Andrea A. Kühn MD,&nbsp;Mark S. LeDoux MD, PhD,&nbsp;Ebba Lohmann MD,&nbsp;Abhimanyu Mahajan MD, MHS,&nbsp;Alexander Münchau MD,&nbsp;Trisha Multhaupt-Buell MS, CGC,&nbsp;Alexander Pantelyat MD,&nbsp;Sarah E. Pirio Richardson MD,&nbsp;Deborah Raymond MS, CGC,&nbsp;Stephen G. Reich MD,&nbsp;Rachel Saunders Pullman MD, MPH, MSc,&nbsp;Barbara Schormair PhD,&nbsp;Nutan Sharma MD, PhD,&nbsp;Azadeh Hamzehei Sichani MA,&nbsp;Kristina Simonyan MD, PhD, DrMed,&nbsp;Jens Volkmann MD,&nbsp;Aparna Wagle Shukla MD,&nbsp;Juliane Winkelmann MD,&nbsp;Laura J. Wright MA,&nbsp;Michael Zech MD,&nbsp;Kirsten E. Zeuner MD,&nbsp;Simone Zittel MD,&nbsp;Meike Kasten MD,&nbsp;Yan V. Sun PhD,&nbsp;Tobias Bäumer MD,&nbsp;Norbert Brüggemann MD,&nbsp;Laurie J. Ozelius PhD,&nbsp;Hyder A. Jinnah MD, PhD,&nbsp;Christine Klein MD,&nbsp;Inke R. König PhD","doi":"10.1002/mds.29968","DOIUrl":"10.1002/mds.29968","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite considerable heritability, previous smaller genome-wide association studies (GWASs) have not identified any robust genetic risk factors for isolated dystonia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to perform a large-scale GWAS in a well-characterized, multicenter sample of &gt;6000 individuals to identify genetic risk factors for isolated dystonia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Array-based GWASs were performed on autosomes for 4303 dystonia participants and 2362 healthy control subjects of European ancestry with subgroup analysis based on age at onset, affected body regions, and a newly developed clinical score. Another 736 individuals were used for validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This GWAS identified no common genome-wide significant loci that could be replicated despite sufficient power to detect meaningful effects. Power analyses imply that the effects of individual variants are likely very small.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Moderate single-nucleotide polymorphism–based heritability indicates that common variants do not contribute to isolated dystonia in this cohort. Sequence-based GWASs (eg, by whole-genome sequencing) might help to better understand the genetic basis. © 2024 The Author(s). <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"39 11","pages":"2110-2116"},"PeriodicalIF":7.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Clarity in Tremor Network Gene Expression Analysis","authors":"Ting Yu MD,&nbsp;Dan Shan MSc,&nbsp;Dong Chen MD","doi":"10.1002/mds.29974","DOIUrl":"10.1002/mds.29974","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"39 9","pages":"1655-1656"},"PeriodicalIF":7.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}