Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2025-08-21 DOI:10.1002/mds.70016

Aline Delva, Cinzia Zatti, Amélie Pelletier, Jacques Montplaisir, Jean‐François Gagnon, Gwendlyn Kollmorgen, Tony Kam‐Thong, Thomas Kustermann, Venissa Machado, Ronald B. Postuma

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引用次数: 0

Abstract

BackgroundPlasma biomarkers of neurodegeneration, astrogliosis, and neuroinflammation have been studied as potential biomarkers in neurodegenerative diseases. This study investigated whether these markers may predict phenoconversion to Parkinson's disease or dementia with Lewy bodies (DLB) in idiopathic/isolated REM sleep behavior disorder (iRBD).MethodsIn this longitudinal, single‐center, iRBD cohort study (enrolled 2004–2022), plasma glial fibrillary acidic protein (GFAP), interleukin‐6 (IL‐6), neurofilament light chain (NfL), snare‐associated protein 25 (SNAP25), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), and chitinase 3‐like protein (YKL‐40) were measured using NeuroToolKit (Roche Diagnostics International Ltd). Associations between baseline plasma biomarkers and eventual development of manifest synucleinopathy during follow‐up (up to 11 years) were assessed.ResultsA total of 143 iRBD participants (110 male, 67.7 ± 8.0 years) were included. Compared with non‐phenoconverters, DLB‐converters had higher baseline GFAP (0.115 vs. 0.071 ng/ml, P = 0.002) and NfL (3.55 vs. 2.51 pg/ml, P = 0.010). Baseline levels predicted DLB using non‐phenoconverters without mild cognitive impairment as reference with area under the curve (AUC) = 0.79 for GFAP and 0.84 for NfL.ConclusionHigher plasma GFAP and NfL were associated with increased risk of developing DLB in prodromal synucleinopathies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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特发性/孤立性快速眼动睡眠行为障碍（iRBD）中星形细胞和轴突完整性的血浆标志物作为路易体痴呆的预测因子

神经退行性疾病、星形胶质细胞增生和神经炎症的血浆生物标志物已被研究作为神经退行性疾病的潜在生物标志物。本研究探讨了这些标志物是否可以预测特发性/孤立性快速眼动睡眠行为障碍（iRBD）患者向帕金森病或路易体痴呆（DLB）的表型转化。方法在这项研究中，使用NeuroToolKit（罗氏诊断国际有限公司）测量了血浆胶质纤维酸性蛋白（GFAP）、白细胞介素- 6 （IL - 6）、神经丝轻链（NfL）、陷阱相关蛋白25 （SNAP25）、髓样细胞表达的可溶性触发受体2 （sTREM2）和几次质酶3样蛋白（YKL - 40）。基线血浆生物标志物与随访期间（长达11年）明显突触核蛋白病的最终发展之间的关系进行了评估。结果共纳入iRBD受试者143例，其中男性110例，年龄67.7±8.0岁。与非表型转化者相比，DLB转化者的基线GFAP （0.115 vs. 0.071 ng/ml, P = 0.002）和NfL （3.55 vs. 2.51 pg/ml, P = 0.010）更高。基线水平预测无轻度认知障碍的非表型转换者的DLB， GFAP的曲线下面积(AUC) = 0.79， NfL为0.84。结论血浆GFAP和NfL升高与前驱突触核蛋白病发生DLB的风险增加有关。©2025作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.