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Monomeric C-reactive protein as a therapeutic target in inflammatory diseases. 单核c反应蛋白作为炎症性疾病的治疗靶点。
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-15 DOI: 10.1136/rmdopen-2024-005379
Chitose Fujita, Yasuo Sakurai, Yuki Yasuda, Masaaki Fujita
{"title":"Monomeric C-reactive protein as a therapeutic target in inflammatory diseases.","authors":"Chitose Fujita, Yasuo Sakurai, Yuki Yasuda, Masaaki Fujita","doi":"10.1136/rmdopen-2024-005379","DOIUrl":"10.1136/rmdopen-2024-005379","url":null,"abstract":"","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12530421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topography of entheseal lesions on ultrasound: a comparative study between axial spondyloarthritis, psoriatic arthritis and healthy controls. 轴型脊柱炎、银屑病关节炎与健康对照的超声地形图比较研究。
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-15 DOI: 10.1136/rmdopen-2025-006088
Gehad G Elsehrawy, Delphine S Courvoisier, Erik Deman, Diana Dan, Raphael Micheroli, Pascal Zufferey, Laure Brulhart, Michael J Nissen
{"title":"Topography of entheseal lesions on ultrasound: a comparative study between axial spondyloarthritis, psoriatic arthritis and healthy controls.","authors":"Gehad G Elsehrawy, Delphine S Courvoisier, Erik Deman, Diana Dan, Raphael Micheroli, Pascal Zufferey, Laure Brulhart, Michael J Nissen","doi":"10.1136/rmdopen-2025-006088","DOIUrl":"10.1136/rmdopen-2025-006088","url":null,"abstract":"<p><strong>Objectives: </strong>To determine which anatomical sites and which ultrasonographic entheseal lesions are best able to discriminate between spondyloarthritis (SpA) patients and healthy controls (HC).</p><p><strong>Methods: </strong>We included patients with psoriatic arthritis (PsA) and axial SpA (axSpA), from six Swiss hospital outpatient clinics, as well as HC. Participants completed quality of life and physical activity questionnaires and underwent a clinical examination of both joints and entheses, followed by a detailed musculoskeletal ultrasound examination including nine entheseal sites bilaterally. Entheses were scored according to the Outcome Measures in Rheumatology criteria, with an additional evaluation of bursae and power Doppler (PD) in the 2-5 mm zone.</p><p><strong>Results: </strong>Overall, 121 participants were included, including 41 with PsA (mean age in years (SD), percentage male: 54.5±11.0, 63.4%), 39 with axSpA (45.1±10.0, 51.3%) and 41 HC (43.9±10.9, 56.1%), with a total of 2178 entheses evaluated. The PsA and axSpA groups showed no significant differences regarding inflammatory markers or disease activity scores.In the univariable analysis, all ultrasonographic lesions at the enthesis showed a significant association with SpA vs HC. Only B-mode inflammatory lesions (OR=1.38, p=0.034) and active enthesitis (OR=4.45, p=0.030) retained this association in multivariable analyses. While 4/9 entheses were associated with SpA in univariable analyses, only the distal patellar ligament insertion remained significantly associated with SpA (OR=1.74, p=0.039) in multivariable analyses.</p><p><strong>Conclusion: </strong>To distinguish SpA patients from controls, the sonographic scoring system used should account not only for the presence of specific entheseal lesions (structural and inflammatory) but also for the individual site affected.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12530400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis. 针对系统性硬化症患者血管紧张素II型1受体和内皮素1型A受体的自身抗体
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-15 DOI: 10.1136/rmdopen-2025-005787
Katherine E van der Wouden, Saad Ahmed, Wieke M van Oostveen, Eva M Hoekstra, Sophie I E Liem, Tom W J Huizinga, René E M Toes, Alexandre E Voskuyl, Gabriela Riemekasten, Cynthia M Fehres, Madelon Vonk, Jeska K de Vries-Bouwstra
{"title":"Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis.","authors":"Katherine E van der Wouden, Saad Ahmed, Wieke M van Oostveen, Eva M Hoekstra, Sophie I E Liem, Tom W J Huizinga, René E M Toes, Alexandre E Voskuyl, Gabriela Riemekasten, Cynthia M Fehres, Madelon Vonk, Jeska K de Vries-Bouwstra","doi":"10.1136/rmdopen-2025-005787","DOIUrl":"10.1136/rmdopen-2025-005787","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the clinical applicability of autoantibodies (AAbs) measured by ELISA against the angiotensin II type 1 receptor (AT<sub>1</sub>R) and endothelin-1 type A receptor (ET<sub>A</sub>R) in systemic sclerosis (SSc) patients.</p><p><strong>Methods: </strong>Serum samples from n=279 SSc patients from the Leiden Systemic Sclerosis cohort, n=42 patients with primary Raynaud's phenomenon, n=24 patients with rheumatoid arthritis and n=20 healthy controls were tested for anti-AT<sub>1</sub>R- and anti-ET<sub>A</sub>R AAbs. Levels were compared between groups with Mann-Whitney U tests or Kruskal-Wallis tests. Risk ratios and Kaplan-Meier analyses were used to determine associations between AAbs and disease manifestations or all-cause mortality. Analyses were repeated in an independent cohort with n=310 SSc patients from the Radboud University Medical Center.</p><p><strong>Results: </strong>AAbs against AT<sub>1</sub>R and ET<sub>A</sub>R could be detected by ELISA in the sera of all groups tested. Levels were slightly higher in the SSc group compared with the pooled non-SSc group (p=0.043). No associations could be found between anti-AT<sub>1</sub>R AAbs or anti-ET<sub>A</sub>R AAbs and disease manifestations or all-cause mortality. In the Radboud cohort, patients with diffuse cutaneous SSc (p=0.001) and interstitial lung disease (p=0.007) had higher median anti-ET<sub>A</sub>R AAb levels. Patients who died during follow-up had lower levels of anti-AT<sub>1</sub>R- (p=0.005) and anti-ET<sub>A</sub>R AAbs (p=0.020).</p><p><strong>Conclusions: </strong>We confirm positive ELISAs for anti-AT<sub>1</sub>R AAbs and anti-ET<sub>A</sub>R AAbs in the sera of several patient groups and healthy controls. Previously described associations with disease manifestations and all-cause mortality could not be confirmed in our cohorts. Based on the current study, the determination of these AAbs is of limited predictive value in clinical practice.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12530366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rheumatic and musculoskeletal disorders in musicians: risks, adaptations and management. 音乐家的风湿病和肌肉骨骼疾病:风险、适应和管理。
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-13 DOI: 10.1136/rmdopen-2025-006149
Lou Autret, Émilie Shipley, Brice Lodde, Andrea Hinojosa-Azaola, Alain Saraux
{"title":"Rheumatic and musculoskeletal disorders in musicians: risks, adaptations and management.","authors":"Lou Autret, Émilie Shipley, Brice Lodde, Andrea Hinojosa-Azaola, Alain Saraux","doi":"10.1136/rmdopen-2025-006149","DOIUrl":"10.1136/rmdopen-2025-006149","url":null,"abstract":"<p><p>Music therapy is recognised as a complementary or alternative therapy for osteoarthritis and fibromyalgia, but playing music can have health repercussions for musicians in the field of rheumatology.Limited articles exist on artists developing rheumatic diseases before 1900, possibly due to underestimation, poor understanding or a lack of awareness. Conditions like Marfan syndrome may confer hypermobility-enhancing virtuosity, as seen in Paganini and Rachmaninov.Among contemporary musicians, Edith Piaf, Lady Gaga, Selena Gomez and Céline Dion suffered from rheumatic diseases, and it was true obstacles for their careers.Repetitive movements, inadequate posture and instrument-specific physical demands contribute to musculoskeletal disorders in musicians, particularly tendinopathies and entrapment syndromes affecting the upper limbs. These conditions result in chronic pain, reduced mobility and performance decline. String and wind instrument players face heightened vulnerability due to the unique constraints of their instruments.Given the longevity of musical careers compared with athletic ones, specialised medical management and targeted prevention strategies are crucial. Minimising the impact of these conditions is paramount to ensuring musicians can maintain optimal performance and extend their careers under the best possible conditions, enabling a preventive approach, follow-up and specialised care for as long as needed. Therefore, further exploration of rheumatic diseases in musicians is warranted, particularly with an emphasis on the evolution of medical knowledge and clinical practices. These pathologies are complex and require specific treatment. Some European health professionals and musicians are training in the practice of 'arts medicine'.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-validation and sensitivity to change of EULAR ScleroID as a measure of function and impact of disease in patients with systemic sclerosis. 作为系统性硬化症患者功能和疾病影响衡量指标的EULAR硬化改变的交叉验证和敏感性
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-10 DOI: 10.1136/rmdopen-2025-005999
Seda Yurumez Colak, Stefano Di Donato, Riccardo Bixio, Lesley-Anne Bissell, Theresa Barnes, Muhammad Nisar, Vishal Kakkar, Chris Denton, Francesco Del Galdo
{"title":"Cross-validation and sensitivity to change of EULAR ScleroID as a measure of function and impact of disease in patients with systemic sclerosis.","authors":"Seda Yurumez Colak, Stefano Di Donato, Riccardo Bixio, Lesley-Anne Bissell, Theresa Barnes, Muhammad Nisar, Vishal Kakkar, Chris Denton, Francesco Del Galdo","doi":"10.1136/rmdopen-2025-005999","DOIUrl":"10.1136/rmdopen-2025-005999","url":null,"abstract":"<p><strong>Objective: </strong>To determine the distribution of the EULAR SSc Impact of Disease (ScleroID) and its domain questions in very early (Ve), limited (lc) and diffuse cutaneous (dc) subsets, its value in reflecting clinical severity, and to assess its sensitivity to change and minimal clinically important difference (MCID) in a 12-month interval.</p><p><strong>Methods: </strong>Patients with ScleroID questionnaires from the observational cohort STRIKE were included in the study. Changes (Δ) were calculated as the difference between 12-month follow-up and compared MCIDs of the other measures.</p><p><strong>Results: </strong>Data were available for 271 patients, 69 with Ve, 139 lc and 63 dc systemic sclerosis (SSc). Median (IQR) ScleroID scores were progressively higher in the 3 subsets with 2.1 (3.6) for VeSSc, 3.4 (4.4) for lcSSc and 4.7 (4) for dcSSc (p<0.001). ScleroID showed strong content validity against clinical measures. Patients with high disease activity had significantly higher ScleroID scores than low ones (p=0.003). Presence of digital ulcers, pulmonary disease or small intestinal bacterial overgrowth was all reflected in higher scores in their relative domains (p<0.005 for all). Accordingly, ScleroID scores and its relative domains showed high correlations with all other patient-reported outcomes (PROs) (p<0.05). Changes in ScleroID strongly correlated with changes in clinical measures and other PROs with specific thresholds identified for MCID changes in Health Assessment Questionnaire Disability Index, the University of California Los Angeles Scleroderma Clinical Trials Consortium gastrointestinal tract 2.0 and Cochin Hand Function Scale.</p><p><strong>Conclusion: </strong>ScleroID demonstrates strong correlation with validated clinical measures and responsiveness to changes in standard of care, supporting its use in both clinical practice and trials. ScleroID captures the multidimensional burden of SSc regardless of disease subsets.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Distribution of nailfold videocapillaroscopy parameters in systemic lupus erythematosus and their association with disease activity: an international blinded case-control analysis on behalf of the EULAR study group on microcirculation in rheumatic diseasesEffectiveness of ixekizumab in 709 real-world patients with axial spondyloarthritis and psoriatic arthritis: a nationwide cohort study. 修正:系统性红斑狼疮患者甲折视频毛细血管镜参数的分布及其与疾病活动性的关联:代表EULAR风湿病微循环研究组的一项国际盲法病例对照分析。ixekizumab在709例真实世界的轴性脊柱炎和银屑病关节炎患者中的有效性:一项全国性队列研究。
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-09 DOI: 10.1136/rmdopen-2025-005772corr1
{"title":"Correction: Distribution of nailfold videocapillaroscopy parameters in systemic lupus erythematosus and their association with disease activity: an international blinded case-control analysis on behalf of the EULAR study group on microcirculation in rheumatic diseasesEffectiveness of ixekizumab in 709 real-world patients with axial spondyloarthritis and psoriatic arthritis: a nationwide cohort study.","authors":"","doi":"10.1136/rmdopen-2025-005772corr1","DOIUrl":"10.1136/rmdopen-2025-005772corr1","url":null,"abstract":"","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Hydroxychloroquine and pregnancy outcomes in patients with anti-phospholipid syndrome: a systematic review and meta-analysis. 更正:羟氯喹与抗磷脂综合征患者妊娠结局:一项系统回顾和荟萃分析。
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-09 DOI: 10.1136/rmdopen-2025-005825corr1
{"title":"Correction: Hydroxychloroquine and pregnancy outcomes in patients with anti-phospholipid syndrome: a systematic review and meta-analysis.","authors":"","doi":"10.1136/rmdopen-2025-005825corr1","DOIUrl":"10.1136/rmdopen-2025-005825corr1","url":null,"abstract":"","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the clinical and genetic impact of neuropsychiatric involvement in systemic lupus erythematosus. 揭示系统性红斑狼疮中神经精神疾病的临床和遗传影响。
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-07 DOI: 10.1136/rmdopen-2025-006033
Soojin Cha, Ga Young Ahn, Kwangwoo Kim, Hye-Soon Lee, Sang-Cheol Bae, So-Young Bang
{"title":"Unveiling the clinical and genetic impact of neuropsychiatric involvement in systemic lupus erythematosus.","authors":"Soojin Cha, Ga Young Ahn, Kwangwoo Kim, Hye-Soon Lee, Sang-Cheol Bae, So-Young Bang","doi":"10.1136/rmdopen-2025-006033","DOIUrl":"10.1136/rmdopen-2025-006033","url":null,"abstract":"<p><strong>Objectives: </strong>Despite the clinical significance of neuropsychiatric systemic lupus erythematosus (NPSLE), which is a severe complication of SLE, clinical and genetic studies on NPSLE remain limited. This study aimed to identify the clinical features of NPSLE and explore genetic factors associated with NPSLE in a prospective lupus cohort.</p><p><strong>Methods: </strong>The clinical features, disease activity and organ damage of 1205 Korean patients with SLE were assessed at least annually, and genome-wide genotyping with imputation was performed. The clinical and genetic associations of NPSLE, excluding minor events, and its specific subsets (seizure or psychosis) compared with those of non-NPSLE were analysed using genome-wide association studies (GWASs). The biological relevance of the identified loci was investigated through functional analyses.</p><p><strong>Results: </strong>A total of 271 patients with NPSLE exhibited more clinically diverse manifestations (p=2.40×10<sup>-4</sup>), especially in patients with seizure (N=84, p=4.86×10<sup>-14</sup>) and psychosis (N=26, p=8.29×10<sup>-5</sup>), compared with 934 patients with non-NPSLE. Notably, NPSLE patients significantly had greater organ damage (total Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score: OR 1.49, p=3.28×10<sup>-17</sup>; non-NP SDI score: OR 1.22, p=7.61×10<sup>-5</sup>) than patients with non-NPSLE, adjusting for age, sex, hypertension, disease duration and antiphospholipid antibodies. GWAS revealed nine NPSLE-associated loci at a suggestive significance level (p<5×10⁻⁶). The nine nearest mapped genes were exclusively expressed in the brain (adjusted p=5.28×10<sup>-4</sup>), particularly in the basal ganglia, cortex and hippocampus (adjusted p<0.05).</p><p><strong>Conclusions: </strong>Neuropsychiatric involvement in SLE increases clinical manifestations and extends organ damage beyond the nervous system, with NPSLE-related genetic variants highlighting their potential functional roles in various brain regions.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seventeen-year reassessment of diagnostic transitions, biologic therapy initiation and mortality in spondyloarthritis: results from the REGISPON-3 study. 17年对脊椎关节炎的诊断转变、生物治疗开始和死亡率的重新评估:来自REGISPON-3研究的结果
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-05 DOI: 10.1136/rmdopen-2025-006031
María Ángeles Puche-Larrubia, Lourdes Ladehesa-Pineda, María Carmen Ábalos-Aguilera, Desirée Ruiz-Vílchez, Laura Berbel-Arcobé, Xavier Juanola-Roura, Marta Arévalo-Salaet, Mireia Moreno, Raquel Almodóvar-González, Cristina Pijoan-Moratalla, Beatriz Joven-Ibáñez, Marta Valero-Expósito, Verónica García-García, Manuel Moreno-Ramos, Enrique Ornilla, Raquel Ena María Granados, Diana Maria Margareta Moldovan, Carlos M Collantes-Sánchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estévez, Clementina López-Medina
{"title":"Seventeen-year reassessment of diagnostic transitions, biologic therapy initiation and mortality in spondyloarthritis: results from the REGISPON-3 study.","authors":"María Ángeles Puche-Larrubia, Lourdes Ladehesa-Pineda, María Carmen Ábalos-Aguilera, Desirée Ruiz-Vílchez, Laura Berbel-Arcobé, Xavier Juanola-Roura, Marta Arévalo-Salaet, Mireia Moreno, Raquel Almodóvar-González, Cristina Pijoan-Moratalla, Beatriz Joven-Ibáñez, Marta Valero-Expósito, Verónica García-García, Manuel Moreno-Ramos, Enrique Ornilla, Raquel Ena María Granados, Diana Maria Margareta Moldovan, Carlos M Collantes-Sánchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estévez, Clementina López-Medina","doi":"10.1136/rmdopen-2025-006031","DOIUrl":"10.1136/rmdopen-2025-006031","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate disease evolution, diagnostic transitions, time to biologic treatment initiation and mortality in patients with spondyloarthritis (SpA) after 17 years from the original Spanish Registry of Spondyloarthritis (REGISPONSER).</p><p><strong>Methods: </strong>Spondyloarthritis Registry 3 (REGISPON-3) is a two-timepoint longitudinal study with patients fulfilling the European Spondyloarthropathy Study Group criteria participating in the REGISPONSER study and re-evaluated after 17 years. Clinical, laboratory, radiological and treatment data were collected and compared with baseline. Diagnostic changes according to the rheumatologist's judgement and their associated factors were analysed using multivariable logistic regression. Time to initiation of biologic therapy was evaluated using Kaplan-Meier survival analysis.</p><p><strong>Results: </strong>A total of 536 patients from the REGISPONSER study conducted in 2004 were contacted in 2021 for the REGISPON-3 visit. Of these, 411 were physically re-evaluated, while 125 were confirmed deceased. Among the 411 patients, 31.6% experienced a change in diagnosis in the REGISPON-3 visit, mainly from undifferentiated SpA to axial SpA or psoriatic arthritis. In multivariable analysis, dactylitis, younger age and lower Bath Ankylosing Spondylitis Radiology Index scores were associated with diagnostic change. The use of biologic disease-modifying antirheumatic drugs (bDMARDs) increased from 13.1% to 52.1%. However, the median time to first bDMARD from symptom onset was 32 years (95% CI 30 to 35) and 28 years from diagnosis (95% CI 26 to 32). Among the 125 patients who died, the leading causes were infections (21.6%), cardiovascular (CV) events (20.0%) and cancer (19.2%).</p><p><strong>Conclusions: </strong>This long-term reassessment reveals significant diagnostic changes in SpA and a mortality burden mainly attributed to infections and CV diseases.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 4","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preterm birth in women with psoriatic arthritis: what are the risks and risk factors? A collaborative cohort study from Sweden, Denmark and Norway. 银屑病关节炎妇女早产的危险和危险因素是什么?一项来自瑞典,丹麦和挪威的合作队列研究。
IF 4.7 2区 医学
RMD Open Pub Date : 2025-10-05 DOI: 10.1136/rmdopen-2025-005614
Anne Emilie Pape Secher, Fredrik Granath, Katarina Remaeus, Bente Glintborg, Ane Lilleøre Rom, Brigitte Michelsen, Merete Lund Hetland, Karin Hellgren
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