局限性和弥漫性皮肤系统性硬化症甲襞毛细血管镜检查差异的详细分析。

IF 4.7 2区 医学 Q1 RHEUMATOLOGY
Ana Margarida Correia, Rosanna Campitiello, Carmen Pizzorni, Emanuele Gotelli, Alberto Sulli, Sabrina Paolino, Vanessa Smith, Maurizio Cutolo
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引用次数: 0

摘要

目的:探讨和区分局限性(lcSSc)和弥漫性(dcSSc)皮肤系统性硬化症(SSc)患者甲襞视频毛细血管镜(NVC)的详细表现。方法:共招募157例患者,其中lcSSc 100例,dcSSc 27例,原发性雷诺现象(pRP) 30例。在第一次NVC分析中进行了NVC SSc模式和毛细血管的绝对数量(每线性毫米)。对“早期”/“活跃”NVC状态(毛细血管扩张、微出血和巨毛细血管)和“晚期”NVC状态(毛细血管数量、微血管结构改变和毛细血管形状异常)进行评分。结果:lcSSc、dcSSc和pRP患者的毛细血管绝对数量差异有统计学意义(p)。结论:本研究强调了NVC详细分析和评分对区分lcSSc和dcSSc微血管损伤严重程度的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differences in nailfold capillaroscopy findings between limited and diffuse cutaneous systemic sclerosis: a detailed analysis.

Objective: To investigate and distinguish detailed nailfold videocapillaroscopy (NVC) findings in patients with limited (lcSSc) and diffuse (dcSSc) cutaneous systemic sclerosis (SSc).

Methods: A total of 157 patients was recruited, 100 with lcSSc, 27 with dcSSc and 30 with primary Raynaud phenomenon (pRP). The NVC SSc pattern and the absolute number of capillaries (per linear millimetre) were performed at the first NVC analysis. 'Early'/'Active' NVC status (capillary dilations, microhaemorrhages and giant capillaries) and 'Late' NVC status (number of capillaries, altered microvascular architecture and abnormal capillary shapes) were scored.

Results: A statistically significant difference in the absolute number of capillaries between patients with lcSSc, dcSSc and pRP was found (p<0.001). Capillary number loss was present in both SSc subgroups and it was significantly higher in patients with dcSSc compared with lcSSc (4.89±1.53 vs 6.18±1.75, p<0.001). A significantly higher 'Late' NVC status score was observed in patients with dcSSc (p<0.001), including lower capillary density (p<0.001), altered shapes (p<0.001) and presence of abnormal shapes (p=0.005). Correlations showed that higher modified Rodnan Skin Score is associated with decreased capillary number and higher 'Late' NVC status score (p<0.001). Additionally, a statistically significant association was established between 'Late' SSc pattern and dcSSc (p=0.004) and between 'Early' SSc pattern and lcSSc (p=0.010). The absolute capillary number was normal and significantly higher in patients with pRP (p<0.001) than in all patients with SSc.

Conclusions: The current investigation underlines the importance of NVC detailed analysis and scoring in discriminating the severity of microvascular damage between lcSSc and dcSSc.

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来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
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