RMD Open最新文献

{"title":"When generative artificial intelligence answers to Google Trends about spondyloarthritis: what does a French expert panel think about it?","authors":"Frank Verhoeven, Olivier Fakih, Corinne Miceli-Richard, Thao Pham, Hubert Marotte, Philippe Goupille, Renaud Felten, Maxime Breban, Thierry Lequerre, Adeline Ryussen-Witrand, Anne Tournadre, Laura Pina Vegas, Pascal Claudepierre, Athan Baillet, Damien Loeuille, Félicie Costantino, Cédric Lukas, Emmanuelle Dernis, Daniel Wendling, Clement Prati","doi":"10.1136/rmdopen-2025-005727","DOIUrl":"https://doi.org/10.1136/rmdopen-2025-005727","url":null,"abstract":"","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of the 6 min walk test in detecting cardiopulmonary involvement in patients with systemic sclerosis.","authors":"Saad Ahmed, Sophie I E Liem, Jacopo Ciaffi, Eva M Hoekstra, A A Schouffoer, Sytske Anne Bergstra, D Ueckert, Maarten Ninaber, Cosimo Bruni, Suzana Jordan, Oliver Distler, Tom Wj Huizinga, Hubert Vliegen, Jeska De Vries-Bouwstra","doi":"10.1136/rmdopen-2024-005154","DOIUrl":"10.1136/rmdopen-2024-005154","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiopulmonary involvement (CPI) is a major cause of morbidity and mortality in systemic sclerosis (SSc). The 6 min walk test (6MWT) is widely used to assess functional capacity, but its ability to detect incident CPI remains uncertain. This study aimed to evaluate the determinants and trajectory of 6MWT parameters over time and its diagnostic utility in identifying incident CPI in SSc.</p><p><strong>Methods: </strong>Two large prospective SSc cohorts were analysed. Multivariable regression identified factors associated with baseline 6MWT parameters. Longitudinal changes were assessed using linear mixed models, and diagnostic accuracy for incident CPI was evaluated using predefined thresholds for a decline in 6 min walking distance (6MWD) (≥33 m) and oxygen desaturation (<95%).</p><p><strong>Results: </strong>Patients with CPI walked 89 m less than those without (95% CI -116 to 61) and exercise-induced desaturation was more frequent in CPI (OR 17.0, 95% CI 8.7 to 33). Over time, 6MWD increased slightly by 3.0 m per year (95% CI 1.7 to 4.3). Linear mixed model analysis showed an independent association of 6MWD (-33 m, 95% CI -45 to 21) and occurrence of exercise-induced desaturation (OR 15, 95% CI 8.5 to 30) in patients with CPI. A ≥33 m decline in 6MWD had 34.7% sensitivity and 79% specificity for detecting incident CPI, while new desaturation had 10.6% sensitivity and 92.6% specificity.</p><p><strong>Conclusion: </strong>6MWT parameters are associated with CPI in SSc. A stable 6MWD and absence of desaturation may help rule out CPI, but their low sensitivity suggests that 6MWT alone is insufficient for screening and should be complemented by additional diagnostic modalities.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement properties of disease activity instruments in peripheral spondyloarthritis: a post-hoc analysis of the CRESPA trial.","authors":"Clementina López-Medina, Dafne Capelusnik, Casper Webers, Filip Van den Bosch, Annelies Boonen, Philippe Carron, Anna Molto, Sofia Ramiro","doi":"10.1136/rmdopen-2025-005525","DOIUrl":"10.1136/rmdopen-2025-005525","url":null,"abstract":"<p><strong>Background: </strong>Unravelling the performance of disease activity measures in peripheral spondyloarthritis (pSpA) is crucial for the development of clinical studies. We aimed to evaluate the construct validity and discriminatory capacity of various instruments assessing disease activity and response criteria in patients with pSpA.</p><p><strong>Methods: </strong>Post-hoc analysis of the CRESPA randomised controlled trial including patients with early active pSpA. Patients were randomised to golimumab (GOL) or placebo (PBO). Data of the placebo-controlled part until week 12 were used. Construct validity (known group discrimination assessed with standardised mean difference, SMD) in the 12-week data, longitudinal construct validity (ie, standardised response mean and effect size) and trial discrimination (SMD) of several disease activity instruments were assessed. As part of trial discrimination, a χ² test was performed for binary outcomes.</p><p><strong>Results: </strong>A total of 60 patients (40 GOL, 20 PBO) were included. Construct validity was better for composite outcomes (ie, Disease Activity in Psoriatic Arthritis (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Axial Spondyloarthritis Disease Activity Score (ASDAS)-higher SMD between active and inactive patients). Longitudinal construct validity was consistently good for composite outcomes (eg, ASDAS, DAPSA) and global assessments (Patient Global Assessment (PGA), Physician Global Assessment (PhGA)). Clinical trial discrimination was good for composites (BASDAI, ASDAS, DAPSA), global assessments (PGA, PhGA) and joint counts (swollen joint count (SJC66) and tender joint count (TJC68)).Among binary outcomes, trial discrimination was strongest for clinical remission (ie, absence of arthritis, enthesitis and dactylitis), BASDAI50, DAPSA-Low Disease Activity (LDA) and ASDAS-LDA.</p><p><strong>Conclusion: </strong>While both composite and global outcome measurement instruments performed well in pSpA, composite scores like DAPSA, ASDAS and BASDAI showed better construct validity. The clinical remission definition was the most discriminatory response criterion.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of lipopolysaccharides in the joint: fibronectin as a novel protective mechanism.","authors":"Kajetana Bevc, Shipin Zhang, Andres Pazos-Perez, Ana Alonso-Perez, David Fercher, Sami Kauppinen, Tuomas Frondelius, Valentino Bruhin, Gian Salzmann, Thomas Rauer, Hans-Christoph Pape, Mikko Arttu Jalmari Finnilä, Caroline Ospelt, Rodolfo Gomez, Kari K Eklund, Marcy Zenobi Wong, Goncalo Barreto","doi":"10.1136/rmdopen-2025-005622","DOIUrl":"10.1136/rmdopen-2025-005622","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the presence and bioactivity of lipopolysaccharides (LPS) in synovial fluid (SF) of osteoarthritis (OA) patients and elucidate mechanisms modulating their inflammatory potential.</p><p><strong>Methods: </strong>SF samples from 56 OA, 7 rheumatoid arthritis and 39 trauma patients were analysed for LPS concentration and bioactivity. Lipid A composition was assessed using liquid chromatography-mass spectrometry (LC-MS). In a rat model, LPS was administered systemically for 32 days to evaluate its impact on joint degeneration. The interaction between LPS and synovial proteins, particularly fibronectin (Fn), was examined through in vitro assays and a 3D synovial membrane model.</p><p><strong>Results: </strong>LPS was detected in all SF samples with comparable concentrations and lipid A profiles across all groups. LC-MS measurements indicated higher LPS levels than those obtained from standard endotoxin assays, suggesting limitations in conventional detection methods. Despite elevated LPS presence, bioactivity assays revealed minimal proinflammatory responses, implying the existence of intrinsic SF factors neutralising LPS. In vivo, prolonged systemic LPS exposure did not induce OA-like changes in rat joints. Notably, LPS colocalised with Fn in the synovial membrane, and Fn binding attenuated LPS bioactivity and hindered its migration in vitro.</p><p><strong>Conclusions: </strong>LPS is prevalent in SF across various joint conditions but exhibits low bioactivity, indicating it is not a primary driver of joint inflammation. Fn plays a crucial role in sequestering and neutralising LPS within the synovial environment, offering a protective mechanism against LPS-induced inflammation. These findings underscore the need for accurate LPS measurement techniques and suggest potential therapeutic targets for modulating joint inflammation.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Windows for intervention in the prearthritis phase of rheumatoid arthritis? A narrative review of key triggering events and potential preventive strategies.","authors":"Alf Kastbom, Sara Turcinov, Vivianne Malmström","doi":"10.1136/rmdopen-2025-005778","DOIUrl":"10.1136/rmdopen-2025-005778","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is an autoimmune disease that often evolves over several years, which in the presence of risk factors, is termed the at-risk phase. Several of the currently approved treatments for RA have been evaluated for the prevention of RA during the at-risk phase, but without showing effects sufficient to warrant their use prior to diagnosis. There is an ongoing surge in research efforts to understand mechanisms underlying the onset of RA, in particular concerning deviations in the adaptive immune system and the role of mucosal surfaces in the breach of self-tolerance and triggering of arthritis. With this focus, we here aimed to review current knowledge on RA development prior to arthritis onset. Also, since the pre-arthritis phase may contain windows of opportunity to prevent RA onset, we present and conceptualise different strategies to potentially interfere with steps leading to RA. While the body of knowledge is increasing, our understanding of RA development remains incomplete, and available studies highlight that RA appears similarly heterogeneous prior to onset as is seen after diagnosis. Hence, the timing and the selection of subjects will be crucial for the success of future potential interventions.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biochemical marker of synovial tissue turnover, C1M, predicts radiological progression in early rheumatoid arthritis.","authors":"Patrick Garnero, Sofie Falkenløve Madsen, Florent Eymard, Jérémie Sellam, Roland Chapurlat, Anne-C Bay-Jensen","doi":"10.1136/rmdopen-2025-005501","DOIUrl":"10.1136/rmdopen-2025-005501","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate whether serum C1M and C2M, biochemical markers of synovial and cartilage tissue destruction, were associated with progression of joint damage in patients with early arthritis.</p><p><strong>Methods: </strong>813 early arthritis patients (<6 months of symptoms, 82% with rheumatoid arthritis, 18% undifferentiated arthritis) from the prospective ESPOIR study were followed for 5 years. Radiographic progression was assessed using the van der Heijde Sharp score, and progression was defined as an increase of 1 or 5 unit(s) between baseline and 1 year or 5 years. Associations between baseline C1M and C2M and progression were assessed by logistic regression.</p><p><strong>Results: </strong>Increased baseline continuous serum C1M levels were associated with the risk of progression at 1 year, after adjustment for age, gender and body mass index (BMI). Patients with levels in the highest quartile of C1M had an OR (95% CI) of total joint damage progression of 2.75 (1.70-4.45) compared with patients in the lowest quartile. When disease activity score 28, C reactive protein and anticyclic citrullinated peptide 2 antibodies positivity were included in the model, high C1M remained significantly associated with progression with an OR (95% CI) of 2.12 (1.06-4.23). At 5 years, C1M was significantly associated with the risk of total joint damage progression after adjustment for age, gender and BMI. There was no significant association of C2M with progression at 1 year or 5 years.</p><p><strong>Conclusions: </strong>High baseline serum C1M, but not C2M, is associated with increased radiographic progression in early arthritis, independently of classical risk factors. C1M, in conjunction with other risk factors, may help identify patients at higher risk of joint damage.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning using genotype and gene-expression data identifies alterations of genes involved in infection susceptibility, antigen presentation and cytokine signalling as key contributors to JIA risk prediction.","authors":"Nicholas Pudjihartono, Daniel Ho, Justin Martin O'Sullivan","doi":"10.1136/rmdopen-2025-005737","DOIUrl":"10.1136/rmdopen-2025-005737","url":null,"abstract":"<p><strong>Background: </strong>Previous genome-wide association studies (GWAS) have identified numerous genetic loci associated with juvenile idiopathic arthritis (JIA). However, the functional impact of these variants-particularly on tissue-specific gene expression-and which regulatory interactions make the greatest relative contribution to JIA risk remain unclear. Identifying these key single-nucleotide polymorphism (SNP)-gene-tissue combinations can help prioritise targets for future functional studies and therapeutic interventions.</p><p><strong>Method: </strong>We performed two-sample Mendelian randomisation (2SMR) using spatial expression quantitative trait loci (eQTLs) from nine tissue-specific gene-regulatory networks as instrumental variables (IVs). We also identified JIA-associated SNPs from previous GWAS and mapped their spatial eQTL effects across 49 human tissues. These SNP sets were then used as features in a Lasso-regularised logistic regression model to predict JIA disease status. The model weight magnitudes served as proxies for each SNP's contribution to JIA risk. We evaluated the robustness of our model's feature ranking across 50 cross-validation runs.</p><p><strong>Results: </strong>The top-ranked SNPs included rs7775055, which tags the human leukocyte antigen (HLA) class II haplotype <i>DRB1*0801-DQA1*0401-DQB1*0402</i>, and rs6679677, a non-coding variant that is in 100% linkage with with a coding variant in <i>PTPN22</i>. IVs for genes implicated in infection-related immune processes (eg, <i>MSH5</i>, <i>MICA</i> and <i>LINC01149</i>) also made significant contributions to JIA risk. We additionally identified a spatial eQTL (rs10849448) that upregulated the cytokine signalling gene <i>LTBR</i> across all 49 tissues. Overall, our model highlighted the roles of genes involved in antigen presentation, infection susceptibility and cytokine signalling.</p><p><strong>Conclusion: </strong>By applying a machine learning approach to rank SNP-gene-tissue contributions to JIA risk, our findings offer insights into the genetic mechanisms underlying JIA pathogenesis. Future experimental validation could facilitate new therapeutic targets for the treatment or prevention of JIA.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clusters in paediatric Behçet's disease: a multicentre international study.","authors":"Ummusen Kaya Akca, Farhad Shahram, Erdem Karabulut, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Ozlem Akgun, Mustafa Çakan, Esra Esen, Caterina Matucci-Cerinic, Ruya Torun, Erbil Unsal, Marco Gattorno, Nuray Aktay Ayaz, Ayşenur Paç Kısaarslan, Betul Sozeri, Ezgi Deniz Batu, Isabelle Koné-Paut, Seza Ozen","doi":"10.1136/rmdopen-2024-005335","DOIUrl":"10.1136/rmdopen-2024-005335","url":null,"abstract":"<p><strong>Objectives: </strong>Clinical features of Behçet's disease (BD) exhibit significant variability, not only from patient to patient but also according to gender and geographical region. This study aims to describe the clinical characteristics, identify distinct clusters in a large cohort of paediatric BD patients and compare the clinical manifestations of patients across three geographical regions: Turkey, Europe and Iran.</p><p><strong>Method: </strong>Patients with paediatric-onset BD (<18 years of age) from Turkey, Iran and European countries (France and Italy) were retrospectively evaluated. A follow-up period of at least 6 months was required for inclusion.</p><p><strong>Results: </strong>The study included 600 patients (297 females, 49.5%), with cases from Turkey (n=231), Iran (n=306), France (n=44) and Italy (n=19). The most common presentations were mucocutaneous involvement (97.5%), followed by ocular (48.0%), musculoskeletal (43.2%), neurological (11.8%), vascular (11.5%), gastrointestinal (9.0%) and cardiac (2.0%) involvement. Ocular involvement was more prevalent in Iran, gastrointestinal involvement in Europe, and musculoskeletal and vascular involvement in Turkey compared with the other geographical regions. Seven distinct clusters of paediatric BD as vascular (cluster 1 (C1)), mucocutaneous only (C2), ocular (C3), gastrointestinal (C4), mixed (C5), neurologic and ocular (C6), and mucocutaneous-musculoskeletal cluster (C7) were identified, although there was some overlap in system involvements.</p><p><strong>Conclusions: </strong>Our study supports the notion that BD may tend to present in certain clusters in children as well. Since BD is a complex disease with a multifactorial aetiology, involving the interaction of pathogenic pathways, classification of clusters presents a significant challenge. We have also shown that certain clinical features vary among geographical regions.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive immune responses to SARS-CoV-2 in DMARD-treated patients with chronic inflammatory rheumatisms.","authors":"Maxime Beretta, Emmanuel Martin, Olivier Fogel, Clementina López-Medina, Cyril Planchais, Thomas Bruneau, Pedro Goncalves, Jerome Avouac, Francis Berenbaum, Jérémie Sellam, Bruno Fautrel, Jacques Morel, Beatrice Parfait, James P Di Santo, Sylvie Behillil, Sylvie van der Werf, Helene Péré, Sylvain Latour, Hugo Mouquet, Corinne Miceli-Richard","doi":"10.1136/rmdopen-2025-005673","DOIUrl":"10.1136/rmdopen-2025-005673","url":null,"abstract":"<p><strong>Background: </strong>Patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) are at an increased risk for infection related to the use of immunomodulatory therapies (ITs). The objective of this study is to assess the impact of ITs on the adaptive immune responses to SARS-CoV-2.</p><p><strong>Methods: </strong>The study population comprised 94 patients (48 SpA; 46 RA; mean age of 53±14 years) with a confirmed SARS-CoV-2 infection. 20 age-matched individuals (50±17 years), corresponding to the patients' household contacts infected at the same time, were included as the control population. Patients were stratified by treatment groups: methotrexate (MTX)/sulfasalazine (n=17/2), anti-TNF (n=24), anti-TNF+MTX (n=23), RTX (N=11), anti-IL17 (n=7) and others (n=11). The study compared the viral loads in plasma, stools and nasal swabs and the SARS-CoV-2-specific humoral and cellular immune responses (antibodies, B and T lymphocytes) following SARS-CoV-2 infection.</p><p><strong>Results: </strong>Viral persistence was not observed in the blood, nasopharynx and stools of patients undergoing ITs. Overall, the SARS-CoV-2-specific humoral and T-cell responses were preserved. Patients receiving RTX showed significantly lower IgA and IgG responses to SARS-CoV-2 compared with other treatment groups. Most patients, including RTX recipients, exhibited significant CD4+T cell responses. However, RTX therapy was associated with reduced SARS-CoV-2-specific activated CD8+T cells. A correlation was observed between humoral immune parameters and CD8⁺ T cell activation.</p><p><strong>Conclusions: </strong>While most patients demonstrated the capacity to mount an immune response to SARS-CoV-2, treatment with RTX impacted both humoral and CD8+cell responses. Developing vaccines that elicit robust CD8+T cell responses could offer benefits to individuals undergoing ITs for inflammatory rheumatic diseases.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in nailfold capillaroscopy findings between limited and diffuse cutaneous systemic sclerosis: a detailed analysis.","authors":"Ana Margarida Correia, Rosanna Campitiello, Carmen Pizzorni, Emanuele Gotelli, Alberto Sulli, Sabrina Paolino, Vanessa Smith, Maurizio Cutolo","doi":"10.1136/rmdopen-2025-005716","DOIUrl":"10.1136/rmdopen-2025-005716","url":null,"abstract":"<p><strong>Objective: </strong>To investigate and distinguish detailed nailfold videocapillaroscopy (NVC) findings in patients with limited (lcSSc) and diffuse (dcSSc) cutaneous systemic sclerosis (SSc).</p><p><strong>Methods: </strong>A total of 157 patients was recruited, 100 with lcSSc, 27 with dcSSc and 30 with primary Raynaud phenomenon (pRP). The NVC SSc pattern and the absolute number of capillaries (per linear millimetre) were performed at the first NVC analysis. 'Early'/'Active' NVC status (capillary dilations, microhaemorrhages and giant capillaries) and 'Late' NVC status (number of capillaries, altered microvascular architecture and abnormal capillary shapes) were scored.</p><p><strong>Results: </strong>A statistically significant difference in the absolute number of capillaries between patients with lcSSc, dcSSc and pRP was found (p<0.001). Capillary number loss was present in both SSc subgroups and it was significantly higher in patients with dcSSc compared with lcSSc (4.89±1.53 vs 6.18±1.75, p<0.001). A significantly higher 'Late' NVC status score was observed in patients with dcSSc (p<0.001), including lower capillary density (p<0.001), altered shapes (p<0.001) and presence of abnormal shapes (p=0.005). Correlations showed that higher modified Rodnan Skin Score is associated with decreased capillary number and higher 'Late' NVC status score (p<0.001). Additionally, a statistically significant association was established between 'Late' SSc pattern and dcSSc (p=0.004) and between 'Early' SSc pattern and lcSSc (p=0.010). The absolute capillary number was normal and significantly higher in patients with pRP (p<0.001) than in all patients with SSc.</p><p><strong>Conclusions: </strong>The current investigation underlines the importance of NVC detailed analysis and scoring in discriminating the severity of microvascular damage between lcSSc and dcSSc.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 3","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}