RhinologyPub Date : 2024-06-01DOI: 10.4193/RhinRhin23.325
Z Zhang, B Xu, L Wang, X Yan, S Li, Y Jiang, L Yu
{"title":"Diagnostic value of serum squamous cell carcinoma antigen and cytokeratin fragment antigen 21-1 for sinonasal inverted papilloma: an exploratory study.","authors":"Z Zhang, B Xu, L Wang, X Yan, S Li, Y Jiang, L Yu","doi":"10.4193/RhinRhin23.325","DOIUrl":"10.4193/RhinRhin23.325","url":null,"abstract":"<p><strong>Background: </strong>Serum tumor markers have not yet been developed for the clinical diagnosis and treatment of sinonasal inverted papilloma (SNIP), one of the most significant sinonasal tumors. Therefore, this study aimed to determine the diagnostic value of serum squamous cell carcinoma antigen (SCCA) and cytokeratin fragment antigen 21-1 (CYFRA 21-1) for SNIP.</p><p><strong>Methods: </strong>Clinical data were obtained from 101, 56, and 116 patients with SNIP, sinonasal squamous cell carcinoma (SNSCC), and unilateral chronic rhinosinusitis (CRS), respectively. Preoperative serum SCCA and CYFRA 21-1 levels were compared, and logistic regression analyses were performed to screen serum tumor markers, which may be used to diagnose SNIP. Diagnostic cut-off values were determined using receiver operating characteristic (ROC) curves, and their diagnostic power was verified.</p><p><strong>Results: </strong>Serum SCCA and CYFRA 21-1 differentiated SNIP from CRS with the cut-off values of 1.97 ng/mL and 2.64 ng/mL and the areas under the ROC curves (AUC) of 0.895 and 0.766, respectively, and the AUC of the combination of the two markers was 0.909. CYFRA 21-1 differentiated SNIP with malignant transformation from that without malignant transformation with a cut-off value of 3.51 ng/mL and an AUC of 0.938. CYFRA 21-1 distinguished SNIP with malignant transformation from SNSCC with a cut-off value of 3.55 ng/mL and an AUC of 0.767.</p><p><strong>Conclusions: </strong>This study provides novel potential diagnostic tools for SNIP by demonstrating the use of serum SCCA and CYFRA 21-1 in the diagnosis of SNIP.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"353-361"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-06-01DOI: 10.4193/Rhin23.261
J K Han, J Perkins, D Lerner, M T Yim, L E Ishii
{"title":"Comparison of nasal valve dysfunction treatment outcomes for temperature-controlled radiofrequency and functional rhinoplasty surgery: a systematic review and meta-analyses.","authors":"J K Han, J Perkins, D Lerner, M T Yim, L E Ishii","doi":"10.4193/Rhin23.261","DOIUrl":"10.4193/Rhin23.261","url":null,"abstract":"<p><strong>Background: </strong>Nasal valve dysfunction (NVD) is a substantial contributor to nasal airway obstruction. Minimally-invasive temp-erature-controlled radiofrequency (TCRF) treatment of the nasal valve is available and comparison with surgical techniques is warranted.</p><p><strong>Methodology: </strong>Databases: Medline (PubMed), Embase, Cochrane Library.</p><p><strong>Population: </strong>adults with preprocedural nasal obstruction symptom evaluation (NOSE) score >=45. Treatment effects were derived from a random effects model and reported as weighted mean difference in NOSE score between baseline; 3, 6, and 12 months postprocedure.</p><p><strong>Results: </strong>Of 2529 initial articles, 5 studies describing TCRF treatment and 63 studies describing functional rhinoplasty were included. Pooled effect sizes for TCRF treatment and functional rhinoplasty were comparable in all analyses.</p><p><strong>Conclusions: </strong>TCRF treatment of the internal nasal valve for NVD was associated with sustained effects comparable to functional rhinoplasty addressing the nasal valve only, rhinoplasty without concomitant turbinate treatment, and all rhinoplasty.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"258-270"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-06-01DOI: 10.4193/Rhin23.296
A Machado, J Pereira, F Alvarez, H R Briner, D Simmen
{"title":"Prelacrimal window approach to the maxillary sinus: a systematic review and meta-analysis of the literature.","authors":"A Machado, J Pereira, F Alvarez, H R Briner, D Simmen","doi":"10.4193/Rhin23.296","DOIUrl":"10.4193/Rhin23.296","url":null,"abstract":"<p><strong>Background: </strong>The prelacrimal window approach (PLWA) is a minimally invasive surgical technique that has been proposed as an alternative to the traditional approaches to access the maxillary sinus.</p><p><strong>Methodology: </strong>A systematic review with meta-analysis was performed following PRISMA guidelines and identified 368 articles for initial review of which 14 (610 participants) met the criteria for meta-analysis. Four databases, including PubMed, Google Scholar, Web of Science and Scopus, were searched to identify relevant articles. Two independent reviewers conducted the eligibility assessment for the included studies. Methodology quality and risk of bias were evaluated by New Castle Ottawa scale. The outcomes assessed were recurrence of the pathology, postoperative morbidity including epiphora, dry nose, facial, gingival numbness, epistaxis or local infection.</p><p><strong>Results: </strong>The present data suggest a significant reduction in the recurrence rate of maxillary sinus pathology following PLWA when compared to conventional surgery (endoscopic medial maxillectomy, endoscopic sinus surgery and the Caldwell-Luc operation). The rates of epiphora, facial or gingival numbness, epistaxis or infection requiring intervention, were not significantly different between the procedures.</p><p><strong>Conclusions: </strong>Maxillary sinus pathology can be effectively treated using the PLWA technique, as it has been shown to result in a lower recurrence rate compared to conventional surgeries.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"271-286"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-06-01DOI: 10.4193/Rhin23.267
A Abiri, B F Bitner, T V Nguyen, J C Pang, K M Roman, M Vasudev, D D Chung, S H Tripathi, J C Harris, N Kosaraju, R M Shih, M Ko, J E Miller, J E Douglas, D J Lee, J G Eide, R S Kshirsagar, K M Phillips, A R Sedaghat, M Bergsneider, M B Wang, J N Palmer, N D Adappa, F P K Hsu, E C Kuan
{"title":"Clinical and technical factors in endoscopic skull base surgery associated with reconstructive success.","authors":"A Abiri, B F Bitner, T V Nguyen, J C Pang, K M Roman, M Vasudev, D D Chung, S H Tripathi, J C Harris, N Kosaraju, R M Shih, M Ko, J E Miller, J E Douglas, D J Lee, J G Eide, R S Kshirsagar, K M Phillips, A R Sedaghat, M Bergsneider, M B Wang, J N Palmer, N D Adappa, F P K Hsu, E C Kuan","doi":"10.4193/Rhin23.267","DOIUrl":"10.4193/Rhin23.267","url":null,"abstract":"<p><strong>Background: </strong>In this study, we identified key discrete clinical and technical factors that may correlate with primary reconstructive success in endoscopic skull base surgery (ESBS).</p><p><strong>Methods: </strong>ESBS cases with intraoperative cerebrospinal fluid (CSF) leaks at four tertiary academic rhinology programs were retrospectively reviewed. Logistic regression identified factors associated with surgical outcomes by defect subsite (anterior cranial fossa [ACF], suprasellar [SS], purely sellar, posterior cranial fossa [PCF]).</p><p><strong>Results: </strong>Of 706 patients (50.4% female), 61.9% had pituitary adenomas, 73.4% had sellar or SS defects, and 20.5% had high-flow intraoperative CSF leaks. The postoperative CSF leak rate was 7.8%. Larger defect size predicted ACF postoperative leaks; use of rigid reconstruction and older age protected against sellar postoperative leaks; and use of dural sealants compared to fibrin glue protected against PCF postoperative leaks. SS postoperative leaks occurred less frequently with the use of dural onlay. Body-mass index, intraoperative CSF leak flow rate, and the use of lumbar drain were not significantly associated with postoperative CSF leak. Meningitis was associated with larger tumors in ACF defects, nondissolvable nasal packing in SS defects, and high-flow intraoperative leaks in PCF defects. Sinus infections were more common in sellar defects with synthetic grafts and nondissolvable nasal packing.</p><p><strong>Conclusions: </strong>Depending on defect subsite, reconstructive success following ESBS may be influenced by factors, such as age, defect size, and the use of rigid reconstruction, dural onlay, and tissue sealants.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"330-341"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strategies for patients with recurrent nasopharyngeal carcinoma involved internal carotid artery who are intolerant to embolization.","authors":"W-B Wu, X-B Zhang, Z-K Feng, H-F Li, Y-P Liu, J-L Liang, Y-L Xie, Y-J Hua, R Sun, S-L Wang, J-H Chen, M-Y Chen","doi":"10.4193/RhinRhin23.130","DOIUrl":"10.4193/RhinRhin23.130","url":null,"abstract":"<p><strong>Background: </strong>The surgical treatment of recurrent nasopharyngeal carcinoma (rNPC) involving the internal carotid artery (ICA) is challenging, as the massive bleeding caused by intraoperative rupture of the ICA is life-threatening. We reported that ICA embolization is an effective pretreatment to avoid fatal bleeding, but some patients cannot tolerate the procedure. We used endovascular vascular protection (ICA stents), vascular sacrifice (bypass grafting) and extravascular vascular protection (transcervical external stent placement) of the ICA to provide alternative options for these patients. METHODOLOGYy: This study enrolled patients with rNPC adjacent to or invading the ICA who were unsuitable for ICA embolization from January 2015 to June 2020. ICA pretreatment combined with endoscopic nasopharyngectomy (ENPG) was performed for the 30 patients. We report the survival outcome and incidence of complications after ICA pretreatment.</p><p><strong>Results: </strong>ICA pretreatment was performed for the 30 enrolled patients, among whom 8 underwent endoscopic-assisted transcervical protection of the parapharyngeal ICA combined with ENPG, 6 underwent bypass grafting, and 16 underwent ICA stent implantation followed by ENPG. After pretreatment, at a median follow-up of 43 months (range, 2-80 months), the 3-year locoregional overall survival (OS), progression-free survival (PFS), locoregional recurrence-free survival (LRRFS), and distant metastasis-free survival (DMFS) were 62.9%, 61.3%, 70.2%, and 71.4%, respectively.</p><p><strong>Conclusions: </strong>ICA pretreatment combined with salvage ENPG enables the feasible and effective resection of rNPC lesions involving the ICA in patients who cannot tolerate ICA embolization. Therefore, this treatment may be an effective method for improving outcomes. Multidisciplinary therapy is needed to reduce operation-related complications.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"342-352"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-06-01DOI: 10.4193/Rhin23.081
R van der Lans, J J Otten, G F J P M Adriaensen, L B L Benoist, M E Cornet, D R Hoven, A B Rinia, W J Fokkens, S Reitsma
{"title":"Eosinophils are the dominant type2 marker for the current indication of biological treatment in severe uncontrolled chronic rhinosinusitis with nasal polyps.","authors":"R van der Lans, J J Otten, G F J P M Adriaensen, L B L Benoist, M E Cornet, D R Hoven, A B Rinia, W J Fokkens, S Reitsma","doi":"10.4193/Rhin23.081","DOIUrl":"10.4193/Rhin23.081","url":null,"abstract":"<p><p>The latest European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2020) defines markers for type2 inflammation in the context of indicating biological therapy in severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) as either a total serum immunoglobulin E (total-IgE) <100 kU/L, a blood eosinophil count (BEC, expressed as -109 cells / L) >=0.25, or a tissue eosinophil count >=10 per high power field (HPF) (1). Recently, an EPOS/EUFOREA expert panel advised to lower the threshold for BEC from >=0.25 (EPOS2020) to >=0.15 (EUFOREA2023) to align with thresholds used for biological indication in asthma patients (2). As far as we know, there is no literature supporting the cut-off value for total-IgE.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"383-384"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-06-01DOI: 10.4193/Rhin23.287
W Backaert, B Steelant, T Wils, Z Qian, E Dilissen, A-C Jonckheere, B Boonen, M Jorissen, R Schrijvers, D M A Bullens, K Talavera, P W Hellings, L Van Gerven
{"title":"Nasal hyperreactivity in allergic rhinitis and chronic rhinosinusitis with polyps: a role for neuronal pathways.","authors":"W Backaert, B Steelant, T Wils, Z Qian, E Dilissen, A-C Jonckheere, B Boonen, M Jorissen, R Schrijvers, D M A Bullens, K Talavera, P W Hellings, L Van Gerven","doi":"10.4193/Rhin23.287","DOIUrl":"10.4193/Rhin23.287","url":null,"abstract":"<p><strong>Background: </strong>Nasal hyperreactivity (NHR) is prevalent in all chronic upper airway inflammatory phenotypes, including allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). Although NHR in patients with non-allergic rhinitis is mediated by neuronal pathways, AR and CRSwNP are mainly characterized by type 2 inflammation.</p><p><strong>Methods: </strong>Eighteen healthy controls and 45 patients with symptomatic AR/CRSwNP underwent a cold, dry air (CDA) provocation test for objective diagnosis of NHR. Before and after, questionnaires were filled out and nasal secretions and biopsies were collected. Markers for neurogenic inflammation (substance P, calcitonin gene-related peptide, neurokinin A), epithelial activation (IL-33), and histamine were measured in secretions by ELISA; and expression of neuronal markers PGP9.5, TRPV1, and TRPM8 was studied in biopsies by RT-q-PCR. Effects of histamine on TRPV1/A1 were studied with Ca2+-imaging using murine trigeminal neurons.</p><p><strong>Results: </strong>CDA-provocation reduced peak nasal inspiratory flow (PNIF) of patients with subjective NHR but not of non-NHR controls/patients CDA-provocation reduced peak nasal inspiratory flow (PNIF) of patients with subjective NHR but not of non-NHR controls/patients. Subjective (subjectively reported effect of CDA) and objective (decrease in PNIF) effects of CDA were significantly correlated. Levels of neuropeptides and histamine in nasal secretions and mRNA expression of PGP9.5, TRPV1, and TRPM8 correlated with CDA-induced PNIF-reduction. CDA-provocation induced an increase in IL-33-levels. Both TRPV1 and TRPA1 expressed on afferent neurons were sensitized by exposure to histamine.</p><p><strong>Conclusion: </strong>NHR is not an on/off phenomenon but spans a continuous spectrum of reactivity. A neurogenic inflammatory background and increased histamine-levels are risk factors for NHR in AR/CRSwNP.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"299-309"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-06-01DOI: 10.4193/RhinRhin23.284
J Lindemann, M O Scheithauer, F Sommer, T K Hoffmann, J Hahn, J Foerg
{"title":"Continuous investigation of the nasal cycle over 48 hours.","authors":"J Lindemann, M O Scheithauer, F Sommer, T K Hoffmann, J Hahn, J Foerg","doi":"10.4193/RhinRhin23.284","DOIUrl":"10.4193/RhinRhin23.284","url":null,"abstract":"<p><strong>Background: </strong>Previous results on the nasal cycle refer to measurements over up to 24h. The long-term rhinoflowmetry (LRFM) allows continuous observations over a longer period. The aim of the study was to observe the nasal cycle for the first time over 48h under everyday conditions.</p><p><strong>Methodology: </strong>The LRFM was continuously applied to 30 rhinologically healthy subjects (20 female, 10 male) over 48h. The different types of nasal cycle were classified as follows: \"classic\", \"in concert\", \"one-sided\", \"no-cycle\" and \"mixed\". The focus of this study was on the results over the entire 48 hours. The comparison of the two consecutive days was also made.</p><p><strong>Results: </strong>A nasal cycle could be detected in 100% of the subjects over 48h. With 97%, the mixed type most commonly occurred as a combination of classical and in concert components. In all subjects, classical cycle components could be detected at least once. The no-cycle type was not observed. In the awake state, the mixed type dominated (80%), as a combination of classical and in concert parts. In the sleep state, the classical type was the most common type (97%). The average phase duration was 206 +- 83 minutes.</p><p><strong>Conclusions: </strong>In the very first continuous 48-hour study on the nasal cycle, 100% of the subjects presented a nasal cycle. The LRFM method is the only one that offers the possibility to perform continuous measurements over a longer period during daily routine. The results of previous single-stage examination methods should thus be questioned.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"362-369"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-06-01DOI: 10.4193/Rhin23.402
W Chen, Y Bai, P Fang, J Chen, X Wang, Y Li, X Luo, Z Xiao, R Iyer, F Shan, T Yuan, M Wu, X Huang, D Fang, Q Yang, Y Zhang
{"title":"Body mass index’s effect on CRSwNP extends to pathological endotype and recurrence.","authors":"W Chen, Y Bai, P Fang, J Chen, X Wang, Y Li, X Luo, Z Xiao, R Iyer, F Shan, T Yuan, M Wu, X Huang, D Fang, Q Yang, Y Zhang","doi":"10.4193/Rhin23.402","DOIUrl":"10.4193/Rhin23.402","url":null,"abstract":"<p><strong>Background: </strong>Elevated body mass index (BMI) has been recognized as an important contributor to corticosteroid insensitivity in chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to delineate the effects of elevated BMI on immunological endotype and recurrence in CRSwNP individuals.</p><p><strong>Methodology: </strong>A total of 325 patients with CRSwNP undergoing FESS were recruited and stratified by BMI. H&E staining was employed for histological evaluation. Characteristics of inflammatory patterns were identified by immunohistochemical staining. The predictive factors for recurrence were determined and evaluated by multivariable logistic regression analysis and the receiver operating characteristic (ROC) curves across all subjects and by weight group.</p><p><strong>Results: </strong>In all patients with CRSwNP, 26.15% subjects were classified as overweight/obese group across BMI categories and exhibited a higher symptom burden. The upregulated eosinophil/neutrophil-dominant cellular endotype and amplified type 2/ type 3 coexisting inflammation was present in overweight/obese compared to underweight/normal weight controls. Additionally, a higher recurrent proportion was shown in overweight/obese patients than that in underweight/normal weight cohorts. Multivariable logistic regression analysis identified BMI as an independent predictor for recurrence. The predictive capacity of each conventional parameter (tissue eosinophil and CLCs count, and blood eosinophil percentage) alone or in combination was poor in overweight/obese subjects.</p><p><strong>Conclusions: </strong>Overweight/obese CRSwNP stands for a unique phenotype and endotype. Conventional parameters predicting recurrence are compromised in overweight/obese CRSwNP, and there is an urgent need for novel biomarkers that predict recurrence for these patients.</p>","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"370-382"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RhinologyPub Date : 2024-04-10DOI: 10.4193/rhin23.434
J C Hernaiz-Leonardo, B M Alim, A Pascual, K Aldossari, J Fan, S Alsaleh, A R Javer
{"title":"Development and validation of the Sinonasal Endoscopic Score (SiNES) for chronic rhinosinusitis.","authors":"J C Hernaiz-Leonardo, B M Alim, A Pascual, K Aldossari, J Fan, S Alsaleh, A R Javer","doi":"10.4193/rhin23.434","DOIUrl":"https://doi.org/10.4193/rhin23.434","url":null,"abstract":"Although there are several endoscopic grading systems for chronic rhinosinusitis (CRS), they are limited in their range and applicability. We developed a SiNonasal Endoscopic Score (SiNES) that builds upon the strengths of previous systems while addressing their limitations.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":"228 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140587800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}