Rhinology最新文献_第8页

Screening olfaction under dupilumab in chronic rhinosinusitis with nasal polyps. 用杜比鲁单抗筛查慢性鼻窦炎伴鼻息肉患者的嗅觉。

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin23.476

T Mauthe, C M Meerwein, F S Ryser, C BrÃ Hlmann, A Yalamanoglu, U C Steiner, M B Soyka

{"title":"Screening olfaction under dupilumab in chronic rhinosinusitis with nasal polyps.","authors":"T Mauthe, C M Meerwein, F S Ryser, C BrÃ Hlmann, A Yalamanoglu, U C Steiner, M B Soyka","doi":"10.4193/Rhin23.476","DOIUrl":"10.4193/Rhin23.476","url":null,"abstract":"Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently leads to olfactory dysfunction. This study aimed to assess the impact of dupilumab on CRSwNP patients, focusing on olfactory outcomes and potential correlations with other clinical factors.Methods: CRSwNP patients eligible for dupilumab therapy received subcutaneous DupixentÂ® injections every two weeks (300mg/2ml dupilumab). The 12-item Sniffin' Sticks Test (SST-12), fractional exhaled nitric oxide (FeNO) and Nasal Polyp Score (NPS) were assessed at baseline and after one, three, and six months. Patients also completed the Sino-Nasal Outcome Test (SNOT-22) weekly.Results: 26 CRSwNP patients were included. After one month, dupilumab led to substantial reductions in FeNO, SNOT scores, andNPS, whereas SST-12 scores improved significantly only after three months. A shift toward normosmia occurred, with 81% achieving normosmia after six months, and a drop in anosmia prevalence to 9.5%. Significant negative correlations between olfaction (SST-12) and polyp severity (NPS) at baseline and after six months were found, while no significant correlations were observed between SST-12 and FeNO or SNOT scores. Age did not correlate with olfaction.Conclusions: Dupilumab demonstrated efficacy in restoring olfaction in CRSwNP patients. Reaching normosmia in over 80% ofpatients after six months of treatment underscores the drug's effectiveness in managing this challenging symptom.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"496-505"},"PeriodicalIF":4.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual and triple modulator therapy for chronic rhinosinusitis in cystic fibrosis patients. 囊性纤维化患者慢性鼻窦炎的双重和三重调节剂疗法。

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin23.487

S Uyttebroek, C Claeyssens, M Jorissen, L Dupont, L Van Gerven

{"title":"Dual and triple modulator therapy for chronic rhinosinusitis in cystic fibrosis patients.","authors":"S Uyttebroek, C Claeyssens, M Jorissen, L Dupont, L Van Gerven","doi":"10.4193/Rhin23.487","DOIUrl":"10.4193/Rhin23.487","url":null,"abstract":"Background: The introduction of CFTR modulators has changed the landscape in the treatment of cystic fibrosis (CF) and early case series have shown improvements in sinonasal outcomes in this patient population.Methodology: A real-word data study was performed to evaluate the impact of dual therapy with tezacaftor/ivacaftor (TEZ/IVA) and triple therapy with elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on CF-related chronic rhinosinusitis (CRS), by comparing subjective and objective outcome measures at baseline, 12 months after treatment with TEZ/IVA and six months after treatment with ELX/TEZ/IVA.Results: In total, 43 CF patients, with a mean age of 32 years, were included. After triple therapy, significant improvements in overall visual analogue scale, SNOT-22, Lund Kennedy, nasal polyps, and Lund-Mackay scores were observed, whereas no beneficial effect could be seen in patients treated with dual therapy. Bacterial upper airway colonization did not differ pre- and postmodulator therapy in the present study. The number of responders to dual and triple therapy is 23.8% and 63.2% of the patients, respectively.Conclusions: Triple therapy with ELX/TEZ/IVA is superior to dual therapy with TEZ/IVA in the treatment of CF-CRS, as significantly reduced sinonasal complaints, nasal endoscopy and CT scores were observed after triple therapy, whereas this was not the case for dual therapy.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"457-465"},"PeriodicalIF":4.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small extracellular vesicles facilitate epithelial-mesenchymal transition in chronic rhinosinusitis with nasal polyps via the miR-375-3p/QKI axis. 小细胞外囊泡通过 miR-375-3p/QKI 轴促进慢性鼻炎伴鼻息肉的上皮-间质转化。

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin23.520

X Wang, R Zheng, W Liang, H Qiu, T Yuan, W Wang, H Deng, W Kong, J Chen, Y Bai, Y Li, Y Chen, Q Wu, S Wu, X Huang, Z Shi, Q Fu, Y Zhang, Q Yang

{"title":"Small extracellular vesicles facilitate epithelial-mesenchymal transition in chronic rhinosinusitis with nasal polyps via the miR-375-3p/QKI axis.","authors":"X Wang, R Zheng, W Liang, H Qiu, T Yuan, W Wang, H Deng, W Kong, J Chen, Y Bai, Y Li, Y Chen, Q Wu, S Wu, X Huang, Z Shi, Q Fu, Y Zhang, Q Yang","doi":"10.4193/Rhin23.520","DOIUrl":"10.4193/Rhin23.520","url":null,"abstract":"Background: Epithelial-mesenchymal transition (EMT) plays a crucial role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the involvement of small extracellular vesicles (sEVs) in EMT and their contributions to CRSwNP has not been extensively investigated.Methods: SEVs were isolated from nasal mucosa through ultracentrifugation. MicroRNA sequencing and reverse-transcription quantitative polymerase chain reaction were employed to analyze the differential expression of microRNAs carried by sEVs. Human nasal epithelial cells (hNECs) were used to assess the EMT-inducing effect of sEVs/microRNAs. EMT-associated markers were detected by western blotting and immunofluorescence. Dual-luciferase reporter assay was performed to determine the target gene of miR-375-3p. MicroRNA mimic, lentiviral, and plasmid transduction were used for functional experiments.Results: In line with the greater EMT status in eosinophilic CRSwNP (ENP), sEVs derived from ENP (ENP-sEVs) could induce EMT in hNECs. MiR-375-3p was elevated in ENP-sEVs compared to that in control and nonENP. MiR-375-3p carried by ENP-sEVs facilitated EMT by directly targeting KH domain containing RNA binding (QKI) at seed sequences of 913-919, 1025-1033, and 2438-2444 in 3â€™-untranslated region. Inhibition of QKI by miR-375-3p overexpression promoted EMT, which could be reversed by restoration of QKI. Furthermore, the abundance of miR-375-3p in sEVs was closely correlated with the clinical symptom score and disease severity.Conclusions: MiR-375-3p-enriched sEVs facilitated EMT by suppressing QKI in hNECs. The association of miR-375-3p with disease severity underscores its potential as both a diagnostic marker and a therapeutic target for the innovative management of CRSwNP.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"466-479"},"PeriodicalIF":4.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of smell training on COVID-19 induced smell loss. 嗅觉训练对 COVID-19 引起的嗅觉丧失的影响。

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin23.191

E J A Schepens, C J M de Haas, E M Postma, B van Dijk, S Boesveldt, I Stegeman, D M A Kamalski

{"title":"The effect of smell training on COVID-19 induced smell loss.","authors":"E J A Schepens, C J M de Haas, E M Postma, B van Dijk, S Boesveldt, I Stegeman, D M A Kamalski","doi":"10.4193/Rhin23.191","DOIUrl":"10.4193/Rhin23.191","url":null,"abstract":"Objective: while smell training appears to be effective for post viral smell loss, its effectiveness in COVID-19 induced smell loss is currently not well known. Therefore, we aim to investigate the potential effect of smell training on patients with COVID-19 induced smell loss.Methods: we conducted a case-control study with two comparable cohorts. One of which (n=111) was instructed to perform smell training twice daily for 12 weeks, therapeutical adherence was monitored on a daily schedule, while the other cohort (n=50) did not perform smell training. The Sniffin' Sticks Test (SST) was used to objectify participants' sense of smell at baseline and after 12 weeks, reported as a Threshold, Discrimination, and Identification (TDI) score. We also determined the association between therapeutical adherence and the TDI scores.Results: we found a significant difference in psychophysical smell function between patients with COVID-19 induced smell disorders who performed 12 weeks of smell training and those who did not. Median TDI difference between groups was 2.00 However, there was no association between the therapeutical adherence and olfactory function.Conclusion: we discovered a significant moderate difference in psychophysical smell function between patients with COVID-19-induced smell disorders who performed smell training and those who did not, implying a possible advantage of training. However, no relationship was found between therapeutical adherence of smell training and olfactory function.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"386-393"},"PeriodicalIF":4.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revision surgery, biologics, or both? 翻修手术、生物制剂，还是两者兼而有之？

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin24.904

W J Fokkens

引用次数: 0

Taste loss in COVID-19 â€" psychophysical evidence supporting a low prevalence. COVID-19 中的味觉缺失--心理物理证据支持低流行率。

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin24.040

C A Hintschich, S Le Bon, E Trecca, S Saussez, T Hummel

引用次数: 0

Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain. 西班牙无鼻息肉/有鼻息肉的慢性鼻炎患病率（按严重程度分类）。

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin23.341

J Mullol, J Sastre, J Dominguez-Ortega, M Blanco-Aparicio, J A Castillo Vizuete, I Alobid, M Garcia-Vitoria, P I Palomo-Jimenez

{"title":"Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain.","authors":"J Mullol, J Sastre, J Dominguez-Ortega, M Blanco-Aparicio, J A Castillo Vizuete, I Alobid, M Garcia-Vitoria, P I Palomo-Jimenez","doi":"10.4193/Rhin23.341","DOIUrl":"10.4193/Rhin23.341","url":null,"abstract":"Background: The worldwide prevalence range of chronic rhinosinusitis (CRS) is 5-12%; from this, 20 % have nasal polyps. Due to the little epidemiological data about CRS in the Spanish population, this study analyses the prevalence and severity of CRS with (CRSwNP) or without (CRSsNP) nasal polyps, and their connection with other coexisting type 2 inflammatory diseases in Spain.Methodology: This is a retrospective, large-scale, nationwide, epidemiological study based on the electronic medical records from the BIG-PAC® database. Patients diagnosed of CRSsNP and CRSwNP were identified using specific disease codes. The severe form of the disease was defined as patients who received at least a long course of antibiotics in CRSsNP or ≥2 short courses of systemic corticosteroids in CRSwNP in ≤12 months during the last 2 years, and/or had previous sinus surgery. Physician diagnosed prevalence, sociodemographic and clinical characteristics, and disease severity were assessed.Results: Out of a cohort of 1,012,257 patients (≤18 years old), 42,863 and 7,550 patients with diagnosed CRSsNP and CRSwNP, respectively, were analysed. The overall prevalence of diagnosed CRS was 5.1%, being 4.3% and 0.8% for CRSsNP and CRSwNP, respectively. Patients with CRSwNP and severe forms of the disease were older and had higher levels of type 2 inflammatory biomarkers than CRSsNP patients and non-severe disease.Conclusions: Although CRSsNP was more prevalent than CRSwNP, the severe forms of CRS were more frequent in patients with CRSwNP. In addition, CRSwNP patients had a higher incidence of coexisting type 2 inflammatory diseases.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"421-431"},"PeriodicalIF":4.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation and shortcomings of the most common mouse model of chronic rhinosinusitis with nasal polyps. 最常见的慢性鼻炎伴鼻息肉小鼠模型的验证与缺陷

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin23.331

A Sanchez-Montalvo, M Lecocq, E Bouillet, B Steelant, S Gohy, A Froidure, D Bullens, C Pilette, V Hox

{"title":"Validation and shortcomings of the most common mouse model of chronic rhinosinusitis with nasal polyps.","authors":"A Sanchez-Montalvo, M Lecocq, E Bouillet, B Steelant, S Gohy, A Froidure, D Bullens, C Pilette, V Hox","doi":"10.4193/Rhin23.331","DOIUrl":"10.4193/Rhin23.331","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is a highly prevalent airway disease worldwide. Whereas eosinophilic CRS with nasal polyps (eCRSwNP) represents its most severe phenotype, pathogenic mechanisms remain poorly understood despite a wide spectrum of in vitro and in vivo experimental models. A mouse model of experimental ovalbumin (OVA)-induced airway allergy with coadministration of Staphylococcus aureus enterotoxin B (SEB) has been widely used to study eosinophilic eCRSwNP. This study revisits the features of this model and its suitability for studying eCRS.Methodology: We implemented the most used eCRSwNP mouse model based on OVA+SEB intranasal challenges. Readouts including inflammatory features by (immuno)histology of the sinonasal epithelium (NP formation, eosinophils, epithelial and basement membrane thickness, fibrosis, goblet cells, Charcot-Leyden crystals (CLC)-like, tight junctions) and IgE production by enzyme-linked immunosorbent assay (ELISA), were compared to features of the corresponding human disease.Results: The OVA+SEB model induced eosinophilic inflammation of upper and lower airways, with epithelial and basement membrane thickening, goblet cell hyperplasia and subepithelial fibrosis in the sinuses, along increased IgE production. Except local IgE in nasal lavage (NL), which was only increased in OVA+SEB group, all other features did not differ between OVA and OVA+SEB groups. Macro- or microscopic NP were not detected.Conclusions: With the notable exception of local IgE production, the addition of SEB did not induce additional inflammatory or structural change in the sinuses from mice exposed to and challenged with OVA. This model might represent a model for severe upper airway allergy rather than a specific model of human eCRSwNP.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"446-456"},"PeriodicalIF":4.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the outcome of septoplasty. 关于鼻中隔成形术的结果。

IF 4.8 2区医学

Rhinology Pub Date : 2024-08-01 DOI: 10.4193/Rhin23.472

O Sunnergren, C Alexandersson, F Eliasson, M Jangard, Y Lilja, K Sandelin, C Ahlstrom Emanuelsson

引用次数: 0

Definitions for chronic rhinosinusitis: just more words or is there meaning? 慢性鼻炎的定义：只是字数增多还是有意义？

IF 7.2 2区医学

Rhinology Pub Date : 2024-06-01 DOI: 10.4193/Rhin24.903

A R Sedaghat

引用次数: 0