Saudi Journal of Kidney Diseases and Transplantation最新文献_第8页

A Rare Case of Nephrotic Syndrome in the Setting of Sjogren Syndrome-related Cryoglobulinemic Vasculitis. 与 Sjogren 综合征相关的冷球蛋白血症血管炎并发肾病综合征的罕见病例。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.394001

Zoi Alexakou, Katerina Damianaki, Emelina Stambolliu, Dimitrios Kourniotis, Margarita Mpora, Dimitrios Petras

引用次数: 0

An Uncommon Complication of Emphysematous Cystitis and Pyelitis. 气肿性膀胱炎和肾盂炎的罕见并发症。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.394003

Nishy Mathew, Jojo K Pullockara

引用次数: 0

CYP3A5 Polymorphisms Leading to Tacrolimus Toxicity Following an Adult Renal Transplant. 导致成人肾移植后他克莫司毒性的 CYP3A5 多态性

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.393998

Nouf Alotaibi

引用次数: 0

Collapsing Glomerulopathy in a Patient with a TRPC6 Mutation Presenting as Rapidly Progressive Glomerulonephritis: A Case Report and Review of the Literature. 一名 TRPC6 基因突变患者的塌陷性肾小球病表现为快速进展性肾小球肾炎：病例报告和文献综述。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.393999

Ibrahim Gokce, Mehtap Kaya, Neslihan Cicek, Sercin Guven, Yigit Ercetin, Nurdan Yildiz, Handan Kaya, Harika Alpay

引用次数: 0

A Nine-year-old Boy with Renovascular Hypertension: Knowing Where to Look. 一名患有肾血管性高血压的九岁男孩：知道从哪里看。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.394002

Sare Gulfem Ozlu, İbrahim Ece, Serhat Koca, Nilgun Isiksalan Ozbulbul

引用次数: 0

Lactoferrin: A Promising New Player in Treatment of Iron Deficiency Anemia in Patients on Regular Hemodialysis: A Randomized Controlled Trial. 乳铁蛋白：治疗定期血液透析患者缺铁性贫血的有效新方法：随机对照试验。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.393996

Rabab Mahmoud Ahmed Mahmoud, AbdelAal Mohammed

{"title":"Lactoferrin: A Promising New Player in Treatment of Iron Deficiency Anemia in Patients on Regular Hemodialysis: A Randomized Controlled Trial.","authors":"Rabab Mahmoud Ahmed Mahmoud, AbdelAal Mohammed","doi":"10.4103/1319-2442.393996","DOIUrl":"10.4103/1319-2442.393996","url":null,"abstract":"Hepcidin is secreted in inflammatory states as in patients on regular hemodialysis (HD). Therefore, novel agents modulating hepcidin secretion may have the potential to effectively reverse anemia in HD patients. Bovine milk derivative lactoferrin (BLF) is a glycoprotein that was found to decrease serum interleukin-6, therefore, having anti-inflammatory properties. Thus, it can downregulate hepcidin secretion in various inflammatory states including patients on regular HD, so improving iron absorption and utilization in those patients. In addition, BLF is a source of iron as each BLF molecule chelates two ferric ions. We started an interventional study. Seventy patients on regular HD with iron deficiency anemia received 100 mg of 20%-30% iron-saturated BLF (corresponding to 70-84 μg of elemental iron) orally b.i.d for 6 months. We compared those patients with another 70 patients on regular HD with iron deficiency anemia who were given 576 mg of ferrous glycine sulfate (corresponding to 100 mg of elemental iron) orally b.i.d for 6 months. BLF significantly decreased serum hepcidin level (from 340-350 ng/mL to 101-112 ng/mL), P <0.0001 and significantly increased hemoglobin (Hb) concentration (from 7.5-8.1 g/dL to 9.3-10 g/dL), P <0.0001, and transferrin saturation (TSAT) (from 5%-9% to 26%-31%), P <0.0001. Furthermore, ferrous glycine sulfate significantly decreased serum hepcidin level (from 335-350 ng/mL to 330--341 ng/mL), P <0.0001, and significantly increased Hb (from 7.5-8.1 to 7.6-8.5 g/dL), P <0.0001, and TSAT (from 5%-9% to 7%-12%), P <0.0001. However, the magnitude of decrease in serum hepcidin level and rise in Hb and TSAT in the BLF group was significantly higher than in the ferrous glycine sulfate group, P <0.0001. Oral BLF can be considered a promising novel agent in treatment of iron deficiency anemia in patients on regular HD.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of Chronic Kidney Disease in Adults: A 10 years' Experience in North Indian City on World Kidney Day. 成人慢性肾病筛查：世界肾脏日：北印度城市的十年经验

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.393993

Pradeep Kumar Rai, Punam Rai, Sonam Bedi, Anubhav Bansal, Yashwin Rai

{"title":"Screening of Chronic Kidney Disease in Adults: A 10 years' Experience in North Indian City on World Kidney Day.","authors":"Pradeep Kumar Rai, Punam Rai, Sonam Bedi, Anubhav Bansal, Yashwin Rai","doi":"10.4103/1319-2442.393993","DOIUrl":"10.4103/1319-2442.393993","url":null,"abstract":"Chronic kidney disease (CKD) is a complex disease that is asymptomatic in its early stages. Its delayed recognition may predispose patients to adverse outcomes. Early detection and management of kidney disease through screening programs is widely recommended. In the present study, we conducted a screening program at a hospital set up on World Kidney Day for 10 years to detect patients with CKD. The current study constituted 1324 apparently healthy adults, aged >18 years. Information on age, sex, height, weight, history of diabetes mellitus (DM) and hypertension (HTN), and familial history of kidney disease was recorded. Systolic and diastolic blood pressure, random blood sugar; urinalysis, and serum creatinine (Cr) levels were measured. The study outcome was the presence of CKD. Binary logistic regression analysis was applied to find the predictors of CKD. The median age of the study subjects was 40 years. CKD was found in 35.6% of subjects. Age, DM, HTN, and abnormal Cr levels were associated with increasing risk of CKD. The main objective of the present study was to identify the extent of risk relative to the co-factors of CKD and thereby target those who are potentially modifiable, like DM, to intervene at the earliest possible stage to treat the current disease condition and prevent the future health impairment.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Kidney Injury Following Naphthalene (Mothball) Poisoning. 萘（樟脑丸）中毒后的急性肾损伤。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.394000

Piyush Mathur, Shalini Garg

引用次数: 0

Incidence, Determinants, and Outcome of Contrast-induced Acute Kidney Injury following Percutaneous Coronary Intervention at a Tertiary Care Hospital. 一家三级医院经皮冠状动脉介入术后造影剂诱发急性肾损伤的发生率、决定因素和预后。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-05-01 Epub Date: 2024-01-17 DOI: 10.4103/1319-2442.393994

Aashaq Hussain Khandy, Rayees Shiekh, Tauseef Nabi, Mohamad Tahir Sheikh, Rayees Yousuf Sheikh

{"title":"Incidence, Determinants, and Outcome of Contrast-induced Acute Kidney Injury following Percutaneous Coronary Intervention at a Tertiary Care Hospital.","authors":"Aashaq Hussain Khandy, Rayees Shiekh, Tauseef Nabi, Mohamad Tahir Sheikh, Rayees Yousuf Sheikh","doi":"10.4103/1319-2442.393994","DOIUrl":"10.4103/1319-2442.393994","url":null,"abstract":"Contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) is the common cause of in-hospital acquired AKI and is associated with in-hospital mortality and prolonged hospital stay. We studied the incidence of CI-AKI after PCI, determinants of CI-AKI, and also assessed their length of hospital stay, in-hospital mortality, and need for dialysis. This was a hospital-based prospective observational study done on 204 adult subjects, who were candidates for PCI, at a tertiary care center in North India. Various clinical and biochemical parameters were monitored. Renal function was estimated at admission and 48 and 72 h after PCI. The incidence of CI-AKI post-PCI was 12.7%. Factors predicting the CI-AKI post-PCI on multiple logistic regression analysis are as follows: age ≥70 years, chronic kidney disease (CKD), hypotension, acute decompensated heart failure (ADHF), severe left ventricular systolic dysfunction (LVSD), and intra-aortic balloon pump (IABP) support. Contrast medium volume ≥200 mL and baseline estimated glomerular filtration rate <60 mL/min/1.73 m2 were significantly found to increase the risk of CI-AKI. Patients developing CI-AKI had significantly longer duration of hospital stay (6.4 ± 1.8 days vs. 3.1 ± 0.9 days; P <0.001). 15.4% of CI-AKI patients needed dialysis. In-hospital mortality was significantly higher in patients with CI-AKI (P <0.001). CI-AKI is a common complication following PCI, especially if the patient is elderly, has impaired renal function, hypotension, ADHF, severe LVSD and requires IABP support. The incidence of CI-AKI increases with the increases in contrast volume above 200 mL. The development of CI-AKI leads to a longer duration of hospital stay and increases in-hospital mortality.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Profile and Treatment Outcomes of Patients with Malaria Complicated by Acute Kidney Injury. 疟疾并发急性肾损伤患者的临床概况和治疗效果。

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Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-03-01 Epub Date: 2023-12-25 DOI: 10.4103/1319-2442.391889

Haladhar Naik, Aruna Acharya, Sasibhusan Rout

{"title":"Clinical Profile and Treatment Outcomes of Patients with Malaria Complicated by Acute Kidney Injury.","authors":"Haladhar Naik, Aruna Acharya, Sasibhusan Rout","doi":"10.4103/1319-2442.391889","DOIUrl":"10.4103/1319-2442.391889","url":null,"abstract":"As Odisha is an endemic region for malaria with many acute kidney injury (AKI) cases, this study evaluated the clinical profile and treatment outcomes of patients with malaria complicated by AKI. This prospective observational study was conducted between December 2015 and September 2017. Detailed histories and clinical examinations were recorded. On admission, tests for routine hematology, plasma glucose, liver function, renal function, serum electrolytes, thick smears, thin smears, and malarial parasites were performed. Of the 958 AKI malarial patients admitted, 202 (82.6 % males) were included in the study, with a mean age of 38.37 years. In total, 86.14%, 3.46%, and 10.39% of patients had Plasmodium falciparum, Plasmodium vivax, and mixed malaria, respectively. Headache and decreased urination (83.66% each) were the most common symptoms after fever (100%). Anuria and oliguria were reported in 5.95% and 67.82% of patients, respectively, whereas 26.23% reported a urine output of >400 mL/24 h. All patients had raised serum creatinine and urea levels, and >60% had anemia, proteinuria, and/or hyponatremia. Multiple organ dysfunction syndrome was observed in 62.87% of patients. Acute tubular necrosis was seen in 60% of renal biopsy specimens (n = 15). Of the 75.75% of patients requiring dialysis, 82.12% and 17.88% of patients required hemodialysis and peritoneal dialysis, respectively, during which 11 patients died. AKI, a serious complication of P. falciparum or P. vivax malaria, is a life-threatening condition. Fever, anemia, oligo/anuria, hepatic involvement, cerebral malaria, high serum creatinine and urea, and disseminated intravascular coagulation were the main predictors of mortality in our study.","PeriodicalId":21356,"journal":{"name":"Saudi Journal of Kidney Diseases and Transplantation","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0