Rheumatology Advances in Practice最新文献

{"title":"Recombinant zoster vaccine immunization rate in patients on Janus kinase inhibitors for rheumatologic and dermatologic conditions.","authors":"Jessica B Michaud, Ruta Brazauskas, Sarah Wigfield, Shelby Shepard, Teresa Mysliwiec, Kylie Perez, Shikha Singla","doi":"10.1093/rap/rkag071","DOIUrl":"10.1093/rap/rkag071","url":null,"abstract":"<p><strong>Objectives: </strong>Patients who receive Janus kinase (JAK) inhibitors are at an increased risk of varicella zoster virus reactivation. The primary objective of this study was to evaluate the vaccination rates of recombinant zoster vaccine (RZV) for patients taking a JAK inhibitor for dermatologic or rheumatologic conditions.</p><p><strong>Methods: </strong>A facility-based cross-sectional study design was employed to select patients who were ≥18 years of age and were prescribed a JAK inhibitor for at least 6 months by a rheumatologist or dermatologist for any rheumatologic or dermatologic condition. Data analysis was undertaken using descriptive methods.</p><p><strong>Results: </strong>There were 102 patients included in this study, with most patients being female (77.5%), ≥50 years of age (71.6%), White (77.5%) and with RA (76.5%). The proportion of patients who received at least one RZV (at any time in relation to JAK inhibitor initiation) was 27.5% (28/102). Only three patients received at least one dose of RZV within 30 days before or after initiation of a JAK inhibitor.</p><p><strong>Conclusion: </strong>Many patients receiving JAK inhibitors are not vaccinated with RZV, and of those who are vaccinated, the timing of vaccination rarely coincided with JAK inhibitor initiation and thus did not appear to be the motivation for vaccination. These data will be used to optimize vaccination workflow within ambulatory clinics to mitigate herpes zoster risk in this population.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag071"},"PeriodicalIF":2.8,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A test of a conceptual model of uncertainty, benefit and burden in children and young people with juvenile dermatomyositis.","authors":"Polly Livermore, Klaudia H Kupiec, Kathleen Mulligan, Shashi P Hirani, Faith Gibson, Claire Deakin, Deborah Ridout, Andrea M Knight, Lucy R Wedderburn, Brian M Feldman","doi":"10.1093/rap/rkag070","DOIUrl":"10.1093/rap/rkag070","url":null,"abstract":"<p><strong>Objectives: </strong>Mental health concerns are highly prevalent in children and young people (CYP) with chronic conditions. This is further exacerbated by perceived feelings of illness uncertainty and illness burden, which have negative implications for CYP with childhood-onset chronic conditions and their families. Understanding the mechanisms that reduce health-related quality of life (HRQoL) and identifying resilience factors is important to improve outcomes for these vulnerable populations. The current study aimed to assess HRQoL in CYP with juvenile dermatomyositis (JDM) and to test a new conceptual model of illness representations and resilience in depression and anxiety.</p><p><strong>Methods: </strong>CYP ages ≥8 years who were enrolled in the UK-wide JDM cohort and Biomarker Study (JDCBS) in 15 UK National Health Service tertiary paediatric rheumatology services were invited to complete five validated paediatric measures: PedsQL 4.0 Core, PedsQL 3.0 Rheumatology Module, Paediatric Index of Emotional Distress (PI-ED), Childhood Uncertainty in Illness Scale (CUIS) and Benefit and Burden Scale for Children (BBSC). Data were analysed using descriptive statistics and structural equation modelling.</p><p><strong>Results: </strong>Results showed that the HRQoL in CYP with JDM is affected as a result of their chronic condition. Moreover, the proposed model revealed that illness uncertainty and burden are key driving factors that cause an increase in anxiety and depression, while benefit finding did not ameliorate poor mental health outcomes.</p><p><strong>Conclusion: </strong>Addressing illness uncertainty and reducing the perceived disease burden is vital to improve HRQoL and well-being in CYP with JDM who struggle to cope with the unpredictable nature of their disease.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag070"},"PeriodicalIF":2.8,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13335649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish adaptation and psychometric testing of the Perceived Workplace Support Scale in people with inflammatory arthritis.","authors":"Gonca Bumin, Ezginur Gündoğmuş, Alan Tennant, Sevilay Karahan, Umut Kalyoncu, Yeliz Prior","doi":"10.1093/rap/rkag066","DOIUrl":"10.1093/rap/rkag066","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to adapt the Perceived Workplace Support Scale (PWSS) into Turkish and evaluate its psychometric properties among individuals diagnosed with inflammatory arthritis (IA).</p><p><strong>Methods: </strong>A total of 200 employed individuals with IA (mean age = 37.9 ± 10.6 years; 66.5% female) participated in the study. The cultural adaptation followed Beaton's method, including forward translation, synthesis, back-translation, expert committee review and cognitive debriefing. Construct validity was assessed using Rasch analysis. Internal consistency was examined with Cronbach's alpha, and test-retest reliability was evaluated in a subsample using intraclass correlation coefficients (ICCs). Concurrent validity was examined by correlating PWSS dimension scores with the Work Limitation Questionnaire-Short Form (WLQ-SF), Rheumatoid Arthritis Work Instability Scale (RA-WIS) and Work Productivity and Activity Impairment Questionnaire: General Health (WPAI: GH).</p><p><strong>Results: </strong>Rasch analysis supported the structural validity of the Turkish PWSS, showing adequate model fit after addressing local item dependencies. Cronbach's alpha ranged from 0.59 (manager) to 0.81 (coworker). Test-retest reliability indicated fair stability, with ICCs of 0.47 (manager), 0.52 (coworker) and 0.59 (organization). These findings suggest that the scale is more appropriate for group-level comparisons rather than individual-level assessment. The scores for PWSS subdimensions showed moderate correlations with work and health measures, supporting concurrent validity.</p><p><strong>Conclusions: </strong>The Turkish version of the PWSS demonstrates potential utility for assessing perceived workplace support in individuals with IA. However, given the fair level of test-retest reliability, it should be used with caution and primarily for group-level analyses.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag066"},"PeriodicalIF":2.8,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of healthcare professionals in rheumatology on the use of prediction models in clinical practice.","authors":"Sina Fadaei, Patty de Groot, Rob R G Kuin, Julia Spierings, Amin Herman, Paco M J Welsing, Lise M Verhoef","doi":"10.1093/rap/rkag065","DOIUrl":"10.1093/rap/rkag065","url":null,"abstract":"<p><strong>Objectives: </strong>Prediction models are increasingly developed to aid decision-making in RA, but none are currently included in guidelines. The aim of this study was to explore rheumatology healthcare professionals' perceptions of using prediction models in everyday clinical practice.</p><p><strong>Methods: </strong>An exploratory qualitative study was conducted using semi-structured interviews with rheumatologists and nurse practitioners involved in RA care in the Netherlands. Participants were purposively sampled based on work experience, academic degree, profession and care setting. Interviews were transcribed and analysed thematically following Braun and Clarke's framework.</p><p><strong>Results: </strong>Fifteen interviews uncovered for overarching themes. First, building support for prediction models depended on trust, awareness, understanding of model inputs and limitations, perceived clinical usefulness, evidence and cost-effectiveness. Second, making prediction models workable in routine care required integration into electronic health records, minimal additional workload, reliance on routinely collected data and actionable outputs. Third, healthcare professionals (HCPs) positioned prediction models within clinical judgement and patient care: models were considered valuable when supporting, rather than replacing, professional judgement and shared decision-making, while helping to communicate uncertainty and clarify difficult decisions. Fourth, HCPs anticipated consequences for care organization, medication use, professional autonomy and personalized care, including concerns about misuse by external parties, compulsion and unintended workload or loss of patient visibility.</p><p><strong>Conclusion: </strong>Rheumatology healthcare professionals value prediction models, but only if they are interpretable, clearly beneficial, integrated into workflows and protect professional autonomy. Addressing these concerns is essential for turning models into useful clinical decision tools.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag065"},"PeriodicalIF":2.8,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurse-supported self-monitoring of serum urate by gout patients using a treat-to-target approach: a feasibility study.","authors":"Jeffrey van der Ven, Marcel Flendrie, Anouk Brokking, Noortje van Herwaarden, Bart J F van den Bemt, Lise M Verhoef","doi":"10.1093/rap/rkag064","DOIUrl":"10.1093/rap/rkag064","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility of a nurse-supported, treat-to-target (T2T) self-monitoring approach for gout patients initiating urate-lowering therapy (ULT) using point-of-care testing (POCT) of serum urate (SU) levels.</p><p><strong>Methods: </strong>A 24-week prospective feasibility study was conducted at the Sint Maartenskliniek in the Netherlands among 32 patients starting ULT, or recently started ULT and not at target. Participants received a POCT device to self-measure SU levels at home and report results every 4 weeks via a digital platform. Nurses provided education and dosing advice based on SU levels and monitored patient follow-up. Feasibility was assessed using Bowen's framework. Patient data were obtained through questionnaires and chart review, and stakeholder perspectives were collected through semi-structured interviews.</p><p><strong>Results: </strong>Patients found the intervention highly acceptable. Adherence to SU measurements was 93%, with minimal burden and few problems reported. The majority of the patients reached their SU target (75%). Patients had a median of 2 gout flares (interquartile range [IQR] 0-3). Stakeholders valued the intervention for the potential to increase patient engagement and care efficiency, though they emphasized the need for evidence on cost-effectiveness, clear protocols and appropriate patient selection.</p><p><strong>Conclusion: </strong>Nurse-supported self-monitoring for gout was acceptable, feasible and practical in this selected group of gout patients. The short-term SU target attainment was encouraging, warranting larger comparative randomized studies with longer follow-up to establish (cost-) effectiveness, and long-term disease control.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag064"},"PeriodicalIF":2.8,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and screening of interstitial lung disease in rheumatoid arthritis.","authors":"Takahisa Gono","doi":"10.1093/rap/rkag062","DOIUrl":"10.1093/rap/rkag062","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag062"},"PeriodicalIF":2.8,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13275310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of interventions to prevent anxiety and depression in people with inflammatory rheumatological conditions: a systematic review.","authors":"Lauren Gray, Matilda Bjorklund, Samantha L Hider, Tom Kingstone, Carolyn A Chew-Graham, Nadia Corp","doi":"10.1093/rap/rkag059","DOIUrl":"10.1093/rap/rkag059","url":null,"abstract":"<p><strong>Objectives: </strong>Anxiety and depression are associated with poorer outcomes for people with inflammatory rheumatological conditions (IRCs). A systematic review of psychosocial interventions to prevent anxiety and/or depression in people with long-term conditions was conducted. This analysis aimed to explore the effectiveness of such interventions in IRCs and the subsequent impact on condition and quality of life.</p><p><strong>Methods: </strong>A systematic review examining psychosocial interventions to prevent anxiety and/or depression in people with IRCs. Studies reporting a psychosocial intervention for IRCs and no clinical diagnosis of anxiety or depression at baseline were included. Seven databases (MEDLINE, EMBASE, AMED, CINAHL Plus, PsycINFO, Cochrane Central, Web of Science Core Collection) were searched.</p><p><strong>Results: </strong>The search identified 24 001 unique papers, with 46 being included in the main review. Twelve of these focused on IRCs and are reported in this paper: 10 Randomised Controlled Trials (RCT) and 2 non-RCTs with 830 participants. Three categories of interventions were identified: psychological therapies (<i>n</i> = 5), exercise (<i>n</i> = 3) and educational programmes (<i>n</i> = 4). Eight studies reported a positive effect on anxiety and/or depression prevention. Three of these studies also reported an improvement in fatigue. Only one study reported a positive impact on pain outcomes. Only one study showed improvement in disease activity. Studies predominantly focused on depression outcomes; anxiety was rarely the primary focus. Studies generally scored very low/low certainty of evidence.</p><p><strong>Conclusions: </strong>Offering psychological therapies may help prevent anxiety and/or depression in people with IRCs and may also lead to improvements in fatigue. Given the impact of mood and fatigue on outcomes, further high-quality studies are needed.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag059"},"PeriodicalIF":2.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"900 patients evaluated within a median of 1 day from referral in a very early arthritis clinic in France.","authors":"Esther Ebstein, Pierre-Antoine Juge, Marine Forien, Leslie Benattar, Marie Péan de Ponfilly, Madeleine Franc, Bastien Léger, Anne Dupont, Manon Lemee, Chloé Jessen, Margaux Moret, Léa Bastard, Laurinda Carré, Sirine Mahjoub, Monika Klimek, Anna Molto, Marie-Christine Gallais, Mylène Dousset, Sébastien Ottaviani, Philippe Dieudé","doi":"10.1093/rap/rkag055","DOIUrl":"10.1093/rap/rkag055","url":null,"abstract":"<p><strong>Objective: </strong>In order to fit with National Institute for Health and Care Excellence (NICE) guidelines on arthritis, we established a 'very early arthritis clinic' (v-EAC) to evaluate patients within 48 h of a medical referral for any suspected arthritis of <1-month duration. We describe the characteristics of patients referred to the v-EAC from 2 October 2023 to 1 October 2024.</p><p><strong>Methods: </strong>Delay of referral was recorded. A systematic and standardized clinical, biological and ultrasound evaluation of all consecutive patients was conducted. Patients and disease characteristics are described.</p><p><strong>Results: </strong>A total of 900 patients were evaluated within a median delay of 1 day after referral: 51% were women and the median age was 55 years (IQR 42-67). Among these patients, 37% were referred by emergency departments, 28% by rheumatologists, 18% by general practitioners and 17% by other specialists. For 46% of patients, it was the first episode of a swollen joint, with a median symptom duration of 14 days (IQR 5-44) and a mean number of 1.3 (s.d. 1.9) swollen joints. Inflammatory arthritis was confirmed in 63% of cases and diagnoses were flare of immune-mediated inflammatory disease (IMID)-related arthritis in 35% of cases (half of which represented the first manifestation of an IMID-related arthritis), crystal-related arthritis in 27% (mostly gout) and infectious disease in 8.0% (including 34 bursitis and 13 septic arthritis). Joint aspiration was performed in 414 patients (46%). Corticosteroid-derivative injections were administered to 31% of patients and hospitalization was required in 10% of cases [median stay 6 days (IQR 4-8)].</p><p><strong>Conclusion: </strong>A dedicated care pathway can make the NICE guidelines regarding management of arthritis reachable.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag055"},"PeriodicalIF":2.8,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two lenses, one disease: the power of joint working in SARD-ILD to 'focus' on the best care.","authors":"Laura White, Mia Rodziewicz, Lisa G Spencer, Elizabeth Perry","doi":"10.1093/rap/rkag058","DOIUrl":"10.1093/rap/rkag058","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag058"},"PeriodicalIF":2.8,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female genital tract polyarteritis nodosa associated with cutaneous lymphocytic thrombophilic arteritis.","authors":"Abuelmagd Abdalla, Aoife Boyle, Mohamed Hag, Ian McDonald, Graham Woods","doi":"10.1093/rap/rkag056","DOIUrl":"10.1093/rap/rkag056","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"10 3","pages":"rkag056"},"PeriodicalIF":2.8,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}