Rheumatology Advances in Practice最新文献

{"title":"Building a stronger future together: a message from the new Editor-in-Chief.","authors":"Mwidimi Ndosi","doi":"10.1093/rap/rkaf021","DOIUrl":"https://doi.org/10.1093/rap/rkaf021","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 2","pages":"rkaf021"},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WORKWELL process evaluation: qualitative data analyses of the participant interviews at 12- and 36-month follow-ups.","authors":"Simone Battista, Jennifer Parker, Angela Ching, June Culley, Sarah Long, Alison Heard, Alison Hammond, Kathryn Radford, Paula Holland, Terence O'Neill, Karen Walker-Bone, Yeliz Prior","doi":"10.1093/rap/rkaf034","DOIUrl":"10.1093/rap/rkaf034","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to qualitatively examine the delivery of the WORKWELL trial, a job retention vocational rehabilitation (JRVR) programme designed to help individuals with inflammatory arthritis (IA) maintain employment. A qualitative process evaluation used the Normalization Process Theory (NPT) to understand participant experiences and identify factors influencing implementation and outcomes.</p><p><strong>Methods: </strong>Data were collected via one-to-one telephone interviews with trial participants at 12 and 36 months. An inductive reflexive thematic analysis was followed by a deductive analysis based on NPT's four constructs (coherence, cognitive participation, collective action and reflexive monitoring).</p><p><strong>Results: </strong>Sixty-two participants (mean age 51.0; 82.3% female) were interviewed, most diagnosed with RA (75.8%). Four secondary themes were generated under NPT constructs. For 'Coherence', themes included 'Exploring the Purpose and Impact of Taking Part in WORKWELL' and 'Questionnaires as Instrument for Reflection'. In 'Cognitive Participation', the theme was 'Commitment and Investment to WORKWELL'. For 'Collective Action', we identified 'Key Actions for Successful WORKWELL', and under 'Reflexive Monitoring', the theme was 'Suggestions for Improving WORKWELL'. These themes reflected participants' mixed feelings about the intervention, finding value in the intervention but highlighting the need for more tailored, timely and relevant content. Workplace support was crucial but often insufficient. Follow-up calls from researchers to ensure questionnaire completion were seen as a way to reflect and monitor their conditions. The pandemic's impact on work environments also influenced outcomes.</p><p><strong>Conclusion: </strong>Findings suggest that WORKWELL provided work support for participants, though its impact could be enhanced through greater customization, early intervention and stronger workplace engagement.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT03942783. Registered on 8 May 2019. ISRCTN Registry ISRCTN61762297. Registered on 13 May 2019. Retrospectively registered.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 2","pages":"rkaf034"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular corticosteroid injections for the treatment of people with foot and ankle osteoarthritis: a systematic review.","authors":"Katherine Jones, Julie Bruce, Thomas L Lewis, Ciaran N Nolan, Shannon E Munteanu, Hylton B Menz, Michael R Backhouse","doi":"10.1093/rap/rkaf030","DOIUrl":"10.1093/rap/rkaf030","url":null,"abstract":"<p><strong>Objective: </strong>Intra-articular corticosteroid injections are commonly used in the management of foot and ankle OA. Although current clinical guidelines advocate the judicious use of corticosteroid injection as an adjunct therapy, none of these recommendations are specific to the foot and ankle. Therefore, the aim of this review is to examine the effectiveness of intra-articular corticosteroid injections in people with foot or ankle OA.</p><p><strong>Methods: </strong>Four databases (Cumulative Index to Nursing and Allied Health Literature [CINAHL], MEDLINE, EMBASE and CENTRAL) and one clinical trial register (International Clinical Trials Registry Platform [ICTRP]) were searched from inception to June 2024 for randomized control trials (RCTs) and quasi-RCTs evaluating corticosteroid injection in the treatment of foot or ankle OA on pre-specified outcomes: pain, function, quality of life, safety (adverse events) and/or cost-effectiveness. Two independent reviewers conducted record screening, data extraction (Cochrane data extraction tool) and assessment of methodological quality (Cochrane Risk of Bias tool [RoB 2.0]).</p><p><strong>Results: </strong>From 1711 citations, two RCTs (57 participants, 49% males) were identified. There were no differences in pain or function over 8 weeks after a single injection of intra-articular corticosteroid compared with prolotherapy for treatment of first metatarsal joint OA. Pain and function significantly improved in people having three corticosteroid injections combined with hyaluronic acid compared with corticosteroid injections alone for treatment of post-traumatic subtalar OA. Methodological quality was graded as some concerns in both trials.</p><p><strong>Conclusion: </strong>There is insufficient evidence to guide the use of intra-articular corticosteroid injections for OA of the foot or ankle. Future robust research is needed to provide reliable evidence for this commonly performed treatment.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 2","pages":"rkaf030"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring patient activation and self-management experiences in adults with fibromyalgia: a qualitative evidence synthesis.","authors":"Kit Yung, Durva Jadhav, Cheuk Ma, Sakshee Majgaonkar, Eya Manai, Jennifer Pearson","doi":"10.1093/rap/rkaf025","DOIUrl":"https://doi.org/10.1093/rap/rkaf025","url":null,"abstract":"<p><strong>Objectives: </strong>Fibromyalgia syndrome (FMS) is a chronic pain condition that affects involvement in daily activities, including self-care and household responsibilities. Self-management strategies are a primary focus in treatment recommendations. However, their effectiveness depends on an individual's readiness and capacity to adopt health-promoting behaviours. This study aims to explore the experiences of adults in their self-management journey, focusing on the barriers and facilitators influencing patient activation (PA) and effective self-management.</p><p><strong>Methods: </strong>A qualitative evidence synthesis was conducted. An electronic search was performed using the following databases: CINAHL, PsycINFO, PubMed, Medline, ScienceDirect and AMED. The studies were screened against eligibility criteria to ensure their relevance. The quality of the included studies was assessed against the Critical Appraisal Skills Programme (CASP) questionnaire for qualitative studies and the Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist. Findings from the papers were synthesized via the three-stage thematic synthesis process, and common themes were identified.</p><p><strong>Results: </strong>Nine studies with a total of 130 participants were included. Four major analytical themes were identified, including legitimizing FMS, the value of medical support, receiving peer and social support, and learning to self-manage.</p><p><strong>Conclusion: </strong>Self-management of FMS requires patients to be actively involved in managing their health. These findings highlight that support from HCPs, family members and peers helps patients learn how to self-manage and engage in health-promoting behaviours. Clinicians treating people with FMS should prioritize education, empathy and personalized support.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 2","pages":"rkaf025"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical cardiovascular complications during non-immunosuppressive therapy for VEXAS syndrome.","authors":"Yuna Saito, Satoshi Suzuki, Keigo Ikeda, Shinji Morimoto","doi":"10.1093/rap/rkaf028","DOIUrl":"https://doi.org/10.1093/rap/rkaf028","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 2","pages":"rkaf028"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dysfunction in women with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: an online community-based study.","authors":"Emily Fuster, Omid Mirmosayyeb, Svetlana Blitshteyn","doi":"10.1093/rap/rkaf023","DOIUrl":"10.1093/rap/rkaf023","url":null,"abstract":"<p><strong>Objectives: </strong>Hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (h-EDS) are connective tissue disorders associated with joint hypermobility, pain, fatigue and autonomic dysfunction. We sought to assess sexual function in women with h-EDS/HSD.</p><p><strong>Methods: </strong>In this cross-sectional community-based case-control study, women with h-EDS/HSD completed the following online questionnaires: Female Sexual Function Index (FSFI), 31-item Composite Autonomic Symptom Score (COMPASS-31), Beck Depression Inventory-II (BDI-II) and an additional short form with questions pertaining to comorbidities and sexual activity. Scores were compared with those of healthy female controls.</p><p><strong>Results: </strong>A total of 84 women with h-EDS/HSD [mean age 37.1 years (s.d. 8.4)] and 75 healthy women [mean age 29.79 years (s.d. 5.38)] completed the questionnaires. Of these, 75% were diagnosed with h-EDS, 25% with HSD and 58% had concurrent postural orthostatic tachycardia syndrome. A majority of women with h-EDS/HSD (52%) did not engage in any sexual activity, and only 25% reported having sexual intercourse with a partner in the past 6 months. The mean COMPASS-31 score was 51.5 (s.d. 13.8), mean BDI-II score was 24.6 (s.d. 11.4) and mean FSFI score was 15.3 (s.d. 7.9) in the patient group. Compared with healthy controls, women with h-EDS/HSD had decreased FSFI scores in the subdomains of desire, arousal, lubrication, orgasm and sexual satisfaction. Neither BDI-II nor COMPASS-31 scores were predictive of the FSFI score.</p><p><strong>Conclusion: </strong>Compared with healthy women, we found significant sexual dysfunction in women with h-EDS/HSD, which did not correlate with depressive or autonomic symptoms in this cohort. Given its health implications, sexual dysfunction represents a significant unmet need that calls for development of targeted diagnostic and therapeutic approaches in the care of women with h-EDS/HSD.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 2","pages":"rkaf023"},"PeriodicalIF":2.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jeopardy to life and limb-using immunogenotyping to characterize inflammatory phenotypes: a case report.","authors":"Kirishananth Rajaseelan, Saad Ahmed, Frances Hall, Emese Balogh, Dinakantha Kumararatne, Anita Chandra, Ania Manson","doi":"10.1093/rap/rkaf020","DOIUrl":"10.1093/rap/rkaf020","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 1","pages":"rkaf020"},"PeriodicalIF":2.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pericarditis to giant cell arteritis: leveraging FDG PET CT for accurate diagnosis and treatment.","authors":"Fatima K Alduraibi","doi":"10.1093/rap/rkaf019","DOIUrl":"https://doi.org/10.1093/rap/rkaf019","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 1","pages":"rkaf019"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thank you to the reviewers of Rheumatology Advances in Practice 2024.","authors":"Ai Lyn Tan","doi":"10.1093/rap/rkaf002","DOIUrl":"10.1093/rap/rkaf002","url":null,"abstract":"","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 1","pages":"rkaf002"},"PeriodicalIF":2.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal risk of serious infections in patients with inflammatory arthritis on immunomodulating therapy compared to controls.","authors":"Ingrid Egeland Christensen, Siri Lillegraven, Joseph Sexton, Tore K Kvien, Till Uhlig, Sella Aarrestad Provan","doi":"10.1093/rap/rkaf017","DOIUrl":"10.1093/rap/rkaf017","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the risk of serious infection across time cohorts in patients with inflammatory arthritis (IA) initiating their first biologic/targeted synthetic DMARD (b/tsDMARD), to that of the general population. Secondarily, to compare the development in infection risk during treatment across diagnoses and examine risk dynamics during the course of b/tsDMARD treatment.</p><p><strong>Methods: </strong>Patients with IA starting their first b/tsDMARD were included from the prospective NOR-DMARD study. Controls were randomly drawn from the general population. Cox regressions were used to compare the 12-month risk of serious infections across three time cohorts following initiation (2009-2011, 2012-2014, 2015-2018) and risk during the course of treatment at 6-month intervals up to 24 months.</p><p><strong>Results: </strong>A total of 4309 patients (RA, 1581; PsA, 1032; SpA, 1696) and 86 640 controls were included. From 2009 through 2018, 51 serious infections occurred during the first year of b/tsDMARD treatment in RA patients [hazard ratio (HR) 2.42 (95% CI 1.83, 3.21)] compared with controls and 52 serious infections were observed in patients with PsA/SpA [HR 1.91 (95% CI 1.44, 2.52)]. There were no significant differences in 12-month risk of serious infections during b/tsDMARD exposure between time cohorts. PsA/SpA patients had a consistently lower risk of serious infection compared with RA patients. The risk of serious infections did not change during the treatment course.</p><p><strong>Conclusion: </strong>Patients with IA starting their first b/tsDMARD between 2009 and 2018 had a consistently higher 12-month risk of serious infection compared with controls. No change in the risk of serious infection across time cohorts of b/tsDMARD initiation was observed, nor during the treatment course.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 1","pages":"rkaf017"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}