Rheumatology International最新文献

{"title":"Fatal case of pancreatic panniculitis and polyarthritis due to pancreatic neuroendocrine tumor: a case report and review of literature.","authors":"Dorota Suszek, Ewa Wielosz, Mateusz Suszek, Maksymilian Seweryn, Natalia Wilczek, Kacper Niewęgłowski, Klaudia Miller, Bożena Targońska-Stępniak","doi":"10.1007/s00296-025-05823-5","DOIUrl":"10.1007/s00296-025-05823-5","url":null,"abstract":"<p><p>Pancreatic panniculitis (PP) and arthritis may be extrapancreatic manifestations of pancreatic disease. The triad of pancreatic disease, panniculitis and polyarthritis, described in the literature as the PPP syndrome, is sometimes observed in patients with acute or chronic pancreatitis, pancreatic cancer or neuroendocrine tumors (NETs). We present a 60-year-old man with polyarthritis and clinically aggressive PP of the limbs. Computed tomography showed a large tumor in the uncinate process of the pancreas and multiple metastatic lesions in the liver and lungs. The skin nodules developed before the diagnosis of the occult pancreatic tumor and metastases. Biopsy of the skin nodules was performed and showed lobular panniculitis. In addition, immunopathology of the liver metastasis showed NET, a rare pathological variant. The skin lesions immediately spread to the upper limbs with extensive ulceration and necrosis, accompanied by high serum lipase levels. The patient died 4 months after the initial development of the skin lesion. PPP syndrome is a rarely recognized clinical entity. The present case report and literature review highlight the key clinical features of PPP syndrome. The absence of general or abdominal symptoms and skin changes mimicking other forms of panniculitis may lead to delayed diagnosis. It is important to broaden the diagnostic work-up for pancreatic disease in patients presenting with panniculitis and arthritis.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 4","pages":"69"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and factors associated with treatment response among patients with eosinophilic fasciitis: a systematic review and meta-analysis.","authors":"Omar Hamdan, Roa'a Alshajrawi, Qais Mussa, Yazeed Alajlouni, Yazan Dabbah, Rawan Fratekh, Yousef Al-Mabrouk, Shatha Al-Mabrok, Ahmad A Toubasi, Fatima Alnaimat","doi":"10.1007/s00296-025-05826-2","DOIUrl":"10.1007/s00296-025-05826-2","url":null,"abstract":"<p><strong>Background/objectives: </strong>Eosinophilic Fasciitis (EF) is a rare connective tissue disorder characterized by skin thickening. Few studies explored its characteristics and factors associated with treatment response.</p><p><strong>Methods: </strong>PubMed, CENTRAL, Web of Sciences, and Scopus databases were searched in July 2023 to identify all published case reports of EF without restrictions on publication year or language. We extracted patients' demographics, clinical symptoms, laboratory findings, biopsy results and treatment outcomes.</p><p><strong>Results: </strong>We analyzed 476 published case reports with an aggregate number of 597 patients. The mean age of the patients was 44.52, with a 1:1 male-to-female ratio. Comorbid autoimmune diseases were present in 13.3% of patients. The most common reported skin manifestation was induration (80.7%), with the most commonly affected body part being the legs (77.1%). Only 1.6% of patients had Raynaud's phenomena and 3.1% of patients had Dysphagia. Hypereosinophilia was present in 90.2% and hypergammaglobulinemia was present in 65.9%. Corticosteroids were received by 89.7% of patients. The majority of patients (82.2%) exhibited a clinical response to treatment, but 24.5% of patients who initially responded to treatment relapsed. Patients who received oral corticosteroid monotherapy were significantly more likely to respond to treatment compared to those who received other treatments (56.2% Vs. 39.4%). Patients who had forearm skin involvement (OR = 3.459; 95% CI: 1.334-8.966) had significantly higher odds of clinical response to treatment.</p><p><strong>Conclusions: </strong>EF is a complex disease with non-specific symptoms. Our study offers comprehensive insights into patient characteristics and treatment outcomes, aiding clinicians in enhancing their approach.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 4","pages":"71"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and management of systemic sclerosis-related osteomyelitis: a retrospective cohort study.","authors":"Toshiki Miwa, Koh Okamoto, Hayakazu Sumida, Satoshi Toyama, Shinichi Sato, Takeya Tsutsumi","doi":"10.1007/s00296-025-05815-5","DOIUrl":"10.1007/s00296-025-05815-5","url":null,"abstract":"<p><p>Digital ulcers in patients with systemic sclerosis (SSc) can be complicated by SSc-related osteomyelitis (SRO). The microbiological data and optimal management of SRO remain unclear. This single-center retrospective study involved patients with SSc aged 18 or older from April 2005 to March 2022. Diagnosis of SRO was based on clinical presentation and MRI findings. The accuracy of the superficial swab culture results was estimated using the bone culture as a reference. Temporal changes in local signs for up to a year were collected, and their association with (1) duration of antimicrobial therapy (> 6 weeks) or (2) surgical interventions was assessed using univariable analyses. Among the 2,126 patients, 46 (2.2%) were diagnosed with SRO. In seven patients whose swab and bone cultures were both available, two (28.6%) had swab cultures identifying all the organisms detected in bone cultures. Resolution of local inflammatory signs consistently preceded wound closure. Three months after therapy initiation, prolonged antimicrobial therapy was not significantly associated with the resolution of local inflammatory signs (16/19 [84.2%] vs. 12/14 [85.7%]; P = 1.00), and surgical intervention was not significantly associated with wound dehiscence (6/9 [66.7%] vs. 20/24 [83.3%]; P = 0.36). Superficial swab cultures may not reliably reflect the true causative organism of SRO. Prolonging antimicrobial therapy beyond six weeks may be of little benefit for patients with SRO when local inflammatory signs improve. Surgical intervention may be a safe and effective option for selected patients with SRO.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 4","pages":"73"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short- and Medium-Term effects of major Ozone therapy on disease parameters in fibromyalgia syndrome: A retrospective study.","authors":"Ahmet Üşen, Didem Sezgin Özcan, Mehmet Ağirman, Hilal Güner, Burhan Fatih Kocyigit","doi":"10.1007/s00296-025-05827-1","DOIUrl":"10.1007/s00296-025-05827-1","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia syndrome (FMS) is a chronic condition causing widespread pain, fatigue, and sleep disturbances. Conventional treatments often provide limited relief, leading to growing interest in complementary therapies like ozone therapy.</p><p><strong>Objective: </strong>This study aims to retrospectively evaluate the short- and medium-term efficacy of ozone therapy in patients with FMS, focusing on changes in pain, functional status, sleep quality, fatigue, anxiety, and depression.</p><p><strong>Methods: </strong>Twenty-five FMS patients treated at the Physical Medicine and Rehabilitation outpatient clinic of University Hospital were included. Participants underwent a 10-session major ozone autohemotherapy protocol administered twice weekly. Key outcomes were measured using the Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI), and Fatigue Severity Scale (FSS) at baseline, post-treatment, and six months post-treatment. Generalized Estimating Equations were used for data analysis.</p><p><strong>Results: </strong>VAS scores decreased from 6.4 to 3.68 post-treatment (p < 0.001) and partially increased to 4.12 at six months (p = 0.01). Similar trends were observed for FIQ, HADS, PSQI, and FSS. Tender points declined from 14.36 to 9.8 post-treatment (p < 0.001) and remained stable at 10.12 at six months (p = 0.289). FIQ scores improved from 59.2 to 39.08 post-treatment (p < 0.001) and stabilized at 40.12 at six months (p = 0.328).</p><p><strong>Conclusion: </strong>Ozone therapy demonstrates promising short- and medium-term efficacy in managing FMS symptoms, with significant improvements post-treatment. However, partial symptom recurrence at six months suggests the need for optimized protocols and further studies to ensure long-term sustainability.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 4","pages":"72"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANCA-associated vasculitis and the impact of diffuse alveolar hemorrhage in elderly patients: a retrospective cohort study.","authors":"Matthias Schaier, Florian Kälble, Louise Benning, Paula Reichel, Christoph Mahler, Christian Nusshag, Jonas Rusnak, Tobias Gutting, Michael Preusch, Martin Zeier, Christian Morath, Claudius Speer","doi":"10.1007/s00296-025-05812-8","DOIUrl":"10.1007/s00296-025-05812-8","url":null,"abstract":"<p><p>The ANCA-associated vasculitis (AAV) has an exceptionally high morbidity and mortality especially in patients with diffuse alveolar hemorrhage (DAH). Data on DAH in elderly AAV patients is still very limited. To investigate the impact of DAH on patient survival, relapse-free survival, death from infectious complications, and the incidence of pneumonia in one of the most vulnerable but often underrepresented AAV subpopulation-elderly patients. We included 139 AAV patients in this retrospective cohort study and performed a 5-year follow-up. AAV patients were divided into patients ≤ 65 and > 65 years (\"elderly\"). Elderly AAV patients were further subdivided into patients with and without DAH. Relapse-free survival was comparable (P = 0.49) whereas overall patient survival (P = 0.01) was significantly lower in patients > 65 as compared to ≤ 65 years. Death due to infectious complications occurred more frequently in the elderly cohort (log-rank P = 0.02). Especially the incidence of pneumonia (including opportunistic pathogens) was considerably higher in elderly AAV patients (log-rank P = 0.001). Overall survival in elderly patients was significantly lower in patients with as compared to patients without DAH [8/18 (44%) versus 9/52 (17%) deaths (P = 0.02)] while relapse-free survival was again comparable (P = 0.87) between both groups. Notably, 6 out of 8 fatal outcomes in elderly DAH patients were associated with severe infections. In multivariate analyses, age and glucocorticoid (GC) dose at 3 months were the only predictors of death from infectious complications, whereas this could not be independently demonstrated for DAH. Life-threatening infections with (opportunistic) pneumonia are common in elderly AAV patients with DAH during the first 12 months and higher GC dose was an independent predictor of death from infectious complications.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"68"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and diagnosis of sarcopenia in rheumatic and musculoskeletal diseases: findings from a cross-sectional study.","authors":"Eleni C Pardali, Katerina-Maria Kontouli, Arriana Gkouvi, Irene A Tsakmaki, Eleni Patrikiou, Maria Karapli, Christos Liaskos, Nektarios Marios Liapis, Vasiliki Syrmou, Ioannis Alexiou, Theodora Simopoulou, Sousana K Papadopoulou, Christina G Katsiari, Efterpi Zafiriou, Dimitrios G Goulis, Dimitrios P Bogdanos, Maria G Grammatikopoulou","doi":"10.1007/s00296-025-05821-7","DOIUrl":"10.1007/s00296-025-05821-7","url":null,"abstract":"<p><p>Sarcopenia is characterized by loss of muscle mass and reduced muscle function, presenting various adverse events, especially when inflammation is present. The present study aimed to determine the prevalence of sarcopenia and sarcopenic obesity among patients with rheumatic and musculoskeletal diseases (RMDs) and identify the risk for sarcopenia using two screening tools the Strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) and the Mini Sarcopenia Risk Assessment (MSRA). In this single-center cross-sectional study, 220 consecutive patients visiting the Department of Rheumatology and Clinical Immunology at the University General Hospital of Larissa were interviewed. The EWGSOP criteria were used for the diagnosis of sarcopenia, while sensitivity, specificity, positive predictive values, number needed to screen, and positive and negative likelihood ratios were used to validate the diagnostic validity of the SARC-F and the MSRA. Univariate and multivariate logistic regression analyses were also applied to model the relationship between sarcopenia and other variables. In the total sample, 15.9% of patients were diagnosed with sarcopenia and one patient with sarcopenic obesity. The SARC-F (sensitivity 22.2%, specificity 75.6%), the 5-item (sensitivity 88.9%, specificity 18.9%), and the 7-item MSRA (sensitivity 91.7%, specificity 9.2%) presented poor clinical performance when used for screening alone. Univariate logistic regression analyses showed that underweight status, systemic sclerosis and appetite loss are strong contributors to sarcopenia diagnosis. Sarcopenia is prevalent among RMDs, and screening is essential within RMD clinics. None of the screening tools (SARC-F and MSRA) can stand alone in assessing sarcopenia in patients with RMDs. More research is required to understand sarcopenia in RMDs and validate the wide-using screening tools.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"67"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased retinal thickness in sarcoidosis patients with ocular system involvement visualized with optical coherence tomography: a cross-sectional study.","authors":"Keld-Erik Byg, Torkell Ellingsen, Jimmi Wied, Michella Peiris, Simon Joel Lowater, Tobias Sejbaek, Jakob Grauslund","doi":"10.1007/s00296-025-05818-2","DOIUrl":"10.1007/s00296-025-05818-2","url":null,"abstract":"<p><p>This study investigates the thickness of retinal structures in patients with neurosarcoidosis (NS) and ocular sarcoidosis (OS). We compared the central macular thickness (CMT), retinal thickness (RT), central nerve fiber layer (RNFL) thickness, and ganglion cell layer (GCL) thickness using optical coherence tomography. In a cross-sectional study, we categorized 97 sarcoidosis patients (185 eyes) into four groups: patients without ocular or central nervous system sarcoidosis (Non-Ocular/Non-CNS, n = 53), patients with OS (Ocular, n = 13), patients with NS (CNS, n = 16), and patients with combined OS and NS (Ocular/CNS, n = 15). The mean age was 51 (14) years. We found no overall difference between the groups in the CMT (p = 0.3), RT (p = 0.9), RNFL (p = 0.3), and GCL measurements (p = 0.9). Only in patients with a disease duration of more than five years, the CMT was significantly thicker in the Ocular group (278 μm, p < 0.001), the CNS group (267 μm, p = 0.04), and the Ocular/CNS group (268 μm, p = 0.04), compared to the Non-Ocular/Non-CNS group (249 μm). The RT was significantly thicker in the Ocular group (296 μm, p = 0.008) and the Ocular/CNS group (291 μm, p = 0.03) compared to the Non-Ocular/Non-CNS group (283 μm). In the RNFL measurements, the Ocular group (33.7 μm, p = 0.002) was thicker than the Non-ocular/Non-CNS group (29.1 μm). We found an increased retinal thickness in patients with ocular sarcoidosis and long disease duration.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"66"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovitis and its association with elevated circulating interferons and hydroxychloroquine response in discoid lupus erythematosus: a cross-sectional study.","authors":"Magdalena Stec, Monika Krezelok, Magdalena Awsiuk, Ewa Wypasek, Bogdan Batko, Maciej Pastuszczak","doi":"10.1007/s00296-025-05816-4","DOIUrl":"10.1007/s00296-025-05816-4","url":null,"abstract":"<p><p>A significant proportion of patients with discoid lupus erythematosus (DLE) experience joint pain, yet its underlying pathomechanism remains unclear. Recent ultrasound studies in systemic lupus erythematosus (SLE) patients indicate synovitis in up to 90%, even in clinically silent cases, with interferon-mediated immune responses implicated in joint inflammation. This study aimed to investigate joint pathology in DLE, focusing on synovitis and its immunological profile. We analyzed 23 patients with histologically confirmed DLE and joint pain, all treated for ≥ 5 months with prednisone (≤ 10 mg/day) and hydroxychloroquine (HCQ, 200 mg/day). Ultrasonographic assessment (24 joints per patient) was performed using power Doppler (PD) ultrasonography, with synovitis graded using the OMERACT-EULAR PDUS synovitis score. Serum levels of 37 cytokines were measured via Bio-Plex Pro™ Human Inflammation Panel (37Plex). Synovitis (OMERACT-EULAR score ≥ 1) was identified in 30% (7/23) of DLE patients, with minimal (grade 1) synovitis in six cases and moderate (grade 2) synovitis in one. Patients with synovitis had significantly higher levels of IFN-α2, IFN-γ, MMP-1, MMP-3, sTNF-R1, and sTNF-R2 (p < 0.05), more painful joints, and poorer response to HCQ treatment (71.4% vs. 25% non-responders). Joint pain in DLE may result from synovitis, with an interferon-mediated immune response contributing to inflammation. Patients with synovitis exhibited elevated interferon levels and a worse response to HCQ therapy. These findings suggest a shared pathogenic mechanism between DLE and SLE-related arthritis, warranting further investigation into targeted therapeutic strategies.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"64"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral adipose tissue is related to interleukin 6 and resistin in juvenile idiopathic arthritis - a case-control study.","authors":"Kristine Risum, Nicoleta Cristina Olarescu, Kristin Godang, Henriette Schermacher Marstein, Jens Bollerslev, Helga Sanner","doi":"10.1007/s00296-025-05820-8","DOIUrl":"10.1007/s00296-025-05820-8","url":null,"abstract":"<p><p>To compare visceral adipose tissue (VAT) mass, lipid profile, and selected adipokines/cytokines in patients with juvenile idiopathic arthritis (JIA) with controls, and to explore associations between these markers and VAT. We included 60 JIA patients (30 oligoarticular,30 polyarticular), aged 10-16 years, and 60 age-and sex-matched controls. VAT (g) was estimated by dual-energy x-ray absorptiometry. Lipid profile and selected adipokines/cytokines were analyzed by standard methods and ELISA, respectively. VAT (g) was comparable between patients and controls [median (25th-75th percentile): 64 (23-149) g vs. 66 (30-99) g, p = 0.98] and between oligoarticular and polyarticular disease courses [46 (22-123) g vs. 80 (23-167) g, p = 0.32]. Patients had lower serum levels of apolipoprotein A1 (APOA1) and elevated levels of interleukin- 6 (IL-6) and progranulin compared to controls. As compared to oligoarticular disease course, patients with polyarticular disease had lower serum levels of low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) (Lp(a)), interleukin 1 receptor antagonist (IL-1RA) and progranulin, and elevated levels of interleukin-1 beta (IL-1b) and IL-1b/IL-1RA ratio. In patients (B, 95% CI), higher IL-6 (48.7, 25.1 to72.2, p < 0.001), resistin (8.5, 5.1 to 11.8, p < 0.001), and leptin (2.5, 0.9 to 4.0, p = 0.002) were associated with higher VAT. In controls, higher leptin (5.3, 3.7 to 6.9), p < 0.001) was associated with higher VAT. Despite similar VAT mass between patients and controls, VAT was related to IL-6 and resistin in patients only, suggesting an active metabolic role in JIA. Several pro-inflammatory adipokines/cytokines were increased in JIA, with differences in Lp(a) between oligoarticular and polyarticular disease courses.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"63"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized physical activity recommendations for people with axial spondyloarthritis using wearable activity tracker data: an exploratory study.","authors":"A-W de Leeuw, M A T van Wissen, T P M Vliet Vlieland, A M van Tubergen, M G J Gademan, M A M Berger, S F E van Weely","doi":"10.1007/s00296-024-05755-6","DOIUrl":"10.1007/s00296-024-05755-6","url":null,"abstract":"<p><strong>Objective: </strong>Benefits of physical activity (PA) on sleep in people with axial SpondyloArthritis (axSpA) are largely unknown. Our aim is to explore the relationships between PA and sleep on both a group level and an individual level using Wearable Activity Trackers (WATs) and machine learning.</p><p><strong>Methods: </strong>A sample of 64 axSpA participants received a WAT to monitor their PA and sleep. Participants with more than 30 days data of PA and sleep duration were included in the analyses. Spearman's correlation and the machine learning technique Subgroup Discovery were used to determine relationships between PA during the three prior days and light and deep sleep duration.</p><p><strong>Results: </strong>Number of daily steps (n = 64) was (median (first quartile (Q1) - third quartile (Q3) )) 4026 (1915 - 6549), total sleep (daily light and deep sleep) duration of the participants was 7 h 29 min (6 h 41 min - 8 h 8 min). Nearly 30% (n = 18) of the participants were eligible for inclusion in analyses (> 30 days of data). No significant relationships between prior PA and sleep were obtained on a group level. On an individual level, for 8 of the 18 included participants, significant relationships (p < 0.05) could be identified between PA during the three prior days and daily sleep duration. These significant relationships differed from participant to participant with a varying qualification of PA (number of steps, intensity level PA) and relevant time window (previous one, two or three days).</p><p><strong>Conclusion: </strong>Significant relationships between PA and daily sleep duration could be obtained on an individual level with details of the significant relationships varying between participants.</p><p><strong>Registration number: </strong>Netherlands Trial Register NL8238, included in the International Clinical Trial Registry Platform (ICTRP) ( https://trialsearch.who.int/Trial2.aspx?TrialID=NL8238 ).</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"65"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}