Rheumatology International最新文献

{"title":"The quality of life assessment in children with juvenile idiopathic arthritis- comparison of PROMIS^® generic and disease-specific cut-off points: a pilot study.","authors":"Justyna Młyńczyk, Paweł Abramowicz, Izabela Bernacka-Kusznierko, Jerzy Konstantynowicz","doi":"10.1007/s00296-025-05797-4","DOIUrl":"10.1007/s00296-025-05797-4","url":null,"abstract":"<p><strong>Objectives: </strong>Decreased quality of life (QoL) is a significant complication of most rheumatic conditions in adults, whereas data on health-related quality of life (HRQoL) in children with juvenile idiopathic arthritis (JIA) are limited. Patient-Reported Outcomes Measurement Information System^® (PROMIS^® ) instruments assessing quality of life (QoL) components can be scored using disease-specific severity thresholds. Our study aimed to compare the results of generic and one of the JIA-specific scorings regarding PROMIS^® Pediatric Mobility, Pain Interference, and Fatigue questionnaires, introduce PROMIS^® Pediatric Global Health 7 questionnaire as a valuable method to assess QoL specifically in patients with JIA and determine differences in self-reported QoL in juvenile idiopathic arthritis (JIA) patients and their healthy peers in the Polish population.</p><p><strong>Methods: </strong>In this single-center cross-sectional study, four self-reported questionnaires derived from the PROMIS^® Pediatric Item Bank (Global Health, Pain Interference, Fatigue, Mobility) were administered to 52 patients with JIA (8-17 years; mean 13.2 ± 2.9; girls 59.6%) and 101 age-matched healthy controls. Questionnaires were scored based on generic or JIA-specific cut-off points.</p><p><strong>Results: </strong>Regardless of the domain (PROMIS^® Pain Interference, Fatigue, or Mobility), JIA patients assigned by generic cut-off points to a more severe outcome were classified into milder outcomes when cut-off points for JIA were used. The usefulness of the PROMIS^® Pediatric Global Health 7 questionnaire was evidenced in children with JIA. No significant differences were found in QoL assessment between children with JIA and healthy children; however, self-reported impaired mobility was more prevalent in patients with JIA. A negative correlation was found between overall QoL and the assessment of three domains: pain, fatigue, and mobility impairment.</p><p><strong>Conclusions: </strong>Our study underscores the importance of JIA-specific scoring in clinical practice. While more research is needed to establish a single disease-specific scoring, our findings provide valuable insights into the negative influence of pain, fatigue, and mobility impairment on QoL in JIA. These results have the potential to significantly impact patient care and improve the health-related quality of life in children with JIA.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"61"},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very long-term remission in behcet's disease following withdrawal of anti-TNF treatment exceeds relapses: a reappraisal of an outcome study.","authors":"Aikaterini Arida, Nikos Markomichelakis, George E Fragoulis, Petros P Sfikakis","doi":"10.1007/s00296-025-05806-6","DOIUrl":"10.1007/s00296-025-05806-6","url":null,"abstract":"<p><strong>Background: </strong>Introduction of anti-TNF treatment has greatly improved prognosis of Behcet's disease (BD). Withdrawal of anti-TNF treatment in chronic inflammatory arthritis or bowel disease has been associated with sustained remission in subsets of patients. Herein, we examined the probability of very long-term quiescence after withdrawal of TNF inhibitors in BD.</p><p><strong>Methods: </strong>Retrospective longitudinal outcome single-center study focusing on BD patients who discontinued successful ant-TNF treatment since 2001. Endpoint was their proportion with sustained clinical remission for 5 years after withdrawal.</p><p><strong>Results: </strong>Thirty-three patients with severe BD refractory to non-biologic treatment (mean age 47.5 ± 11.5 years, 55% men) achieved TNF inhibitor-induced remission for a median of 2 years (IQR [1-2.6]). TNF inhibitors had been given for sight-threatening disease (28/33, 82%), for mucocutaneous (3/33), central nervous system (2/33) and gastrointestinal involvement (1/33). After withdrawal, BD remained in remission in 15/33 patients for 6.6 to 20.6 years (mean 13.5 ± 3.8). Conversely, 18/33 patients relapsed after a median of 9.5 months [IQR 8-12, range 4-32] following withdrawal but retreatment with TNF inhibitors was effective in 13/18. Of them, 9/13 discontinued for a second time and achieved again the study's endpoint, remaining in remission for median of 7.4 years ([IQR 5-9.3, range 5-15 years). Study's end-point was met by 24/33 patients (73%); 17and 7 patients remain any-drug free or on azathioprine only, respectively.</p><p><strong>Conclusion: </strong>Discontinuation of successful anti-TNF treatment is frequently associated with durable very long-term remission in severe BD. Additional studies are needed since relapses not responding to anti-TNF re-treatment may occur.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"60"},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic, musculoskeletal and organ characteristics on computed tomography in knee osteoarthritis - an explorative study in the IMI-APPROACH cohort.","authors":"Netanja I Harlianto, Pim A de Jong, Wouter Foppen, Edwin Bennink, Stijn Bunk, Simon C Mastbergen, Adriane D M Vorselaars, Mareye Voortman, Margreet Kloppenburg, Francisco J Blanco, Ida K Haugen, Francis Berenbaum, Karteek Popuri, Mirza Faisal Beg, Mylène P Jansen","doi":"10.1007/s00296-025-05817-3","DOIUrl":"10.1007/s00296-025-05817-3","url":null,"abstract":"<p><p>The systemic associations with knee osteoarthritis (KOA) are incompletely understood. This study explores aortic disease, musculoskeletal and organ findings in patients with KOA in relation to their symptoms or radiographic abnormalities. Full body computed tomography (CT) scans of 255 IMI-APPROACH participants were investigated using an automated analysis of multislice CT (Voronoi Health Analytics) that extracts aortic size and calcifications, and volumes and densities of bones, muscles, fat compartments and thoracic and abdominal organs. The CT measurements were primarily related to KOA as measured with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual scores and automated knee radiograph analysis of osteophytes, bone sclerosis and joint space width. The median age was 67 years, body mass index (BMI) 26.8 kg/m² and 78% were female. About half had Kellgren-Lawrence grade ≥ 2. Larger knee osteophyte area was associated with a larger aortic volume (R_Spearman=0.21,P = 0.001), which can be due to elongation or dilatation. We observed an association between more symptoms and increased psoas (R_Spearman=-0.23,P < 0.001) and lower leg (R_Spearman=-0.23,P < 0.001) muscle density, suggesting less microscopic muscle fat. Symptomatic KOA was associated with substantially lower lung volume (771 ml difference between 50% worst and 50% best WOMAC), but not with visible lung disease. Lung volume and density were significantly associated with the physical functioning WOMAC component. These associations remained significant after adjustment for age, sex and BMI. KOA is associated with significant systemic changes, including altered aortic and organ volumes. These correlations suggest that KOA's impact may extend beyond the joints. Future research should explore the causal relationships and therapeutic implications associations.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"62"},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mortality and acute complications of large vessel vasculitis patients hospitalized with COVID-19 in the US: a nationwide inpatient sample analysis (2020).","authors":"Nattanicha Chaisrimaneepan, Chanokporn Puchongmart, Pannathorn Nakaphan, Panat Yanpiset, Ben Thiravetyan","doi":"10.1007/s00296-025-05811-9","DOIUrl":"10.1007/s00296-025-05811-9","url":null,"abstract":"<p><p>COVID-19 was an emerging pandemic in 2020 which resulted in millions of deaths worldwide. It has been known that COVID-19 can cause secondary vasculitis. However, the impact of large vessel vasculitis, giant cell arteritis (GCA) and Takayasu (TAK), on COVID-19 infection is not known. This retrospective analysis used data from the US National Inpatient Survey 2020. Patients of all ages hospitalized due to COVID-19 in 2020 were identified on the database. A primary diagnosis of COVID-19 and a secondary diagnosis of LVV were included. Characteristics of patients, comorbidities, and clinical outcomes were compared. The primary outcome was the mortality rate. Secondary outcomes included resource utilization and acute in-hospital complications of COVID-19 infection. Multivariate logistic regression and univariate logistic regression analyses were conducted, with P values < 0.05 considered statistically significant. A total of 675 patients hospitalized with COVID-19 had concurrent LVV. Patients with LVV were older (73.70 vs 62.61; P < 0.001) and more likely female (75.00% vs 48.20%; p < 0.001). There is no difference in in-hospital mortality of COVID patients with and without LVV (aOR 0.95, p = 0.834), GCA (aOR 0.94, p = 0.827), or TAK (aOR 2.30, p = 0.394). There is an increase in the in-hospital risk of developing acute MI in COVID patients with LVV (aOR = 1.54; p = 0.04) but not with subgroup GCA and TAK. There were no significant differences in resource utilization and other acute in-hospital complications. Hospitalized COVID-19 patients with LVV and GCA were more likely to develop acute MI than those without. Further studies are required to minimize confounders to better explore the causal relationship of COVID-19 and LVV.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"59"},"PeriodicalIF":3.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of deep tendon reflex responses in rectus femoris and triceps brachii in fibromyalgia: a clinical and electrophysiological study.","authors":"Ilke Coskun Benlidayi, Volkan Deniz, Ceren Ornek, Aylin Sariyildiz","doi":"10.1007/s00296-025-05808-4","DOIUrl":"10.1007/s00296-025-05808-4","url":null,"abstract":"<p><p>The aim of this study was to evaluate deep tendon reflex responses and associated electrophysiological parameters of the muscles in patients with fibromyalgia. This cross-sectional study included 38 patients with fibromyalgia and 32 age- and sex-matched controls. Deep tendon reflexes of the rectus femoris and triceps brachii were tested using a reflex hammer. Electromyographic (amplitude and duration of activation), inertial measurement unit (angular velocity, acceleration), and electromechanical (delay) analyses were performed using a surface electromyography (sEMG) device. Comparative analyses were carried out between patients and controls. Additionally, Receiver Operating Characteristic (ROC) analysis was performed to evaluate the ability of hyperreflexia in distinguishing fibromyalgia patients from controls. Hyperactive deep tendon reflexes in the right/left rectus femoris and/or triceps brachii were observed in more than 85% (ranging from 86.8 to 94.7%) of the fibromyalgia group. Patients with fibromyalgia exhibited significantly increased deep tendon reflex responses compared to controls (p < 0.001). Patients revealed significantly higher amplitude, longer duration of muscle activation, greater sagittal acceleration and angular velocity, and shorter electromechanical delay. Normalized muscle activation (right and left rectus femoris and right triceps brachii) in response to deep tendon reflex test showed acceptable ability in differentiating fibromyalgia patients from controls (Area under curve (AUC) = 0.890, 0.784 and 0.782, respectively). For the right rectus femoris, values ≤ 28.3 (clinically corresponding to normoactive/hypoactive deep tendon reflexes) appeared to rule-out fibromyalgia with 94.1% sensitivity and 61.3% specificity. Patients with fibromyalgia exhibit increased deep tendon reflex responses. Normal or decreased deep tendon reflex responses may probably be used as a rule-out criterion for fibromyalgia.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"57"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of abdominal and lumbar multifidus muscles thickness and relation to endurance, pain, fatigue and functional mobility in patients with Fibromyalgia syndrome: a case-control study.","authors":"Yasemin Mirza, Fulden Sari, Pınar Diydem Yılmaz, Adem Küçük","doi":"10.1007/s00296-025-05813-7","DOIUrl":"10.1007/s00296-025-05813-7","url":null,"abstract":"<p><strong>Objective: </strong>The aim of present study was to compare abdominal (transversus abdominis (TrA), internal oblique (IO) and external oblique (EO)) and lumbar multifidus muscles (LM) evaluated with ultrasonographic (US) imaging in patients with FM (Fibromyalgia) and asymptomatic individuals and to examine the relationship between these muscle thickness and endurance, pain, fatigue and functional mobility.</p><p><strong>Methods: </strong>Women with FM group (n: 53, age: 45.96 ± 9.96 years), and asymptomatic control group (n: 49, age: 45.12 ± 7.28), were included in this study. Pain severity, disease activity, physical activity level, fatique, thickness of TrA, IO, EO and LM muscles and endurance, and functional mobility were evaluated with the Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), International Physical Activity Questionnaire- Short Form (IPAQ-SF), Fatigue Severity Scale (FSS), US imaging, McGill core endurance tests, and physical fitness tests, respectively. FM patients were classified according to the FSS score.</p><p><strong>Results: </strong>The thickness of the IO (right side) (p = 0.013) and LM (both sides) (p < 0.001) muscles, lumbopelvic muscle endurance (all p < 0.001) and physical fitness tests (all p < 0.001) were lower in FM group compared to the asymptomatic group. No statistically significant differences were found in TrA, IO (left side), EO muscles thickness between the two groups (all p > 0.05). LM muscle thickness was significantly correlated with lumbopelvic muscle endurance (all p < 0.05), physical fitness tests (all p < 0.001) and fatique (p = 0.001). Moreover, significant differences in LM muscle thickness (p = 0.007), trunk flexor muscle endurance (p = 0.016), left trunk lateral flexor muscle endurance (p = 0.045) and 30-s chair stand test (p = 0.025) in favor of the low-fatigue group were detected.</p><p><strong>Conclusion: </strong>The thickness of LM muscle, lumbopelvik endurance and functional mobility in FM patients have been affected negatively. These findings should be considered in management of FM.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"56"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilising multiple discharge coding will improve identification of patients with giant cell arteritis: a retrospective analysis of a hospital discharge dataset.","authors":"Andrew Dermawan, Julia Murdoch, Jean Louis De Sousa, Andrew Taylor, Helen Keen","doi":"10.1007/s00296-025-05814-6","DOIUrl":"10.1007/s00296-025-05814-6","url":null,"abstract":"<p><p>To determine whether the discharge diagnosis codes used within tertiary hospitals accurately identified patients with Giant Cell Arteritis (GCA), as determined by expert opinion at 6 months. The study was performed across three major hospitals within Perth, Western Australia. Patients with an International Classification of Diseases (ICD) code for GCA (M31.5 and M31.6) at discharge on first inpatient presentation were identified. Review of case notes, discharge summaries, letters, pathology, and imaging results were undertaken. The percentage of patients with an ICD code for GCA at initial discharge with confirmed GCA by expert opinion at 6 months (as the anchor diagnosis) was calculated. As validation of the anchor diagnosis, the percentage who fulfilled the 2022 ACR/EULAR criteria was also calculated, the number of hospital discharges per patient with an ICD code for GCA was calculated, to determine if multiple discharges with an ICD code for GCA increased the specificity of the ICD coding. 93 out of 157 admissions with an ICD for GCA were identified as a first inpatient presentation. At 6 months follow up, 65.6%, 95 CI [55.0%, 75.1%] had confirmed GCA by expert opinion. 88.2%, 95 CI [79.8%, 93.9%] met the 2022 ACR/EULAR criteria for GCA. The specificity of the ICD coding increased with increasing number of discharges- 67.4% with single episode, 80% with two episodes, and 100% with three or more episodes (p = 0.1373). Only 43.8%, 95 CI [26.4%, 62.3%] of patients who did not have GCA had an alternative diagnosis provided. 31.3%, 95 CI [16.1%, 50.0%] of patients who did not have GCA still have the GCA diagnosis listed in their subsequent clinical records and discharge summaries. Only 2/3rds of those patients with an initial discharge ICD code for GCA were found to have confirmed GCA at follow-up. This poor correlation between the ICD coding and confirmed diagnosis of GCA will impact the quality of data extracted from administrative health datasets for epidemiological and longitudinal studies. Selecting patients with two or more GCA coded episodes could improve the homogeneity of the cohort for recruitment into GCA studies, but a larger sample size study is required.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"58"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of complementary and alternative medicine (CAM) among people living with Sjögren's: a cross-sectional survey using a modified international CAM questionnaire (I-CAM-Q).","authors":"Michelle Flood, Joan Ní Gabhann-Dromgoole, Gráinne Tynan, Niamh Dillon, Deirdre Collins, Monika Lauder, Eileen Sheehy, Frank Moriarty, James W Barlow","doi":"10.1007/s00296-025-05802-w","DOIUrl":"10.1007/s00296-025-05802-w","url":null,"abstract":"<p><p>Sjögren's is a chronic autoimmune disease with diverse symptomatology, and varying patient satisfaction with management. Patients with chronic conditions are known to be higher users of complementary and alternative (CAM) practices, yet little information regarding extent of such use exists. This paper describes usage of CAM practices among people living with Sjögren's, encompassing visits to healthcare providers, CAM practitioners, self-administered CAM and self-help practices. We explored both purposes and perceived helpfulness of the various modalities utilised. 296 respondents completed an online survey administered through Sjögren's Research Ireland in 2023. An adapted form of the International Complementary and Alternative Medicine Questionnaire (I-CAM-Q) was utilised as the survey instrument. 88.5% of respondents had a formal diagnosis of Sjögren's. The majority (93.6%) were female, across all age groups. Over half (52%) of non-retired respondents were at least partially unable to work due to their diagnosis. Over half of all respondents (58.8%) listed at least one concomitant health problem. Most respondents (248, 83.8%) had used some form of CAM within the preceding 12 months. One-in-four had attended a CAM practitioner, most commonly chiropractors (8.4%) or acupuncturists (7.8%). Conventional healthcare and CAM providers were both consulted more commonly for management of chronic conditions or for well-being than for acute symptom management, although this was particularly stark for CAM consultations. 196 respondents (66.2%) reported use of self-administered CAM, predominantly vitamins/minerals or dietary supplements. 69.9% used various self-care practices, with the most reported being meditation, relaxation techniques and prayer. People living with Sjögren's attend both conventional healthcare providers and CAM practitioners to a high degree and use a diverse range of complementary therapies and practices. Health care professionals need to consider and discuss potential CAM use by this patient cohort and offer evidence-based patient education about therapies and practices encountered.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"55"},"PeriodicalIF":3.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial radiographic structural damage in patients with Enthesitis-Related Arthritis presents a distinct phenotype compared to adults with axial spondyloarthritis: A cross-sectional cohort study.","authors":"Annelyse de Araújo Pereira, Adham do Amaral E Castro, Isabel Ahn, Paola Cecy Kuenzer Goes Esmanhotto, Andre Yui Aihara, Francisco Irochima Pinheiro, Ana Paula Sakamoto, Marcelo de Medeiros Pinheiro, Maria Teresa Terreri","doi":"10.1007/s00296-025-05799-2","DOIUrl":"10.1007/s00296-025-05799-2","url":null,"abstract":"<p><p>Enthesitis-related arthritis (ERA), a distinct subtype of juvenile idiopathic arthritis (JIA) related to HLA-B27 and peripheral and axial involvement, presents with insidious onset of arthritis and/or enthesitis. However, there is a lack of data concerning axial new bone formation in patients transitioning into adulthood. To evaluate the axial radiographic structural damage (axRxSD), encompassing the sacroiliac joints (SIJ), hips, and spine, in ERA patients across various age groups. A cross-sectional cohort study was conducted with patients aged up to 35 years. Specific tools were used for measuring disease activity (BASDAI, ASDAS), function (BASFI, HAQ-S), mobility (BASMI), clinical enthesitis (MASES), ultrasound evaluation (MASEI), and axRxSD, including mSASSS for spine, Kellgren-Lawrence for hips and modified New York criteria for SIJ. A total of 26 patients were included, of whom 76.9% were males, with a mean age at diagnosis and assessment of 11.9 and 19.7 years, respectively. HLA-B27 positivity was found in 58.3%. Current active arthritis and enthesitis were present in 19.2% and 23%, respectively, with mean MASEI score of 12 (IQR 6-17). Peripheral joint limitation was observed in 50%, despite a BASMI score of 2.2 and 16% occurrence of abnormal FABER test. Most patients were in remission or low disease activity [ASDAS-ESR = 1.2 (0.6-2.3); ASDAS-CRP = 1.55 (0.6-2.4)]. Modified New York criteria were fulfilled by 73.1% of patients and 15.4% had radiographic hip involvement. Spine involvement, measured by mSASSS, was low (IQR 0-4.2), with only two patients exhibiting syndesmophytes. There was no statistical association between any imaging methods and clinical, laboratory, and ultrasound variables, including scores for activity, functionality, and mobility. Significant association was found only between axRxSD and BASMI. Our results showed high frequency of SIJ ankylosis alongside lower radiographic involvement in the spine and hips, suggesting a distinct structural damage phenotype. The early recognition of this outcome and the use of immunobiological therapy may mitigate syndesmophyte occurrence over time.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"54"},"PeriodicalIF":3.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric rheumatology on social media: experts ensure accuracy, public drives engagement - a comparative analysis.","authors":"Saverio La Bella, Marina Attanasi, Armando Di Ludovico, Francesca Mainieri, Federico Lauriola, Luisa Silvestrini, Francesca Ciarelli, Jacopo Osmelli, Virginia Girlando, Marta Rinaldi, Francesco Chiarelli, Seza Ozen, Marco Gattorno, Luciana Breda","doi":"10.1007/s00296-025-05809-3","DOIUrl":"10.1007/s00296-025-05809-3","url":null,"abstract":"<p><p>We aimed to investigate the quality and characteristics of content related to pediatric rheumatology on social media, comparing posts by health professionals (HPs) and non-HP (NHPs). Content creators, engagement metrics, sentiment, and misinformation were evaluated in the 150 most popular posts from 18 hashtags related to pediatric rheumatology on Facebook, Instagram, and TikTok. The Journal of American Medical Association Benchmark Scale (JAMA) and the Patient Education Materials Assessment Tool for Audiovisual Materials (PEMAT-A/V) were used to assess quality, understandability and actionability in educational videos, respectively. Overall, 6723 posts were included (3130 photos, 3593 videos). The content accounted for 37.6 million interactions and 520.8 million views. NHPs represented the majority of creators (5160, 76.8%). Among educational posts (2074, 30.8%), HPs provided longer (59 [IQR 85] sec vs. 50 [IQR 77] sec; p < 0.001) more understandable (PEMAT-A/V 85.7 [IQR 18.9] vs. 75 [IQR 25]; p < 0.001), more actionable (PEMAT-A/V 66.7 [IQR 33.3] vs. 50 [IQR 41.7]; p < 0.001), and higher-quality (JAMA 3 [IQR 0] vs. 3 [IQR 1]; p < 0.001) videos than NHPs. In contrast, NHPs shared more commented educational photos (3 [IQR 11] vs. 1 [IQR 8]; p < 0.001) and videos (8 [IQR 50] vs. 4 [IQR 27]; p < 0.001) and more viewed videos (6181 [IQR 23417] vs. 2967.5 [IQR 20943]; p = 0.034) than HPs. Despite high interest in content related to pediatric rheumatology on social media, HPs are a minority of creators but provide better educational content than NHPs. There is a significant opportunity to provide high-quality educational content through these popular digital platforms.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"53"},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}