Rheumatology International最新文献

{"title":"Medication adherence is associated with the necessity-concern differential in newly diagnosed primary Sjögren disease: a prospective observational cohort study.","authors":"Kemal Erol, Ezgi Akyıldız Tezcan, Naciye Baş Bilen, Cemal Gürbüz","doi":"10.1007/s00296-026-06201-5","DOIUrl":"10.1007/s00296-026-06201-5","url":null,"abstract":"<p><p>The objectives of this study were, firstly, to assess medication adherence and, secondly, to evaluate the relationships between medication adherence and symptoms, disease activity, and patient-reported outcomes in patients with newly diagnosed primary Sjögren disease (pSjD). In this prospective observational cohort study, 54 patients with newly diagnosed pSjD were enrolled in a tertiary rheumatology clinic. Forty patients (74.1%) were reassessed after a mean follow-up of 21.36 ± 4.79 months. Medication adherence was evaluated using the Compliance Questionnaire for Rheumatology-5 (CQR-5), classifying patients as low or high adherence. Disease activity, symptom burden, psychological symptoms, fatigue, functional status, health-related quality of life, and medication beliefs were evaluated using ESSDAI, ESSPRI, HADS, fatigue severity assessment, HAQ, SF-12, and the Beliefs about Medicines Questionnaire (BMQ). The necessity-concern differential (NCD) was calculated as the BMQ-specific necessity score minus the concern score. Logistic regression analysis was exploratory. The cohort was predominantly female (52/54, 96.3%), with a mean age of 49.7 ± 9.5 years. At follow-up, 16 patients (40%) were classified as low adherence and 24 (60%) as high adherence. Baseline clinical and sociodemographic characteristics were comparable between groups. ESSDAI scores remained low and stable over time, and ESSPRI increased modestly in both groups without significant between-group differences. Psychological status, fatigue, functional status, and quality of life were similar across adherence categories. Specific necessity scores were numerically higher in high-adherence patients (3.37 ± 0.79 vs. 3.04 ± 1.06; p = 0.267), whereas concern scores tended to be higher in low-adherence patients (3.46 ± 0.92 vs. 3.07 ± 0.63; p = 0.115). The NCD was significantly lower in the low-adherence group than in the high-adherence group (- 0.43 ± 1.16 vs. 0.30 ± 0.96; p = 0.038). In exploratory logistic regression, higher NCD was associated with high adherence (OR 1.95, 95% CI 1.01-3.76). In patients with newly diagnosed pSjD, low medication adherence was frequent and was associated with patients' necessity-concern balance rather than clinical disease activity or patient-reported burden. Because adherence and medication beliefs were assessed at the same time point and CQR-5 has not been specifically validated in pSjD, these findings should be interpreted as exploratory and non-causal.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between disease activity, arterial stiffness, and 10-year cardiovascular risk in patients with rheumatoid arthritis: a cross-sectional study.","authors":"Senning Liu, Ming Jiang, Mengjiao Zhang, Zhenyi Li, Hanwen Tong, Hairong Wang, Panpan Hu, Wenling Fang, Rong Yu, Tianyu Wu, Lin Jin, Zhaojun Li","doi":"10.1007/s00296-026-06274-2","DOIUrl":"10.1007/s00296-026-06274-2","url":null,"abstract":"<p><p>Patients with rheumatoid arthritis (RA) are at increased cardiovascular risk. This study explored the association of RA disease activity with arterial stiffness (AVI) and 10-year atherosclerotic cardiovascular disease (ASCVD) risk. This retrospective cross-sectional study enrolled 1,152 RA patients (484 inactive, 668 active, no prior cardiovascular/cerebrovascular disease) and 235 healthy controls. Clinical characteristics, laboratory parameters, and AVI were compared among groups. Multivariable logistic regression was performed to identify factors independently associated with high AVI. The interaction between disease activity and disease duration on AVI was also assessed using two-way analysis of variance (two-way ANOVA). AVI levels and high AVI prevalence were significantly higher in active RA patients than in inactive RA and controls (p < 0.05). With increasing disease activity, Disease Activity Score 28 based on C-reactive protein (DAS28-CRP), C-reactive protein (CRP), and erythrocyte sedimentation rate increased significantly (all p < 0.001). Multivariable regression showed that systolic blood pressure (OR = 1.025, 95% CI 1.010-1.040), moderate disease activity (OR = 4.932, 95% CI 1.018-23.900), and high disease activity (OR = 6.342, 95% CI 1.239-32.475) were independently associated with high AVI. Two-way ANOVA indicated that disease activity had a significant main effect on AVI (F = 5.343, p < 0.001), whereas disease duration and its interaction with disease activity were not significant. RA disease activity is closely associated with increased arterial stiffness and higher estimated 10-year ASCVD risk. In this cross-sectional cohort, disease activity was more strongly associated with AVI than disease duration.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported reproductive concerns and care needs among women with systemic lupus erythematosus: a descriptive qualitative study using patient journey mapping.","authors":"Si-Yu Xie, Zhao-Bin Wan, Yan Shao, Wen-Yan Jiang, Min Hao, Wei Zhao","doi":"10.1007/s00296-026-06279-x","DOIUrl":"10.1007/s00296-026-06279-x","url":null,"abstract":"<p><p>To explore reproductive concerns and care needs across reproductive contexts among women with systemic lupus erythematosus (SLE) and develop a composite patient journey map. A descriptive qualitative study was conducted with 18 women purposively recruited from a tertiary hospital in Hefei, Anhui Province, China. Semi-structured interviews were analysed using Colaizzi's seven-step method and organised across four reproductive contexts and four mapping dimensions. Participants contributed only to contexts relevant to their reproductive histories. Reporting followed the Consolidated Criteria for Reporting Qualitative Research (COREQ). The composite journey map included four reproductive contexts and four dimensions: emotional experiences, behaviours, support resources, and key pain points. At diagnosis, women reported limited fertility-related information and uncertainty about future marriage and childbearing. During reproductive decision-making, they balanced perceived disease and medication risks with reproductive wishes, family expectations, caregiving resources, and financial capacity. During preconception and pregnancy, repeated monitoring, medication adjustment, and uncertainty about maternal and fetal safety were prominent. After childbirth, concerns centred on disease relapse, infant feeding, physical limitations, and combining treatment with childcare. Across these contexts, family involvement could provide emotional and practical support but could also create pressure. For some women, specific guidance on disease control, pregnancy timing, and medication adjustment was obtained only after they raised pregnancy plans. Reproductive concerns differed across reproductive contexts and involved pregnancy-related risks, family decision-making, practical constraints, and post-childbirth disease management and caregiving. The composite map may inform tailored reproductive communication, coordinated rheumatology-obstetric assessment, and postpartum support.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosavin, but not its combination with salidroside, lowers total β-catenin in human osteoblast cultures: an exploratory in vitro study under mineralizing conditions.","authors":"Piotr Wojdasiewicz, Edyta Wróbel, Maria Maślińska, Paweł Turczyn, Elżbieta U Stolarczyk, Krzysztof Stolarczyk, Agnieszka Mikulska, Dariusz Szukiewicz","doi":"10.1007/s00296-026-06278-y","DOIUrl":"10.1007/s00296-026-06278-y","url":null,"abstract":"<p><p>Osteoblast dysfunction and altered Wnt/β-catenin-dependent responses accompany bone-remodeling imbalance in rheumatic and degenerative joint disease. Rosavin and salidroside are constituents of Rhodiola rosea preparations used without prescription, and are always encountered together rather than separately. This exploratory in vitro study asked whether the two compounds and their combination differentially affect total β-catenin concentration and cell-covered area in human osteoblasts (HOBs). HOBs from one commercial preparation (passage 7) were cultured in growth medium (GM) or mineralization medium (MM) and exposed to rosavin 50 µM (R50), salidroside 50 µM (Sal50) or both (R50/Sal50). Total β-catenin was quantified by ELISA in four independently cultured, treated, harvested and lysed wells per condition at days 7, 14 and 21. Cell-covered area was estimated from 79 phase-contrast fields. Welch ANOVA with Games-Howell post-hoc testing was pre-specified. Total β-catenin differed between conditions at day 14 (Welch ANOVA p = 0.003, Holm-adjusted p = 0.009; η² = 0.43): 8.9 ± 3.8 ng/mL in R50 versus 28.5 ± 3.8 in Sal50, 26.5 ± 16.9 in R50/Sal50, 23.5 ± 7.9 in MM and 27.4 ± 8.6 in GM. Sal50 versus R50 was the only contrast surviving correction (difference 19.6 ng/mL, 95% CI 13.1-26.1; p = 0.002). No difference was detected at day 7 (p = 0.87) or day 21 (p = 0.23). Cell-covered area differed at days 7 and 21, with R50/Sal50 lowest and most variable (54.5 ± 23.4% versus 98.1 ± 1.8% in GM at day 7). Cell-covered area explained 12% of the variance in group-mean β-catenin (r = - 0.35). Rosavin alone was associated with a marked reduction in total β-catenin at day 14; its combination with salidroside was not. The two constituents therefore do not act interchangeably on human osteoblasts. These observations derive from a single experimental series and require replication before mechanistic or clinical interpretation.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low albumin-to-globulin ratio is associated with interstitial lung disease in primary Sjögren's syndrome: a single-center retrospective cohort study with propensity score matching.","authors":"Jianbin Li, Suiran Li, Yuzhen Gesang, Wenwen Wang, Wei Liu","doi":"10.1007/s00296-026-06281-3","DOIUrl":"10.1007/s00296-026-06281-3","url":null,"abstract":"&lt;p&gt;&lt;p&gt;To investigate the association between albumin-to-globulin ratio (AGR) and interstitial lung disease (ILD) in patients with primary Sjögren's syndrome (pSS), to identify high-risk clinical phenotypes for SS-ILD, and to construct an AGR-based nomogram risk stratification model. This was a single-center retrospective cohort study enrolling pSS patients who met the 2016 ACR/EULAR classification criteria between January 2014 and December 2024. Patients were divided into ILD and non-ILD groups based on the presence or absence of ILD. Propensity score matching (PSM) was applied to balance baseline characteristics. Univariable and multivariable logistic regression analyses were performed to evaluate the independent association between AGR and ILD. A nomogram risk stratification model was constructed based on predictors identified in the multivariable analysis, and its predictive performance was assessed using receiver operating characteristic (ROC) curve analysis. A total of 1,087 pSS patients were enrolled (93.6% female; mean age 58.25 ± 12.16 years; ILD group n = 69; non-ILD group n = 1,018). In the total cohort, AGR was significantly lower in the ILD group than in the non-ILD group (1.01 ± 0.30 vs. 1.18 ± 0.31), and the prevalence of documented dry eye was markedly lower in the ILD group (2.9% vs. 19.4%). Multivariable regression analysis demonstrated that AGR was independently and inversely associated with ILD risk (OR = 0.138, 95% CI 0.038-0.502); CRP was also an independent risk factor (OR = 1.009, 95% CI 1.000-1.017); and absence of documented dry eye symptoms was independently associated with ILD (OR = 0.196, 95% CI 0.047-0.821). After PSM (1:2 nearest-neighbor matching on age, sex, and BMI), 67 of 69 ILD patients were successfully matched, yielding a balanced cohort of 201 patients (ILD n = 67; non-ILD n = 134), with all covariate standardized mean differences (SMDs) &lt; 0.1. In the matched cohort, AGR remained significantly lower in the ILD group (1.01 ± 0.30 vs. 1.19 ± 0.30) and these associations remained robust in the multivariable model (AGR: OR = 0.127, 95% CI 0.024-0.687; absence of dry eye: OR = 0.145, 95% CI 0.029-0.720). Three layers of sensitivity analysis (basic IPTW, extended-covariate IPTW with 11 covariates, and E-value analysis) confirmed the robustness of the AGR-ILD association, with the E-value point estimate of 12.30 substantially exceeding the strength of known confounders. The exploratory nomogram constructed from AGR, dry eye, age, and LDH demonstrated an AUC of 0.710 (95% CI 0.647-0.774) at an optimal cutoff of 0.096, with a sensitivity of 54.5% (95% CI 42.4%-66.7%), specificity of 81.3% (95% CI 79.0%-83.6%), PPV of 16.6% (95% CI 12.9%-20.2%), NPV of 96.3% (95% CI 95.4%-97.2%), and accuracy of 79.6% (95% CI 77.2%-81.9%). In this single-center retrospective cohort, low AGR was independently associated with the occurrence of ILD in pSS patients. Low AGR combined with absence of documented dry eye symptoms may identify ","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission and treatment persistence during sequential therapy in rheumatoid arthritis: results from the Estonian Biologic Treatment Registry.","authors":"Joaquín Borrás-Blasco, Alejandro Valcuende-Rosique, Silvia Cornejo-Uixeda","doi":"10.1007/s00296-026-06280-4","DOIUrl":"10.1007/s00296-026-06280-4","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum visfatin level and subfoveal choroidal thickness as independent associates of radiographic ankylosing spondylitis: a case-control study.","authors":"Mahmut Kul, Fatih Mehmet Adıbelli, Nurten Aksoy, Alparslan Yetişgin","doi":"10.1007/s00296-026-06273-3","DOIUrl":"10.1007/s00296-026-06273-3","url":null,"abstract":"<p><p>Adipocytokines have been implicated in the pathogenesis of ankylosing spondylitis (AS), although their exact role remains unclear. Optical coherence tomography (OCT) provides quantitative ocular measurements and may detect subclinical ocular changes in AS. This study evaluated serum adipocytokine levels and OCT findings in patients with radiographic AS and investigated possible correlations between these parameters. This cross-sectional study included 47 patients with radiographic AS diagnosed according to the modified New York criteria and 23 age- and sex-similar healthy controls. Serum visfatin, resistin, adiponectin, and fetuin-A levels were measured using enzyme-linked immunosorbent assay. OCT parameters, including retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), macular thickness, and subfoveal choroidal thickness, were recorded using spectral-domain OCT. Multivariable logistic regression was performed to identify biomarkers independently associated with AS. Visfatin levels were higher (6.7 [3.9-14.0] vs. 4.5 [3.9-8.1] ng/mL, p<0.001), whereas fetuin-A levels were lower (3253 [1652-5565] vs 3724 [2204-5651] ng/mL, p=0.017) in patients with AS compared with controls. Adiponectin and resistin levels did not differ (both p>0.05). Subfoveal choroidal thickness was greater in AS patients (262 [124-387] vs. 197 [101-300] µm, p<0.001), whereas RNFL, GCC, and macular thickness were similar between the groups (all p>0.05). On multivariable analyses adjusted for age, sex, BMI, and CRP, visfatin (OR=3.894, 95% CI 1.378-11.004) and choroidal thickness (OR=1.047, 95% CI 1.007-1.088) remained independently associated with AS (both p<0.05). Conclusion: Elevated visfatin and increased choroidal thickness were independently associated with AS, suggesting subclinical ocular involvement even in the absence of uveitis. Prospective, larger studies are needed to confirm the clinical utility of these parameters.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking Behçet's disease in the European population: a case series report.","authors":"Paweł Głuszak, Mateusz Lucki, Natalia Kasprzyk, Vicky Chou, Aleksandra Dańczak-Pazdrowska, Bogna Grygiel-Górniak","doi":"10.1007/s00296-026-06270-6","DOIUrl":"10.1007/s00296-026-06270-6","url":null,"abstract":"<p><p>Behçet's disease (BD) is rare in European populations. Because clinical and immunological characteristics may differ between Caucasians and Middle Eastern patients, we analyzed BD patients from the Polish population. Data from eight patients with BD treated at a rheumatology clinic were analyzed and collected, including demographic data, clinical features, laboratory test results, comorbidities, and treatment options. The study included eight patients (mean age 38.2 ± 13.7 years; 75% female). None of the patients had a family history of the disease. The mean delay in diagnosis was 5.28 ± 4.6 years. The disease began with the development of mucosal ulcerations and a maculopapular rash, and some patients also developed anemia, alopecia, headaches, and arthritis. All patients had mucosal ulcerations and an erythematous or maculopapular rash; joint involvement occurred in 62.5%. Vascular complications (37.5%) included superior sagittal sinus thrombosis, ischemic stroke, and cephalic vein thrombosis. The most common comorbidities were hypertension (50%), dyslipidemia (37.5%), and depression (25%). Inflammatory markers were elevated in half of the patients and normalized after treatment. Antinuclear antibodies were positive in 62.5%, and antineutrophil cytoplasmic antibodies in 25%. Patients were treated with glucocorticosteroids (100%) in combination with azathioprine (62.5%), cyclosporine (25%), methotrexate (12.5%), and hydroxychloroquine (25%). Data from a single center indicate that BD in Caucasians is characterized by heterogeneity in clinical manifestations and develops predominantly in women. The presence of ANA and ANCA antibodiescan be misleading and requires differential diagnosis. The course is generally mild, but severe symptoms (especially thrombosis) require close monitoring by a multidisciplinary team.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with clinically significant nephritis in systemic lupus erythematosus patients who present with glomerular hematuria: a cross-sectional study.","authors":"Konstantinos Drougkas, Eda Otman, Spyridon Katechis, Maria Pappa, Ozge Yogurtcu, Sofia Flouda, Petros Nikolopoulos, Sophia Lionaki, Aggelos Banos, George Liapis, George Bertsias, Dimitrios T Boumpas, Antonis Fanouriakis","doi":"10.1007/s00296-026-06264-4","DOIUrl":"10.1007/s00296-026-06264-4","url":null,"abstract":"<p><p>EULAR recommends kidney biopsy in systemic lupus erythematosus (SLE) patients with glomerular hematuria, whereas both ACR and KDIGO require the presence of proteinuria and/or impaired kidney function. We explored the value of hematuria for the diagnosis of new-onset lupus nephritis (LN). Cross-sectional study of SLE patients who underwent diagnostic kidney biopsy in two independent centers. Clinically significant LN was defined as ISN/RPS class III, IV, V, or mixed III/IV + V. Presentation patterns were categorized by glomerular hematuria, proteinuria, and impaired kidney function. Among patients with glomerular hematuria, regression models identified factors associated with clinically significant LN, and a nomogram was constructed. Of 227 biopsies, 181 (79.7%) showed clinically significant LN. Isolated glomerular hematuria was evident in 11 patients, of whom 9 revealed non-LN pathology; the two LN cases (class II and III) both demonstrated concurrent SLE serologic activity. Among patients with glomerular hematuria (n = 137), independent factors associated with clinically significant LN included anti-dsDNA positivity (OR 12.00, 95% CI 3.36-51.40), higher non-renal SLEDAI score (OR 1.20 per point, 95% CI 1.02-1.46), higher proteinuria (OR 3.77 per 1 g/d, 95% CI 2.00-9.03), and younger age (OR 0.96 per year, 95% CI 0.91-1.00). The combined presence of these factors yielded a predicted probability of 97% (95% CI 90-99%) of clinically significant LN, whereas their absence was associated with a probability of only 6% (95% CI 1-23%). When considering the need for kidney biopsy in patients with lupus, hematuria should be evaluated in the context of overall disease activity; extra-renal and serologic activity substantially increase the likelihood of clinically significant LN.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive health awareness and family planning practices among women with systemic autoimmune diseases: survey based study.","authors":"Lucija Šimunić, Lucija Prtenjača, Miroslav Mayer, Branimir Anić, Marko Barešić","doi":"10.1007/s00296-026-06267-1","DOIUrl":"10.1007/s00296-026-06267-1","url":null,"abstract":"<p><p>Systemic autoimmune diseases can adversely affect the health of childbearing women and pregnancy outcomes. Additionally, some of theadministered medications are teratogenic, prompting international rheumatological societies to recommend effective contraception and preconception counselling. Given the limited structured education in this field, this study aimed to assess reproductive health awareness and perceptions of family planning among women with systemic autoimmune diseases. A survey-based study was conducted at the Division of Clinical Immunology and Rheumatology, University Hospital Centre Zagreb, Zagreb, Croatia. The sample included 165 women aged 18-50 years who completed the ReproKnow questionnaire assessing reproductive health knowledge, while sociodemographic and clinical data were obtained through interviews and medical records. The median ReproKnow score was 5/10 correct answers indicating moderate knowledge of the studied topic. Greater reproductive health awareness was observed among patients with higher education levels and those diagnosed with SLE or vasculitis. Although one-third of participants stated that their diagnosis affected family planning, only one-fifth reported consistent contraception use, even among those receiving teratogenic medications. Knowledge of contraception efficacy was low (25%), but associated with consistent use. Substantial gaps remain in contraception knowledge and use, highlighting the need for targeted educational interventions and further research to improve reproductive health counselling and contraception practice.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}