Rheumatology International最新文献

{"title":"Toward standardized surgical indications and outcome measures in autoimmune-associated calcinosis.","authors":"Sara Al Shamimi, Anahata Kaur","doi":"10.1007/s00296-026-06301-2","DOIUrl":"10.1007/s00296-026-06301-2","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes toward dermocosmetic and aesthetic procedures in patients with systemic sclerosis: a cross-sectional survey.","authors":"Fatma Basibuyuk, Tuba Demirci Yildirim, A Merih Birlik","doi":"10.1007/s00296-026-06299-7","DOIUrl":"10.1007/s00296-026-06299-7","url":null,"abstract":"<p><p>Systemic sclerosis (SSc) frequently causes visible changes in physical appearance that may adversely affect body image and quality of life. Although dermocosmetic and aesthetic procedures are increasingly used to improve appearance and function in selected patients with SSc, little is known about patients' knowledge, attitudes, and expectations regarding these interventions. This study aimed to evaluate patients' attitudes toward dermocosmetic and aesthetic procedures using a purpose-designed questionnaire. In this cross-sectional study, 70 patients fulfilling the 2013 ACR/EULAR classification criteria for SSc completed a purpose-designed questionnaire. Demographic data were obtained from the questionnaire, while clinical characteristics were verified using medical records. The questionnaire evaluated knowledge, attitudes, previous experiences, future intentions, appearance-related concerns, perceived effects on self-confidence, willingness to consult a rheumatologist before aesthetic procedures, and preferred anatomical sites for potential interventions. The mean age was 54.6 ± 13.3 years, 90.0% were female, and 55.7% had diffuse cutaneous SSc. Disease-related changes in physical appearance were reported by 70.0% of participants, and 41.4% expressed discomfort with these changes. Nearly half (47.1%) reported no knowledge of any dermocosmetic procedure, and 85.7% had not previously undergone a dermocosmetic/medical aesthetic procedure. Nevertheless, 61.4% expressed positive attitudes toward dermocosmetic procedures, and 64.3% believed that these procedures could improve self-confidence. Nearly all participants (97.2%) stated that they would consult their rheumatologist before undergoing a dermocosmetic or aesthetic procedure. After false discovery rate (FDR) correction, diffuse cutaneous SSc remained associated with greater appearance-related discomfort than limited disease (53.8% vs. 25.8%; FDR-adjusted p = 0.032). Participants with at least a high school education more frequently expressed positive attitudes (83.9% vs. 43.6%; FDR-adjusted p = 0.014) and reported plans for future dermocosmetic/medical aesthetic (45.2% vs. 20.5%; FDR-adjusted p = 0.038) and surgical aesthetic procedures (22.6% vs. 2.6%; FDR-adjusted p = 0.032). In multivariable logistic regression adjusted for age and SSc subtype, higher education remained independently associated with a positive attitude (adjusted OR 6.43, 95% CI 1.73-23.91, p = 0.006). Appearance-related concerns are common among patients with SSc and represent an important yet often overlooked aspect of patient care. Despite limited knowledge, patients generally expressed favorable attitudes toward dermocosmetic and aesthetic procedures and strongly preferred consulting their rheumatologists before considering such interventions. These findings support the integration of appearance-related counselling into routine, patient-centered rheumatology care.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vagus nerve stimulation in rheumatic diseases: linking autonomic nervous system regulation, inflammation, and clinical outcomes.","authors":"Anna Wysokińska, Bożena Jaszczyk, Teresa Sadura-Sieklucka","doi":"10.1007/s00296-026-06293-z","DOIUrl":"10.1007/s00296-026-06293-z","url":null,"abstract":"<p><p>Patients with autoimmune and inflammatory diseases most often exhibit sympathetic overactivity and dominance at the expense of the parasympathetic system, including the vagus nerve. It leads to dysfunction of the negative feedback mechanism within the hypothalamic-pituitary-adrenal axis, resulting in impaired regulation of cortisol levels, stress responses, and pro-inflammatory cytokines. Furthermore, vagal dysfunction affects the mechanism by which acetylcholine binds to α7 nicotinic receptors on macrophage surfaces, thereby inhibiting the release of TNF-α and other pro-inflammatory cytokines. The aim of this review was to identify reports elucidating the mechanisms underlying the anti-inflammatory effects of the vagus nerve and to evaluate the efficacy of VNS as a potential method for modulating autonomic nervous system function. A literature search was conducted using the electronic databases PubMed, focusing on the role of the vagus nerve in autoimmune disorders, and on vagus nerve stimulation (VNS). Based on the collected data, a reduction in inflammatory activity and decreased production of pro-inflammatory cytokines were observed following vagus nerve stimulation. Moreover, the authors of the studies analyzed reported additional therapeutic effects, including pain modulation, suppression of disease activity, and a reduction in fatigue. Vagus nerve stimulation represents a promising alternative therapeutic modality for the treatment of rheumatologic diseases. However, further high-quality studies conducted in substantially larger cohorts are required, taking into account variability in stimulation parameters and their differential impact on clinical outcomes.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric manifestation of neurosarcoidosis: a systematic review with pooled descriptive analysis of case reports and case series.","authors":"Nour Alhaj Qassim, Fatima Algroosh, Omar Hamdan, Noor Haj Mohammad, Shorouq Eraidi, Fatima Alnaimat","doi":"10.1007/s00296-026-06294-y","DOIUrl":"10.1007/s00296-026-06294-y","url":null,"abstract":"<p><p>Neurosarcoidosis is a rare inflammatory disease with a heterogeneous presentation. Psychiatric manifestations may precede neurological involvement, but their prevalence, diagnostic pattern, and treatment outcomes remain insufficiently defined. PubMed, Web of Science and Scopus databases were searched on July 8, 2025, to identify all published case reports reporting psychiatric manifestations in patients with sarcoidosis or neurosarcoidosis without language or publication year restriction. All relevant data were extracted based on study characteristics, patient demographics, clinical history, psychiatric and neurological manifestations, diagnostic investigations, treatment modalities, and clinical outcomes. Eighty-nine studies describing 93 patients' cases were included. The mean age was 45.48 ± 14.46 years, with a male predominance (58.1%). 74.2% had systemic sarcoidosis, while 25.8% presented with isolated neurosarcoidosis. Diagnosis was confirmed by histopathology in 84.9% of patients. Psychiatric symptoms preceded neurological manifestations in 78.5% of cases. The most common psychiatric manifestation was cognitive impairment followed by personality changes (88.2%, 65.6% respectively). MRI frequently showed parenchymal lesions (66.7%) and leptomeningeal enhancement (57.7%), while CSF analysis commonly revealed elevated protein (80%) and pleocytosis (71.3%). Corticosteroids were used in (93.5%) of patients, with 58.1% achieving complete remission. Acute psychiatric onset (48.1% vs. 15.4%, p = 0.002) and delirium (70.4% vs. 41.0%, p = 0.013) were observed with higher remission. Isolated neurosarcoidosis (33.3% vs. 16.7%, p = 0.040), parenchymal lesions (59.0% vs. 50.0%, p = 0.034) and basal ganglia involvement (30.8% vs. 16.7%, p = 0.045) were significantly more common among patients who did not achieve complete remission. Systemic sarcoidosis is more frequently linked with higher remission rates due to earlier recognition and less irreversible CNS damage. Neuropsychiatric presentations are heterogeneous, with delirium associated with favorable remission outcomes. Corticosteroids remain the mainstay of therapy. Further prospective studies are needed to phenotype and optimize management strategies. PROSPERO: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251140210 .</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large language models show high clinical safety but differences in completeness for reproductive counselling in women with inflammatory rheumatic and musculoskeletal diseases: a comparative expert evaluation.","authors":"Diana Vossen, Xenofon Baraliakos, Maria Polyzou","doi":"10.1007/s00296-026-06271-5","DOIUrl":"10.1007/s00296-026-06271-5","url":null,"abstract":"<p><p>Specialized pregnancy counselling improves maternal and infant outcomes in women with inflammatory rheumatic and musculoskeletal diseases (iRMDs). As such services are not universally available, large language models (LLMs) may increasingly serve as an accessible source of information for patients seeking guidance on family planning, pregnancy, and lactation. This highlights the need to evaluate this software in terms of their adequacy, accuracy and overall reliability. The aim of the analysis is to evaluate the possibility of using LLMs as reliable sources of information regarding female patients suffering from iRMD and going through the period of pregnancy. 54 questions were formulated, which concern the impact and general relationship between pregnancy and rheumatic diseases. The questions were given to four LLMs, ChatGPT, DeepSeek, Gemini and Grok, and the corresponding answers were obtained. The responses were rated across three clinical domains on a 5-point Likert scale (ranging from 1 = strongly disagree/very poor to 5 = strongly agree/excellent) by ten European rheumatology experts and with the help of appropriate statistical indicators calculated, the reliability of the LLMs was assessed. 2160 items were evaluated. All models demonstrated high performance in \"Clinical Safety\" (Means > 4.10). For \"Clinical Accuracy\", DeepSeek and ChatGPT scored highest (Median 4.40 for both). Significant deviations were observed in \"Completeness and Relevance\", where DeepSeek dominated (Mean 4.24, 95% CI 4.17-4.30) and Gemini showed the lowest performance (Mean 3.46, 95% CI 3.27-3.64). Inter-rater agreement was poor to slight (Fleiss' kappa range: -0.043 to 0.059) and moderate for ICC (range: 0.259 to 0.692). LLMs currently exhibit uniformly strong safety behaviors when providing medical information about family planning, pregnancy and lactation in iRMD. However, significant differences exist regarding completeness and relevance, where DeepSeek and ChatGPT are currently the most reliable and complete models for this domain. Furthermore, the variability in responses and low inter-rater agreement highlight that LLMs require further parameterization, are useful tools for routine care, but cannot replace expert medical judgment.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation of the association between Juvenile rheumatic disease and growth: a retrospective matched cohort study.","authors":"Nivethigha Elango, Liza J McCann, David M Hughes","doi":"10.1007/s00296-026-06287-x","DOIUrl":"10.1007/s00296-026-06287-x","url":null,"abstract":"<p><p>Childhood-onset rheumatic diseases including Juvenile Idiopathic Arthritis (JIA), Juvenile Systemic Lupus Erythematosus (jSLE), and Juvenile Dermatomyositis (JDM) could impact growth, but this is not well described within the UK population, particularly over the long term. This study aims to compare the growth patterns of patients with JIA, jSLE, and JDM to those of their peers. This population-based cohort study used primary care data from the Clinical Practice Research Datalink (CPRD) with follow up through to March 2023. Patients diagnosed with JIA, JDM and jSLE, were matched with up to five healthy controls by age, sex and general practice. Age and sex standardised Z-scores were calculated for height and weight. Linear mixed models were used to investigate differences in growth patterns over time. Height measurements from 3736, 182 and 111 children with JIA, jSLE and JDM and weight measurements from 5088, 251 and 144 children with JIA, jSLE and JDM respectively were extracted. JIA patients showed significant baseline differences in height compared to healthy controls (Estimate= -0.061, 95% CI 0.002, 0.121) but this initial reduction was countered by an increased rate of catch up growth over time. Similar patterns were observed in jSLE and JDM, although differences were less consistent and largely confined to specific subgroups. Overall, weight trajectories were broadly similar to those of matched controls across all three diseases. Stratified analyses suggested that growth patterns varied according to age at disease onset, with the clearest differences observed in JIA. Children with JIA, jSLE and JDM demonstrated altered longitudinal growth patterns, with the clearest evidence observed in JIA. Growth trajectories varied according to age at disease onset, particularly during the pre and peri-pubertal period, suggesting that the timing of disease onset may influence long-term growth. These findings support the importance of longitudinal growth monitoring, particularly among children diagnosed during key developmental periods.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nailfold videocapillaroscopy-defined capillaroscopic abnormality burden in systemic lupus erythematosus: a controlled cross-sectional study.","authors":"Burak Okyar, Servet Yüce, Zeynep Tüzün, Alper Yıldırım","doi":"10.1007/s00296-026-06286-y","DOIUrl":"10.1007/s00296-026-06286-y","url":null,"abstract":"<p><strong>Introduction/objectives: </strong>Nailfold videocapillaroscopy (NVC) abnormalities are recognized in systemic lupus erythematosus (SLE), but their meaning remains uncertain. We examined whether standardized NVC quantifies structural capillaroscopic abnormality burden in SLE.</p><p><strong>Methods: </strong>In this single-centre cross-sectional study, 65 SLE patients and 46 non-autoimmune controls underwent standardized NVC. Six parameters were semi-quantitatively scored and combined into microangiopathy, morphological, and total scores. Between-group associations were assessed using adjusted negative binomial regression. Within-SLE correlation, treatment-adjusted, and exploratory cluster analyses were performed.</p><p><strong>Results: </strong>Total score was higher in SLE than controls (15 [10-21] vs. 2 [0-4], p < 0.001). After adjustment for age, sex, BMI, smoking, diabetes, and hypertension, SLE was associated with total (IRR 7.64, 95% CI 4.93-11.84), microangiopathy (IRR 9.48, 95% CI 5.94-15.14), and morphological scores (IRR 5.99, 95% CI 3.84-9.35; all p < 0.001). Density loss showed the largest component-level estimate (IRR 129.68, 95% CI 30.67-548.26) and was interpreted cautiously because of sparse controls. Microhaemorrhages were not associated with SLE (IRR 1.35, p = 0.452). Within SLE, only giant capillaries showed nominal correlations with disease duration (ρ = 0.298, p = 0.016) and neutrophils (ρ = 0.271, p = 0.029); serological signals were FDR-negative. Organ-level models were largely negative; musculoskeletal and discoid signals attenuated after treatment adjustment. Exploratory clustering identified low/high-burden groups (n = 52/13; silhouette 0.479), with limited high-burden stability.</p><p><strong>Conclusions: </strong>Standardized NVC identified greater structural capillaroscopic abnormality burden in SLE, but not a surrogate for activity, serology, organ involvement, or treatment response. Prognostic or clinical utility requires prospective multicentre validation incorporating cumulative treatment exposure.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining muscle-dominant ANCA-associated vasculitis: the importance of systematic muscle MRI assessment.","authors":"Tahir Saygın Öğüt, Mert Ünal, Veli Yazisiz","doi":"10.1007/s00296-026-06277-z","DOIUrl":"10.1007/s00296-026-06277-z","url":null,"abstract":"","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength relative to age- and sex-specific reference values in hospitalised patients with highly active rheumatoid arthritis: a single-centre cross-sectional study.","authors":"Umida Khojakulova, Marlen Yessirkepov, Bekaidar Nurmashev, Olena Zimba, Maidan Mukhamediyarov","doi":"10.1007/s00296-026-06292-0","DOIUrl":"10.1007/s00296-026-06292-0","url":null,"abstract":"<p><p>Handgrip strength (HGS) is a valuable indicator of muscle function that can be used to identify patients with rheumatoid arthritis (RA) at risk of sarcopenia and other functional impairments. The aim of this study was to describe grip strength (HGS) in patients with rheumatoid arthritis (RA), to assess the frequency of low HGS, to quantify grip strength relative to age- and sex-specific reference values, and to identify the clinical factors associated with HGS. In this single-centre cross-sectional study, 70 patients with RA had their HGS measured sequentially on both arms using an electronic hand dynamometer, with three measurements taken per arm; the higher of the HGSmeasurementse was taken as the maximum. Low HGS was defined as < 27 kg for men and < 16 kg for women. The maximum HGS was additionally expressed as an age- and sex-adjusted z-score relative to normative data; deviations from the norm were tested using the Wilcoxon signed-rank test (with an assumed median z = 0). Spearman's correlation and multivariate linear regression were used to determine the presence of an association with the maximum HGS value. The patients were predominantly women (n = 55; 78.6%), with a mean age of 53.6 ± 13.3 years, presenting with a long-standing course of RF-positive, erosive, highly active disease (median DAS28-ESR 5.6). The mean maximum HGS was 23.9 ± 8.8 kg. Low HGS was observed in 28.6% of patients (20% of women, 60% of men). Compared with age- and sex-matched norms, grip strength was significantly lower in men (median z = -1.71, p = 0.001) and in women (median z = -0.55, p < 0.001) . HGS scores were inversely correlated with age (ρ = -0.4, p = 0.001) and current smoking (ρ = -0.41, p = 0.001) and positively associated with body mass index (BMI) (ρ = 0.35, p = 0.003). Older age was the only variable independently associated with lower grip strength (B = -0.21 kg/year, p = 0.012). In this study, grip strength was low relative to established sarcopenia thresholds and age- and sex-specific reference values.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of association between the Dudley Inflammatory Bowel Symptom Questionnaire and fecal calprotectin in axial spondyloarthritis: a cross-sectional study.","authors":"Meryem Ozoglu, Neslihan Gokcen, Duygu Temiz Karadag, Ozlem Ozdemir Isik, Ayse Cefle, Ayten Yazici","doi":"10.1007/s00296-026-06290-2","DOIUrl":"10.1007/s00296-026-06290-2","url":null,"abstract":"<p><p>To investigate the relationship between gastrointestinal symptom burden assessed by the Dudley Inflammatory Bowel Symptom Questionnaire (DISQ), fecal calprotectin (FC), a non-invasive biomarker suggestive of intestinal inflammation, disease activity, and clinical characteristics in patients with axial spondyloarthritis (axSpA). In this cross-sectional study, 174 patients with axSpA were enrolled. Gastrointestinal symptom burden was assessed using the DISQ, disease activity using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional status using the Bath Ankylosing Spondylitis Functional Index (BASFI), and health-related quality of life using the Short Form-36 (SF-36). FC levels were measured by enzyme-linked immunosorbent assay. Correlation analyses, receiver operating characteristic (ROC) analyses, and multivariable logistic regression models were performed. FC levels were normal (< 50 μg/g) in 52.9%, mildly elevated (50-200 μg/g) in 38.5%, and markedly elevated (> 200 μg/g) in 8.6%. DISQ scores demonstrated a moderate positive correlation with BASDAI (rs = 0.432, p < 0.001) and a weak positive correlation with BASFI (rs = 0.248, p < 0.001), while showing moderate inverse correlations with all SF-36 domains (rs = - 0.310 to -0.470, all p < 0.001). In contrast, DISQ scores were not associated with FC levels (rs = 0.066, p = 0.386), ESR (rs = 0.013, p = 0.868), or CRP (rs = 0.029, p = 0.706). ROC analyses demonstrated poor discriminatory performance between DISQ and FC (AUC 0.529 and 0.475, respectively). In multivariable analyses, BASDAI independently predicted clinically significant gastrointestinal symptoms (OR 1.635, 95% CI 1.285-2.081) and elevated FC levels (OR 1.254, 95% CI 1.004-1.567), whereas neither DISQ nor FC independently predicted the other. Gastrointestinal symptom burden assessed by the DISQ was associated with disease activity, functional impairment, and reduced quality of life, but not with FC levels in axSpA.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"46 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}