Rheumatology International最新文献

{"title":"Synovitis and its association with elevated circulating interferons and hydroxychloroquine response in discoid lupus erythematosus: a cross-sectional study.","authors":"Magdalena Stec, Monika Krezelok, Magdalena Awsiuk, Ewa Wypasek, Bogdan Batko, Maciej Pastuszczak","doi":"10.1007/s00296-025-05816-4","DOIUrl":"10.1007/s00296-025-05816-4","url":null,"abstract":"<p><p>A significant proportion of patients with discoid lupus erythematosus (DLE) experience joint pain, yet its underlying pathomechanism remains unclear. Recent ultrasound studies in systemic lupus erythematosus (SLE) patients indicate synovitis in up to 90%, even in clinically silent cases, with interferon-mediated immune responses implicated in joint inflammation. This study aimed to investigate joint pathology in DLE, focusing on synovitis and its immunological profile. We analyzed 23 patients with histologically confirmed DLE and joint pain, all treated for ≥ 5 months with prednisone (≤ 10 mg/day) and hydroxychloroquine (HCQ, 200 mg/day). Ultrasonographic assessment (24 joints per patient) was performed using power Doppler (PD) ultrasonography, with synovitis graded using the OMERACT-EULAR PDUS synovitis score. Serum levels of 37 cytokines were measured via Bio-Plex Pro™ Human Inflammation Panel (37Plex). Synovitis (OMERACT-EULAR score ≥ 1) was identified in 30% (7/23) of DLE patients, with minimal (grade 1) synovitis in six cases and moderate (grade 2) synovitis in one. Patients with synovitis had significantly higher levels of IFN-α2, IFN-γ, MMP-1, MMP-3, sTNF-R1, and sTNF-R2 (p < 0.05), more painful joints, and poorer response to HCQ treatment (71.4% vs. 25% non-responders). Joint pain in DLE may result from synovitis, with an interferon-mediated immune response contributing to inflammation. Patients with synovitis exhibited elevated interferon levels and a worse response to HCQ therapy. These findings suggest a shared pathogenic mechanism between DLE and SLE-related arthritis, warranting further investigation into targeted therapeutic strategies.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"64"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral adipose tissue is related to interleukin 6 and resistin in juvenile idiopathic arthritis - a case-control study.","authors":"Kristine Risum, Nicoleta Cristina Olarescu, Kristin Godang, Henriette Schermacher Marstein, Jens Bollerslev, Helga Sanner","doi":"10.1007/s00296-025-05820-8","DOIUrl":"10.1007/s00296-025-05820-8","url":null,"abstract":"<p><p>To compare visceral adipose tissue (VAT) mass, lipid profile, and selected adipokines/cytokines in patients with juvenile idiopathic arthritis (JIA) with controls, and to explore associations between these markers and VAT. We included 60 JIA patients (30 oligoarticular,30 polyarticular), aged 10-16 years, and 60 age-and sex-matched controls. VAT (g) was estimated by dual-energy x-ray absorptiometry. Lipid profile and selected adipokines/cytokines were analyzed by standard methods and ELISA, respectively. VAT (g) was comparable between patients and controls [median (25th-75th percentile): 64 (23-149) g vs. 66 (30-99) g, p = 0.98] and between oligoarticular and polyarticular disease courses [46 (22-123) g vs. 80 (23-167) g, p = 0.32]. Patients had lower serum levels of apolipoprotein A1 (APOA1) and elevated levels of interleukin- 6 (IL-6) and progranulin compared to controls. As compared to oligoarticular disease course, patients with polyarticular disease had lower serum levels of low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) (Lp(a)), interleukin 1 receptor antagonist (IL-1RA) and progranulin, and elevated levels of interleukin-1 beta (IL-1b) and IL-1b/IL-1RA ratio. In patients (B, 95% CI), higher IL-6 (48.7, 25.1 to72.2, p < 0.001), resistin (8.5, 5.1 to 11.8, p < 0.001), and leptin (2.5, 0.9 to 4.0, p = 0.002) were associated with higher VAT. In controls, higher leptin (5.3, 3.7 to 6.9), p < 0.001) was associated with higher VAT. Despite similar VAT mass between patients and controls, VAT was related to IL-6 and resistin in patients only, suggesting an active metabolic role in JIA. Several pro-inflammatory adipokines/cytokines were increased in JIA, with differences in Lp(a) between oligoarticular and polyarticular disease courses.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"63"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized physical activity recommendations for people with axial spondyloarthritis using wearable activity tracker data: an exploratory study.","authors":"A-W de Leeuw, M A T van Wissen, T P M Vliet Vlieland, A M van Tubergen, M G J Gademan, M A M Berger, S F E van Weely","doi":"10.1007/s00296-024-05755-6","DOIUrl":"10.1007/s00296-024-05755-6","url":null,"abstract":"<p><strong>Objective: </strong>Benefits of physical activity (PA) on sleep in people with axial SpondyloArthritis (axSpA) are largely unknown. Our aim is to explore the relationships between PA and sleep on both a group level and an individual level using Wearable Activity Trackers (WATs) and machine learning.</p><p><strong>Methods: </strong>A sample of 64 axSpA participants received a WAT to monitor their PA and sleep. Participants with more than 30 days data of PA and sleep duration were included in the analyses. Spearman's correlation and the machine learning technique Subgroup Discovery were used to determine relationships between PA during the three prior days and light and deep sleep duration.</p><p><strong>Results: </strong>Number of daily steps (n = 64) was (median (first quartile (Q1) - third quartile (Q3) )) 4026 (1915 - 6549), total sleep (daily light and deep sleep) duration of the participants was 7 h 29 min (6 h 41 min - 8 h 8 min). Nearly 30% (n = 18) of the participants were eligible for inclusion in analyses (> 30 days of data). No significant relationships between prior PA and sleep were obtained on a group level. On an individual level, for 8 of the 18 included participants, significant relationships (p < 0.05) could be identified between PA during the three prior days and daily sleep duration. These significant relationships differed from participant to participant with a varying qualification of PA (number of steps, intensity level PA) and relevant time window (previous one, two or three days).</p><p><strong>Conclusion: </strong>Significant relationships between PA and daily sleep duration could be obtained on an individual level with details of the significant relationships varying between participants.</p><p><strong>Registration number: </strong>Netherlands Trial Register NL8238, included in the International Clinical Trial Registry Platform (ICTRP) ( https://trialsearch.who.int/Trial2.aspx?TrialID=NL8238 ).</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"65"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quality of life assessment in children with juvenile idiopathic arthritis- comparison of PROMIS^® generic and disease-specific cut-off points: a pilot study.","authors":"Justyna Młyńczyk, Paweł Abramowicz, Izabela Bernacka-Kusznierko, Jerzy Konstantynowicz","doi":"10.1007/s00296-025-05797-4","DOIUrl":"10.1007/s00296-025-05797-4","url":null,"abstract":"<p><strong>Objectives: </strong>Decreased quality of life (QoL) is a significant complication of most rheumatic conditions in adults, whereas data on health-related quality of life (HRQoL) in children with juvenile idiopathic arthritis (JIA) are limited. Patient-Reported Outcomes Measurement Information System^® (PROMIS^® ) instruments assessing quality of life (QoL) components can be scored using disease-specific severity thresholds. Our study aimed to compare the results of generic and one of the JIA-specific scorings regarding PROMIS^® Pediatric Mobility, Pain Interference, and Fatigue questionnaires, introduce PROMIS^® Pediatric Global Health 7 questionnaire as a valuable method to assess QoL specifically in patients with JIA and determine differences in self-reported QoL in juvenile idiopathic arthritis (JIA) patients and their healthy peers in the Polish population.</p><p><strong>Methods: </strong>In this single-center cross-sectional study, four self-reported questionnaires derived from the PROMIS^® Pediatric Item Bank (Global Health, Pain Interference, Fatigue, Mobility) were administered to 52 patients with JIA (8-17 years; mean 13.2 ± 2.9; girls 59.6%) and 101 age-matched healthy controls. Questionnaires were scored based on generic or JIA-specific cut-off points.</p><p><strong>Results: </strong>Regardless of the domain (PROMIS^® Pain Interference, Fatigue, or Mobility), JIA patients assigned by generic cut-off points to a more severe outcome were classified into milder outcomes when cut-off points for JIA were used. The usefulness of the PROMIS^® Pediatric Global Health 7 questionnaire was evidenced in children with JIA. No significant differences were found in QoL assessment between children with JIA and healthy children; however, self-reported impaired mobility was more prevalent in patients with JIA. A negative correlation was found between overall QoL and the assessment of three domains: pain, fatigue, and mobility impairment.</p><p><strong>Conclusions: </strong>Our study underscores the importance of JIA-specific scoring in clinical practice. While more research is needed to establish a single disease-specific scoring, our findings provide valuable insights into the negative influence of pain, fatigue, and mobility impairment on QoL in JIA. These results have the potential to significantly impact patient care and improve the health-related quality of life in children with JIA.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"61"},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very long-term remission in behcet's disease following withdrawal of anti-TNF treatment exceeds relapses: a reappraisal of an outcome study.","authors":"Aikaterini Arida, Nikos Markomichelakis, George E Fragoulis, Petros P Sfikakis","doi":"10.1007/s00296-025-05806-6","DOIUrl":"10.1007/s00296-025-05806-6","url":null,"abstract":"<p><strong>Background: </strong>Introduction of anti-TNF treatment has greatly improved prognosis of Behcet's disease (BD). Withdrawal of anti-TNF treatment in chronic inflammatory arthritis or bowel disease has been associated with sustained remission in subsets of patients. Herein, we examined the probability of very long-term quiescence after withdrawal of TNF inhibitors in BD.</p><p><strong>Methods: </strong>Retrospective longitudinal outcome single-center study focusing on BD patients who discontinued successful ant-TNF treatment since 2001. Endpoint was their proportion with sustained clinical remission for 5 years after withdrawal.</p><p><strong>Results: </strong>Thirty-three patients with severe BD refractory to non-biologic treatment (mean age 47.5 ± 11.5 years, 55% men) achieved TNF inhibitor-induced remission for a median of 2 years (IQR [1-2.6]). TNF inhibitors had been given for sight-threatening disease (28/33, 82%), for mucocutaneous (3/33), central nervous system (2/33) and gastrointestinal involvement (1/33). After withdrawal, BD remained in remission in 15/33 patients for 6.6 to 20.6 years (mean 13.5 ± 3.8). Conversely, 18/33 patients relapsed after a median of 9.5 months [IQR 8-12, range 4-32] following withdrawal but retreatment with TNF inhibitors was effective in 13/18. Of them, 9/13 discontinued for a second time and achieved again the study's endpoint, remaining in remission for median of 7.4 years ([IQR 5-9.3, range 5-15 years). Study's end-point was met by 24/33 patients (73%); 17and 7 patients remain any-drug free or on azathioprine only, respectively.</p><p><strong>Conclusion: </strong>Discontinuation of successful anti-TNF treatment is frequently associated with durable very long-term remission in severe BD. Additional studies are needed since relapses not responding to anti-TNF re-treatment may occur.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"60"},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic, musculoskeletal and organ characteristics on computed tomography in knee osteoarthritis - an explorative study in the IMI-APPROACH cohort.","authors":"Netanja I Harlianto, Pim A de Jong, Wouter Foppen, Edwin Bennink, Stijn Bunk, Simon C Mastbergen, Adriane D M Vorselaars, Mareye Voortman, Margreet Kloppenburg, Francisco J Blanco, Ida K Haugen, Francis Berenbaum, Karteek Popuri, Mirza Faisal Beg, Mylène P Jansen","doi":"10.1007/s00296-025-05817-3","DOIUrl":"10.1007/s00296-025-05817-3","url":null,"abstract":"<p><p>The systemic associations with knee osteoarthritis (KOA) are incompletely understood. This study explores aortic disease, musculoskeletal and organ findings in patients with KOA in relation to their symptoms or radiographic abnormalities. Full body computed tomography (CT) scans of 255 IMI-APPROACH participants were investigated using an automated analysis of multislice CT (Voronoi Health Analytics) that extracts aortic size and calcifications, and volumes and densities of bones, muscles, fat compartments and thoracic and abdominal organs. The CT measurements were primarily related to KOA as measured with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual scores and automated knee radiograph analysis of osteophytes, bone sclerosis and joint space width. The median age was 67 years, body mass index (BMI) 26.8 kg/m² and 78% were female. About half had Kellgren-Lawrence grade ≥ 2. Larger knee osteophyte area was associated with a larger aortic volume (R_Spearman=0.21,P = 0.001), which can be due to elongation or dilatation. We observed an association between more symptoms and increased psoas (R_Spearman=-0.23,P < 0.001) and lower leg (R_Spearman=-0.23,P < 0.001) muscle density, suggesting less microscopic muscle fat. Symptomatic KOA was associated with substantially lower lung volume (771 ml difference between 50% worst and 50% best WOMAC), but not with visible lung disease. Lung volume and density were significantly associated with the physical functioning WOMAC component. These associations remained significant after adjustment for age, sex and BMI. KOA is associated with significant systemic changes, including altered aortic and organ volumes. These correlations suggest that KOA's impact may extend beyond the joints. Future research should explore the causal relationships and therapeutic implications associations.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"62"},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mortality and acute complications of large vessel vasculitis patients hospitalized with COVID-19 in the US: a nationwide inpatient sample analysis (2020).","authors":"Nattanicha Chaisrimaneepan, Chanokporn Puchongmart, Pannathorn Nakaphan, Panat Yanpiset, Ben Thiravetyan","doi":"10.1007/s00296-025-05811-9","DOIUrl":"10.1007/s00296-025-05811-9","url":null,"abstract":"<p><p>COVID-19 was an emerging pandemic in 2020 which resulted in millions of deaths worldwide. It has been known that COVID-19 can cause secondary vasculitis. However, the impact of large vessel vasculitis, giant cell arteritis (GCA) and Takayasu (TAK), on COVID-19 infection is not known. This retrospective analysis used data from the US National Inpatient Survey 2020. Patients of all ages hospitalized due to COVID-19 in 2020 were identified on the database. A primary diagnosis of COVID-19 and a secondary diagnosis of LVV were included. Characteristics of patients, comorbidities, and clinical outcomes were compared. The primary outcome was the mortality rate. Secondary outcomes included resource utilization and acute in-hospital complications of COVID-19 infection. Multivariate logistic regression and univariate logistic regression analyses were conducted, with P values < 0.05 considered statistically significant. A total of 675 patients hospitalized with COVID-19 had concurrent LVV. Patients with LVV were older (73.70 vs 62.61; P < 0.001) and more likely female (75.00% vs 48.20%; p < 0.001). There is no difference in in-hospital mortality of COVID patients with and without LVV (aOR 0.95, p = 0.834), GCA (aOR 0.94, p = 0.827), or TAK (aOR 2.30, p = 0.394). There is an increase in the in-hospital risk of developing acute MI in COVID patients with LVV (aOR = 1.54; p = 0.04) but not with subgroup GCA and TAK. There were no significant differences in resource utilization and other acute in-hospital complications. Hospitalized COVID-19 patients with LVV and GCA were more likely to develop acute MI than those without. Further studies are required to minimize confounders to better explore the causal relationship of COVID-19 and LVV.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"59"},"PeriodicalIF":3.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of deep tendon reflex responses in rectus femoris and triceps brachii in fibromyalgia: a clinical and electrophysiological study.","authors":"Ilke Coskun Benlidayi, Volkan Deniz, Ceren Ornek, Aylin Sariyildiz","doi":"10.1007/s00296-025-05808-4","DOIUrl":"10.1007/s00296-025-05808-4","url":null,"abstract":"<p><p>The aim of this study was to evaluate deep tendon reflex responses and associated electrophysiological parameters of the muscles in patients with fibromyalgia. This cross-sectional study included 38 patients with fibromyalgia and 32 age- and sex-matched controls. Deep tendon reflexes of the rectus femoris and triceps brachii were tested using a reflex hammer. Electromyographic (amplitude and duration of activation), inertial measurement unit (angular velocity, acceleration), and electromechanical (delay) analyses were performed using a surface electromyography (sEMG) device. Comparative analyses were carried out between patients and controls. Additionally, Receiver Operating Characteristic (ROC) analysis was performed to evaluate the ability of hyperreflexia in distinguishing fibromyalgia patients from controls. Hyperactive deep tendon reflexes in the right/left rectus femoris and/or triceps brachii were observed in more than 85% (ranging from 86.8 to 94.7%) of the fibromyalgia group. Patients with fibromyalgia exhibited significantly increased deep tendon reflex responses compared to controls (p < 0.001). Patients revealed significantly higher amplitude, longer duration of muscle activation, greater sagittal acceleration and angular velocity, and shorter electromechanical delay. Normalized muscle activation (right and left rectus femoris and right triceps brachii) in response to deep tendon reflex test showed acceptable ability in differentiating fibromyalgia patients from controls (Area under curve (AUC) = 0.890, 0.784 and 0.782, respectively). For the right rectus femoris, values ≤ 28.3 (clinically corresponding to normoactive/hypoactive deep tendon reflexes) appeared to rule-out fibromyalgia with 94.1% sensitivity and 61.3% specificity. Patients with fibromyalgia exhibit increased deep tendon reflex responses. Normal or decreased deep tendon reflex responses may probably be used as a rule-out criterion for fibromyalgia.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"57"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of abdominal and lumbar multifidus muscles thickness and relation to endurance, pain, fatigue and functional mobility in patients with Fibromyalgia syndrome: a case-control study.","authors":"Yasemin Mirza, Fulden Sari, Pınar Diydem Yılmaz, Adem Küçük","doi":"10.1007/s00296-025-05813-7","DOIUrl":"10.1007/s00296-025-05813-7","url":null,"abstract":"<p><strong>Objective: </strong>The aim of present study was to compare abdominal (transversus abdominis (TrA), internal oblique (IO) and external oblique (EO)) and lumbar multifidus muscles (LM) evaluated with ultrasonographic (US) imaging in patients with FM (Fibromyalgia) and asymptomatic individuals and to examine the relationship between these muscle thickness and endurance, pain, fatigue and functional mobility.</p><p><strong>Methods: </strong>Women with FM group (n: 53, age: 45.96 ± 9.96 years), and asymptomatic control group (n: 49, age: 45.12 ± 7.28), were included in this study. Pain severity, disease activity, physical activity level, fatique, thickness of TrA, IO, EO and LM muscles and endurance, and functional mobility were evaluated with the Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), International Physical Activity Questionnaire- Short Form (IPAQ-SF), Fatigue Severity Scale (FSS), US imaging, McGill core endurance tests, and physical fitness tests, respectively. FM patients were classified according to the FSS score.</p><p><strong>Results: </strong>The thickness of the IO (right side) (p = 0.013) and LM (both sides) (p < 0.001) muscles, lumbopelvic muscle endurance (all p < 0.001) and physical fitness tests (all p < 0.001) were lower in FM group compared to the asymptomatic group. No statistically significant differences were found in TrA, IO (left side), EO muscles thickness between the two groups (all p > 0.05). LM muscle thickness was significantly correlated with lumbopelvic muscle endurance (all p < 0.05), physical fitness tests (all p < 0.001) and fatique (p = 0.001). Moreover, significant differences in LM muscle thickness (p = 0.007), trunk flexor muscle endurance (p = 0.016), left trunk lateral flexor muscle endurance (p = 0.045) and 30-s chair stand test (p = 0.025) in favor of the low-fatigue group were detected.</p><p><strong>Conclusion: </strong>The thickness of LM muscle, lumbopelvik endurance and functional mobility in FM patients have been affected negatively. These findings should be considered in management of FM.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"56"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilising multiple discharge coding will improve identification of patients with giant cell arteritis: a retrospective analysis of a hospital discharge dataset.","authors":"Andrew Dermawan, Julia Murdoch, Jean Louis De Sousa, Andrew Taylor, Helen Keen","doi":"10.1007/s00296-025-05814-6","DOIUrl":"10.1007/s00296-025-05814-6","url":null,"abstract":"<p><p>To determine whether the discharge diagnosis codes used within tertiary hospitals accurately identified patients with Giant Cell Arteritis (GCA), as determined by expert opinion at 6 months. The study was performed across three major hospitals within Perth, Western Australia. Patients with an International Classification of Diseases (ICD) code for GCA (M31.5 and M31.6) at discharge on first inpatient presentation were identified. Review of case notes, discharge summaries, letters, pathology, and imaging results were undertaken. The percentage of patients with an ICD code for GCA at initial discharge with confirmed GCA by expert opinion at 6 months (as the anchor diagnosis) was calculated. As validation of the anchor diagnosis, the percentage who fulfilled the 2022 ACR/EULAR criteria was also calculated, the number of hospital discharges per patient with an ICD code for GCA was calculated, to determine if multiple discharges with an ICD code for GCA increased the specificity of the ICD coding. 93 out of 157 admissions with an ICD for GCA were identified as a first inpatient presentation. At 6 months follow up, 65.6%, 95 CI [55.0%, 75.1%] had confirmed GCA by expert opinion. 88.2%, 95 CI [79.8%, 93.9%] met the 2022 ACR/EULAR criteria for GCA. The specificity of the ICD coding increased with increasing number of discharges- 67.4% with single episode, 80% with two episodes, and 100% with three or more episodes (p = 0.1373). Only 43.8%, 95 CI [26.4%, 62.3%] of patients who did not have GCA had an alternative diagnosis provided. 31.3%, 95 CI [16.1%, 50.0%] of patients who did not have GCA still have the GCA diagnosis listed in their subsequent clinical records and discharge summaries. Only 2/3rds of those patients with an initial discharge ICD code for GCA were found to have confirmed GCA at follow-up. This poor correlation between the ICD coding and confirmed diagnosis of GCA will impact the quality of data extracted from administrative health datasets for epidemiological and longitudinal studies. Selecting patients with two or more GCA coded episodes could improve the homogeneity of the cohort for recruitment into GCA studies, but a larger sample size study is required.</p>","PeriodicalId":21322,"journal":{"name":"Rheumatology International","volume":"45 3","pages":"58"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}