Revista de neurologia最新文献

[Abusive Head Trauma in Infants: A Case Review (2016-Present) and Prevention Strategies].

IF 0.8 4区医学

Revista de neurologia Pub Date : 2025-03-07 DOI: 10.31083/RN38855

Raquel Pérez Delgado, Jose Luis Peña Segura, María Zenaida Galve Pradel, Elena Javierre Miranda, Paula Almudena Madurga Revilla, Cintia Soro Lorente

引用次数: 0

[Clinical Features and Functional Prognosis in Patients with Possible Autoimmune Encephalitis in a Neurological Emergency Department].

IF 0.8 4区医学

Revista de neurologia Pub Date : 2025-03-05 DOI: 10.31083/RN36202

Paula Catalina Robles-Monroy, Victoria Martínez-Angeles, Jesús Ramírez-Bermúdez, Arturo Violante-Villanueva, Lilia Salas-Alvarado, Xiomara García, Juan Carlos López-Hernández

{"title":"[Clinical Features and Functional Prognosis in Patients with Possible Autoimmune Encephalitis in a Neurological Emergency Department].","authors":"Paula Catalina Robles-Monroy, Victoria Martínez-Angeles, Jesús Ramírez-Bermúdez, Arturo Violante-Villanueva, Lilia Salas-Alvarado, Xiomara García, Juan Carlos López-Hernández","doi":"10.31083/RN36202","DOIUrl":"10.31083/RN36202","url":null,"abstract":"Introduction: Autoimmune encephalitis (AE) represents a severe neuropsychiatric disorder that requires early diagnosis. This study describes the frequency, clinical characteristics, and paraclinical findings in patients with possible autoimmune encephalitis treated in a neurological emergency department, as well as factors associated with poor functional prognosis at discharge.Material and methods: This was an observational ambispective cohort study including patients diagnosed with AE who were treated in a neurological emergency department in 2022. Demographic, clinical, and paraclinical characteristics were evaluated, along with functional outcomes using the modified Rankin scale (mRS); ≤2 points, was considered as good prognosis. In the statistical analysis we used the chi-squared test, Fisher's exact test, Student's T-test, and Mann-Whitney U test.Results: Out of 9046 patients, 31 (0.3%) met the criteria for probable autoimmune encephalitis (PAE). The average age was 28.4 ± 12.1 years and 51.6% were female. Cognitive alterations (90.3%), psychosis (74.2%), abnormal movements (71%), catatonia (67.7%), seizures/status epilepticus (64.5%, 19.4%), and dysautonomia (58.1%) were observed; 58.1% had a good functional prognosis. Factors associated with poor prognosis included older age (24.8 ± 5.0 vs. 33.4 ± 16.8, p = 0.049), status epilepticus (0% vs. 46.2%, p = 0.002), and lower frequency of headache (61.1% vs. 15.4%, p = 0.025).Conclusions: AE represents a rare diagnosis even in a neurological emergency center; older age, status epilepticus and absence of headache were associated with poor functional prognosis at discharge.","PeriodicalId":21281,"journal":{"name":"Revista de neurologia","volume":"80 1","pages":"36202"},"PeriodicalIF":0.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unforeseen Sequelae: Myxomatous Aneurysm and Cerebral Metastasis in a Case of Atrial Myxoma-A Clinical Image.

IF 0.8 4区医学

Revista de neurologia Pub Date : 2025-02-12 DOI: 10.31083/RN37950

Sukalyan Purkayastha, Rajinder Kumar, Dinesh Verma, Deepak Dhurvey, Nitin Kumar, Surajit Jana

引用次数: 0

A Rare Guillain-Barré Syndrome Variant with Multi-Ganglioside Reactivity: A Case of Severe Cranial Nerve Involvement.

IF 0.8 4区医学

Revista de neurologia Pub Date : 2025-02-12 DOI: 10.31083/RN37744

Laura Gómez-Dabó, Arnau Llaurado, Daniel Sánchez-Tejerina, Victoria González, Carmen Montalvo-Olmedo, Carlos Lázaro-Hernández, Marc Rodrigo-Gisbert, Samuel López-Maza, Maider Iza-Achutegui, Lídia Giramé-Rizzo, Nuria Raguer, Raúl Juntas

{"title":"A Rare Guillain-Barré Syndrome Variant with Multi-Ganglioside Reactivity: A Case of Severe Cranial Nerve Involvement.","authors":"Laura Gómez-Dabó, Arnau Llaurado, Daniel Sánchez-Tejerina, Victoria González, Carmen Montalvo-Olmedo, Carlos Lázaro-Hernández, Marc Rodrigo-Gisbert, Samuel López-Maza, Maider Iza-Achutegui, Lídia Giramé-Rizzo, Nuria Raguer, Raúl Juntas","doi":"10.31083/RN37744","DOIUrl":"10.31083/RN37744","url":null,"abstract":"Introduction: We present a rare case of acute immune-mediated polyradiculoneuritis, a Guillain-Barré Syndrome (GBS) variant, manifesting as ophthalmoparesis-ataxia, facial diplegia, and acute bulbar palsy, accompanied by a unique autoimmune profile.Clinical case: A 75-year-old female developed rapidly progressive symptoms, including bilateral non-reactive mydriasis, ptosis, complete ophthalmoplegia, bilateral facial weakness, tongue immobility, palatal paralysis, limb dysmetria, ataxia, and brisk generalized tendon reflexes, all while maintaining a preserved mental state. Symptoms emerged 10 days after a probable gastrointestinal infection. Severe bulbar dysfunction necessitated orotracheal intubation and a tracheotomy. Extensive cranial nerve involvement initially suggested a brainstem lesion, with oculomotor and acute bulbar palsy as prominent signs. However, brainstem and spinal magnetic resonance imaging along with cerebrospinal fluid analysis yielded negative results. Electromyography reveled a sensorimotor demyelinating polyradiculoneuropathy, and serum testing identified IgG antibodies targeting multiple gangliosides, including the disialosyl group and terminal NeuNAc(α2-3)Gal. Treatment with intravenous immunoglobulin (IVIG) led to gradual clinical improvement.Conclusions: This case highlights a rare and severe GBS phenotype characterized by reactivity to multiple gangliosides. It highlights the role of shared ganglioside epitopes in antibody-mediated neurological damage and expands the clinical spectrum of GBS variants.","PeriodicalId":21281,"journal":{"name":"Revista de neurologia","volume":"80 1","pages":"37744"},"PeriodicalIF":0.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies].

IF 0.8 4区医学

Revista de neurologia Pub Date : 2025-01-24 DOI: 10.31083/RN37385

María Alejandra Tudorache Pantazi, Marien Gadea-Doménech, Raúl Espert Tortajada

{"title":"[Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies].","authors":"María Alejandra Tudorache Pantazi, Marien Gadea-Doménech, Raúl Espert Tortajada","doi":"10.31083/RN37385","DOIUrl":"10.31083/RN37385","url":null,"abstract":"Introduction: Long COVID is defined by National Institute for Health and Care Excellence (NICE) as the set of signs and symptoms that develop during or after a SARS-CoV-2 infection and continue for more than twelve weeks without any alternative diagnosis. One of the most frequent persistent symptoms reported by patients and verified in neuroimaging studies is cognitive dysfunction, due to a generalized hypoconnectivity and a diffuse axonal lesion in white matter. Therefore, the objectives of the present review are to determine how long cognitive functions remain affected during Long COVID and to explore which cognitive functions are most affected beyond three months of follow-up in patients up to 65 years of age without previous neuropsychological or psychiatric complications.Methods: A systematic review was performed using PRISMA criteria and 11 articles were included through a comprehensive search of five different databases: PubMed, Medline, Scopus, WOS and ProQuest. The risk of bias of the articles was assessed using the Newcastle-Ottawa scale.Results: Cognitive problems in Long COVID persist over time and improve slowly, although studies seem to agree that most areas improved significantly after one year. The cognitive functions that remained impaired the longest were processing speed and attention.Conclusions: These cognitive alterations cause a reduction in the quality of life of the patients and a reduction in work capacity and manifest the need for a cognitive intervention.","PeriodicalId":21281,"journal":{"name":"Revista de neurologia","volume":"79 12","pages":"37385"},"PeriodicalIF":0.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neurology in Bohemian Lights].

IF 0.8 4区医学

Revista de neurologia Pub Date : 2025-01-20 DOI: 10.31083/RN37281

Alfredo Puy-Núñez, Ana Guitián-Pena, Irene Expósito-Ruiz, Mercedes Macías-Arribí, Jose Manuel Aldrey-Vázquez, Juan Manuel Pías-Peleteiro

引用次数: 0

The Efficacy of Boxing Training on Patients with Parkinson's Disease: Systematic Review and Meta-Analysis. 拳击训练对帕金森病患者的疗效：系统回顾和meta分析。

IF 0.8 4区医学

Revista de neurologia Pub Date : 2024-12-20 DOI: 10.31083/RN36478

Daniel González-Devesa, Carlos Ayán, Miguel Adriano Sanchez-Lastra, Ciro Gutiérrez-Hong, Adrián García-Fresneda, José Carlos Diz

{"title":"The Efficacy of Boxing Training on Patients with Parkinson's Disease: Systematic Review and Meta-Analysis.","authors":"Daniel González-Devesa, Carlos Ayán, Miguel Adriano Sanchez-Lastra, Ciro Gutiérrez-Hong, Adrián García-Fresneda, José Carlos Diz","doi":"10.31083/RN36478","DOIUrl":"10.31083/RN36478","url":null,"abstract":"Objective: This study aimed to systematically review the available evidence on the effects of boxing interventions on people with Parkinson disease.Methods: Four electronic databases were searched systematically from their inception until December 2023. The methodological quality of the included studies was assessed using the Physiotherapy Evidence Database and Methodological Index for Non-Randomized Studies scales.Results: A total of 13 studies were included. Data synthesis indicated that participants who performed boxing programs did not have a significant effect in the polled data on functional mobility, balance, motor symptoms, gait and cardiorespiratory fitness Accordingly, for the effects of boxing on self-reported quality of life, the polled data showed a non-significant trend towards improving Hedges' g. Also, when the analysis was performed by comparing the experimental and control groups, the results remained non-significant.Conclusions: The evidence regarding the use of boxing as a program exercise for patients with Parkinson disease remains uncertain. Preliminary findings indicate that participation in boxing does not demonstrate a substantial impact on either physical or mental health outcomes.","PeriodicalId":21281,"journal":{"name":"Revista de neurologia","volume":"79 11","pages":"36478"},"PeriodicalIF":0.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Referral Profile of Adult Patients Attended in the Neuropsychology Consultation at Hospital Universitario La Paz in Madrid from 2018 to 2023]. [2018 - 2023年马德里拉巴斯大学医院神经心理学会诊成人患者转诊情况分析]。

IF 0.8 4区医学

Revista de neurologia Pub Date : 2024-12-18 DOI: 10.31083/RN36419

Julia Castellanos Segado, Cristina Campoy Lacasa, Diego Carracedo Sanchidrián, Jesús Martí Esquitino

{"title":"[Referral Profile of Adult Patients Attended in the Neuropsychology Consultation at Hospital Universitario La Paz in Madrid from 2018 to 2023].","authors":"Julia Castellanos Segado, Cristina Campoy Lacasa, Diego Carracedo Sanchidrián, Jesús Martí Esquitino","doi":"10.31083/RN36419","DOIUrl":"10.31083/RN36419","url":null,"abstract":"Introduction: Neuropsychology is an area of psychology that studies, through different methodologies, the relationship between the nervous system and behavior. This study aims to describe the profile of the patient who most frequently received a neuropsychological assessment at HULP between 2018 and 2023.Patients and methods: This is a retrospective observational study of 394 clinical records of subjects aged 18 years or older who were attended in the neuropsychology consultation of HULP between 2018 and 2023. The data was recorded and anonymized in a database properly guarded. Frequency tables were extracted and χ2 tests were made. SPSS 26 was the programme used to make data analysis.Results: A total of 232 women (mean age of 46,47 years) and 162 men (mean age 43,31 years) were evaluated. The most frequent reason for consultation in both groups was suspicion of dementia (112 consultations for this reason in the female group; 76 in the male group). Regardless of the reason for consultation, there were more cases of patients who had studied up to the age of 18 years. Binomial analysis reveals a statistically significant relationship between being assessed in the neuropsychology consultation at HULP and having completed studies before the age of 18.Conclusions: The profile of the patient who is most frequently attended at the neuropsychology consultation of HULP is a middle-aged woman with education up to 18 years of age, referred by the Mental Health Service for suspected dementia. The information obtained from this analysis will help to guide future planning of assessment strategies for patients with neuropsychological problems.","PeriodicalId":21281,"journal":{"name":"Revista de neurologia","volume":"79 11","pages":"36419"},"PeriodicalIF":0.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Characteristics of patients with drug-resistant epilepsy in a tertiary hospital]. [一家三级医院中耐药性癫痫患者的特征]。

IF 0.8 4区医学

Revista de neurologia Pub Date : 2024-11-16 DOI: 10.33588/rn.7910.2024321

M Iglesias-Rodríguez, V Navarro-Abia, B Barbadillo-Mariscal, F J Gil-Calderón, A Gonzalo-San Esteban, A Mañaricua-Arnaiz, L Tejero-Pastor, D Conejo-Moreno

{"title":"[Characteristics of patients with drug-resistant epilepsy in a tertiary hospital].","authors":"M Iglesias-Rodríguez, V Navarro-Abia, B Barbadillo-Mariscal, F J Gil-Calderón, A Gonzalo-San Esteban, A Mañaricua-Arnaiz, L Tejero-Pastor, D Conejo-Moreno","doi":"10.33588/rn.7910.2024321","DOIUrl":"10.33588/rn.7910.2024321","url":null,"abstract":"Introduction: Drug-resistant epilepsy has a cumulative incidence between 14 and 20% of patients with epilepsy. It is associated with more comorbidities and with higher healthcare expenditure and impact on quality of life.Patients and methods: A retrospective longitudinal descriptive study was performed covering the period from 01/01/2010 to 02/28/2024. All patients with epilepsy seen in the Pediatric Neurology unit of our center were collected and a review of medical records was carried out to collect the characteristics and evolution during the study period. The classification and definitions used were those established by the International League Against Epilepsy.Results: A total of 325 patients with epilepsy were identified, with a cumulative incidence of DRE of 29%. The most frequent etiology was structural both in all patients with epilepsy (22%), and in drug-resistant epilepsy (36%). A statistically significant association was established between refractoriness and genetic and structural causes, and between having status epilepticus and the development of drug-resistant epilepsy. Seventy-nine percent of patients with drug-resistant epilepsy developed epileptic encephalopathy. The most commonly used antiseizure drug was valproic acid (90%), 19% received a ketogenic diet and 4.2% received epilepsy surgery.Conclusions: In our setting the incidence of drug-resistant epilepsy is high, more so than previously described. Genetic and structural etiologies are associated with a higher incidence. Having suffered status epilepticus is associated with refractoriness. A higher incidence was observed in patients with defined electroclinical syndromes, probably influenced by epileptic and developmental encephalopathies.","PeriodicalId":21281,"journal":{"name":"Revista de neurologia","volume":"79 10","pages":"273-277"},"PeriodicalIF":0.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Glioblastoma and its interaction with neurogenesis]. [胶质母细胞瘤及其与神经发生的相互作用]。

IF 0.8 4区医学

Revista de neurologia Pub Date : 2024-11-16 DOI: 10.33588/rn.7910.2024226

B Rodríguez-Mendoza, A Figueroa-González, G Cano-Herrera, L E Gutierrez-Rosas, C I Romero-Torres, L O Victoria-Garcia, P Gonzalez-Castillo, H Guerrero-Cázares, A Ibarra

引用次数: 0