Revista Brasileira de Psiquiatria最新文献_第2页

Association between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort. 甲基- cpg结合结构域蛋白5基因与墨西哥人群抑郁症状的关系：来自MxGDAR/Encodat队列的结果

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-09 DOI: 10.47626/1516-4446-2024-3859

Marco Antonio Sanabrais-Jiménez, Beatriz Camarena, Alejandro Aguilar-García, Alma Delia Genis-Mendoza, José Jaime Martínez-Magaña, Humberto Nicolini, Jorge Ameth Villatoro-Velá, Marycarmen Bustos-Gamiño, María de Lourdes Gutiérrez-López, María Elena Medina-Mora

{"title":"Association between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort.","authors":"Marco Antonio Sanabrais-Jiménez, Beatriz Camarena, Alejandro Aguilar-García, Alma Delia Genis-Mendoza, José Jaime Martínez-Magaña, Humberto Nicolini, Jorge Ameth Villatoro-Velá, Marycarmen Bustos-Gamiño, María de Lourdes Gutiérrez-López, María Elena Medina-Mora","doi":"10.47626/1516-4446-2024-3859","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3859","url":null,"abstract":"Objective: To explore the association between 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive symptoms (DS) in a Mexican cohort.Methods: The sample included 2012 individuals from the Mexican Genomic Database for Addiction Research (MxGDAR/Encodat) cohort, 198 showed AS, 266 DS, 66 anxiety and depressive symptoms (ADS), and 1482 healthy controls. The DI-PAD screening questionnaire was used to evaluate lifetime AS and DS. The sample was genotyped with the commercial microarray PsychArray BeadChip. We identified 707 SNPs of 75 genes previously associated with AS and DS. PLINK's logistic regression approach was performed.Results: The analysis showed association between the rs2437092 (p=3.89x10-5) of LAMA and rs11066591 (p=4.06x10-5) of MYO1H with anxiety and depressive symptomatology. Additionally, rs7578002 (p=7.9x10-6) and rs1234428 (p=1.94x10-5) of MBD5 found association with DS. However, after adjustment for age, sex, and the three genetic principal components, only the association of rs7578002 (p=5.85x10-5) and rs1234428 (p=8.15x10-5) of MBD5 with DS remained.Conclusions: Our study replicated the association between MBD5 and DS. The MBD5 protein is involved in gene silencing, suggesting its potential implication in the development of DS in the Mexican population.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood family adversities and recurrence of depression in adulthood: finds of three ELSA-Brasil visits. 童年时期的家庭逆境和成年期抑郁症的复发：三次elsa巴西访问的发现。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-04 DOI: 10.47626/1516-4446-2024-3914

Maíra Barroso Léo, Sandhi Maria Barreto, Rosane Harter Griep, Ana Luísa Patrão, Lidyane do Valle Camelo, Maria Carmen Viana, Luana Giatti

{"title":"Childhood family adversities and recurrence of depression in adulthood: finds of three ELSA-Brasil visits.","authors":"Maíra Barroso Léo, Sandhi Maria Barreto, Rosane Harter Griep, Ana Luísa Patrão, Lidyane do Valle Camelo, Maria Carmen Viana, Luana Giatti","doi":"10.47626/1516-4446-2024-3914","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3914","url":null,"abstract":"Objective: To investigate the association between family adversities in childhood and depression in three follow-up visits of a cohort of Brazilian adults.Methods: A total of 12,636 participants from the Longitudinal Study of Adult Health (ELSA-Brasil), who attended three interview/examination visits (2008-2010, 2012-2014, and 2017-2019), were included. Five family dysfunctions and the childhood family dysfunction score (0, 1, and 2+ dysfunctions) were used. The Clinical Interview Schedule-Revised-CIS-R assessed depression in 3 visits (no, 1, and 2 or 3) Multinomial logistic regression models estimated crude and adjusted Odds Ratios (OR) and 95% confidence intervals (95%CI).Results: Mean age was 59.6 years (SD=8.8), 7.4% presented depression in 1 visit and 2.2% in 2 or 3 visits. After adjustments, compared to the absence of family dysfunction the presence of mental disorder (OR: 3.91; 95%CI: 2.94-5.21), substance abuse (OR: 2.14; 95%CI: 1.65-2.77) and parental separation (OR: 1.55; 95%CI: 1.12-2.15) increased the odds of depression in 2 or 3 visits. Exposure to 2+ family dysfunctions increased the odds of depression in 1 and in 2 or 3 visits, with a dose-response gradient.Conclusion: Exposure to family dysfunction in childhood contributes to the occurrence and recurrence of depression in adults. Interventions to prevent dysfunctional family environments and their repercussions on children can reduce the burden of depression.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Patterns of Disordered Eating Behaviors in Children and Adolescents from the Brazilian High-Risk Cohort Study for Mental Conditions. 来自巴西精神疾病高危队列研究的儿童和青少年饮食失调行为的纵向模式

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-12-28 DOI: 10.47626/1516-4446-2024-3867

Iara Peixoto de Oliveira, Ana C Fernandéz, Giovanni A Salum, Ary Gadelha, Pedro Pan, Eurípedes Constantino Miguel, Daniel C Mograbi, Patricia P Bado

{"title":"Longitudinal Patterns of Disordered Eating Behaviors in Children and Adolescents from the Brazilian High-Risk Cohort Study for Mental Conditions.","authors":"Iara Peixoto de Oliveira, Ana C Fernandéz, Giovanni A Salum, Ary Gadelha, Pedro Pan, Eurípedes Constantino Miguel, Daniel C Mograbi, Patricia P Bado","doi":"10.47626/1516-4446-2024-3867","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3867","url":null,"abstract":"Objective: Disordered Eating Behaviors (DEB) are associated with dysfunctional changes in eating behavior, not meeting diagnostic criteria for eating disorders. DEB affects a significant percentage of individuals, yet it remains under-researched. The current study investigates the developmental trajectory and psychopathological correlates of DEB in children and adolescents in Brazil.Methods: The sample included 1,583 participants from the Brazilian High-Risk Cohort, assessed across three waves between 2010 (age 6-12 years) and 2019 (age 12-21 years). Psychopathology diagnoses were evaluated using the Development and Well-Being Assessment (DAWBA) and DEB was assessed through the DAWBA eating disorders screening. Dimensional psychopathology was measured with the Child Behavior Checklist.Results: Participants were divided into dysfunctional and non-dysfunctional eating groups. DEB showed significant variability, with few maintaining persistent patterns. DEB was strongly linked to higher internalizing symptoms, especially in girls, but less to externalizing behaviors. DEB increased the likelihood of Eating Disorders, Major Depressive Disorder, and higher BMI.Conclusions: This study reveals that DEB are frequent among Brazilian children and adolescents and linked to psychopathology, especially internalizing symptoms, and BMI. Future research should investigate the underlying mechanisms of DEB and develop strategies for early detection and effective interventions.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65. 白质高强度及其在重度抑郁发作中的作用：一项65岁以下成年人的横断面研究。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-12-28 DOI: 10.47626/1516-4446-2024-3921

Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle

{"title":"White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65.","authors":"Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle","doi":"10.47626/1516-4446-2024-3921","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3921","url":null,"abstract":"Objective: White matter hyperintensities (WMH) are associated with Major Depressive Episodes (MDE) in individuals aged 65 and over. WMH are prevalent in adults under 65, yet the association between their volume and MDE in this population remains uncertain. This study aimed to assess the association between WMH volume and MDE and its severity in patients < 65.Methods: This cross-sectional study included subjects under the age of 65, 69 patients with MDE and 32 healthy controls (HCs). Severity was assessed with the Hamilton Rating Scale and WMH were quantified by 2 experts. Post-hoc mediation analyses were conducted if associations were found between independent variables and WMH.Results: Mean was 34.5 (12.4) years old. There was no difference in WMH between patients and HCs. Higher WMH volume were observed in extremely severe MDE (2170.2 (3767.9) mm3 vs 416.6 (594.9) mm3 (r = 0.21; p < 0.05)), which completely mediated the effect of age on severity.Conclusions: In adults under 65, this study failed to identify higher WMH volume in MDE compared to HCs. However, WMH may act as a mediator of the association between age and MDE severity. This finding suggests that WMH could contribute to more severe depression in late-life.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leme Lopes: the pioneering multiaxial diagnosis and the dilemma of subjectivity. Leme Lopes：开创性的多轴诊断与主体性困境。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-12-27 DOI: 10.47626/1516-4446-2024-3990

Larissa Junkes, Walmor J Piccinini, Antonio E Nardi

引用次数: 0

Item-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace. 事件影响量表-修订版（IES-R）的项目有效性研究：医院工作人员对工作场所压力反应的自我报告。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-27 DOI: 10.47626/1516-4446-2024-3882

Vitor A Petrilli-Mazon, Marcos O Carvalho-Alves, Eurípedes Constantino Miguel, Felipe Corchs, Mariana Curi, Yuan-Pang Wang

{"title":"Item-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace.","authors":"Vitor A Petrilli-Mazon, Marcos O Carvalho-Alves, Eurípedes Constantino Miguel, Felipe Corchs, Mariana Curi, Yuan-Pang Wang","doi":"10.47626/1516-4446-2024-3882","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3882","url":null,"abstract":"Objective: Recent studies have revealed a heterogeneous prevalence and presentation of PTSD across countries. It is crucial to assess the methodological and item-level measurement factors that contribute to variations in mental disorder rates across cultures. This study aimed to investigate the traumatic experiences of hospital workers by employing item analysis of the Impact of Event Scale-Revised (IES-R).Methods: Data were collected from 1,000 employees of a large hospital during the COVID-19 pandemic and were further subjected to item response theory (IRT) analysis with respect to the discrimination (a) and difficulty (b) parameters of the item pool.Results: Our results demonstrated that the IES-R items had a good discriminative ability (a) and covered a range of distress severity (b) associated with traumatic experiences. The IES-R was found to be a reliable and informative instrument for assessing individuals with moderate to severe trauma-related distress across the spectrum of traumatic symptoms. In particular, items #10 (\"jumpy or easily startled\") and #6 (\" thought about it when didn't mean to\"), reflecting the PTSD domains of hyperarousal and intrusion, excelled in discriminating between different levels of traumatic distress. Conversely, items related to avoidance and sleep disturbance showed diminished discriminative ability.Conclusions: The item analysis of the IES-R may be used to assess trauma symptoms in the context of a traumatic exposure, thereby identifying the most discriminative and informative items of the PTSD measure in our context. Our findings may refine the IES-R and facilitate the development of a more effective scale with optimized item parameters.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual reality, social intelligence, mirror neurons and bipolar spectrum a new perspective. 虚拟现实、社交智能、镜像神经元和躁郁症谱的新视角。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-17 DOI: 10.47626/1516-4446-2024-3901

Mauro G Carta, Antonio E Nardi

引用次数: 0

Costs of dementia in Brazil. 巴西老年痴呆症的成本。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-17 DOI: 10.47626/1516-4446-2024-3611

Fabiana Araújo Figueiredo da Mata, Ari Alex Ramos, Laiss Bertola, Thais Suarez, Cleusa Pinheiro Ferri, Haliton Alves de Oliveira Júnior

{"title":"Costs of dementia in Brazil.","authors":"Fabiana Araújo Figueiredo da Mata, Ari Alex Ramos, Laiss Bertola, Thais Suarez, Cleusa Pinheiro Ferri, Haliton Alves de Oliveira Júnior","doi":"10.47626/1516-4446-2024-3611","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3611","url":null,"abstract":"Background: Given the increasing number of people with dementia in Brazil, there is an urgency for health and social systems to plan strategies to meet the needs of this population and their families. Therefore, research on dementia costs is essential. This study estimated direct and indirect costs related to dementia in Brazil.Methods: We employed the cost of illness study methodology to estimate dementia-related costs. Moreover, we used household interview data from the ReNaDe project and public, free-of-charge national databases to collect service use and values information. The societal and the SUS (Brazilian Universal Health System) perspectives were adopted.Results: The monthly cost of dementia per individual increases with the syndrome's progression from US$ 843.04 in the initial stage to US$ 1,317.81 in the intermediate stage, peaking at US$ 1,576.15 in the advanced stage. Indirect costs constitute at least 73% of total expenses. When considering the costs for Brazil, it is in the intermediate stage of dementia that the country's total expenses are the highest.Conclusions: Family caregivers shoulder at least 73% of the health-related costs of dementia in Brazil, highlighting the need to improve and create supporting strategies for people with dementia and their families.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signal Mining and Risk Analysis of Olanzapine Adverse Events in the FAERS Database. FAERS 数据库中奥氮平不良事件的信号挖掘和风险分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-17 DOI: 10.47626/1516-4446-2024-3880

Aiguo Dong, Lingyi Shi, Zhiqiang Du, Qin Zhou, Ying Jiang, Haohao Zhu, Anqing Zhu

{"title":"Signal Mining and Risk Analysis of Olanzapine Adverse Events in the FAERS Database.","authors":"Aiguo Dong, Lingyi Shi, Zhiqiang Du, Qin Zhou, Ying Jiang, Haohao Zhu, Anqing Zhu","doi":"10.47626/1516-4446-2024-3880","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3880","url":null,"abstract":"Objective: This study aims to assess the safety profile of Olanzapine by analyzing adverse events (AEs) reported in the FAERS database, particularly focusing on newly identified risks.Method: The study involved adverse events (AEs) related to Olanzapine from January 1, 2004, to June 30, 2023. Four signal mining methods were used for a comprehensive analysis of the frequency and strength of AEs, including ROR, PRR, BCPNN, and EBGM.Results: A total of 43,664 reports with Olanzapine as the primary suspect drug were collected. 776 PT signals involving 27 SOCs were identified. The main affected groups were females and the age group of 18 to 45 years. Psychiatric disorders and Nervous system disorders were the most common adverse reactions. Moreover, the analysis revealed some adverse reactions not recorded in the manual, including cardiovascular risks like Pancreatitis, Chylomicron increased, Hyperchylomicronaemia, and Myocardial reperfusion injury, as well as rare but serious adverse reactions like Neuroleptic malignant syndrome and Anosognosia.Conclusion: This study identified new cardiovascular risks associated with Olanzapine, including pancreatitis and myocardial reperfusion injury, which require further investigation.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Satisfactory Levels of Functionality and Quality of Life in Caregivers of Patients with Bipolar Disorder: Is this Possible? 双相情感障碍患者照顾者的功能和生活质量达到令人满意的水平：这可能吗？

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-16 DOI: 10.47626/1516-4446-2024-3866

Mariana Troesch, Sarah Prates, Stella Sarmento, Thiago Cerqueira-Silva, Gabriela Léda-Rêgo, Caroline Dallalana, Juliana S Casqueiro, Paula Studart-Bottó, Ângela Miranda-Scippa

{"title":"Satisfactory Levels of Functionality and Quality of Life in Caregivers of Patients with Bipolar Disorder: Is this Possible?","authors":"Mariana Troesch, Sarah Prates, Stella Sarmento, Thiago Cerqueira-Silva, Gabriela Léda-Rêgo, Caroline Dallalana, Juliana S Casqueiro, Paula Studart-Bottó, Ângela Miranda-Scippa","doi":"10.47626/1516-4446-2024-3866","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3866","url":null,"abstract":"Objectives: To measure the levels of functionality and QoL of caregivers of patients with BD, investigating the association between them, as well as the relationship with clinical and sociodemographic data of these caregivers.Method: A cross-sectional study was conducted between 2020 and 2022 with caregivers of patients with BD treated in an outpatient clinic of a university hospital. The following instruments were applied: Clinical and sociodemographic questionnaire, WHODAS 2.0, SF-36, MINI-PLUS, and SCID II.Results: The median score on WHODAS 2.0 was less than 20. In SF-36, the medians found in its domains were above 60. Those who demonstrated greater functional impairment had lower QoL. Being younger, being a parent, having non-psychiatric clinical conditions, and having mental disorders were associated with worse QoL and lower functionality.Conclusion: The results obtained indicate less functional impairment and a better perception of QoL when compared to literature data, demonstrating that there is a subgroup of caregivers who perform their caregiving role without significant compromise in these health aspects. Exploring other factors associated with functionality and QoL, such as resilience, the presence of psychological support, or others, may allow for better targeting of public health interventions, optimizing comprehensive bidirectional care for patients and caregivers.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0