Revista Brasileira de Psiquiatria最新文献_第2页

It is unlikely that major depression severity correlates with white matter lesion volume. 重度抑郁症的严重程度不太可能与白质病变体积相关。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-03-16 DOI: 10.47626/1516-4446-2025-4121

Josef Finsterer, Joao Gama Marques

引用次数: 0

Challenges and future directions of Transcranial Direct Current Stimulation for Depression: insights from a systematic review and meta-analysis. 经颅直流电刺激治疗抑郁症的挑战和未来方向：来自系统回顾和荟萃分析的见解。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-03-16 DOI: 10.47626/1516-4446-2024-3989

Pedro Henrique Rodrigues da Silva, Marie-Anne Vanderhasselt, Giuseppina Pilloni, Leigh Charvet, Frank Padberg, Marom Bikson, André R Brunoni, Lais B Razza

{"title":"Challenges and future directions of Transcranial Direct Current Stimulation for Depression: insights from a systematic review and meta-analysis.","authors":"Pedro Henrique Rodrigues da Silva, Marie-Anne Vanderhasselt, Giuseppina Pilloni, Leigh Charvet, Frank Padberg, Marom Bikson, André R Brunoni, Lais B Razza","doi":"10.47626/1516-4446-2024-3989","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3989","url":null,"abstract":"Depression is a common and debilitating disorder affecting millions. First-line treatments fail to achieve remission in about one-third of patients, highlighting a critical treatment need. Transcranial direct current stimulation (tDCS) has emerged as a novel treatment for depression. Therefore, the aim of this review was to provide a comprehensive overview of the last decade of tDCS trials for depression and propose future research directions. To compile studies of the past decade, we conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) of tDCS for depression. A total of 21 RCTs were included, presenting a moderate effect for active tDCS compared to placebo. We also provided a description of study designs, stimulation parameters, and patients' characteristics. Following, we proposed possible strategies to enhance clinical effectiveness and reduce variability in results, including 1) optimization/personalization of tDCS via spatial and temporal target localization; 2) optimized methodological strategies, including home-based, accelerated tDCS protocols and novel trial designs; and 3) investigate patient profile to identify features that can predict treatment response. In conclusion, tDCS holds promise as a treatment for depression, but variability in trial parameters and outcomes underscores the need for its further optimization. Refining and standardizing protocols may enhance its effectiveness.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabis use patterns and different phenotypes in relation to other drugs use: latent class analyses from the Sao Paulo Megacity Mental Health Survey. 大麻使用模式和与其他药物使用相关的不同表型：来自圣保罗大城市心理健康调查的潜在类别分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-03-16 DOI: 10.47626/1516-4446-2024-3833

Camila Magalhães Silveira, João Maurício Castaldelli-Maia, Erica Rosanna Siu, Maria Carmen Viana, Yuan-Pang Wang, Laura Helena Andrade

{"title":"Cannabis use patterns and different phenotypes in relation to other drugs use: latent class analyses from the Sao Paulo Megacity Mental Health Survey.","authors":"Camila Magalhães Silveira, João Maurício Castaldelli-Maia, Erica Rosanna Siu, Maria Carmen Viana, Yuan-Pang Wang, Laura Helena Andrade","doi":"10.47626/1516-4446-2024-3833","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3833","url":null,"abstract":"Cannabis is the most widely used substance in Brazil. This study examined subtypes of individuals who use cannabis based on usage characteristics and correlates with other substance consumption and harms. Data are from the São Paulo Megacity Mental Health Survey (N = 5,037). Latent class analysis (LCA) was performed considering age of onset, use frequency , tobacco consumption, heavy episodic drinking (HED), alcohol use disorder (AUD) and substance use disorder. Logistic regression assessed class correlates, and further analysis compared socio-demographic, health and behavioral indicators. A 4-class model was optimal for 496 individuals. The 'Polydrug' class (26.2%) and the 'Former' class (5.9%) showed earlier onset and highest frequency of cannabis use, with strongest harm associations. 'Polydrug' class had higher odds of other drug use (OR=3.0), tobacco use (OR=2.5), HED (OR=1.8), and AUD (OR=1.5), compared to lighter-use groups. About 30% of those who use cannabis are at increased risk for negative outcomes, particularly those with early, frequent, and polydrug use patterns. Brazil's public health should prioritize targeted prevention on the risks associated with early and frequent cannabis, and polydrug use. Addressing this at-risk group is essential for harm reduction and a health-focused approach.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No changes in plasma Brain-Derived Neurotrophic Factor (BDNF) levels in Treatment-Resistant Depression patients submitted to Convulsive Therapies. 接受抽搐治疗的难治性抑郁症患者血浆脑源性神经营养因子（BDNF）水平无变化。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-03-16 DOI: 10.47626/1516-4446-2024-3983

Leonardo Afonso Dos Santos, Eric Cretaz, Helena Bellini, Adriana Munhoz Carneiro, José Gallucci-Neto, Leda Leme Tallib, André Russowsky Brunoni

{"title":"No changes in plasma Brain-Derived Neurotrophic Factor (BDNF) levels in Treatment-Resistant Depression patients submitted to Convulsive Therapies.","authors":"Leonardo Afonso Dos Santos, Eric Cretaz, Helena Bellini, Adriana Munhoz Carneiro, José Gallucci-Neto, Leda Leme Tallib, André Russowsky Brunoni","doi":"10.47626/1516-4446-2024-3983","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3983","url":null,"abstract":"Background: Convulsive therapies are often effective for Treatment-Resistant Depression (TRD), although their mechanisms of action are unclear. Increases in Brain-Derived Neurotrophic Factor (BDNF) levels are observed after Electroconvulsive Therapy (ECT), but more recent evidence calls this claim into question. Moreover, Magnetic Seizure Therapy (MST), a new convulsive technique, has not yet been studied regarding possible neurotrophic modulation.Methods: We performed plasma BDNF measures before and throughout treatment of adult patients (18 to 65 years old) diagnosed with TRD and submitted to treatment with convulsive therapy (ECT or MST) in the arms of the EMCODE project.Results: We enrolled 31 participants (mean age = 38.4 years, SD = 11.88), 14 (45.16%) were submitted to ECT and 17 (54.84%) to MST. Notable improvements in depressive symptoms were observed in both groups, with no significant difference between them (p = 0.1046). Meanwhile, no significant changes in BDNF plasma levels were observed for any technique, pre and post-treatment (MD = -93.01 pg/ml, 95% CI -545.88 to 359.86), or over time (Coefficient = -67.95, SE = 37.75, p = 0.072).Conclusion: The findings suggested no significant changes in plasma BDNF following convulsive therapies, challenging the notion of BDNF as a biomarker for treatment-resistant depression.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdiagnostic Clinical Staging in Youth Mental Health: A primer for clinical practice. 青少年心理健康的跨诊断临床分期：临床实践的入门。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-03-15 DOI: 10.47626/1516-4446-2024-3979

Letícia Müller Haas, Pedro Mario Pan, Ian B Hickie, Letícia Sanguinetti Czepielewski

{"title":"Transdiagnostic Clinical Staging in Youth Mental Health: A primer for clinical practice.","authors":"Letícia Müller Haas, Pedro Mario Pan, Ian B Hickie, Letícia Sanguinetti Czepielewski","doi":"10.47626/1516-4446-2024-3979","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3979","url":null,"abstract":"Clinical staging models are tools used in healthcare that have the potential to enhance diagnostic precision, improve treatment decisions, articulate more personalized care pathways, and optimize service models. In youth mental health, clinical staging has been increasingly applied to conditions where progression from non-specific symptoms to full-blown syndromes, such as schizophrenia, bipolar disorder, and depression, is possible. However, novel transdiagnostic staging models have also been proposed, recognizing the limitations of current classification systems and the substantial overlap of symptoms, particularly early in the illness course. Models incorporating an appropriate developmental and transdiagnostic lens may offer significant advances for research and clinical practice, supporting early intervention and secondary prevention. This narrative review critically examines theoretical premises and empirical applications of transdiagnostic clinical staging models in youth. Peer-reviewed studies were identified in PubMed using search terms related to clinical staging, focusing on sociodemographic, cognitive, and clinical factors investigated in youth samples (12-30 years). Evidence is synthesized in three main sections: progression, extension, and stage-based treatment. Additionally, a stage-based care model and directions for future research are presented. Early findings partially support important assumptions for the model, suggesting stage-related differences in cognition and functionality. Furthermore, new extension features have been recently proposed, including substance use, circadian disturbances, and physical illnesses. The long-term outcomes of stage-based interventions remain an open question. While the transdiagnostic clinical staging model offers a promising alternative for classifying youth psychopathology, further empirical validation is essential before its widespread implementation.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response: to "Prevalence of Antidepressant Use in Brazil: A Systematic Review with Meta-Analysis". 回应：“巴西抗抑郁药使用的患病率：荟萃分析的系统回顾”。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-03-15 DOI: 10.47626/1516-4446-2024-4031

Frederico Giovanetti, Gustavo Goulart, Rafael Bertoni, Vanessa Venâncio, Chaiana Esmeraldino Mendes Marcon

引用次数: 0

Association of Typical and Atypical Antipsychotics with Mortality in Older Adults with Schizophrenia: a 5-year multicenter prospective study. 典型和非典型抗精神病药物与老年精神分裂症患者死亡率的关系：一项5年多中心前瞻性研究

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-03-15 DOI: 10.47626/1516-4446-2024-3954

Raphaëlle Haddad, Marina Sánchez-Rico, Katayoun Rezaei, Sandra Abou Kassm, Carlos Blanco, Mark Olfson, Frédéric Limosin, Nicolas Hoertel

{"title":"Association of Typical and Atypical Antipsychotics with Mortality in Older Adults with Schizophrenia: a 5-year multicenter prospective study.","authors":"Raphaëlle Haddad, Marina Sánchez-Rico, Katayoun Rezaei, Sandra Abou Kassm, Carlos Blanco, Mark Olfson, Frédéric Limosin, Nicolas Hoertel","doi":"10.47626/1516-4446-2024-3954","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3954","url":null,"abstract":"Objective: Uncertainty exists over whether atypical and typical antipsychotics differ in the strength of their association with mortality among older people with schizophrenia. Here, we examined whether mortality rates and its causes significantly differ between older adults with schizophrenia taking atypical or typical antipsychotics.Methods: In a 5-year prospective multicenter study of patients aged ≥55 years with an ICD-10 diagnosis of schizophrenia, we used a multivariable logistic regression model to examine the association of atypical versus typical antipsychotics with mortality, adjusting for sociodemographic and clinical characteristics.Results: Of 313 older adults with schizophrenia, the 5-year all-cause mortality rates in patients taking atypical (N=192) and typical (N=167) antipsychotics were 36.4% and 24.3%, respectively. Following adjustment, there were not significant differences in all-cause mortality (AOR=1.56; 95%CI=0.75-3.27; p=0.24) or in death causes (all p-values>0.05) between patients taking atypical or typical antipsychotics. Atypical versus typical antipsychotics were significantly associated with decreased overall mortality in the subpopulation of participants with a baseline MMSE score<24 (AOR=0.24; 95%CI=0.07-0.84; p=0.025).Conclusions: Use of atypical antipsychotics compared to typical antipsychotics may not associated with different odds of overall mortality in older people with schizophrenia, but might be associated with reduced mortality among those with substantial cognitive impairment.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the role of impulsivity, aggression, lipid profiles, and inflammatory markers in suicide attempts: A cross-diagnostic study. 探索冲动、攻击性、血脂和炎症标志物在自杀企图中的作用：一项交叉诊断研究。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-02-28 DOI: 10.47626/1516-4446-2024-4026

Hasan Gökçay, Uğur Takım, Merve Gul Açıkgöz, Mustafa Nuray Namli, Yasin Hasan Balcioglu

{"title":"Exploring the role of impulsivity, aggression, lipid profiles, and inflammatory markers in suicide attempts: A cross-diagnostic study.","authors":"Hasan Gökçay, Uğur Takım, Merve Gul Açıkgöz, Mustafa Nuray Namli, Yasin Hasan Balcioglu","doi":"10.47626/1516-4446-2024-4026","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-4026","url":null,"abstract":"Objective: The current study aimed to investigate the relationship between suicidal behavior and peripheral inflammatory markers, atherogenic indices, serum albumin levels, impulsivity, and aggression.Methods: This cross-sectional study included 100 patients hospitalized for a recent suicide attempt, 74 psychiatric patients without a recent suicide attempt, and 85 healthy controls. Inflammatory markers, atherogenic indices, and serum albumin levels were assessed from fasting blood samples. Impulsivity and aggression were measured using the Barratt Impulsiveness Scale (BIS-11) and Buss-Perry Aggression Questionnaire (BPAQ).Results: Serum albumin levels were significantly lower (p = 0.001), and the Neutrophil-to-Albumin Ratio (NAR) was elevated (p < 0.001) in the group of individuals who recently attempted suicide compared to both psychiatric patients without a recent suicide attempt and healthy controls. Logistic regression identified NAR (p = 0.001), low albumin (p = 0.017), impulsivity (β = 0.041, p = 0.001), and aggression (p < 0.001) as significant predictors of suicidal behavior. Lower education (p = 0.001) and lifetime substance use disorders (p = 0.003) were also significant predictors. No significant differences were found in atherogenic indices.Conclusion: Low albumin levels and elevated NAR are significant predictors of suicide risk, highlighting the role of inflammation.Moreover, educational disparities and substance use must be addressed in suicide prevention strategies.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copy Number Variations in the Brazilian High-Risk Cohort for Mental Conditions. 巴西精神疾病高危人群的拷贝数变化

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-02-27 DOI: 10.47626/1516-4446-2024-3765

Júlia Arendt, Malú Zamariolli, Liriel Almodobar, Lucas Toshio Ito, Rafaella Ormond, Adrielle M Oliveira, Vanessa Ota, Luis Augusto Rohde, Euripedes Constantino Miguel, Pedro Pan, Rodrigo Bressan, Giovanni Salum, Sintia Belangero, Marcos Santoro

{"title":"Copy Number Variations in the Brazilian High-Risk Cohort for Mental Conditions.","authors":"Júlia Arendt, Malú Zamariolli, Liriel Almodobar, Lucas Toshio Ito, Rafaella Ormond, Adrielle M Oliveira, Vanessa Ota, Luis Augusto Rohde, Euripedes Constantino Miguel, Pedro Pan, Rodrigo Bressan, Giovanni Salum, Sintia Belangero, Marcos Santoro","doi":"10.47626/1516-4446-2024-3765","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3765","url":null,"abstract":"Copy number variations (CNVs) are genetic variants with a known major impact on the development of mental health disorders (MHDs). Here, we aim to characterize CNVs in a Brazilian cohort regarding frequency and inheritance pattern and verify the impact of CNVs previously associated with MHDs on the risk of developing these disorders in the cohort. A total of 2,250 probands and 3,174 parents (897 trios) from the Brazilian High-Risk Cohort Study for Mental Conditions (BHRCS) were genotyped and CNVs were detected using PennCNV software. In total, 56.03% of the CNVs were inherited. Among the distinct CNVs, 96.15% were rare (frequency lower than 1% in the BHRCS). Duplications at 2q13 and 15q13.3 showed lower frequencies, while those at 2q11.2 and 16p11.2 exhibited higher frequencies in the BHRCS when compared to databases such as the Database of Genomic Variants (DGV) and the Genome Aggregation Database (gnomAD). Of 40 previously associated CNVs with MHDs, 18 were identified in the sample. While the 7q11.2 duplication has been considered protective for Schizophrenia, we identified that 7q11.2 deletion was protective for MHDs in BHRCS (p-value=0.033, OR=0.103). For the other CNVs, no statistical significance was identified, even with mild effect sizes. This is one of the largest CNV studies in a Brazilian sample and will be a valuable resource for future meta-analysis to advance the understanding of the genetics of MHDs, especially regarding diverse populations.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of home-use transcranial direct current stimulation on clusters of depressive symptoms: an ancillary analysis of the PSYLECT study. 家用经颅直流电刺激对抑郁症状簇的影响：PSYLECT研究的辅助分析

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-02-27 DOI: 10.47626/1516-4446-2024-3972

Matthias S Luethi, Lucas Borrione, Beatriz A Cavendish, Luana V M Aparicio, Stephan Goerigk, Matheus R F Ramos, Natasha K S Moran, Adriana M Carneiro, Leandro Valiengo, Darin O Moura, Juliana P de Souza, Mariana P Batista, Valquiria Aparecida da Silva, Izio Klein, Paulo Suen, José Gallucci-Neto, Frank Padberg, Lais B Razza, Marie-Anne Vanderhasselt, Paulo A Lotufo, Isabela M Bensenor, Felipe Fregni, Andre R Brunoni

{"title":"Effects of home-use transcranial direct current stimulation on clusters of depressive symptoms: an ancillary analysis of the PSYLECT study.","authors":"Matthias S Luethi, Lucas Borrione, Beatriz A Cavendish, Luana V M Aparicio, Stephan Goerigk, Matheus R F Ramos, Natasha K S Moran, Adriana M Carneiro, Leandro Valiengo, Darin O Moura, Juliana P de Souza, Mariana P Batista, Valquiria Aparecida da Silva, Izio Klein, Paulo Suen, José Gallucci-Neto, Frank Padberg, Lais B Razza, Marie-Anne Vanderhasselt, Paulo A Lotufo, Isabela M Bensenor, Felipe Fregni, Andre R Brunoni","doi":"10.47626/1516-4446-2024-3972","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3972","url":null,"abstract":"Objective: Major depressive disorder (MDD) is heterogeneous. While transcranial direct current stimulation (tDCS) is an effective treatment, its impact on symptoms remains underexplored. This ancillary study investigated home-use tDCS effects on depression symptom clusters.Methods: Data were from the Psylect study, where 210 depressed patients were randomized to active (n = 137) or sham tDCS (n = 73) for six weeks. Items from the Hamilton Depression Rating Scale were grouped into symptom clusters using hierarchical clustering. Treatment effects were analyzed with mixed regressions. An alternative clustering solution, established with a bigger sample, was also evaluated.Results: Four clusters were identified: emotional, sleep, psychomotor, and psychosomatic symptoms. None showed significant group differences (sleep: P = 0.058, Cohen's d = 0.36, emotional: P = 0.976, d = -0.01, psychosomatic: P = 0.157, d = 0.27, psychomotor: P = 0.944, d = 0.01). The alternative clustering solution produced a similar sleep cluster, where tDCS led to significant reductions (P = 0.033, d = 0.41), while other clusters exhibited no differences (emotional: P = 0.707, d = 0.07, atypical: p = 0.537, d = 0.12).Conclusions: Associations of tDCS with sleep improvements warrant further study. tDCS may be more effective for specific symptom clusters.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0