{"title":"Comment on \"Prognostic value of T-wave positivity in lead aVR in COVID-19 pneumonia\".","authors":"Weihua Chen","doi":"10.1590/1806-9282.20230192","DOIUrl":"https://doi.org/10.1590/1806-9282.20230192","url":null,"abstract":"The study 1 entitled “Prognostic value of T-wave positivity in lead aVR in COVID-19 pneumonia” investigated the relationship between T-wave positivity in lead aVR and the prognosis of patients with COVID-19 pneumonia. The findings suggest that T-wave positivity in lead aVR is a useful predictor of poor prognosis in COVID-19 patients. While the findings of this study are interesting, I would like to point out some potential limitations.","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 6","pages":"e20230192"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/f4/1806-9282-ramb-69-06-e20230192.PMC10241080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Izzet Islamoglu, Mehmet Çebi, Fevziye Canbaz Tosun
{"title":"The bone mineral density and isokinetic knee strength in amputee soccer players.","authors":"Izzet Islamoglu, Mehmet Çebi, Fevziye Canbaz Tosun","doi":"10.1590/1806-9282.20230100","DOIUrl":"https://doi.org/10.1590/1806-9282.20230100","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the isokinetic knee strength, H/Q ratio (%), and bone mineral density values between amputees (n=14; amputee soccer players) and healthy football players (n=14; non-amputee soccer players).</p><p><strong>Methods: </strong>A total of 28 amputee soccer players and non-amputee soccer players participated in the study. An isokinetic dynamometer was used to determine the knee flexion/extension forces of the dominant legs of the athletes at 60, 180, and 240°/s. Bone mineral density scans were performed using dual-energy X-ray absorptiometry.</p><p><strong>Results: </strong>H/Q ratio and 60º/s flexion and 180 and 240º/s flexion/extension strength (p<0.05) were found to be high (180º/s, p=0.03; 240º/s, p=0.048) in the non-amputee soccer player group. Accordingly, the bone mineral density values of the lumbar vertebra, femoral neck, proximal metaphysis of the femur (p<0.01), tibia/fibula proximal metaphysis, and tibia/fibula distal metaphysis (p<0.05) were found to be high. A correlation was observed between the 60º/s knee extension strength and tibia/fibula diaphyseal bone mineral density (p=0.025; r=0.594) and tibia/fibula distal metaphysis bone mineral density (p=0.017; r=0.623) values in the amputee soccer players group. The Z-scores of the amputee soccer players and non-amputee soccer players were in the expected range according to age (>-2).</p><p><strong>Conclusion: </strong>The bone mineral density, H/Q ratio, and all measured angular velocities of isokinetic strength were high in non-amputee soccer players. This finding made us think that lower extremity amputation may also be associated with losing strength. However, it was observed that the relationship between strength and bone mineral density in amputee athletes might vary according to different angular velocities. It is recommended that isokinetic strength measurement can be evaluated together with bone mineral density in athletes.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20230100"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/4a/1806-9282-ramb-69-08-e20230100.PMC10427187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irmak Icen Taskin, Sevim Gurbuz, Mehmet Sait Icen, Dilek Cam Derin, Fatih Mehmet Findik
{"title":"Expression of sirtuin 2 and 7 in placenta accreta spectrum.","authors":"Irmak Icen Taskin, Sevim Gurbuz, Mehmet Sait Icen, Dilek Cam Derin, Fatih Mehmet Findik","doi":"10.1590/1806-9282.20230360","DOIUrl":"https://doi.org/10.1590/1806-9282.20230360","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.</p><p><strong>Methods: </strong>A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).</p><p><strong>Conclusion: </strong>Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20230360"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/80/1806-9282-ramb-69-08-e20230360.PMC10427185.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between hyperuricemia and hypertension and the mediatory role of obesity: a large cohort study in China.","authors":"Changyi Wang, Pei Qin, Yinxing Liu, Li Wang, Shan Xu, Hongen Chen, Shuhong Dai, Ping Zhao, Fulan Hu, Yanmei Lou","doi":"10.1590/1806-9282.20220241","DOIUrl":"https://doi.org/10.1590/1806-9282.20220241","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the sex-specific association between hyperuricemia and the risk of hypertension and whether obesity mediates this association.</p><p><strong>Methods: </strong>This study included 31,395 (47.0% women) adults without hypertension, cardiovascular disease, or cancer at baseline who completed at least one follow-up annual examination between 2009 and 2016. Cox regression models were performed to calculate hazard ratios and 95% confidence intervals. Mediation analysis was conducted to estimate the effect of body mass index on the association between hyperuricemia and hypertension.</p><p><strong>Results: </strong>During a median 2.9-year follow-up, hyperuricemia was significantly associated with a higher risk of hypertension (HR 1.15, 95%CI 1.07-1.24 for all participants; HR 1.12, 95%CI 1.03-1.22 for men; and HR 1.23, 95%CI 1.02-1.48 for women) after adjustment for potential confounders. Additional adjustment for body mass index attenuated this association (HR 1.09, 95%CI 1.08-1.10 for all participants; HR 1.07; 95%CI 0.98-1.16 for men; HR 1.18; 95%CI 0.96-1.44 for women). Mediation analysis showed that BMI partially mediated the relationship between hyperuricemia and incident hypertension (indirect effect HR 1.09, 95%CI 1.08-1.10; direct effect: HR 1.08, 95%CI 1.02-1.15). The percentage of the mediation effect was 53.2% (95%CI 37.9-84.5).</p><p><strong>Conclusion: </strong>Hyperuricemia is associated with a risk of hypertension in both sexes, and BMI partially mediates hyperuricemia-related incident hypertension.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20220241"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/3c/1806-9282-ramb-69-08-e20220241.PMC10443908.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nese Kiskac, Mahruk Rashidi, Egemen Cebeci, Ilkay Coban, Muharrem Kiskac
{"title":"Determination of the relationship between self-care agency and sleepiness in chronic hemodialysis patients.","authors":"Nese Kiskac, Mahruk Rashidi, Egemen Cebeci, Ilkay Coban, Muharrem Kiskac","doi":"10.1590/1806-9282.20230423","DOIUrl":"https://doi.org/10.1590/1806-9282.20230423","url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to determine the relationship between self-care agency and sleepiness in chronic hemodialysis patients.</p><p><strong>Methods: </strong>The study was conducted with 75 patients with chronic renal failure in the hemodialysis unit of a training and research hospital in our country. In the descriptive study, the data were collected through a face-to-face questionnaire. The IBM SPSS Statistics 22.0 program was used to evaluate the data.</p><p><strong>Results: </strong>It was determined that there was no significant relationship between self-care agency and sleepiness total scores in chronic hemodialysis patients (p>0.05) and a significant relationship between sleepiness and drug use compliance and mental status in female patients and between diet compliance and sleepiness in patients younger than 52 years of age (p<0.05).</p><p><strong>Conclusion: </strong>As a result, it was observed that there was no relationship between self-care agency and sleepiness in chronic hemodialysis patients. We think that working with a larger sample group can lead to clearer results.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20230423"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/50/1806-9282-ramb-69-08-e20230423.PMC10443915.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gürkan Altuntaş, Mehmet Altuntaş, Melih Imamoğlu, Muhammet Kadri Çolakoğlu, Hüseyin Avni Uydu, Recep Bedir
{"title":"Diagnostic value of serum signal peptide-CUB-EGF-like domain-containing protein 1 levels in patients with acute appendicitis.","authors":"Gürkan Altuntaş, Mehmet Altuntaş, Melih Imamoğlu, Muhammet Kadri Çolakoğlu, Hüseyin Avni Uydu, Recep Bedir","doi":"10.1590/1806-9282.20230076","DOIUrl":"https://doi.org/10.1590/1806-9282.20230076","url":null,"abstract":"<p><strong>Objective: </strong>Acute appendicitis is one of the most common surgical causes of an acute abdomen among patients admitted to the emergency room due to abdominal pain. The clinical diagnosis of acute appendicitis is usually difficult and is made by evaluating the clinical, laboratory, and radiological findings together. The aim of this study was to investigate the diagnostic potential of signal peptide-CUB-EGF-like domain-containing protein 1 as a biomarker for acute appendicitis.</p><p><strong>Methods: </strong>A total of 67 adult patients without any comorbidities who presented to the emergency department with abdominal pain and were clinically diagnosed with acute appendicitis were included in the case group. The patients included in the study were classified into the negative appendectomy group and the acute appendicitis group according to their histopathological final diagnosis. In addition, 48 healthy volunteers without comorbidities were included in the control group. Signal peptide-CUB-EGF-like domain-containing protein 1 levels of patients and the control group were measured.</p><p><strong>Results: </strong>According to postoperative histopathological examinations of the patients, 7 (10.4%) patients were diagnosed with negative appendectomy, and 60 (89.6%) patients were diagnosed with acute appendicitis. Signal peptide-CUB-EGF-like domain-containing protein 1 levels were higher in the patients with acute appendicitis than in negative appendectomy patients (p=0.012). Signal peptide-CUB-EGF-like domain-containing protein 1 levels were also higher in the case group compared to the control group (p=0.001).</p><p><strong>Conclusion: </strong>The admission signal peptide-CUB-EGF-like domain-containing protein 1 level was significantly higher in adults with acute appendicitis. The SCUBE1 level is a novel but promising biomarker that aids in the diagnosis of acute appendicitis.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20230076"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/ec/1806-9282-ramb-69-08-e20230076.PMC10427172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10103450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Kaplangoray, Cihan Aydın, Kenan Toprak, Yusuf Cekici
{"title":"Selvester score and myocardial performance index in acute anterior myocardial infarction.","authors":"Mustafa Kaplangoray, Cihan Aydın, Kenan Toprak, Yusuf Cekici","doi":"10.1590/1806-9282.20221252","DOIUrl":"https://doi.org/10.1590/1806-9282.20221252","url":null,"abstract":"<p><strong>Background: </strong>The simplified Selvester QRS score is a parameter for estimating myocardial damage in ST-elevation myocardial infarction. ST-elevation myocardial infarction leads to varying degrees of impairment in left ventricular systolic and diastolic function. Myocardial performance index is a single parameter that can predict combined left ventricular systolic and diastolic performance.</p><p><strong>Objective: </strong>We investigated the relationship between Selvester score and myocardial performance index in patients undergoing primary percutaneous coronary intervention for acute anterior myocardial infarction.</p><p><strong>Methods: </strong>The study included 58 patients who underwent primary percutaneous coronary intervention for acute anterior myocardial infarction. Selvester score of all patients was also calculated at 72 h. Patients were categorized into two groups according to the Selvester score. Those with a score <6 (low score) were considered group 1 and those with a score ≥6 (high score) were considered group 2.</p><p><strong>Results: </strong>When compared with group 1, patients in group 2 were older (p=0.01) and had lower left ventricular ejection fractions (50.3±4 vs. 35.6±6.9, p=0.001), and conventional myocardial performance index (0.52±0.06 vs. 0.69±0.08, p=0.001), lateral tissue Doppler-derived myocardial performance index (0.57±0.08 vs. 0.72±0.08, p=0.001), and septal tissue Doppler-derived myocardial performance index (0.62±0.07 vs. 0.76±0.08, p=0.001) were higher. There was a high correlation between lateral tissue Doppler-derived myocardial performance index and conventional myocardial performance index and Selvester score (r=0.80, p<0.001; r=0.86, p<0.001, respectively) and a moderate correlation between septal tissue Doppler-derived myocardial performance index and Selvester score (r=0.67, p<0.001).</p><p><strong>Conclusions: </strong>The post-procedural Selvester score can predict lateral tissue Doppler-derived myocardial performance index and conventional myocardial performance index with high sensitivity and acceptable specificity in patients undergoing primary percutaneous coronary intervention for acute anterior myocardial infarction.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 2","pages":"325-329"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/38/1806-9282-ramb-69-02-0325.PMC9983492.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9080939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gustavo Rosa Gameiro, Giovana Rosa Gameiro, Bruno Alonso Miotto, Aline Gil Alves Guilloux, Alex Jones Flores Cassenote, Mario César Scheffer
{"title":"Perception of newly graduated physicians toward ethical education in medical schools: a Brazilian cross-sectional nationwide study.","authors":"Gustavo Rosa Gameiro, Giovana Rosa Gameiro, Bruno Alonso Miotto, Aline Gil Alves Guilloux, Alex Jones Flores Cassenote, Mario César Scheffer","doi":"10.1590/1806-9282.20230108","DOIUrl":"https://doi.org/10.1590/1806-9282.20230108","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to evaluate fresh medical graduates' perceptions regarding the general aspects of ethics teaching in Brazilian medical schools.</p><p><strong>Methods: </strong>A structured questionnaire was applied to 4,601 participants among the 16,323 physicians who registered in one of the 27 Regional Medical Councils of Brazil in 2015. Answers to four questions regarding general aspects of ethics education in medical school were analyzed. Sampling procedures involved two stratification variables: legal nature (public vs. private) of medical schools and monthly household income higher than 10 minimum wages.</p><p><strong>Results: </strong>A large percentage of the participants had witnessed unethical behaviors during contact with patients (62.0%), toward coworkers (51.5%), and in relationships with patients' families (34.4%) over the course of their medical training. Even though most of the responders (72.0%) totally agreed that patient-physician relationship and humanities education were part of their medical school curriculum, important topics such as conflicts of interest and end-of-life education were not satisfactorily addressed in the participants' medical training. Statistically significant differences were found between the answers of public and private school graduates.</p><p><strong>Conclusion: </strong>Despite great efforts to improve medical ethics education, our findings suggest the persistence of deficits and inadequacies in the ethics training currently given in medical schools in Brazil. Further modifications in ethics training must be made to address the deficiencies shown in this study. This process should be accompanied by continuous evaluation.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 6","pages":"e20230108"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/f8/1806-9282-ramb-69-06-e20230108.PMC10241081.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9652501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The use of esketamine in the treatment of patients with oral antidepressant-resistant depression: systematic review and meta-analysis.","authors":"Idevaldo Floriano, Antônio Silvinato, Wanderley Marques Bernardo","doi":"10.1590/1806-9282.2023D696","DOIUrl":"https://doi.org/10.1590/1806-9282.2023D696","url":null,"abstract":"<p><p>The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field to standardize how to conduct, and to assist in the reasoning and decision-making of doctors. The information provided by this project must be critically evaluated by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical condition of each patient. Guideline conclusion: April 2023. Societies: Brazilian Medical Association.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 6","pages":"e2023D696"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/26/1806-9282-ramb-69-06-e2023D696.PMC10305833.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9729737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefan Dugalic, Milica Petronijevic, Demet Sengul, Dzenana A Detanac, Ilker Sengul, Eduardo Carvalho de Arruda Veiga, Tamara Stanisavljevic, Maja Macura, Jovana Todorovic, Miroslava Gojnic
{"title":"Hereditary thrombophilia and low -molecular -weight heparin in women: useful determinants, including thyroid dysfunction, incorporating the management of treatment and outcomes of the entity.","authors":"Stefan Dugalic, Milica Petronijevic, Demet Sengul, Dzenana A Detanac, Ilker Sengul, Eduardo Carvalho de Arruda Veiga, Tamara Stanisavljevic, Maja Macura, Jovana Todorovic, Miroslava Gojnic","doi":"10.1590/1806-9282.20221445","DOIUrl":"https://doi.org/10.1590/1806-9282.20221445","url":null,"abstract":"<p><strong>Objective: </strong>Our study purposed to examine the complex relationship between low-molecular-weight heparin therapy, multiple pregnancy determinants, and adverse pregnancy outcomes during the third trimester in women with inherited thrombophilia.</p><p><strong>Methods: </strong>Patients were selected from a prospective cohort of 358 pregnant patients recruited between 2016 and 2018 at the Clinic for Obstetrics and Gynecology, University Clinical Centre of Serbia, Belgrade.</p><p><strong>Results: </strong>Gestational age at delivery (β=-0.081, p=0.014), resistance index of the umbilical artery (β=0.601, p=0.039), and D-dimer (β=0.245, p<0.001) between 36th and 38th weeks of gestation presented the direct predictors for adverse pregnancy outcomes. The model fit was examined using the root mean square error of approximation 0.00 (95%CI 0.00-0.18), the goodness-of-fit index was 0.998, and the adjusted goodness-of-fit index was 0.966.</p><p><strong>Conclusion: </strong>There is a need for the introduction of more precise protocols for the assessment of hereditary thrombophilias and the need for the introduction of low-molecular-weight heparin.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 2","pages":"335-340"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/5d/1806-9282-ramb-69-02-0335.PMC9983488.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}