Expression of sirtuin 2 and 7 in placenta accreta spectrum.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1590/1806-9282.20230360

Irmak Icen Taskin, Sevim Gurbuz, Mehmet Sait Icen, Dilek Cam Derin, Fatih Mehmet Findik

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引用次数: 1

Abstract

Objective: This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.

Methods: A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.

Results: It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).

Conclusion: Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.

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胎盘增生谱中sirtuin 2和7的表达。

目的:研究sirtuin 2和sirtuin 7在胎盘增生谱中的表达水平，探讨其在胎盘增生中的作用。方法:对30例增生性胎盘、20例前置胎盘和30例对照组进行观察。Western blot检测各组胎盘中sirtuin 2和sirtuin 7的表达水平。采用酶联免疫吸附法检测孕妇和胎儿脐带血血清中Sirtuin 2和Sirtuin 7的水平。结果:与对照组和前置胎盘组相比，胎盘增生谱中sirtuin 7含量明显降低(p0.05)。结论:Sirtuin 7可能在胎盘增生谱的形成中起重要作用。sirtuin 7表达降低对胎盘增生谱的影响可能是组织依赖性的，需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.