Expression of sirtuin 2 and 7 in placenta accreta spectrum.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Revista da Associacao Medica Brasileira Pub Date : 2023-01-01 DOI:10.1590/1806-9282.20230360

Irmak Icen Taskin, Sevim Gurbuz, Mehmet Sait Icen, Dilek Cam Derin, Fatih Mehmet Findik

{"title":"Expression of sirtuin 2 and 7 in placenta accreta spectrum.","authors":"Irmak Icen Taskin, Sevim Gurbuz, Mehmet Sait Icen, Dilek Cam Derin, Fatih Mehmet Findik","doi":"10.1590/1806-9282.20230360","DOIUrl":null,"url":null,"abstract":"Objective: This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.Methods: A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.Results: It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).Conclusion: Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/80/1806-9282-ramb-69-08-e20230360.PMC10427185.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista da Associacao Medica Brasileira","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/1806-9282.20230360","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 1

Abstract

Objective: This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.

Methods: A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.

Results: It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).

Conclusion: Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.

Abstract Image

查看原文本刊更多论文

胎盘增生谱中sirtuin 2和7的表达。

目的:研究sirtuin 2和sirtuin 7在胎盘增生谱中的表达水平，探讨其在胎盘增生中的作用。方法:对30例增生性胎盘、20例前置胎盘和30例对照组进行观察。Western blot检测各组胎盘中sirtuin 2和sirtuin 7的表达水平。采用酶联免疫吸附法检测孕妇和胎儿脐带血血清中Sirtuin 2和Sirtuin 7的水平。结果:与对照组和前置胎盘组相比，胎盘增生谱中sirtuin 7含量明显降低(p0.05)。结论:Sirtuin 7可能在胎盘增生谱的形成中起重要作用。sirtuin 7表达降低对胎盘增生谱的影响可能是组织依赖性的，需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista da Associacao Medica Brasileira 医学-医学：内科

CiteScore

2.20

自引率

0.00%

发文量

276

审稿时长

12 weeks

期刊介绍： A Revista da Associação Médica Brasileira (RAMB), editada pela Associação Médica Brasileira, desde 1954, tem por objetivo publicar artigos que contribuam para o conhecimento médico.