Revista da Associacao Medica Brasileira最新文献

{"title":"Evaluation of sexual function and depression in female patients with fibromyalgia.","authors":"İbrahim Halil Erdem,&nbsp;Fatma Ustabaşıoğlu","doi":"10.1590/1806-9282.20230180","DOIUrl":"https://doi.org/10.1590/1806-9282.20230180","url":null,"abstract":"<p><strong>Objective: </strong>Fibromyalgia is one of the most important problems, especially for women. Studies point to disorders in the sexual functions of fibromyalgia patients that reduce their quality of life. The aim of this study was to investigate sexual dysfunction and its relationship with disease severity and depression in women with fibromyalgia.</p><p><strong>Methods: </strong>This study included 98 female patients diagnosed with fibromyalgia and 54 healthy women. The Female Sexual Function Index was used to assess sexual dysfunction. Fibromyalgia disease severity was measured with the Fibromyalgia Impact Questionnaire. Hamilton Depression Scale was filled in to evaluate the depression status of the patients.</p><p><strong>Results: </strong>According to the female sexual function index data, female sexual dysfunction was found in 78 (79.6%) patients with fibromyalgia and only in 12 (22.2%) controls. When the female sexual function index scores of fibromyalgia patients with and without depression were compared, patients with additional depression had lower female sexual function index scores, and this difference was statistically significant (p=0.002). In the correlation analysis, the female sexual function index score showed a significant negative correlation with the hamilton depression scale (rho=-0.235, p=0.020) and fibromyalgia impact questionnaire (rho=-0.215, p=0.033) scores.</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of sexual dysfunction in female fibromyalgia patients and the significant correlation between sexual dysfunction and both disease severity and depression.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 7","pages":"e20230180"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/ea/1806-9282-ramb-69-07-e20230180.PMC10352019.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9841890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Effect of coolant spray on rib fracture pain of geriatric blunt thoracic trauma patients: a randomized controlled trial\".","authors":"André Pontes-Silva,&nbsp;Karolayne Dos Santos Lima,&nbsp;Cassius Iury Anselmo-E-Silva,&nbsp;André Luiz Lopes,&nbsp;Aldair Darlan Santos-de-Araújo","doi":"10.1590/1806-9282.20230091","DOIUrl":"https://doi.org/10.1590/1806-9282.20230091","url":null,"abstract":"This paper 1 aimed to evaluate the effectiveness of cryotherapy in elderly patients with rib fractures due to blunt thoracic trauma via a prospective randomized controlled study (coolant spray group, n=51; placebo spray group, n=50). The authors concluded that coolant spray therapy can be used as a component of multimodal therapy to provide adequate analgesia due to rib fractures in geriatric patients; however, some points of this research do not support this conclusion. First of all, the authors did not describe the study hypothesis (this weakens the results). Second, they did not present the minimal clinically important change of the VAS on the patients’ pain level (making it impossible to analyze clinical relevance). Comparisons of outcomes in clinical trials should consider the minimal clinically important change of the mean differences because the p-value only shows statistical significance, which interpretation translates just a hypothesis test governed by a probability of previously defined error ( α ) 2,3 . Third, they did not present the assess the effect size (e.g., Cohen’s d=[M1–M2]/S pooled ) 4,5 of the comparisons between the times and groups (making it impossible [again] to analyze clinical relevance). Fourth, they should have assessed the patients’ disability for pre-and post-intervention comparisons. As such, the new conclusion is as follows: although this study has shown significant differences between coolant spray therapy and placebo (used as a component of multimodal therapy to provide adequate analgesia due to rib fractures in geriatric patients), its clinical relevance is yet unknown.","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 5","pages":"e20230091"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/00/19/1806-9282-ramb-69-05-e20230091.PMC10204835.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of coolant spray on rib fracture pain of geriatric blunt thoracic trauma patients: a randomized controlled trial.","authors":"İlker Akbaş,&nbsp;Sinem Dogruyol,&nbsp;Abdullah Osman Kocak,&nbsp;Talha Dogruyol,&nbsp;Meryem Betos Koçak,&nbsp;Sultan Tuna Akgol Gur,&nbsp;Zeynep Cakir","doi":"10.1590/1806-9282.20220048","DOIUrl":"https://doi.org/10.1590/1806-9282.20220048","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of cryotherapy in elderly patients with rib fractures due to blunt thoracic trauma.</p><p><strong>Methods: </strong>In this prospective randomized controlled study, geriatric patients were assigned to groups to receive either coolant spray (n=51) or placebo spray (n=50). The visual analog scale scores of all patients were recorded before starting spray application (V0), as well as at 10th (V1), 20th (V2), 30th (V3), 60th (V4), 120th (V5), and 360th (V6) minute. The mean decreases in the visual analog scale scores were calculated.</p><p><strong>Results: </strong>The differences between V0 and V1, V0 and V2, V0 and V3, and V0 and V4 mean visual analog scale scores measured in the coolant spray group were found to be significantly higher (p<0.001). In V1, V2, V3, and V4 measurements, the incidence of \"clinical effectiveness\" in the coolant spray group was significantly higher than in the placebo group (p=0.001).</p><p><strong>Conclusions: </strong>Coolant spray therapy can be used as a component of multimodal therapy to provide adequate analgesia due to rib fractures in geriatric patients.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 1","pages":"30-36"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/38/1806-9282-ramb-69-01-0030.PMC9937612.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an association between endometriosis and thyroid autoimmunity?","authors":"Hilal Şerifoğlu,&nbsp;Sevcan Arzu Arinkan,&nbsp;Ozge Pasin,&nbsp;Fisun Vural","doi":"10.1590/1806-9282.20221679","DOIUrl":"https://doi.org/10.1590/1806-9282.20221679","url":null,"abstract":"<p><strong>Objective: </strong>It has been suggested that non-uterine endometrial implants can express thyroid-stimulating hormone receptors, thus inducing the formation of thyroid-stimulating immunoglobulin. We aimed to compare the autoantibody positivity in patients with and without endometriosis and to determine whether there is a difference in the incidence of thyroid diseases.</p><p><strong>Methods: </strong>This prospective observational study was conducted on 102 women who had been operated on for benign gynecological diseases. Cases enrolling in the study were divided into two groups: the study group with endometriosis (n=51) and the control group without endometriosis (n=51). The blood tests for thyroid-stimulating hormone, free thyroxine (fT4), thyroid-stimulating immunoglobulin, and anti-thyroid peroxidase antibody levels were checked.</p><p><strong>Results: </strong>The mean thyroid-stimulating immunoglobulin level was found to be higher in the endometriosis group than in the control group. However, this difference was not statistically significant. No significant difference was detected between endometriosis and control groups in terms of anti-thyroid peroxidase antibody and thyroid-stimulating hormone levels. The mean fT4 value (0.97±0.13 ng/dL) of the endometriosis patients was found to be significantly lower than the control group (1.08±0.21 ng/dL) (p=0.002; p<0.05). The mean anti-thyroid peroxidase antibody value of cases with bilateral endometrioma (82.21±252.29 IU/mL) was significantly higher than cases with unilateral endometrioma (15.81±83.13 IU/mL) (p=0.028; p<0.05). There is a positive and significant relationship between the size of endometriosis and anti-thyroid peroxidase antibody values (p=0.011; p<0.05).</p><p><strong>Conclusion: </strong>This study points to an association between endometrioma diameter and anti-thyroid peroxidase antibody values which can be a stepping stone for new studies evaluating this hypothesis further.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 6","pages":"e20221679"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/8b/1806-9282-ramb-69-06-e20221679.PMC10234359.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9936683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Assessment of pain and quality of life in patients undergoing cardiac surgery: a cohort study\".","authors":"André Pontes-Silva,&nbsp;André Luiz Lopes,&nbsp;Erika da Silva Maciel,&nbsp;Fernando Rodrigues Peixoto Quaresma,&nbsp;Aldair Darlan Santos-de-Araújo","doi":"10.1590/1806-9282.20230304","DOIUrl":"https://doi.org/10.1590/1806-9282.20230304","url":null,"abstract":"First, Viana et al. 1 evaluated postoperative pain and quality of life in patients undergoing median sternotomy (via comparisons in a cohort study). However, while comparing outcomes, it is important to present the clinical relevance of the differences found because the p-value shows only a statistical observation related to an alpha error probability 2,3 . Classical statistical significance is still the predominant way to analyze cohort studies, but clinical significance analysis has been slowly incorporated into the analysis of health-related studies. Statistical significance does not assure that the results are clinically relevant. The dichotomy that emerged from hypothesis testing 4 , namely, the decision to accept or reject the null hypothesis based on the predetermined levels of probability 5 does not provide any insights into whether the results of the study are important for patients, clinicians, or decision-makers, limiting the value of the tests in the world of evidence-based practice 4,6,7 . It can be solved by adding the effect size to the significant values (p ≤ 0.05) 8 or the minimal clinically important difference 9 of the instruments: Visual Analog Scale (VAS) 10 , Brief Pain Inventory (BPI) 11 , and World Health Organization Quality of Life Questionnaire (WHOQOL) 12 . These adjustments facilitate probabilistic reasoning in the clinical applicability of scientific evidence. Second, the authors used convenience sampling and suggested further studies with larger samples. A convenience sample is one that is drawn from a source that is easily accessible to study. This sample","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 7","pages":"e20230304"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/fe/1806-9282-ramb-69-07-e20230304.PMC10352007.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of breast augmentation on female sexuality.","authors":"Paulo Afonso Monteiro Pacheco Guimarães,&nbsp;Elisa Mayumi Kokuba Aihara,&nbsp;Miguel Sabino Neto,&nbsp;Mateus Leme De Marchi,&nbsp;Lydia Masako Ferreira","doi":"10.1590/1806-9282.2023S105","DOIUrl":"https://doi.org/10.1590/1806-9282.2023S105","url":null,"abstract":"<p><strong>Introduction: </strong>The breasts are symbols of femininity, sexuality, and maternity. Breast augmentation is among the most sought-after procedures for women and has a positive impact on quality of life. Sexuality is one of the items that contribute to increased quality of life. Surgical outcomes can be evaluated from the patients' perspective using developed and validated questionnaires. For the assessment of sexuality, the most commonly used instruments are the Female Sexual Quotient and the Female Sexual Function Index, which estimate several domains of sexuality and can be used to evaluate the impact of surgery on it.</p><p><strong>Objective: </strong>The objective of this study was to evaluate the impact of breast augmentation on female sexuality.</p><p><strong>Methods: </strong>We selected 87 patients from the Plastic Surgery Outpatient Clinic of Hospital São Paulo (Federal University of São Paulo) who wished to undergo breast augmentation. The patients were classified into two groups: the Female Sexual Quotient questionnaire was applied to one group, and the Female Sexual Function Index questionnaire was applied to the other group to evaluate sexuality preoperatively as well as at 2 and 4 months postoperatively.</p><p><strong>Results: </strong>In both groups, there was a significant increase in the total score of the Female Sexual Quotient and Female Sexual Function Index questionnaires, and an individual increase in each domain assessed, with a significant increase in the domains of orgasm and sexual satisfaction, as well as foreplay and arousal, indicating an improvement in the patients' sexuality postoperatively.</p><p><strong>Conclusion: </strong>Breast augmentation has a positive impact on female sexuality; furthermore, the Female Sexual Quotient and Female Sexual Function Index are sensitive in detecting this impact.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 suppl 1","pages":"e2023S105"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/9e/1806-9282-ramb-69-suppl1-e2023S105.PMC10411706.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9975674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Prognostic value of T-wave positivity in lead aVR in COVID-19 pneumonia\".","authors":"Weihua Chen","doi":"10.1590/1806-9282.20230192","DOIUrl":"https://doi.org/10.1590/1806-9282.20230192","url":null,"abstract":"The study 1 entitled “Prognostic value of T-wave positivity in lead aVR in COVID-19 pneumonia” investigated the relationship between T-wave positivity in lead aVR and the prognosis of patients with COVID-19 pneumonia. The findings suggest that T-wave positivity in lead aVR is a useful predictor of poor prognosis in COVID-19 patients. While the findings of this study are interesting, I would like to point out some potential limitations.","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 6","pages":"e20230192"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/f4/1806-9282-ramb-69-06-e20230192.PMC10241080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bone mineral density and isokinetic knee strength in amputee soccer players.","authors":"Izzet Islamoglu,&nbsp;Mehmet Çebi,&nbsp;Fevziye Canbaz Tosun","doi":"10.1590/1806-9282.20230100","DOIUrl":"https://doi.org/10.1590/1806-9282.20230100","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the isokinetic knee strength, H/Q ratio (%), and bone mineral density values between amputees (n=14; amputee soccer players) and healthy football players (n=14; non-amputee soccer players).</p><p><strong>Methods: </strong>A total of 28 amputee soccer players and non-amputee soccer players participated in the study. An isokinetic dynamometer was used to determine the knee flexion/extension forces of the dominant legs of the athletes at 60, 180, and 240°/s. Bone mineral density scans were performed using dual-energy X-ray absorptiometry.</p><p><strong>Results: </strong>H/Q ratio and 60º/s flexion and 180 and 240º/s flexion/extension strength (p<0.05) were found to be high (180º/s, p=0.03; 240º/s, p=0.048) in the non-amputee soccer player group. Accordingly, the bone mineral density values of the lumbar vertebra, femoral neck, proximal metaphysis of the femur (p<0.01), tibia/fibula proximal metaphysis, and tibia/fibula distal metaphysis (p<0.05) were found to be high. A correlation was observed between the 60º/s knee extension strength and tibia/fibula diaphyseal bone mineral density (p=0.025; r=0.594) and tibia/fibula distal metaphysis bone mineral density (p=0.017; r=0.623) values in the amputee soccer players group. The Z-scores of the amputee soccer players and non-amputee soccer players were in the expected range according to age (>-2).</p><p><strong>Conclusion: </strong>The bone mineral density, H/Q ratio, and all measured angular velocities of isokinetic strength were high in non-amputee soccer players. This finding made us think that lower extremity amputation may also be associated with losing strength. However, it was observed that the relationship between strength and bone mineral density in amputee athletes might vary according to different angular velocities. It is recommended that isokinetic strength measurement can be evaluated together with bone mineral density in athletes.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20230100"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/4a/1806-9282-ramb-69-08-e20230100.PMC10427187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of sirtuin 2 and 7 in placenta accreta spectrum.","authors":"Irmak Icen Taskin,&nbsp;Sevim Gurbuz,&nbsp;Mehmet Sait Icen,&nbsp;Dilek Cam Derin,&nbsp;Fatih Mehmet Findik","doi":"10.1590/1806-9282.20230360","DOIUrl":"https://doi.org/10.1590/1806-9282.20230360","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.</p><p><strong>Methods: </strong>A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).</p><p><strong>Conclusion: </strong>Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20230360"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/80/1806-9282-ramb-69-08-e20230360.PMC10427185.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hyperuricemia and hypertension and the mediatory role of obesity: a large cohort study in China.","authors":"Changyi Wang,&nbsp;Pei Qin,&nbsp;Yinxing Liu,&nbsp;Li Wang,&nbsp;Shan Xu,&nbsp;Hongen Chen,&nbsp;Shuhong Dai,&nbsp;Ping Zhao,&nbsp;Fulan Hu,&nbsp;Yanmei Lou","doi":"10.1590/1806-9282.20220241","DOIUrl":"https://doi.org/10.1590/1806-9282.20220241","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the sex-specific association between hyperuricemia and the risk of hypertension and whether obesity mediates this association.</p><p><strong>Methods: </strong>This study included 31,395 (47.0% women) adults without hypertension, cardiovascular disease, or cancer at baseline who completed at least one follow-up annual examination between 2009 and 2016. Cox regression models were performed to calculate hazard ratios and 95% confidence intervals. Mediation analysis was conducted to estimate the effect of body mass index on the association between hyperuricemia and hypertension.</p><p><strong>Results: </strong>During a median 2.9-year follow-up, hyperuricemia was significantly associated with a higher risk of hypertension (HR 1.15, 95%CI 1.07-1.24 for all participants; HR 1.12, 95%CI 1.03-1.22 for men; and HR 1.23, 95%CI 1.02-1.48 for women) after adjustment for potential confounders. Additional adjustment for body mass index attenuated this association (HR 1.09, 95%CI 1.08-1.10 for all participants; HR 1.07; 95%CI 0.98-1.16 for men; HR 1.18; 95%CI 0.96-1.44 for women). Mediation analysis showed that BMI partially mediated the relationship between hyperuricemia and incident hypertension (indirect effect HR 1.09, 95%CI 1.08-1.10; direct effect: HR 1.08, 95%CI 1.02-1.15). The percentage of the mediation effect was 53.2% (95%CI 37.9-84.5).</p><p><strong>Conclusion: </strong>Hyperuricemia is associated with a risk of hypertension in both sexes, and BMI partially mediates hyperuricemia-related incident hypertension.</p>","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":"69 8","pages":"e20220241"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/3c/1806-9282-ramb-69-08-e20220241.PMC10443908.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}