Reviews of environmental contamination and toxicology最新文献

{"title":"Biomonitoring Xenobiotics in Human Biospecimens: Challenges, Advances, and the Future of Exposome Characterization.","authors":"Xinran Zhu, Xuening Tang, Carla Ng, Li Li, Yunjia Lai, Gary W Miller, Chao Jiang, Aaron Barchowsky, Jeanine Buchanich, Peng Gao","doi":"10.1007/s44169-025-00088-2","DOIUrl":"10.1007/s44169-025-00088-2","url":null,"abstract":"<p><p>Xenobiotics, defined as foreign chemical substances not normally produced by or expected to be present in an organism, are pervasive throughout the human body system. While some xenobiotics have known adverse health effects, the impact of many remains unclear, particularly when considering the potential synergistic or additive effects of chemical mixtures. Human biomonitoring, using biospecimens such as blood, urine, placenta, umbilical cord blood, stool, milk, sweat, saliva, tears, teeth, hair, nails, breath, and cerebrospinal fluid, is a common approach to assess xenobiotic exposure. However, these matrices have inherent limitations in accurately measuring the vast array of chemicals constituting the human chemical exposome-the entirety of chemical exposures an individual experiences over time. This comprehensive review critically analyzes the advantages and limitations of both invasive and noninvasive biospecimens used in human biomonitoring. We outline major classes of detectable xenobiotics in these matrices, compare their qualitative and quantitative feasibility, and discuss challenges in using biospecimens to monitor the internal chemical exposome. The review highlights the importance of integrating complementary external monitoring methods alongside biospecimen analysis, given the short half-lives and trace levels of some xenobiotics in accessible biospecimens. We also discuss emerging technologies and methodologies in biomonitoring, including advanced analytical techniques, wearable sensors, and multi-omics approaches. Additionally, we discuss the ethical, legal, and social implications of biomonitoring and external monitoring. By synthesizing current knowledge and identifying research gaps, this review provides a comprehensive overview of xenobiotics in human biospecimens and outlines future directions for better characterizing the human chemical exposome. These insights are crucial for advancing our understanding of xenobiotic exposures and their health impacts, ultimately informing more effective strategies for disease prevention and intervention.</p>","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"263 ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemiological and Toxicological Intersection of Air Pollution and Dementia.","authors":"Sumasri V Kotha, Grace Kuo, Sachin V Kammula, Liuhua Shi, Xuan Zhang, Pengfei Liu, Xiaobo Mao","doi":"10.1007/s44169-025-00092-6","DOIUrl":"10.1007/s44169-025-00092-6","url":null,"abstract":"<p><p>Accumulating evidence indicates that exposure to air pollution can be strongly associated with the development of dementia. However, different components and species of air pollution have been found to have varying associations with incidence of dementia in exposed populations. Among the most broadly studied pollutants in this context are particulate matter (PM), nitrogen dioxide (NO₂), ozone (O₃), and sulfur dioxide (SO₂). Here, we offer a joint toxicological and epidemiological review of the association of each of these well-studied pollutants with dementia, as well as other less-studied pollutants, such as black carbon (BC) and metals (both independently potent components of PM), carbon monoxide (CO), and polyaromatic hydrocarbons (PAHs). Sources and properties of these pollutants are considered in tandem with studies regarding their epidemiological association with dementia and the possible biological basis of these associations. By considering this joint perspective, we identify the pollutants with the greatest association with dementia incidence. Further, we offer a classification of pathological mechanisms and subtypes of dementia associated with exposure to the aforementioned pollutants. Despite variance in exposure assessment, dementia diagnosis and follow-up, and source population, our qualitative review indicates exposure to air pollutants, especially PM_2.5 and NO₂, is associated with increased risk and incidence of dementia. Increasing evidence shows exposure to specific pollutants is tied to pathological mechanisms and dementia subtypes, as summarized here.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s44169-025-00092-6.</p>","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"263 1","pages":"25"},"PeriodicalIF":8.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Impact Assessment in the Entire Life Cycle of Lithium-Ion Batteries","authors":"T. K. Sankar, Abhilash, P. Meshram","doi":"10.1007/s44169-023-00054-w","DOIUrl":"https://doi.org/10.1007/s44169-023-00054-w","url":null,"abstract":"","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"43 20","pages":""},"PeriodicalIF":6.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138949935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Life Cycle Assessment of Soil Remediation Technology: Method Applications and Technological Characteristics","authors":"Ning Ding, Xianhao Meng, Zhan Zhang, Jin Ma, Yongping Shan, Zhong Zhong, Haibo Yu, Man Li, Wentao Jiao","doi":"10.1007/s44169-023-00051-z","DOIUrl":"https://doi.org/10.1007/s44169-023-00051-z","url":null,"abstract":"","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":" 12","pages":""},"PeriodicalIF":6.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Microbe-Driven Ecological Restoration on Bauxite Residue Disposal Areas","authors":"Shengguo Xue, Xinfeng Qin, Yifan Jiang, Ying Guo, Wei Chen, Feng Zhu","doi":"10.1007/s44169-023-00056-8","DOIUrl":"https://doi.org/10.1007/s44169-023-00056-8","url":null,"abstract":"","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"10 13","pages":""},"PeriodicalIF":6.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Additives in Composting Promotes Passivation and Reduction in Bioavailability of Heavy Metals (HMs) in Compost","authors":"Chisom Ejileugha, Uzoma Oluchi Onyegbule, J. O. Osuoha","doi":"10.1007/s44169-023-00055-9","DOIUrl":"https://doi.org/10.1007/s44169-023-00055-9","url":null,"abstract":"","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"20 5","pages":""},"PeriodicalIF":6.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138600891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Agriculture: Nanoparticles as Tools to Mitigate Heavy Metal Toxicity","authors":"N. Kumari, Sushma Rani, Vinay Sharma","doi":"10.1007/s44169-023-00053-x","DOIUrl":"https://doi.org/10.1007/s44169-023-00053-x","url":null,"abstract":"","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"32 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138600514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight into Photodegradation of Diclofenac: Mechanism, Efficiency, Role of Parameters, Toxicity Assessment and Catalyst Stability","authors":"Mohammad Qutob, Sultan Alshehri, Faiyaz Shakeel, Prawez Alam, Mohd Rafatullah","doi":"10.1007/s44169-023-00052-y","DOIUrl":"https://doi.org/10.1007/s44169-023-00052-y","url":null,"abstract":"Pharmaceuticals and personal care products (PPCPs) are one of the emerging pollutants (EPs) groups that attracted the environmentalist’s attention according to the increase in their demand. Diclofenac (DFC) is an anti-inflammatory medication used as a first-line treatment for pain. Around 15% of DFC is unmetabolized after human consumption, leading to an increase in the opportunity to release DFC into the environment. DFC may build up in the environment over time, which increases its negative impacts on the ecosystem. Several biological, physical, and chemical techniques have been applied to treat DFC. This review provides an overview of the photodegradation of DFC including photodegradation efficiency, mechanism, the role of physicochemical parameters, and toxicity assessment. Generally, the photodegradation systems showed high efficiency in the removal. However, each experiment has been applied under different experimental conditions and different parameters such as the type and dosage of catalyst, the chosen wavelength of the radiation, pH, temperature, and additive concentration. This led to the differentiation in the photodegradation efficiency and photodegradation rate of DFC. We revealed that the physicochemical parameters of the photocatalytic process are a double edge sword. On the one hand, raising their values up to a certain point might help the treatment work well. On the other hand, a significant rise has a negative impact on the effectiveness of the treatment and raises the expense of the treatment operation. The toxicity tests indicated that most frequent DFC by-products are not safe, and their release into the environment may negatively affect the ecosystem. This review may provide a useful recommendation for future researchers who want to treat DFC by photodegradation and enables them to enhance the applicability of photodegradation.","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"36 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135042824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Epigenetic Toxicological Mechanisms of Sildenafil and Its Metabolites, the Emerging Pollutants","authors":"Deng Chen, Xia Deng, Shiwei Jin","doi":"10.1007/s44169-023-00050-0","DOIUrl":"https://doi.org/10.1007/s44169-023-00050-0","url":null,"abstract":"Sildenafil is a brand-name prescription drug that is approved to treat illnesses such as erectile dysfunction (ED). It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. There is a need for increased knowledge on epigenetic environmental toxicological mechanisms of new pollutant sildenafil, its metabolites and its potential environmental health impacts. The scope of the review determines the specific aspects of sildenafil metabolites and the impact of sildenafil on DNA methylation, histone modifications, and non-coding RNA expression. The review expounded that the emerging field of epigenetics has continued to reveal that sildenafil may have an impact beyond its intended purpose of treating erectile dysfunction. Several studies have suggested that sildenafil can alter the epigenetic marks on DNA, potentially leading to changes in gene expression and cellular behavior. Even though the full implications of these epigenetic changes are not yet fully understood, they may have far-reaching effects on human health and development. Further research is needed to fully understand the epigenetic effects of sildenafil and other pharmaceuticals and to develop strategies for mitigating any potential risks. It is crucial to consider the broader implications of drug use and to take a proactive approach to promoting public health and safety.","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135996137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the International Management Practice and Treatment Technology of Solid Waste Containing Perfluorooctane Sulfonic Acid","authors":"Jianying Fu, Shengdong Zhang, Mingxiu Zhan, Jinjian Ding, Xu Xu, Wenwen Ye, Hancheng Ma, Tong Chen, Wentao Jiao, Zheng Peng, John P. Giesy","doi":"10.1007/s44169-023-00049-7","DOIUrl":"https://doi.org/10.1007/s44169-023-00049-7","url":null,"abstract":"Perfluorooctane sulfonic acid (PFOS) and its salts were listed as persistent organic pollutants (POPs) in the Stockholm Convention to restrict their worldwide usage. PFOS released from dumped solid waste may pose risks to humans and the environment. Great efforts have been made to identify, manage, and dispose of PFOS-containing solid wastes. Herein, we reviewed the relevant literature and regulations to give a complete view of international management practices and treatment technologies for PFOS-containing solid wastes. First, the occurrence and fate of PFOS in solid waste and in the environment, as well as the development of detection methods for PFOS in solid wastes are introduced. Then, relevant regulations from different countries and regions are reviewed and compared. Specific and feasible PFOS control regulations and standards must be developed based on the economic and pollution situations. Traditional disposal technologies such as incineration and landfill are still the mainstream methods for PFOS-containing solid wastes. However, several innovative and promising technologies, including pyrolysis, plasma, cement kiln co-treatment, and smoldering, have raised concern. The disposal efficiency, cost efficiency, and environmental impact of different technologies remain uncertain and deserve greater consideration. In addition, alternative research is briefly introduced. Based on the international experience, prospects for enhancing disposal technology research, preventing secondary pollution during disposal, and proactively developing safe alternatives are made for a summary.","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":"248 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}