新兴污染物西地那非及其代谢物的表观遗传毒理学机制研究进展

IF 6.1 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Deng Chen, Xia Deng, Shiwei Jin
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引用次数: 0

摘要

西地那非是一种品牌处方药,被批准用于治疗勃起功能障碍(ED)等疾病。它属于一类称为磷酸二酯酶5型(PDE5)抑制剂的药物。有必要增加对新污染物西地那非、其代谢物及其潜在环境健康影响的表观遗传环境毒理学机制的了解。综述的范围确定了西地那非代谢物的具体方面,以及西地那非对DNA甲基化、组蛋白修饰和非编码RNA表达的影响。这篇综述阐述了新兴的表观遗传学领域继续揭示西地那非可能有超出其治疗勃起功能障碍的预期目的的影响。几项研究表明,西地那非可以改变DNA上的表观遗传标记,可能导致基因表达和细胞行为的改变。尽管这些表观遗传变化的全部含义尚未完全了解,但它们可能对人类健康和发育产生深远影响。需要进一步的研究来充分了解西地那非和其他药物的表观遗传效应,并制定减轻任何潜在风险的策略。至关重要的是要考虑吸毒的广泛影响,并采取积极主动的办法促进公共健康和安全。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review on Epigenetic Toxicological Mechanisms of Sildenafil and Its Metabolites, the Emerging Pollutants
Sildenafil is a brand-name prescription drug that is approved to treat illnesses such as erectile dysfunction (ED). It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. There is a need for increased knowledge on epigenetic environmental toxicological mechanisms of new pollutant sildenafil, its metabolites and its potential environmental health impacts. The scope of the review determines the specific aspects of sildenafil metabolites and the impact of sildenafil on DNA methylation, histone modifications, and non-coding RNA expression. The review expounded that the emerging field of epigenetics has continued to reveal that sildenafil may have an impact beyond its intended purpose of treating erectile dysfunction. Several studies have suggested that sildenafil can alter the epigenetic marks on DNA, potentially leading to changes in gene expression and cellular behavior. Even though the full implications of these epigenetic changes are not yet fully understood, they may have far-reaching effects on human health and development. Further research is needed to fully understand the epigenetic effects of sildenafil and other pharmaceuticals and to develop strategies for mitigating any potential risks. It is crucial to consider the broader implications of drug use and to take a proactive approach to promoting public health and safety.
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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
11
审稿时长
>24 weeks
期刊介绍: Reviews of Environmental Contamination and Toxicology publishes reviews pertaining to the sources, transport, fate and effects of contaminants in the environment. The journal provides a place for the publication of critical reviews of the current knowledge and understanding of environmental sciences in order to provide insight into contaminant pathways, fate and behavior in environmental compartments and the possible consequences of their presence, with multidisciplinary contributions from the fields of analytical chemistry, biochemistry, biology, ecology, molecular and cellular biology (in an environmental context), and human, wildlife and environmental toxicology. •Standing on a 55+ year history of publishing environmental toxicology reviews •Now publishing in journal format boasting rigorous review and expanded editorial board •Publishing home for extensive environmental reviews dealing with sources, transport, fate and effect of contaminants •Through Springer Compact agreements, authors from participating institutions can publish Open Choice at no cost to the authors
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