{"title":"新兴污染物西地那非及其代谢物的表观遗传毒理学机制研究进展","authors":"Deng Chen, Xia Deng, Shiwei Jin","doi":"10.1007/s44169-023-00050-0","DOIUrl":null,"url":null,"abstract":"Sildenafil is a brand-name prescription drug that is approved to treat illnesses such as erectile dysfunction (ED). It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. There is a need for increased knowledge on epigenetic environmental toxicological mechanisms of new pollutant sildenafil, its metabolites and its potential environmental health impacts. The scope of the review determines the specific aspects of sildenafil metabolites and the impact of sildenafil on DNA methylation, histone modifications, and non-coding RNA expression. The review expounded that the emerging field of epigenetics has continued to reveal that sildenafil may have an impact beyond its intended purpose of treating erectile dysfunction. Several studies have suggested that sildenafil can alter the epigenetic marks on DNA, potentially leading to changes in gene expression and cellular behavior. Even though the full implications of these epigenetic changes are not yet fully understood, they may have far-reaching effects on human health and development. Further research is needed to fully understand the epigenetic effects of sildenafil and other pharmaceuticals and to develop strategies for mitigating any potential risks. It is crucial to consider the broader implications of drug use and to take a proactive approach to promoting public health and safety.","PeriodicalId":21182,"journal":{"name":"Reviews of environmental contamination and toxicology","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Review on Epigenetic Toxicological Mechanisms of Sildenafil and Its Metabolites, the Emerging Pollutants\",\"authors\":\"Deng Chen, Xia Deng, Shiwei Jin\",\"doi\":\"10.1007/s44169-023-00050-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Sildenafil is a brand-name prescription drug that is approved to treat illnesses such as erectile dysfunction (ED). It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. There is a need for increased knowledge on epigenetic environmental toxicological mechanisms of new pollutant sildenafil, its metabolites and its potential environmental health impacts. The scope of the review determines the specific aspects of sildenafil metabolites and the impact of sildenafil on DNA methylation, histone modifications, and non-coding RNA expression. The review expounded that the emerging field of epigenetics has continued to reveal that sildenafil may have an impact beyond its intended purpose of treating erectile dysfunction. Several studies have suggested that sildenafil can alter the epigenetic marks on DNA, potentially leading to changes in gene expression and cellular behavior. Even though the full implications of these epigenetic changes are not yet fully understood, they may have far-reaching effects on human health and development. Further research is needed to fully understand the epigenetic effects of sildenafil and other pharmaceuticals and to develop strategies for mitigating any potential risks. It is crucial to consider the broader implications of drug use and to take a proactive approach to promoting public health and safety.\",\"PeriodicalId\":21182,\"journal\":{\"name\":\"Reviews of environmental contamination and toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2023-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reviews of environmental contamination and toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s44169-023-00050-0\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews of environmental contamination and toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s44169-023-00050-0","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
A Review on Epigenetic Toxicological Mechanisms of Sildenafil and Its Metabolites, the Emerging Pollutants
Sildenafil is a brand-name prescription drug that is approved to treat illnesses such as erectile dysfunction (ED). It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. There is a need for increased knowledge on epigenetic environmental toxicological mechanisms of new pollutant sildenafil, its metabolites and its potential environmental health impacts. The scope of the review determines the specific aspects of sildenafil metabolites and the impact of sildenafil on DNA methylation, histone modifications, and non-coding RNA expression. The review expounded that the emerging field of epigenetics has continued to reveal that sildenafil may have an impact beyond its intended purpose of treating erectile dysfunction. Several studies have suggested that sildenafil can alter the epigenetic marks on DNA, potentially leading to changes in gene expression and cellular behavior. Even though the full implications of these epigenetic changes are not yet fully understood, they may have far-reaching effects on human health and development. Further research is needed to fully understand the epigenetic effects of sildenafil and other pharmaceuticals and to develop strategies for mitigating any potential risks. It is crucial to consider the broader implications of drug use and to take a proactive approach to promoting public health and safety.
期刊介绍:
Reviews of Environmental Contamination and Toxicology publishes reviews pertaining to the sources, transport, fate and effects of contaminants in the environment. The journal provides a place for the publication of critical reviews of the current knowledge and understanding of environmental sciences in order to provide insight into contaminant pathways, fate and behavior in environmental compartments and the possible consequences of their presence, with multidisciplinary contributions from the fields of analytical chemistry, biochemistry, biology, ecology, molecular and cellular biology (in an environmental context), and human, wildlife and environmental toxicology.
•Standing on a 55+ year history of publishing environmental toxicology reviews
•Now publishing in journal format boasting rigorous review and expanded editorial board
•Publishing home for extensive environmental reviews dealing with sources, transport, fate and effect of contaminants
•Through Springer Compact agreements, authors from participating institutions can publish Open Choice at no cost to the authors