Reviews on recent clinical trials最新文献

{"title":"Regenerative Medicine Regulations: A Tri-continental Comparison of Policies and Progress.","authors":"Prateek Ghatak, Devesh Kumar, Thakur Gurjeet Singh, Sonia Dhiman, Mohit Kumar","doi":"10.2174/0115748871423172251215053447","DOIUrl":"https://doi.org/10.2174/0115748871423172251215053447","url":null,"abstract":"<p><strong>Introduction: </strong>Regenerative medicine, which includes gene therapies, tissue engineering, and stem cell-based interventions, represents a transformative frontier in modern healthcare. As this field rapidly evolves, regulatory bodies worldwide have established frameworks to ensure the safety, efficacy, and ethical deployment of these advanced therapies. This study aims to provide a comparative analysis of the regulatory approaches adopted in the United States, the European Union, and India.</p><p><strong>Methods: </strong>This review synthesizes and evaluates regulatory documents, policy reports, and published literature on regenerative medicine from official and scientific sources. The main aspects analyzed include approval pathways, classification systems, oversight mechanisms, and the pace of policy development in the three regions.</p><p><strong>Results: </strong>The United States adopts a progressive stance with its RMAT (Regenerative Medicine Advanced Therapy) designation, offering expedited approval pathways for therapies addressing unmet clinical needs. The European Union regulates regenerative products under the ATMP (Advanced Therapy Medicinal Products) framework, marked by rigorous clinical trial requirements and post-marketing surveillance. India, in the early stages of regulatory development, is making strides through draft guidelines and policy initiatives that aim to align innovation with patient safety.</p><p><strong>Discussion: </strong>The analysis reveals notable differences in regulatory maturity, with the US promoting faster market access, the EU prioritizing safety through strict compliance, and India striving to build capacity and infrastructure. India's primary challenges lie in execution, enforcement, and establishing a robust clinical and regulatory ecosystem. However, its regulatory trajectory shows promise, particularly with growing interest from governments and the scientific community.</p><p><strong>Conclusion: </strong>This comparative review underscores the importance of harmonizing regulatory standards to ensure equitable access to regenerative therapies worldwide. International collaboration, knowledge sharing, and capacity building are crucial for bridging existing gaps, particularly in emerging markets like India, and for maintaining high standards of safety and efficacy globally.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rupture of Renal Pelvis: A Case Report and Literature Review of a Rare Complication of Ureteral Lithiasis.","authors":"Ilias Giannakodimos, Panagiotis Damianos, Konstantinos Adamos, Aris Kaltsas, Marios Stavropoulos, Dimitrios Deligiannis, Zisis Kratiras, Michael Chrisofos","doi":"10.2174/0115748871449808260225070714","DOIUrl":"https://doi.org/10.2174/0115748871449808260225070714","url":null,"abstract":"<p><strong>Introduction: </strong>Spontaneous rupture of the renal pelvis with urinary extravasation due to ureteral lithiasis is an uncommon entity, and it presents both diagnostic and therapeutic challenges, necessitating a systematic approach for diagnosis confirmation, treatment, and follow-up. Case Presentation and Review of the Literature: This article concerns a case of a 45-year-old male with acute left renal pain. Computed Tomography revealed renal pelvis rupture with perirenal urinary extravasation due to a 3 mm calculus located at the right ureterovesical junction. The patient was successfully managed with the insertion of a percutaneous nephrostomy and a drainage tube in the urinoma. A follow-up CT nephrostomography demonstrated complete healing of the renal pelvis, with no residual extravasation, while no evidence of the obstructing calculus was identified.</p><p><strong>Results and conclusion: </strong>The incidence of renal pelvis rupture due to urolithiasis is rare and warrants heightened suspicion by the urologist for prompt diagnosis and appropriate management.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Phenylketonuria: Bridging Conventional Gaps in Diagnosis and Treatment- A Systematic Review.","authors":"Zulfa Nooreen, Ankita Wal, Himangi Vig, Nishant Kumar, Raghuraj Singh Suryavanshi, Shambaditya Goswami","doi":"10.2174/0115748871444112260226045508","DOIUrl":"https://doi.org/10.2174/0115748871444112260226045508","url":null,"abstract":"<p><strong>Introduction: </strong>Phenylketonuria (PKU) is an autosomal recessive condition of phenylalanine metabolism, characterized by abnormally high phenylalanine concentrations that lead to brain damage. These illnesses are caused by mutations in genes that encode proteins or enzymes involved in metabolic processes. It causes harmful implications by accumulating in the blood and the brain.</p><p><strong>Materials and methods: </strong>The present review aims to compile detailed diagnostic and treatment methods for phenylketonuria. The sources of literature are PubMed, Google Scholar, SciFinder, Scopus, Elsevier, and Web of Science.</p><p><strong>Results: </strong>The prevalence of phenylketonuria in the US is around 1 in 15,000 people. The incidence of phenylketonuria varies greatly across the globe. With 1/4000 live births, the project aims to develop and evaluate a time-aware, healthful food recommender system for PKU patients from birth to maturity using a variety of artificial intelligence and machine learning approaches. To determine the system's accuracy, usefulness, and effect on dietary adherence and health outcomes, more PKU patients will participate in a clinical trial.</p><p><strong>Discussion: </strong>Phenylketonuria is increasingly well understood, diagnosed, and managed through the use of artificial intelligence. To forecast disease course, improve screening accuracy, and identify novel treatment targets, machine learning models are being developed.</p><p><strong>Conclusion: </strong>This study presents a comprehensive overview of pathogenesis, risk factors, pathophysiology, symptoms, diagnoses, and treatment. PKU has no known cure, especially in late-stage cases; however, if the illness is diagnosed earlier, treatment is more feasible. Lifelong dietary treatment aimed at preserving low phenylalanine levels and sufficient.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restricted and Repetitive Behaviors in Intellectual Disabilities: A Scoping Review with a Systematic Search of the Literature.","authors":"Emily Payne, Sara Sarasua, Curtis Rogers, Rebekah Martin, Katy Phelan, Luigi Boccuto","doi":"10.2174/0115748871433137260302042409","DOIUrl":"https://doi.org/10.2174/0115748871433137260302042409","url":null,"abstract":"<p><strong>Background: </strong>Restricted and Repetitive Behaviors (RRBs) are a core feature of autism and are present in numerous neurodevelopmental disorders and Intellectual Disabilities (ID). These behaviors include repetitive movements, restricted interests, and insistence on sameness, among others. RRBs can cause distress, self-injury, and affect development. The proper assessment of RRBs is critical for the design of clinical trials and the identification of outcome measures for patients with ID, but unfortunately, the scientific literature lacks a deeper characterization of RRBs, particularly in individuals with ID. The goal of this study is to review the current literature to describe the RRB profile in ID (mild, moderate, severe, and profound).</p><p><strong>Methods: </strong>A systematic search of the literature in PubMed, Web of Science, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) was performed for articles in the past 10 years.</p><p><strong>Results: </strong>Following de-duplication and screening, a total of 20 articles met the inclusion criteria for this review. Various repetitive behaviors were described across all levels of ID. The most common behaviors included broad repetitive movements, hand- and finger-stereotypies, restricted interests, and self-injury. No major differences were observed between individuals across all levels of ID.</p><p><strong>Discussion: </strong>This review explores the relationship between RRBs and different levels of ID, highlighting the different assessment approaches utilized in various studies. A similar RRB profile across all levels of ID could be beneficial for diagnosis and, potentially, for standardized treatment of RRBs.</p><p><strong>Conclusion: </strong>Standardized assessment tools for RRB profiles are recommended for proper evaluations of the complex behavioral profiles in individuals with ID.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leqembi (Lecanemab) in Early Alzheimer's Disease: A Review of Clinical Trial Evidence and Therapeutic Implications.","authors":"Andrew Ashchi, Andrea Ashchi Lachapelle, Selim Nassirou, Jessica Huston","doi":"10.2174/0115748871418305260224075827","DOIUrl":"https://doi.org/10.2174/0115748871418305260224075827","url":null,"abstract":"<p><p>Lecanemab is an IgG1 monoclonal antibody that has emerged as the first FDAapproved drug to slow the progression of Alzheimer's disease by targeting amyloid plaques, with the potential to serve as a disease-modifying therapy. Ongoing clinical studies are evaluating the efficacy and safety of the medication; however, much of the current literature remains mixed regarding the clinical effectiveness of lecanemab. The results from the Clarity AD study, the largest clinical study regarding the effectiveness of lecanemab to date, revealed a statistically significant 27% reduction in the progression of cognitive decline and favorable secondary endpoints in patients with mild cognitive impairment or mild dementia, particularly in male patients as well as heterozygous APOE4 carriers. However, approximately 21% of participants who received lecanemab treatment developed amyloid-related imaging abnormalities, with a higher incidence in homozygous APOE4 carriers. These findings highlight the need to thoroughly screen patients to confirm amyloid pathology with an amyloid PET scan or CSF biomarkers, and to determine APOE4 status before treatment. Additional barriers to care include the financial cost of the medication as well as the need to administer the drug intravenously at a healthcare facility to ensure proper management. Additional studies must continue to explore the clinical impact and safety of the medication and increase its accessibility. Future research may also include analyzing the utilization of the drug in combination therapies to optimize patient outcomes. This paper aims to provide a comprehensive review of current data on lecanemab, its clinical implications, and potential future directions for the use of lecanemab.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Different Analytical Methods for the Quantification of Natural Bioactives.","authors":"Shashank Rai, Snigdha Bhardwaj, Kandasamy Nagarajan, Tulika Bhardwaj","doi":"10.2174/0115748871415607260226084405","DOIUrl":"https://doi.org/10.2174/0115748871415607260226084405","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Natural bioactive compounds have significant potential for the development of therapeutic interventions, but the success of their discovery and use is greatly influenced by the development of efficient methods for their extraction, structural determination, quantification, and validation. Existing reviews have failed to adequately address the analytical approaches for the efficient determination of bioactive compounds, which is the main purpose of this systematic review: to comprehensively evaluate the current methods used in the extraction, determination of the structure, quantification, validation, and dose-response relationship in the assessment of natural bioactive compounds, which may be derived from plant and marine sources, with the aim of determining their structures for the development of new drugs, as well as validating the results obtained from the use of these compounds.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An extensive simulated search was carried out on prominent scientific information sources, such as PubMed, Scopus, and Google Scholar, to gather literature published from 2000 to 2024. The literature selected for the study was based on the information provided on the extraction methods, structural elucidation mechanisms, analytical validation, and pharmacological investigation of bioactive compounds derived from plants. The information on 40 bioactive compounds and the analytical mechanisms was gathered and synthesized.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Extraction is normally carried out using techniques such as Soxhlet extraction, MicrowaveAssisted Extraction (MAE), and maceration. For structural analysis, the most preferred methods include Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), Fourier Transform Infrared Spectroscopy (FTIR), Ultraviolet-Visible Spectroscopy (UV-Vis), and X-ray crystallography. Validation indicates excellent linearity (R² &gt; 0.99), specificity, and accuracy with %RSD &lt; 2. Dose-response curves for compounds such as curcumin, quercetin, and silymarin indicate excellent potency, as indicated by IC50 values &lt; 50 µM. However, drawbacks include issues such as interference in the matrix, the high cost of equipment, and the lack of universal standardization methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The evidence is sound: modern spectroscopy and chromatography techniques provide impressive accuracy. However, disparities in standardization practices and expenses make it difficult to fully embrace the approach. This review highlights the importance of blending eco-friendly solvents and cost-effective approaches to fill the gap.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;For the purpose of precise characterization of bioactive compounds, it is necessary to integrate extraction techniques with analytical validation and spectroscopy. This review offers a useful guide to help researchers in selecting the best possible strategies depending on the nature of the compound and the objectives of ","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Thyroid Cancer Risks from External Beam Radiation Exposure Modulated by Dose, Field, Sex, Age, and Latency Period","authors":"Georgia Koutsouki, Ilias Katsadouros, Evanthia Giannoula, Paraskevi Exadaktylou, Ioannis Iakovou, Argirios Doumas, Areti Gkantaifi","doi":"10.2174/0115748871377743260220060955","DOIUrl":"10.2174/0115748871377743260220060955","url":null,"abstract":"<p><strong>Introduction: </strong>Exposure to ionizing radiation is a well-established risk factor for the development of thyroid malignancies. Given the fact that the thyroid gland is a particularly radiosensitive organ and consequently vulnerable to radiotherapy in the head and neck area, our review aims to\u0000summarize the related risk factors of second primary thyroid cancer development and exposure to\u0000ionizing radiation.</p><p><strong>Methods: </strong>A comprehensive literature search was performed in MEDLINE (PubMed), Scopus, and\u0000Cochrane Central Register of Controlled Trials (CENTRAL) databases.</p><p><strong>Results: </strong>Dose and field of radiotherapy, age at the time of exposure, sex, and primary disease constitute the main subjects of our study, confirming the etiological connection between head and neck\u0000radiotherapy and malignant thyroid neoplasm.</p><p><strong>Discussion: </strong>Although these risk factors contribute to the occurrence of thyroid malignancies after\u0000radiotherapy, ongoing investigation is required to define the individual effects of these factors and\u0000their combined influence on carcinogenic pathways.</p><p><strong>Conclusion: </strong>In this review, we underscore the relevance of known risk factors, thus highlighting the\u0000importance of tailored follow-up strategies in patients undergoing radiotherapy of the head and neck\u0000area. In the era of advanced radiotherapy (RT) techniques and more effective screening tools, many\u0000questions may arise about the impact of technological advantages on the incidence of second primary thyroid malignancies.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical Preparedness of Developing Nations in the Age of Decentralized Clinical Trials: Comparative Overview of South Asian Regulation.","authors":"Yashika, Amandeep Singh","doi":"10.2174/0115748871459358260114054814","DOIUrl":"https://doi.org/10.2174/0115748871459358260114054814","url":null,"abstract":"<p><p>The advent of decentralized clinical trials (DCTs) has altered the usual trends in clinical trials, and this presents an ethical, regulatory, and operational dilemma, particularly to the low-and middle-income countries (LMICs). This review critically examines the ethical preparedness of countries in South Asia to transform to the DCT paradigm. We consider the readiness of such nations as India, Bangladesh, Pakistan, Sri Lanka, Nepal, Bhutan, and the Maldives by weighing the local regulatory environments and establishing a difference in ethical safeguards, cyber infrastructure, and protection of participants. The paper specifically focuses on some of the fundamental themes, including the concept of informed consent in the virtual world, data security, the digital literacy problem, and the evolving nature of the local ethics committees. Case studies allow us to identify systemic gaps, especially the ones that were provoked by the COVID-19 pandemic, and propose ways to harmonize ethics with the comparative regulatory matrix. The focus is on regionalization of international standards, including ICH-GCP, and intergovernmental cooperation, as well as the effective construction of strong and inclusive systems of governance. This review offers strategic suggestions that policymakers may implement to enhance ethical resilience in the South Asian passage to a decentralized, data-driven future of clinical research.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual Clinical Trials in Clinical Medicine: Economic, Ethical, and Practical Considerations.","authors":"Francisco Epelde, Dolores Rexachs, Alvaro Wong, Emilio Luque","doi":"10.2174/0115748871436258260114105507","DOIUrl":"https://doi.org/10.2174/0115748871436258260114105507","url":null,"abstract":"<p><p>Virtual clinical trials (VCTs) represent an innovative approach to clinical research, using computer simulations and digital modeling rather than traditional human participants. These trials harness computational power and artificial intelligence to model the effects of medical treatments, drastically reducing costs, time, and logistical complexities. As this technology advances, VCTs offer the potential to streamline drug development, enhance precision, and make clinical research more accessible and efficient. However, the shift away from traditional human-based trials raises significant ethical concerns, particularly regarding the validity of results, regulatory oversight, and the potential reduction of human involvement in the research process. This paper explores the economic, ethical, and practical aspects of VCTs in clinical medicine, with a focus on their potential to revolutionize clinical trials and the challenges they present. Future lines of research will also be proposed to address these issues.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral Feeding and Circadian Rhythms: A Useful Liaison in Critical and Non-critical Patients.","authors":"Emidio Scarpellini, Marialaura Scarcella, Giuseppe Guido Maria Scarlata, Fabiola Lucente, Luana Iannone, Mohammad Alharbi, Jan Tack, Ludovico Abenavoli","doi":"10.2174/0115748871392163251206221657","DOIUrl":"https://doi.org/10.2174/0115748871392163251206221657","url":null,"abstract":"<p><p>Central nervous system and peripheral clocks regulate the rhythms of life. Main zeitgebers are light-darkness, nutrition, and fasting cycles. There is a fine interaction among human body clocks, and different stimuli can affect and modulate biorhythms. Nutrition is one of these. Its role is still under investigation, especially in healthy status balance maintenance of critical and noncritical patients. For these reasons, a narrative review of the current literature on the definition of circadian clocks, their regulation, and the role of diet in their fine-tuning in critical and non-critical care patients was conducted. A search was conducted on PubMed and Medline for original articles, reviews, meta-analyses, and case series matching the following keywords and associations: enteral nutrition; circadian rhythms; chrononutrition; critically ill patient; personalized nutrition. A total of 1188 manuscripts were identified according to keywords. Subsequently, 579 articles were removed due to duplication, 208 due to non-English language, book chapter publications, and non-matching keyword combinations. The remaining 401 papers were checked for eligibility, and 170 manuscripts were accepted. Human central and peripheral circadian clocks are affected by several zeitgebers. Food micro- and macronutrients and time of administration can all affect peripheral clocks and interact with central ones. In critical and non-critical care patients, route and timing of artificial nutrition administration should consider the behaviour of different central and peripheral circadian clocks. This is also affected by inherited genetic biotypes. In detail, specific macronutrient patterns modulate peripheral clock gene expression and influence metabolic recovery in critically ill patients. In fact, timed and/or time-restricted setups of enteral nutrition administration (namely, timed enteral nutrition refers to administration according to circadian rhythms) show promising and yet incomplete data on their efficacy for restoring healthy status in the patients. Human circadian rhythms recognize nutrition as one of the main regulators. Both food composition and administration schemes can help to establish effective cycles in critical and non-critical admitted patients.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}