Reviews on recent clinical trials最新文献

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Effect of Colchicine for Prevention of Recurrent Stroke in Ischemic Stroke Patients with Atrial Fibrillation: A Randomized Double-blinded Placebo-- controlled Trial. 心房颤动缺血性卒中患者服用秋水仙碱预防复发性卒中的效果:随机双盲安慰剂对照试验》。
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-09-19 DOI: 10.2174/0115748871325292240904060109
Zahra Molaeimanesh, Davood Kashipazha, Davood Shalilahmadi, Gholamreza Shamsaei, Shooka Mohammadi
{"title":"Effect of Colchicine for Prevention of Recurrent Stroke in Ischemic Stroke Patients with Atrial Fibrillation: A Randomized Double-blinded Placebo-- controlled Trial.","authors":"Zahra Molaeimanesh, Davood Kashipazha, Davood Shalilahmadi, Gholamreza Shamsaei, Shooka Mohammadi","doi":"10.2174/0115748871325292240904060109","DOIUrl":"https://doi.org/10.2174/0115748871325292240904060109","url":null,"abstract":"<p><strong>Background: </strong>It has been proposed that colchicine may have the potential to prevent cardiovascular and cerebrovascular dysfunctions.</p><p><strong>Objective: </strong>This study evaluated the impact of colchicine on preventing recurrent stroke in patients with both ischemic stroke (IS) and atrial fibrillation (AF).</p><p><strong>Methods: </strong>A randomized, double-blinded, placebo-controlled trial was conducted at Golestan Hospital (Ahvaz, Iran) over one year, involving IS patients with AF. Demographic and clinical data were collected from the participants, who were then assigned to either the intervention or placebo groups. The experimental group was administered colchicine at a dosage of 0.05 mg twice daily for one year, while the control group received a placebo at a comparable dosage over the same timeframe.</p><p><strong>Results: </strong>In one year, 108 patients completed the study. There were 55 patients in the intervention group and 53 patients in the placebo group. During the second trimester of the trial, three patients in the colchicine group and 10 patients in the placebo group experienced recurrent strokes. Gastrointestinal issues were the most commonly reported complications (33 cases), followed by myalgia (8 patients). There were significant differences in the frequency of recurrent stroke and serum levels of C-reactive protein (CRP) between the colchicine and placebo groups (P < 0.05) after intervention.</p><p><strong>Conclusion: </strong>In this study, colchicine was effective in reducing recurrent stroke and CRP levels in IS patients with AF compared to the control group. Further randomized controlled trials with larger sample sizes and extended durations are recommended to validate the results of this trial.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Seminal Plasma Malondialdehyde Acid as a Diagnostic Tool for Male Infertility: A Case-Control Study. 将评估精浆丙二醛酸作为男性不育症的诊断工具:病例对照研究
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-09-11 DOI: 10.2174/0115748871306544240826095508
Naina Kumar, K N Deepthi, Suhasini Padugupati, Seetesh Ghose
{"title":"Assessing Seminal Plasma Malondialdehyde Acid as a Diagnostic Tool for Male Infertility: A Case-Control Study.","authors":"Naina Kumar, K N Deepthi, Suhasini Padugupati, Seetesh Ghose","doi":"10.2174/0115748871306544240826095508","DOIUrl":"https://doi.org/10.2174/0115748871306544240826095508","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to assess the role of seminal Malondialdehyde Acid (MDA) in the diagnosis of male infertility.</p><p><strong>Background: </strong>Both male and female infertility is increasing all over the world.</p><p><strong>Objective: </strong>The purpose of this study was to assess the impact of seminal MDA levels on various semen parameters of healthy fertile men and men with infertility, and to know the efficacy of seminal MDA in the diagnosis of male infertility.</p><p><strong>Methods: </strong>This case-control study was carried out at the Department of Obstetrics and Gynaecology of a tertiary care center in rural Southern India over a period of two years. The study included 90 infertile men (≥21-50 years) having some pathology in semen reports as cases and 90 fertile men (having biological children) with normal semen reports as controls. Biochemical tests for MDA were performed using Human MDA Assay kits on 180 cryopreserved semen samples following the standard protocol. Results of seminal MDA levels were assessed among cases and controls and correlated with different semen parameters.</p><p><strong>Results: </strong>The mean±SD age for cases was 30.10 ± 4.75 years, and for controls, it was 29.79 ± 5.08 years. Of all the cases, 44 (48.9%) had asthenozoospermia, 22 (24.4%) had oligoasthenozoospermia, 14(15.6%) had oligozoospermia, and 10 (11.1%) had azoospermia. A statistically substantial variance was observed in mean values of MDA (1.03 ± 0.31 mmol/mL vs. 0.60 ± 0.14 mmol/mL; p =0.001) between fertile men and men with abnormal semen reports. A negative association was observed between semen MDA levels with sperm motility, concentration, and normal morphology in 180 participants. The sensitivity of MDA for male infertility prediction was 86.67% at 76.67% specificity, 78.79% positive predictive value, and 78.79% negative predictive value.</p><p><strong>Conclusion: </strong>MDA has been found to be a promising biomarker for predicting male infertility. However, large sample sizes and prospective cohort studies are required to further confirm its predictive accuracy across various populations.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicentric Post-Marketing Surveillance (PMS) Observational Study of Ascorbic Acid and Zinc Effervescent Tablets in Indian Patients with Vitamin C and Zinc Deficiency. 印度维生素 C 和锌缺乏症患者服用抗坏血酸和锌泡腾片的多中心上市后监测 (PMS) 观察研究。
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-09-10 DOI: 10.2174/0115748871306324240827105922
Ruchika Swami, Sunena
{"title":"Multicentric Post-Marketing Surveillance (PMS) Observational Study of Ascorbic Acid and Zinc Effervescent Tablets in Indian Patients with Vitamin C and Zinc Deficiency.","authors":"Ruchika Swami, Sunena","doi":"10.2174/0115748871306324240827105922","DOIUrl":"https://doi.org/10.2174/0115748871306324240827105922","url":null,"abstract":"<p><strong>Aim: </strong>The objective of this Multicentric Post-Marketing Surveillance (PMS) study was to evaluate the safety and tolerance of vitamin C and zinc tablets in the Indian population experiencing deficiencies of these nutrients. Furthermore, the study aimed to provide insights into physicians' prescription practices and characterise the patient population receiving the study medication.</p><p><strong>Methods: </strong>This prospective observational study involved 358 participants from 8 study sites across India (including 2 government hospital sites), spanning a duration of approximately 12 weeks (3 months). The primary aim was to evaluate the safety and tolerability of zinc and ascorbic acid effervescent tablets for those who were deficient in zinc and vitamin C. Throughout the study period, adverse events were monitored and categorised by MedDRA Primary System Organ Class and Preferred Term. The analysis included evaluating the incidence, percentage, and correlation of adverse events with the treatment (safety population). Additionally, the frequencies of adverse drug reactions were examined across all enrolled patients. Vital signs and symptom-focused physical examinations were conducted during each visit in the safety population.</p><p><strong>Results: </strong>Out of 358 (100%) patients, only 12 (3.35%) experienced minor symptoms in the study period. The majority of patients reported gastrointestinal disorders, i.e., two (0.6%) patients reported constipation and gastritis, respectively. Diarrhoea was reported by four (1.1%) patients. One (0.3%) patient reported gastrointestinal pain. Three (0.8%) patients reported vomiting. Diarrhoea was the most common symptom reported. All patients possess a mild intensity of adverse drug reactions in safety populations. The P-value is less than 0.05 (p-value < 0.05), and therefore there is a statistically significant relationship between the predictor variables and the response variable (i.e., the expected count of adverse drug reactions).</p><p><strong>Conclusion: </strong>The fixed-dose combination of vitamin C and zinc effervescent tablets appears to be safe and tolerable for the treatment of vitamin C and zinc deficiencies in Indian patients. The favorable outcome underscores the mild nature of the adverse reactions and the right medical interventions and support.<p>.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Upright Position during the First Stage of Labour on Maternal Outcomes: A Randomized Controlled Trial. 第一产程直立体位对产妇结局的影响:随机对照试验
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-09-04 DOI: 10.2174/0115748871320194240820202103
Kamlesh Rani, Ramya Kundayi Ravi, Vijeta Attri, Harpreet Kaur, Bharat Pareek, Priya Baby
{"title":"Impact of Upright Position during the First Stage of Labour on Maternal Outcomes: A Randomized Controlled Trial.","authors":"Kamlesh Rani, Ramya Kundayi Ravi, Vijeta Attri, Harpreet Kaur, Bharat Pareek, Priya Baby","doi":"10.2174/0115748871320194240820202103","DOIUrl":"https://doi.org/10.2174/0115748871320194240820202103","url":null,"abstract":"<p><strong>Background: </strong>Maternal position during delivery can affect the physiology of labour and the mechanics of childbirth.</p><p><strong>Objective: </strong>The study aimed to evaluate the impact of an upright position during the first stage of labour on maternal outcomes.</p><p><strong>Methods: </strong>This parallel group randomised control trial was conducted from April to June 2020 among 60 women (30 each in the experimental and control groups) admitted to the selected hospital in Punjab, India. Women who entered the active stage of labour naturally with a single live foetus in cephalic presentation, aged 18-45 years, and with normal body mass index were randomly assigned either to the experimental or control group using a concealed envelope method. Women in the experimental group were informed and encouraged to adopt the upright position, while those in the control group received the standard routine care during the first stage of labour. The effectiveness of upright positions during the first stage of labour was assessed in terms of duration of the first, second, and third stages of labour, mode of delivery, and perineal lacerations. Outcome assessors were blinded to the intervention. The differences in the groups were evaluated by mean, median, frequency, percentage, Chi-square, and t-test.</p><p><strong>Results: </strong>The results of 60 women were analysed. Women in the experimental group experienced a significant reduction in the incidence of instrumental delivery (p =0.005), perineal laceration (p =0.001), and duration of the first stage (p =0.0001) and third stage (p =0.0001) of labour compared to those in the control group. No harm was reported across the study groups.</p><p><strong>Conclusion: </strong>This study urges nurses and midwives to recommend the use of upright positions during the first stage of labour to reduce the duration of labour and incidence of perineal laceration among women.</p><p><strong>Clinical trial registration number: </strong>CTRI/2022/04/041740.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Rapid, Quantitative, and Simultaneous Detection of Drug Residues and Immunoassay in Chickens. 鸡体内药物残留的快速、定量和同步检测及免疫测定研究。
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-08-20 DOI: 10.2174/0115748871305331240724104132
Mohamad Hesam Shahrajabian, Wenli Sun
{"title":"Study on Rapid, Quantitative, and Simultaneous Detection of Drug Residues and Immunoassay in Chickens.","authors":"Mohamad Hesam Shahrajabian, Wenli Sun","doi":"10.2174/0115748871305331240724104132","DOIUrl":"https://doi.org/10.2174/0115748871305331240724104132","url":null,"abstract":"<p><p>Different levels of residual drugs can be monitored within a relatively safe range without causing harm to human health if the appropriate dosing methodology is considered and the drug withdrawal period is controlled during poultry and livestock raising. Antimicrobials are factors that can suppress the growth of microorganisms, and antibiotic residues in livestock farming have been considered as a potential cause of antimicrobial resistance in animals and humans. Antimicrobial drug resistance is associated with the capability of a microorganism to survive the inhibitory effects of the antimicrobial components. Antibiotic residue presence in chicken is a human health concern due to its negative effects on consumer health. Neglected aspects related to the application of veterinary drugs may threaten the safety of both humans and animals, as well as their environment. The detection of chemical contaminants is essential to ensure food quality. The most important antibiotic families used in veterinary medicines are β-lactams (penicillins and cephalosporins), tetracyclines, chloramphenicols, macrolides, spectinomycin, lincosamide, sulphonamides, nitrofuranes, nitroimidazoles, trimethoprim, polymyxins, quinolones, and macrocyclics (glycopeptides, ansamycins, and aminoglycosides). Antibiotic residue presence is the main contributor to the development of antibiotic resistance, which is considered a chief concern for both human and animal health worldwide. The incorrect application and misuse of antibiotics carry the risk of the presence of residues in the edible tissues of the chicken, which can cause allergies and toxicity in hypersensitive consumers. The enforcement of the regulation of food safety depends on efficacious monitoring of antimicrobial residues in the foodstuff. In this review, we have explored the rapid detection of drug residues in broilers.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of a Symbiotic Mixture on Moderate-to-severe Diverticular Disease of the Colon. 共生混合物对中重度结肠憩室病的影响
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-07-24 DOI: 10.2174/0115748871308652240712101604
Antonio Tursi, Giammarco Mocci, Paolo Usai Satta, Walter Elisei
{"title":"Impact of a Symbiotic Mixture on Moderate-to-severe Diverticular Disease of the Colon.","authors":"Antonio Tursi, Giammarco Mocci, Paolo Usai Satta, Walter Elisei","doi":"10.2174/0115748871308652240712101604","DOIUrl":"https://doi.org/10.2174/0115748871308652240712101604","url":null,"abstract":"<p><strong>Background: </strong>Microbial imbalance is thought to play a role in the pathogenesis of Diverticular Disease (DD).</p><p><strong>Objective: </strong>We aimed to assess the efficacy of a symbiotic mixture (Prolactis GG Plus®) in the treatment of moderate to severe DD, scored according to the Diverticular Inflammation and Complication Assessment (DICA) classification.</p><p><strong>Methods: </strong>A retrospective study was conducted enrolling the following patients: at the first diagnosis of DD; in whom DD was diagnosed with colonoscopy and scored according to DICA classification; treated with Prolactis GG Plus® two times/daily for 2 consecutive months; in whom the severity of the abdominal pain was scored with a 10-points visual-analogue scale (VAS) at baseline and the end of follow-up; in whom fecal calprotectin (FC) was assessed at baseline and the end of follow-up as μg/g.</p><p><strong>Results: </strong>Twenty-four patients were identified (10 males, 14 females; 16 as DICA 2, and 8 as DICA 3). Prolactis GG Plus® decreased the severity of abdominal pain both in DICA 2 (p =0.02) and DICA 3 patients (p =0.01), while FC decreased significantly in DICA 2 (p <0.02) but not in DICA 3 (p =0.123) patients. Acute diverticulitis occurred during the follow-up in two DICA 3 patients but none DICA 2 patients. Add-on therapy was required by eight DICA 2 (50%) and six DICA 3 patients (75%).</p><p><strong>Conclusion: </strong>In newly diagnosed patients with DD, the symbiotic mixture Prolactis GG Plus® can be a potential treatment for moderate (DICA 2) DD as a single treatment.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Procalcitonin and qSOFA as a Marker of Mortality in Sepsis. 作为败血症死亡率标志物的降钙素原和 qSOFA。
IF 1.9
Reviews on recent clinical trials Pub Date : 2024-04-19 DOI: 10.2174/0115748871288534240322083746
A. Parrey, Manzoor Koka, B. Kasana, Mohd Ismail
{"title":"Procalcitonin and qSOFA as a Marker of Mortality in Sepsis.","authors":"A. Parrey, Manzoor Koka, B. Kasana, Mohd Ismail","doi":"10.2174/0115748871288534240322083746","DOIUrl":"https://doi.org/10.2174/0115748871288534240322083746","url":null,"abstract":"BACKGROUND\u0000Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The qSOFA and procalcitonin are currently used for both diagnostic as well as prognostic purposes.\u0000\u0000\u0000OBJECTIVE\u0000To explore the combined use of day one procalcitonin level and qSOFA scores for prognostication of sepsis-related mortality Design: This was a prospective observational study.\u0000\u0000\u0000PARTICIPANTS\u0000All patients who fulfilled the inclusion criteria for sepsis with an age of more than 16 years were enrolled in the study Results: In this study of 211 patients, 15 patients died (7.1%) during hospital stay. Among the 15 patients who died, the highest mortality of 29.4% qSOFA of \"2\" had a mortality of 12.8%),qSOFA of \"1\" had a mortality of 1% and qSOFA of \"0\" had zero mortality. In this study, procalcitonin had a statistically significant positive correlation/association with both qSOFA and mortality.\u0000\u0000\u0000CONCLUSION\u0000The qSOFA and procalcitonin at presentation to the emergency department in septic patients have a significant correlation with mortality in patients hospitalized with sepsis. Obtaining these two parameters at presentation will help in managing aggressively these patients who at presentation have higher qSOFA and procalcitonin levels.","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: Comparison of the Efficacy of Oral Magnesium with Oral Ketorolac for Postoperative Pain Management in Anorectal Surgery: A Double-blinded Randomized Clinical Trial 口服镁与口服酮咯酸治疗肛门直肠手术术后疼痛的疗效比较:双盲随机临床试验。
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-03-21 DOI: 10.2174/0115748871290318240218195517
Seyed Jalal Eshagh Hoseini, Farzanesadat Ghazi, Mohsen Eshraghi, Mostafa Vahedian, Mohammad Reza Pashaei, Mohamad Amin Habibi, Sajjad Ahmadpour
{"title":"WITHDRAWN: Comparison of the Efficacy of Oral Magnesium with Oral Ketorolac for Postoperative Pain Management in Anorectal Surgery: A Double-blinded Randomized Clinical Trial","authors":"Seyed Jalal Eshagh Hoseini, Farzanesadat Ghazi, Mohsen Eshraghi, Mostafa Vahedian, Mohammad Reza Pashaei, Mohamad Amin Habibi, Sajjad Ahmadpour","doi":"10.2174/0115748871290318240218195517","DOIUrl":"10.2174/0115748871290318240218195517","url":null,"abstract":"<p><p>The article has been withdrawn at the request of the editor of the journal Reviews on Recent Clinical Trials.</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.</p><p><p>The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction of Various Models of Palliative Oncology Care: A Systematic Review. 介绍各种肿瘤姑息治疗模式:系统性综述。
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-01-01 DOI: 10.2174/0115748871272511231215053624
Mahdieh Arian, Fatemeh Hajiabadi, Zakiyeh Amini, Mohammad Bagher Oghazian, Ali Valinejadi, Amirhossein Sahebkar
{"title":"Introduction of Various Models of Palliative Oncology Care: A Systematic Review.","authors":"Mahdieh Arian, Fatemeh Hajiabadi, Zakiyeh Amini, Mohammad Bagher Oghazian, Ali Valinejadi, Amirhossein Sahebkar","doi":"10.2174/0115748871272511231215053624","DOIUrl":"10.2174/0115748871272511231215053624","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to synthesize the existing evidence on various palliative care (PC) models for cancer patients. This effort seeks to discern which facets of PC models are suitable for various patient cohorts, elucidate their mechanisms, and clarify the circumstances in which these models operate.</p><p><strong>Methods: </strong>A comprehensive search was performed using MeSH terms related to PC and cancer across various databases. The Preferred Reporting Items for Systematic Reviews and a comprehensive evidence map were also applied.</p><p><strong>Results: </strong>Thirty-three reviews were published between 2009 and 2023. The conceptual PC models can be classified broadly into time-based, provider-based, disease-based, nurse-based, issue-based, system-based, team-based, non-hospice-based, hospital-based, community-based, telehealth-based, and setting-based models. The study argues that the outcomes of PC encompass timely symptom management, longitudinal psychosocial support, enhanced communication, and decision-making. Referral methods to specialized PC services include oncologist-initiated referral based on clinical judgment alone, via referral criteria, automatic referral at the diagnosis of advanced cancer, or referral based on symptoms or other triggers.</p><p><strong>Conclusion: </strong>The gold standard for selecting a PC model in the context of oncology is a model that ensures broad availability of early PC for all patients and provides well-timed, scheduled, and specialized care for patients with the greatest requirement.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness. 代谢手术对肝脏硬度影响的系统性回顾和元分析
IF 1.4
Reviews on recent clinical trials Pub Date : 2024-01-01 DOI: 10.2174/0115748871303052240529102003
Tannaz Jamialahamdi, Matthew Kroh, Sorour Ashari, Wael Almahmeed, Ali Jangjoo, Luis E Simental-Mendía, Sepideh Salehabadi, Khalid Al-Rasadi, Amirhossein Sahebkar
{"title":"Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness.","authors":"Tannaz Jamialahamdi, Matthew Kroh, Sorour Ashari, Wael Almahmeed, Ali Jangjoo, Luis E Simental-Mendía, Sepideh Salehabadi, Khalid Al-Rasadi, Amirhossein Sahebkar","doi":"10.2174/0115748871303052240529102003","DOIUrl":"10.2174/0115748871303052240529102003","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgery is one of the effective therapeutic options for people with obesity and obesity-related co-morbidities. In addition to weight-related co-morbid diseases, including diabetes, hypertension, and hypercholesterolemia, non-alcoholic fatty liver disease (NAFLD) is common in patients with morbid obesity. Bariatric surgery is one of the therapeutic options in the management of NAFLD. Hence, this review focused on the potential role of bariatric surgery on hepatic elasticity measured through shear wave elastography.</p><p><strong>Methods: </strong>A systematic literature search was performed, and the studies regarding heterogeneity were evaluated using the random-effects model.</p><p><strong>Results: </strong>The meta-analysis on 6 trials (3-12 months follow-up) including 350 participants showed a significant reduction of liver elasticity after surgery (WMD: -1.149, 95% CI: -1.767, -0.532, p < 0.001; I2:81.55%).</p><p><strong>Conclusion: </strong>Bariatric surgery is associated with decreased liver elasticity. This improvement could be related to weight loss or other mechanisms of bariatric surgery.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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