Assessing Seminal Plasma Malondialdehyde Acid as a Diagnostic Tool for Male Infertility: A Case-Control Study.

IF 1.4 Q4 PHARMACOLOGY & PHARMACY
Naina Kumar, K N Deepthi, Suhasini Padugupati, Seetesh Ghose
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引用次数: 0

Abstract

Aim: The aim of this study was to assess the role of seminal Malondialdehyde Acid (MDA) in the diagnosis of male infertility.

Background: Both male and female infertility is increasing all over the world.

Objective: The purpose of this study was to assess the impact of seminal MDA levels on various semen parameters of healthy fertile men and men with infertility, and to know the efficacy of seminal MDA in the diagnosis of male infertility.

Methods: This case-control study was carried out at the Department of Obstetrics and Gynaecology of a tertiary care center in rural Southern India over a period of two years. The study included 90 infertile men (≥21-50 years) having some pathology in semen reports as cases and 90 fertile men (having biological children) with normal semen reports as controls. Biochemical tests for MDA were performed using Human MDA Assay kits on 180 cryopreserved semen samples following the standard protocol. Results of seminal MDA levels were assessed among cases and controls and correlated with different semen parameters.

Results: The mean±SD age for cases was 30.10 ± 4.75 years, and for controls, it was 29.79 ± 5.08 years. Of all the cases, 44 (48.9%) had asthenozoospermia, 22 (24.4%) had oligoasthenozoospermia, 14(15.6%) had oligozoospermia, and 10 (11.1%) had azoospermia. A statistically substantial variance was observed in mean values of MDA (1.03 ± 0.31 mmol/mL vs. 0.60 ± 0.14 mmol/mL; p =0.001) between fertile men and men with abnormal semen reports. A negative association was observed between semen MDA levels with sperm motility, concentration, and normal morphology in 180 participants. The sensitivity of MDA for male infertility prediction was 86.67% at 76.67% specificity, 78.79% positive predictive value, and 78.79% negative predictive value.

Conclusion: MDA has been found to be a promising biomarker for predicting male infertility. However, large sample sizes and prospective cohort studies are required to further confirm its predictive accuracy across various populations.

将评估精浆丙二醛酸作为男性不育症的诊断工具:病例对照研究
目的:本研究旨在评估精液丙二醛酸(MDA)在诊断男性不育症中的作用:背景:男性和女性不育症在全世界都呈上升趋势:本研究旨在评估精液中丙二醛酸水平对健康育龄男性和不育男性精液各项指标的影响,并了解精液中丙二醛酸在诊断男性不育症中的作用:这项病例对照研究在印度南部农村地区一家三级医疗中心的妇产科进行,为期两年。研究对象包括 90 名精液报告有病变的不育男性(≥21-50 岁)作为病例,90 名精液报告正常的可育男性(有亲生子女)作为对照。按照标准方案,使用人类 MDA 检测试剂盒对 180 份冷冻保存的精液样本进行了 MDA 生化检测。对病例和对照组的精液 MDA 水平进行评估,并将其与不同的精液参数联系起来:病例的平均年龄(±SD)为 30.10 ± 4.75 岁,对照组为 29.79 ± 5.08 岁。在所有病例中,44 例(48.9%)为无精子症,22 例(24.4%)为少精子症,14 例(15.6%)为少精子症,10 例(11.1%)为无精子症。有生育能力的男性和精液报告异常的男性的 MDA 平均值(1.03 ± 0.31 mmol/mL vs. 0.60 ± 0.14 mmol/mL;P =0.001)在统计学上存在显著差异。在 180 名参与者中观察到,精液 MDA 水平与精子活力、浓度和正常形态之间呈负相关。MDA预测男性不育的敏感性为86.67%,特异性为76.67%,阳性预测值为78.79%,阴性预测值为78.79%:结论:MDA被认为是预测男性不育症的一种有前途的生物标志物。结论:MDA 被认为是预测男性不育症的一种很有前景的生物标志物,但还需要大样本量和前瞻性队列研究来进一步证实其在不同人群中的预测准确性。
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来源期刊
Reviews on recent clinical trials
Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-
CiteScore
3.10
自引率
5.30%
发文量
44
期刊介绍: Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.
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