Reviews of Physiology Biochemistry and Pharmacology最新文献_第9页

Curcumin as a MicroRNA Regulator in Cancer: A Review. 姜黄素在癌症中的MicroRNA调节作用综述

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_3

Amir Abbas Momtazi, Fahimeh Shahabipour, Sepideh Khatibi, Thomas P Johnston, Matteo Pirro, Amirhossein Sahebkar

{"title":"Curcumin as a MicroRNA Regulator in Cancer: A Review.","authors":"Amir Abbas Momtazi, Fahimeh Shahabipour, Sepideh Khatibi, Thomas P Johnston, Matteo Pirro, Amirhossein Sahebkar","doi":"10.1007/112_2016_3","DOIUrl":"https://doi.org/10.1007/112_2016_3","url":null,"abstract":"Curcumin is a natural dietary polyphenol for which anti-tumor effects have been documented. Anti-inflammatory and antioxidant properties of curcumin, along with its immunomodulatory, proapoptotic, and antiangiogenic properties, are often referred to as the main mechanisms underlying the anti-tumor effects. At the molecular level, inhibition of NF-kB, Akt/PI3K, and MAPK pathways and enhancement of p53 are among the most important anticancer alterations induced by curcumin. Recent evidence has suggested that epigenetic alterations are also involved in the anti-tumor properties of curcumin. Among these curcumin-induced epigenetic alterations is modulation of the expression of several oncogenic and tumor suppressor microRNAs (miRNAs). Suppression of oncomiRs such as miR-21, miR-17-5p, miR-20a, and miR-27a and over-expression of miR-34 a/c and epithelial-mesenchymal transition-suppressor miRNAs are among the most important effects of curcumin on miRNA homeostasis. The present review will summarize the findings of in vitro and experimental studies on the impact of curcumin and its analogues on the expression of miRNAs involved in different stages of tumor initiation, growth, metastasis, and chemo-resistance.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"171 ","pages":"1-38"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2016_3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34703147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 201

Erratum to: Intrauterine Growth Retardation (IUGR) as a Novel Condition of Insulin-Like Growth Factor-1 (IGF-1) Deficiency. 宫内生长迟缓(IUGR)是胰岛素样生长因子-1 (IGF-1)缺乏的一种新情况。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_1

I. Martín-Estal, R. G. de la Garza, I. Castilla-Cortázar

引用次数: 2

Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart. Ryanodine受体氧化对心脏细胞内钙调节的功能影响。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_2

Aleksey V Zima, Stefan R Mazurek

{"title":"Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart.","authors":"Aleksey V Zima, Stefan R Mazurek","doi":"10.1007/112_2016_2","DOIUrl":"https://doi.org/10.1007/112_2016_2","url":null,"abstract":"Type 2 ryanodine receptor (RyR2) serves as the major intracellular Ca2+ release channel that drives heart contraction. RyR2 is activated by cytosolic Ca2+ via the process of Ca2+-induced Ca2+ release (CICR). To ensure stability of Ca2+ dynamics, the self-reinforcing CICR must be tightly controlled. Defects in this control cause sarcoplasmic reticulum (SR) Ca2+ mishandling, which manifests in a variety of cardiac pathologies that include myocardial infarction and heart failure. These pathologies are also associated with oxidative stress. Given that RyR2 contains a large number of cysteine residues, it is no surprise that RyR2 plays a key role in the cellular response to oxidative stress. RyR's many cysteine residues pose an experimental limitation in defining a specific target or mechanism of action for oxidative stress. As a result, the current understanding of redox-mediated RyR2 dysfunction remains incomplete. Several oxidative modifications, including S-glutathionylation and S-nitrosylation, have been suggested playing an important role in the regulation of RyR2 activity. Moreover, oxidative stress can increase RyR2 activity by forming disulfide bonds between two neighboring subunits (intersubunit cross-linking). Since intersubunit interactions within the RyR2 homotetramer complex dictate the channel gating, such posttranslational modification of RyR2 would have a significant impact on RyR2 function and Ca2+ regulation. This review summarizes recent findings on oxidative modifications of RyR2 and discusses contributions of these RyR2 modifications to SR Ca2+ mishandling during cardiac pathologies.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"171 ","pages":"39-62"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2016_2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34604049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Electromagnetic Fields and Stem Cell Fate: When Physics Meets Biology. 电磁场与干细胞的命运:当物理学与生物学相遇。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_4

Sara Hassanpour Tamrin, Fatemeh Sadat Majedi, Mahdi Tondar, Amir Sanati-Nezhad, Mohammad Mahdi Hasani-Sadrabadi

引用次数: 19

Intrauterine Growth Retardation (IUGR) as a Novel Condition of Insulin-Like Growth Factor-1 (IGF-1) Deficiency. 宫内生长迟缓(IUGR)是胰岛素样生长因子-1 (IGF-1)缺乏的一种新情况。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2015_5001

I. Martín-Estal, R. G. D. L. Garza, I. Castilla-Cortázar

引用次数: 53

Exosomes: From Functions in Host-Pathogen Interactions and Immunity to Diagnostic and Therapeutic Opportunities. 外泌体:从宿主-病原体相互作用和免疫功能到诊断和治疗机会。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_7

Jessica Carrière, Nicolas Barnich, Hang Thi Thu Nguyen

引用次数: 21

Hepatic Stellate Cells in Liver Fibrosis and siRNA-Based Therapy. 肝星状细胞在肝纤维化中的作用及sirna治疗。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_6

Refaat Omar, Jiaqi Yang, Haoyuan Liu, Neal M Davies, Yuewen Gong

{"title":"Hepatic Stellate Cells in Liver Fibrosis and siRNA-Based Therapy.","authors":"Refaat Omar, Jiaqi Yang, Haoyuan Liu, Neal M Davies, Yuewen Gong","doi":"10.1007/112_2016_6","DOIUrl":"https://doi.org/10.1007/112_2016_6","url":null,"abstract":"Hepatic fibrosis is a reversible wound-healing response to either acute or chronic liver injury caused by hepatitis B or C, alcohol, and toxic agents. Hepatic fibrosis is characterized by excessive accumulation and reduced degradation of extracellular matrix (ECM). Excessive accumulation of ECM alters the hepatic architecture leading to liver fibrosis and cirrhosis. Cirrhosis results in failure of common functions of the liver. Hepatic stellate cells (HSC) play a major role in the development of liver fibrosis as HSC are the main source of the excessive production of ECM in an injured liver. RNA interference (RNAi) is a recently discovered therapeutic tool that may provide a solution to manage multiple diseases including liver fibrosis through silencing of specific gene expression in diseased cells. However, gene silencing using small interfering RNA (siRNA) is encountering many challenges in the body after systemic administration. Efficient and stable siRNA delivery to the target cells is a key issue for the development of siRNA therapeutic. For that reason, various viral and non-viral carriers for liver-targeted siRNA delivery have been developed. This review will cover the current strategies for the treatment of liver fibrosis as well as discussing non-viral approaches such as cationic polymers and lipid-based nanoparticles for targeted delivery of siRNA to the liver.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"172 ","pages":"1-37"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2016_6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34376683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

The Zebrafish Heart as a Model of Mammalian Cardiac Function. 斑马鱼心脏作为哺乳动物心脏功能的模型。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_5

Christine E Genge, Eric Lin, Ling Lee, XiaoYe Sheng, Kaveh Rayani, Marvin Gunawan, Charles M Stevens, Alison Yueh Li, Sanam Shafaat Talab, Thomas W Claydon, Leif Hove-Madsen, Glen F Tibbits

{"title":"The Zebrafish Heart as a Model of Mammalian Cardiac Function.","authors":"Christine E Genge, Eric Lin, Ling Lee, XiaoYe Sheng, Kaveh Rayani, Marvin Gunawan, Charles M Stevens, Alison Yueh Li, Sanam Shafaat Talab, Thomas W Claydon, Leif Hove-Madsen, Glen F Tibbits","doi":"10.1007/112_2016_5","DOIUrl":"https://doi.org/10.1007/112_2016_5","url":null,"abstract":"Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and functional genomics as well as in cardiac structure-function studies. The zebrafish heart has been increasingly used as a model of human cardiac function, in part, due to the similarities in heart rate and action potential duration and morphology with respect to humans. The teleostian zebrafish is in many ways a compelling model of human cardiac function due to the clarity afforded by its ease of genetic manipulation, the wealth of developmental biological information, and inherent suitability to a variety of experimental techniques. However, in addition to the numerous advantages of the zebrafish system are also caveats related to gene duplication (resulting in paralogs not present in human or other mammals) and fundamental differences in how zebrafish hearts function. In this review, we discuss the use of zebrafish as a cardiac function model through the use of techniques such as echocardiography, optical mapping, electrocardiography, molecular investigations of excitation-contraction coupling, and their physiological implications relative to that of the human heart. While some of these techniques (e.g., echocardiography) are particularly challenging in the zebrafish because of diminutive size of the heart (~1.5 mm in diameter) critical information can be derived from these approaches and are discussed in detail in this article.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"171 ","pages":"99-136"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2016_5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34379008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Cardiac Response to Oxidative Stress Induced by Mitochondrial Dysfunction. 线粒体功能障碍诱导氧化应激的心脏反应。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2015_5004

Hyoung-Kyu Kim, B. Nilius, Nari Kim, K. Ko, B. Rhee, Jin Han

引用次数: 18

The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias. 心律失常中的应激反应MAP激酶信号传导。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2016-01-01 DOI: 10.1007/112_2016_8

Xun Ai, Jiajie Yan, Elena Carrillo, Wenmao Ding

引用次数: 10