ASIC1a在正常和病理突触可塑性中的作用。

2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2020-01-01 DOI:10.1007/112_2020_45

Dalila Mango, Robert Nisticò

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引用次数: 7

摘要

酸感离子通道(asic)是退行性蛋白/上皮Na+通道超家族的成员，广泛分布于哺乳动物神经系统中，在神经传递和记忆相关行为等多种生理过程中发挥重要作用。在过去的几年里，我们和其他人已经研究了ASIC1a在不同形式的突触可塑性中的作用，特别是在海马的CA1区域。本文综述了ASIC1a在生理或病理条件下与突触功能联系的最新研究。更好地了解这些通道如何在与突触可塑性和记忆相关的脑回路中被调节，可能为神经精神和神经疾病的药物干预提供新的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of ASIC1a in Normal and Pathological Synaptic Plasticity.

Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are broadly distributed in the mammalian nervous system where they play important roles in a variety of physiological processes, including neurotransmission and memory-related behaviors. In the last few years, we and others have investigated the role of ASIC1a in different forms of synaptic plasticity especially in the CA1 area of the hippocampus. This review summarizes the latest research linking ASIC1a to synaptic function either in physiological or pathological conditions. A better understanding of how these channels are regulated in brain circuitries relevant to synaptic plasticity and memory may offer novel targets for pharmacological intervention in neuropsychiatric and neurological disorders.

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来源期刊

Reviews of Physiology Biochemistry and Pharmacology 医学-生化与分子生物学

CiteScore

11.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.