Reviews of Physiology Biochemistry and Pharmacology最新文献_第7页

Ion Channels in Glioma Malignancy. 恶性胶质瘤中的离子通道。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_44

Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, Fabio Franciolini

{"title":"Ion Channels in Glioma Malignancy.","authors":"Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, Fabio Franciolini","doi":"10.1007/112_2020_44","DOIUrl":"https://doi.org/10.1007/112_2020_44","url":null,"abstract":"Brain tumors come in many types and differ greatly in outcome. They are classified by the cell of origin (astrocytoma, ependymoma, meningioma, medulloblastoma, glioma), although more recently molecular markers are used in addition to histology. Brain tumors are graded (from I to IV) to measure their malignancy. Glioblastoma, one of the most common adult primary brain tumors, displays the highest malignancy (grade IV), and median survival of about 15 months. Main reasons for poor outcome are incomplete surgical resection, due to the highly invasive potential of glioblastoma cells, and chemoresistance that commonly develops during drug treatment. An important role in brain tumor malignancy is played by ion channels. The Ca2+-activated K+ channels of large and intermediate conductance, KCa3.1 and KCa1.1, and the volume-regulated anion channel, whose combined activity results in the extrusion of KCl and osmotic water, control cell volume, and in turn migration, invasion, and apoptotic cell death. The transient receptor potential (TRP) channels and low threshold-activated Ca (T-type) channels have equally critical role in brain tumor malignancy, as dysregulated Ca2+ signals heavily impact on glioma cell proliferation, migration, invasion. The review provides an overview of the current evidence involving these channels in brain tumor malignancy, and the application of these insights in the light of future prospects for experimental and clinical practice.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"181 ","pages":"223-267"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_44","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38383026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Developmental Changes in Phosphate Homeostasis. 磷酸盐稳态的发育变化。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_52

Tate MacDonald, Matthew Saurette, Megan R Beggs, R Todd Alexander

引用次数: 1

Potential of Renin-Angiotensin-Aldosterone System Modulations in Diabetic Kidney Disease: Old Players to New Hope! 肾素-血管紧张素-醛固酮系统调节在糖尿病肾病中的潜力:从老玩家到新希望!

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_50

Vajir Malek, Sachin V Suryavanshi, Nisha Sharma, Yogesh A Kulkarni, Shrikant R Mulay, Anil Bhanudas Gaikwad

{"title":"Potential of Renin-Angiotensin-Aldosterone System Modulations in Diabetic Kidney Disease: Old Players to New Hope!","authors":"Vajir Malek, Sachin V Suryavanshi, Nisha Sharma, Yogesh A Kulkarni, Shrikant R Mulay, Anil Bhanudas Gaikwad","doi":"10.1007/112_2020_50","DOIUrl":"https://doi.org/10.1007/112_2020_50","url":null,"abstract":"Due to a tragic increase in the incidences of diabetes globally, diabetic kidney disease (DKD) has emerged as one of the leading causes of end-stage renal diseases (ESRD). Hyperglycaemia-mediated overactivation of the renin-angiotensin-aldosterone system (RAAS) is key to the development and progression of DKD. Consequently, RAAS inhibition by angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) is the first-line therapy for the clinical management of DKD. However, numerous clinical and preclinical evidences suggested that RAAS inhibition can only halt the progression of the DKD to a certain extent, and they are inadequate to cure DKD completely. Recent studies have improved understanding of the complexity of the RAAS. It consists of two counter-regulatory arms, the deleterious pressor arm (ACE/angiotensin II/AT1 receptor axis) and the beneficial depressor arm (ACE2/angiotensin-(1-7)/Mas receptor axis). These advances have paved the way for the development of new therapies targeting the RAAS for better treatment of DKD. In this review, we aimed to summarise the involvement of the depressor arm of the RAAS in DKD. Moreover, in modern drug discovery and development, an advance approach is the bispecific therapeutics, targeting two independent signalling pathways. Here, we discuss available reports of these bispecific drugs involving the RAAS as well as propose potential treatments based on neurohormonal balance as credible therapeutic strategies for DKD.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"179 ","pages":"31-71"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_50","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38424971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Membrane Transporters and Channels in Melanoma. 黑色素瘤中的膜转运蛋白和通道。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_17

Ines Böhme, Roland Schönherr, Jürgen Eberle, Anja Katrin Bosserhoff

引用次数: 9

Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening. 前列腺癌的离子通道分析:面向细胞群体特异性筛选。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_22

Valerio Farfariello, Natalia Prevarskaya, Dimitra Gkika

{"title":"Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening.","authors":"Valerio Farfariello, Natalia Prevarskaya, Dimitra Gkika","doi":"10.1007/112_2020_22","DOIUrl":"https://doi.org/10.1007/112_2020_22","url":null,"abstract":"In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate carcinogenesis, including cell proliferation, apoptosis, migration, and angiogenesis. The changes in the expression of individual ion channels show a specific profile, making these proteins promising clinical biomarkers that may enable better molecular subtyping of the disease and lead to more rapid and accurate clinical decision-making. Expression profiles and channel function are mainly based on the tumoral tissue itself, in this case, the epithelial cancer cell population. To date, little data on the ion channel profile of the cancerous prostate stroma are available, even though tumor interactions with the microenvironment are crucial in carcinogenesis and each distinct population plays a specific role in tumor progression. In this review, we describe ion channel expression profiles specific for the distinct cell population of the tumor microenvironment (stromal, endothelial, neuronal, and neuroendocrine cell populations) and the technical approaches used for efficient separation and screening of these cell populations.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"181 ","pages":"39-56"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_22","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38214150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Histone Deacetylases in Monocyte Function in Health and Chronic Inflammatory Diseases. 组蛋白去乙酰化酶在健康和慢性炎性疾病单核细胞功能中的作用。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2021_59

Rosa María Tordera, María Cortés-Erice

{"title":"Role of Histone Deacetylases in Monocyte Function in Health and Chronic Inflammatory Diseases.","authors":"Rosa María Tordera, María Cortés-Erice","doi":"10.1007/112_2021_59","DOIUrl":"https://doi.org/10.1007/112_2021_59","url":null,"abstract":"Histone deacetylases (HDACs) are a family of 18 members that participate in the epigenetic regulation of gene expression. In addition to histones, some HDACs also deacetylate transcription factors and specific cytoplasmic proteins.Monocytes, as part of the innate immune system, maintain tissue homeostasis and help fight infections and cancer. In these cells, HDACs are involved in multiple processes including proliferation, migration, differentiation, inflammatory response, infections, and tumorigenesis. Here, a systematic description of the role that most HDACs play in these functions is reviewed. Specifically, some HDACs induce a pro-inflammatory response and play major roles in host defense. Conversely, other HDACs reprogram monocytes and macrophages towards an immunosuppressive phenotype. The right balance between both types helps monocytes to respond correctly to the different physiological/pathological stimuli. However, aberrant expressions or activities of specific HDACs are associated with autoimmune diseases along with other chronic inflammatory diseases, infections, or cancer.This paper critically reviews the interesting and extensive knowledge regarding the role of some HDACs in these pathologies. It also shows that as yet, very little progress has been made toward the goal of finding effective HDAC-targeted therapies. However, given their obvious potential, we conclude that it is worth the effort to develop monocyte-specific drugs that selectively target HDAC subtypes with the aim of finding effective treatments for diseases in which our innate immune system is involved.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"180 ","pages":"1-47"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2021_59","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38970134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Placenta as a Target for Alcohol During Pregnancy: The Close Relation with IGFs Signaling Pathway. 妊娠期间胎盘作为酒精的靶点:与IGFs信号通路密切相关

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2021_58

Irene Martín-Estal, Inma Castilla-Cortázar, Fabiola Castorena-Torres

{"title":"The Placenta as a Target for Alcohol During Pregnancy: The Close Relation with IGFs Signaling Pathway.","authors":"Irene Martín-Estal, Inma Castilla-Cortázar, Fabiola Castorena-Torres","doi":"10.1007/112_2021_58","DOIUrl":"https://doi.org/10.1007/112_2021_58","url":null,"abstract":"Alcohol is one of the most consumed drugs in the world, even during pregnancy. Its use is a risk factor for developing adverse outcomes, e.g. fetal death, miscarriage, fetal growth restriction, and premature birth, also resulting in fetal alcohol spectrum disorders. Ethanol metabolism induces an oxidative environment that promotes the oxidation of lipids and proteins, triggers DNA damage, and advocates mitochondrial dysfunction, all of them leading to apoptosis and cellular injury. Several organs are altered due to this harmful behavior, the brain being one of the most affected. Throughout pregnancy, the human placenta is one of the most important organs for women's health and fetal development, as it secretes numerous hormones necessary for a suitable intrauterine environment. However, our understanding of the human placenta is very limited and even more restricted is the knowledge of the impact of toxic substances in its development and fetal growth. So, could ethanol consumption during this period have wounding effects in the placenta, compromising proper fetal organ development? Several studies have demonstrated that alcohol impairs various signaling cascades within G protein-coupled receptors and tyrosine kinase receptors, mainly through its action on insulin and insulin-like growth factor 1 (IGF-1) signaling pathway. This last cascade is involved in cell proliferation, migration, and differentiation and in placentation. This review tries to examine the current knowledge and gaps in our existing understanding of the ethanol effects in insulin/IGFs signaling pathway, which can explain the mechanism to elucidate the adverse actions of ethanol in the maternal-fetal interface of mammals.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"180 ","pages":"119-153"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2021_58","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39017576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes. 姜黄素在类风湿关节炎中的免疫调节作用:从分子机制到临床结果的证据。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_54

Saeed Mohammadian Haftcheshmeh, Arezou Khosrojerdi, Ali Aliabadi, Shadi Lotfi, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni

{"title":"Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes.","authors":"Saeed Mohammadian Haftcheshmeh, Arezou Khosrojerdi, Ali Aliabadi, Shadi Lotfi, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni","doi":"10.1007/112_2020_54","DOIUrl":"https://doi.org/10.1007/112_2020_54","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disorder characterized by the destruction of the joint and bone resorption. The production of pro-inflammatory cytokines and chemokines, dysregulated functions of three important subtypes of T helper (TH) cells including TH1, TH17, and regulator T (Treg) cells are major causes of the initiation and development of RA. Moreover, B cells as a source of the production of several autoantibodies play key roles in the pathogenesis of RA. The last decades have seen increasingly rapid advances in the field of immunopharmacology using natural origin compounds for the management of various inflammatory diseases. Curcumin, a main active polyphenol compound isolated from turmeric, curcuma longa, possesses a wide range of pharmacologic properties for the treatment of several diseases. This review comprehensively will assess beneficial immunomodulatory effects of curcumin on the production of pro-inflammatory cytokines and also dysregulated functions of immune cells including TH1, TH17, Treg, and B cells in RA. We also seek the clinical efficacy of curcumin for the treatment of RA in several recent clinical trials. In conclusion, curcumin has been found to ameliorate RA complications through modulating inflammatory and autoreactive responses in immune cells and synovial fibroblast cells via inhibiting the expression or function of pro-inflammatory mediators, such as nuclear factor-κB (NF-κB), activated protein-1 (AP-1), and mitogen-activated protein kinases (MAPKs). Of note, curcumin treatment without any adverse effects can attenuate the clinical symptoms of RA patients and, therefore, has therapeutic potential for the treatment of the diseases.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"179 ","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_54","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38786207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression. 肿瘤环境对离子通道的影响:对乳腺癌进展的影响。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_19

Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, Ahmed Ahidouch

引用次数: 0

How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer. 失调的离子通道和转运蛋白如何参与食管癌、肝癌和结直肠癌。

2区医学

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2021-01-01 DOI: 10.1007/112_2020_41

Christian Stock

{"title":"How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer.","authors":"Christian Stock","doi":"10.1007/112_2020_41","DOIUrl":"https://doi.org/10.1007/112_2020_41","url":null,"abstract":"Over the last two decades, the understanding of how dysregulated ion channels and transporters are involved in carcinogenesis and tumor growth and progression, including invasiveness and metastasis, has been increasing exponentially. The present review specifies virtually all ion channels and transporters whose faulty expression or regulation contributes to esophageal, hepatocellular, and colorectal cancer. The variety reaches from Ca2+, K+, Na+, and Cl- channels over divalent metal transporters, Na+ or Cl- coupled Ca2+, HCO3- and H+ exchangers to monocarboxylate carriers and organic anion and cation transporters. In several cases, the underlying mechanisms by which these ion channels/transporters are interwoven with malignancies have been fully or at least partially unveiled. Ca2+, Akt/NF-κB, and Ca2+- or pH-dependent Wnt/β-catenin signaling emerge as cross points through which ion channels/transporters interfere with gene expression, modulate cell proliferation, trigger epithelial-to-mesenchymal transition, and promote cell motility and metastasis. Also miRs, lncRNAs, and DNA methylation represent potential links between the misexpression of genes encoding for ion channels/transporters, their malfunctioning, and cancer. The knowledge of all these molecular interactions has provided the basis for therapeutic strategies and approaches, some of which will be broached in this review.","PeriodicalId":21169,"journal":{"name":"Reviews of Physiology Biochemistry and Pharmacology","volume":"181 ","pages":"129-222"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/112_2020_41","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38335962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7