Progress in cardiovascular diseases最新文献

{"title":"Calcified coronary lesions: Imaging, prognosis, preparation and treatment state of the art review","authors":"","doi":"10.1016/j.pcad.2024.06.007","DOIUrl":"10.1016/j.pcad.2024.06.007","url":null,"abstract":"<div><div><span>Calcific coronary artery stenosis<span><span> is a complex disease associated with adverse outcomes and suboptimal percutaneous treatment. Calcium plaque modification has emerged as a key strategy to tackle the issues that accompany calcific stenosis - namely reduced device deliverability, unpredictable lesion characteristics, and difficult dilatation. </span>Atherectomy has traditionally been the treatment modality of choice for heavily calcified coronary stenoses. Contemporary technologies have emerged to aid with planning, preparation, and treatment of calcified coronary stenosis in an attempt to improve procedural success and long-term outcomes. In this </span></span><em>State Of The Art Review</em><span>, we synthesize the body of data surrounding the diagnosis, imaging, and treatment of calcific coronary disease<span>, with a focus on i) intravascular imaging, ii) calcific lesion preparation, iii) treatment modalities including atherectomy, and iv) updated treatment algorithms for the management of calcified coronary stenosis.</span></span></div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"86 ","pages":"Pages 26-37"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of recent issues","authors":"","doi":"10.1016/S0033-0620(24)00133-6","DOIUrl":"10.1016/S0033-0620(24)00133-6","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"86 ","pages":"Page A3"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of artificial intelligence in cardiovascular magnetic resonance imaging","authors":"","doi":"10.1016/j.pcad.2024.06.004","DOIUrl":"10.1016/j.pcad.2024.06.004","url":null,"abstract":"<div><div>Cardiovascular magnetic resonance (CMR) imaging is the gold standard test for myocardial tissue characterization<span> and chamber volumetric and functional evaluation. However, manual CMR analysis can be time-consuming and is subject to intra- and inter-observer variability. Artificial intelligence (AI) is a field that permits automated task performance through the identification of high-level and complex data relationships. In this review, we review the rapidly growing role of AI in CMR, including image acquisition, sequence prescription, artifact detection, reconstruction, segmentation, and data reporting and analysis including quantification of volumes, function, myocardial infarction (MI) and scar detection, and prediction of outcomes. We conclude with a discussion of the emerging challenges to widespread adoption and solutions that will allow for successful, broader uptake of this powerful technology.</span></div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"86 ","pages":"Pages 13-25"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence, patients' characteristics, and hyper-Lp(a)-emia risk factors in the Polish population. The first results from the PMMHRI-Lp(a) Registry","authors":"Bożena Sosnowska ,&nbsp;Joanna Lewek ,&nbsp;Weronika Adach ,&nbsp;Karina Mierczak ,&nbsp;Agata Bielecka-Dąbrowa ,&nbsp;Konrad Szosland ,&nbsp;Arkadiusz Zygmunt ,&nbsp;Jan Dąbrowski ,&nbsp;Maciej Banach","doi":"10.1016/j.pcad.2024.08.004","DOIUrl":"10.1016/j.pcad.2024.08.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The knowledge on the prevalence of elevated lipoprotein(a) (Lp(a)), patients' characteristics, and nongenetic risk factors is scarce in some regions including Poland, the largest Central and Eastern European country. Thus, we aimed to present the results from the Lp(a) registry established in Poland's 2nd largest, supra-regional hospital - the Polish Mother's Memorial Hospital Research Institute (PMMHRI).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The PMMHRI-Lp(a)-Registry was established in January 2022. Since that time all consecutive patients of the Departments of Cardiology, Endocrinology, and outpatient cardiology, diabetology and metabolic clinics have been included. The indications for Lp(a) measurement in the registry are based on the 2021 Polish Lipid Guidelines and new Polish recommendations on the management of elevated Lp(a) (2024). Lp(a) was determined using Sentinel's Lp(a) Ultra, an Immunoturbidimetric quantitative test (Sentinel, Milan, Italy), and the results are presented in mg/dL.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;511 patients were included in the registry between Jan 2022 and 15th May 2024. The mean age of patients was 48.21 years. Female patients represented 53.42 % of the population. Elevated Lp(a) levels above 30 and 50 mg/dL were detected in 142 (27.79 %), and 101 (19.8 %) patients, respectively. The mean Lp(a) level was 30.45 ± 42.50 mg/dL, with no significant sex differences [mean for men: 28.80 mg/dL; women: 31.89 mg/dL]. There were also no significant differences between those with and without: coronary artery disease (CAD), dyslipidemia, stroke, heart failure, cancer, diabetes, chronic kidney disease, and thyroid disease. The significant Lp(a) level difference was observed in those with a history of myocardial infarction (MI) vs those without (51.47 ± 55.16 vs 28.09 ± 37.51 mg/dL, &lt;em&gt;p&lt;/em&gt; &lt; 0.001). However, when we divided those with premature vs no premature MI, no significant difference in Lp(a) level was observed (51.43 ± 57.82 vs 51.52 ± 53.18 mg/dL, &lt;em&gt;p&lt;/em&gt; = 0.95). Lipid-lowering therapy (LLT) at baseline did not significantly affect Lp(a) level, with only significant differences for the highest doses of rosuvastatin (&lt;em&gt;p&lt;/em&gt; &lt; 0.05) and in those treated with ezetimibe (as a part of the combination therapy; 44.73 ± 54.94 vs 26.84 ± 37.11 mg/dL, &lt;em&gt;p&lt;/em&gt; &lt; 0.001). For selected patients (&lt;em&gt;n&lt;/em&gt; = 43; 8.42 %) with at least two Lp(a) measurements (mean time distance: 7 ± 5 months, range 1–20 months) we did not observe statistically significant visit-to-visit variability (mean difference: 3.25 mg/dL; &lt;em&gt;r&lt;/em&gt; = 0.079, &lt;em&gt;p&lt;/em&gt; = 0.616). While dividing the whole population into those with Lp(a) ≤30 mg/dL and &gt; 30 mg/dL, the only hyper-Lp(a)-emia prevalence differences were seen for FH diagnosis (12.88 vs 21.43; &lt;em&gt;p&lt;/em&gt; = 0.017), MI prevalence (6.52 vs 16.90 %; &lt;em&gt;p&lt;/em&gt; &lt; 0.001), thyroid disease diagnosis (18.14 vs 26.76 %; &lt;em&gt;p&lt;/em&gt; = 0.033) and ezetimi","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"86 ","pages":"Pages 54-61"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term continuous exercise training counteracts the negative impact of the menopause transition on cardiometabolic health in hypertensive women - a 9-year RCT follow-up","authors":"","doi":"10.1016/j.pcad.2023.12.001","DOIUrl":"10.1016/j.pcad.2023.12.001","url":null,"abstract":"<div><h3>Purpose</h3><p>The study examined effects of 9-yrs of multicomponent exercise training during the menopause interval on cardiometabolic health in hypertensive women.</p></div><div><h3>Methods</h3><p>Sedentary, middle-aged women (<em>n</em> = 25) with mild-to-moderate arterial hypertension were randomized into a soccer training (multicomponent exercise; EX; <em>n</em> = 12) or control group (CON; <em>n</em> = 13). EX took part in 1-h football training sessions, 1–3 times weekly, for a consecutive 9-years, totaling ∼800 training sessions, while CON did not take part in regular exercise training. 22 participants entered menopause during the intervention.</p></div><div><h3>Results</h3><p>A time×group interaction effect (<em>P</em> = 0.04) of 8.5 mmHg in favour of EX was observed for changes in mean arterial pressure (MAP) (EX: −4.8 [−10.7;1.1] mmHg, CON +3.7 [−2.0;9.3] mmHg). Time×group interaction effects in favour of EX were also observed for total body weight (4.6 kg, <em>P</em> = 0.008, EX: +0.7 [−1.7;3.0] kg, CON: +5.3 [3.0;7.6] kg, total fat percentage (5.7%-points, <em>P</em> = 0.02; EX (−1.9 [−4.4;0.6] %-points; <em>P</em> = 0.13), CON +3.8 [1.4;6.2] %-points and for total cholesterol (1.2 mmol/l, <em>P</em> = 0.03, EX: −0.5 [−1.0;-0.1] mmol/l, CON: +0.7 [0.2;1.1] mmol/l. EX reduced (<em>P</em> = 0.02) plasma low-density lipoprotein cholesterol by −0.4 [−0.8;-0.1] mmol/l, whereas an increase (<em>P</em> = 0.01) of 0.4 [0.1;0.8] mmol/l occurred in CON (interaction. <em>P</em> &lt; 0.001). A time×group interaction (<em>P</em> = 0.004) existed for changes in exercise capacity in favour of EX. Fasting glucose remained unchanged in EX and increased (<em>P</em> &lt; 0.001) by 0.7 [0.4;1.0] mmol/l in CON (time×group interaction <em>P</em> = 0.02).</p></div><div><h3>Conclusion</h3><p>In conclusion, long-term multicomponent exercise training fully counteracts the detrimental effects of the menopause transition on cardiometabolic health in hypertensive women.</p></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"85 ","pages":"Pages 54-62"},"PeriodicalIF":5.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0033062023001238/pdfft?md5=8450c2e1bcf241a5a6b56135466c3567&pid=1-s2.0-S0033062023001238-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138556943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting life expectancy in the United States: The importance of healthy living behaviors and residential geography","authors":"","doi":"10.1016/j.pcad.2024.01.021","DOIUrl":"10.1016/j.pcad.2024.01.021","url":null,"abstract":"<div><p>According to the World Health Organization, 30 countries currently have a life expectancy of ≥80 years: the United States (U.S.) is not among this group of countries. The current analysis assesses the ability of key lifestyle behaviors and characteristics to predict a life expectancy of ≥80 years. Only 577 (19%) of the 3066 U.S. Counties assessed had a life expectancy ≥80 years. These counties had significantly higher life expectancy (81 ± 3 vs. 76 ± 2 years) and lower percent of the population who are physically inactive (20.7 ± 3.9 vs. 27.0 ± 4.7%), actively smoke (15.9 ± 3.1 vs. 21.1 ± 3.6%), obese (31.7 ± 4.7 vs. 37.3 ± 3.9%) and have limited access to healthy food (7.1 ± 6.8 vs. 8.4 ± 6.6%) (all <em>p</em><span> &lt; 0.001). Binary logistic regression revealed percent adults who currently smoke, percent obese, percent physically inactive, and percent with limited access to healthy food were all significant univariate predictors of &lt;/≥80 years life expectancy (</span><em>p</em><span> &lt; 0.001) and retained in the multivariate regression (</span><em>p</em> &lt; 0.05). A better understanding of the driving forces that increase healthy living behaviors should be a primary goal in the effort to increase U.S. life expectancy: an individualized approach recognizing unique regional cultures may significantly improve adoption and maintenance of desirable health behaviors and outcomes.</p></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"85 ","pages":"Pages 26-30"},"PeriodicalIF":5.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maturity-onset diabetes of the young (MODY) - in search of ideal diagnostic criteria and precise treatment","authors":"","doi":"10.1016/j.pcad.2024.03.004","DOIUrl":"10.1016/j.pcad.2024.03.004","url":null,"abstract":"<div><p><span><span>Maturity-onset diabetes of the young (MODY) is a spectrum of clinically heterogenous forms of monogenic diabetes mellitus characterized by autosomal dominant inheritance, onset at a young age, and </span>absence<span><span> of pancreatic islets<span> autoimmunity. This rare form of hyperglycemia<span>, with clinical features<span> overlapping with type 1 and type 2 diabetes mellitus, has 14 subtypes with differences in prevalence and complications occurrence which tailor therapeutic approach. MODY phenotypes differ based on the gene involved, gene penetrance and expressivity. While MODY 2 rarely leads to </span></span></span></span>diabetic complications<span> and is easily managed with lifestyle interventions alone, more severe subtypes, such as MODY 1, 3, and 6, require an individualized treatment approach to maintain a patient's quality of life and prevention of complications. This review summarizes current evidence on the presentation, diagnosis, and management of MODY, an example of a </span></span></span>genetic<span> cause of hyperglycemia that calls for a precision medicine approach.</span></p></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"85 ","pages":"Pages 14-25"},"PeriodicalIF":5.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between testosterone replacement therapy and cardiovascular outcomes: A meta-analysis of 30 randomized controlled trials","authors":"","doi":"10.1016/j.pcad.2024.04.001","DOIUrl":"10.1016/j.pcad.2024.04.001","url":null,"abstract":"<div><h3>Background</h3><p><span>The Cardiovascular safety of testosterone replacement therapy (TRT) among men with </span>hypogonadism<span> is not well established to date. Hence, we sought to evaluate the cardiovascular disease (CVD) outcomes among patients receiving testosterone therapy by using all recently published randomized controlled trials.</span></p></div><div><h3>Methods</h3><p>We performed a systematic literature search on PubMed, EMBASE, and <span><span>Clinicaltrial.gov</span><svg><path></path></svg></span><span> for relevant randomized controlled trials (RCTs) from inception until September 30th, 2023.</span></p></div><div><h3>Results</h3><p>A total of 30 randomized trials with 11,502 patients were included in the final analysis. The mean age was ranging from 61.61 to 61.82 years. Pooled analysis of primary and secondary outcomes showed that the incidence of any CVD events (OR, 1.12 (95%CI: 0.77–1.62), <em>P</em> = 0.55), stroke (OR, 1.01 (95%CI: 0.68–1.51), <em>P</em> = 0.94), myocardial infarction (OR, 1.05 (95%CI: 0.76–1.45), <em>P</em> = 0.77), all-cause mortality (OR, 0.94 (95%CI: 0.76–1.17), <em>P</em> = 0.57), and CVD mortality (OR, 0.87 (95%CI: 0.65–1.15), <em>P</em> = 0.31) was comparable between TRT and placebo groups.</p></div><div><h3>Conclusion</h3><p>Our analysis indicates that for patients with hypogonadism, testosterone replacement therapy does not increase the CVD risk and all-cause mortality.</p></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"85 ","pages":"Pages 45-53"},"PeriodicalIF":5.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratified medicine for acute and chronic coronary syndromes: A patient-tailored approach","authors":"","doi":"10.1016/j.pcad.2024.06.003","DOIUrl":"10.1016/j.pcad.2024.06.003","url":null,"abstract":"<div><p>The traditional approach to management of cardiovascular disease relies on grouping clinical presentations with common signs and symptoms into pre-specified disease pathways, all uniformly treated according to evidence-based guidelines (“one-size-fits-all”). The goal of precision medicine is to provide the right treatment to the right patients at the right time, combining data from time honoured sources (e.g., history, physical examination, imaging, laboratory) and those provided by multi-omics technologies. In patients with ischemic heart disease, biomarkers and intravascular assessment can be used to identify endotypes with different pathophysiology who may benefit from distinct treatments. This review discusses strategies for the application of stratified management to patients with acute and chronic coronary syndromes.</p></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"85 ","pages":"Pages 2-13"},"PeriodicalIF":5.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0033062024000914/pdfft?md5=45089945244c502b4c1bed7ce3f27bc5&pid=1-s2.0-S0033062024000914-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of recent issues","authors":"","doi":"10.1016/S0033-0620(24)00107-5","DOIUrl":"10.1016/S0033-0620(24)00107-5","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"85 ","pages":"Page A3"},"PeriodicalIF":5.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}