Progress in cardiovascular diseases最新文献

{"title":"Socioeconomic milieu and culture: Forcing factors and the Most fundamental determinant of health","authors":"Frederick J. Zimmerman ,&nbsp;Nicolaas P. Pronk","doi":"10.1016/j.pcad.2025.03.007","DOIUrl":"10.1016/j.pcad.2025.03.007","url":null,"abstract":"<div><div>We introduce the concept of forcing factors, analogous to risk factors for population-wide health outcomes, that are attributes of the physical, social, legal, economic, or cultural environment that are common to all people in an identified population and that promote or inhibit particular outcomes of health, wellness, and well-being. Examples include laws governing food or tobacco marketing, the built environment, and climate change. Culture also functions as a forcing factor of health outcomes. In contrast to past explanations of adverse health outcomes that have relied on cultural attributes of a specific sub-population, we draw on work of John McKinlay to make the point that it is the shared culture of a country or a region that influences health outcomes. Culture itself operates in a particular cultural context.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 62-70"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preprocedural CT angiography and machine learning for mortality prediction after transcatheter aortic valve replacement","authors":"Jacek Kwiecinski ,&nbsp;Kajetan Grodecki ,&nbsp;Konrad Pieszko ,&nbsp;Maciej Dabrowski ,&nbsp;Zbigniew Chmielak ,&nbsp;Wojciech Wojakowski ,&nbsp;Julia Niemierko ,&nbsp;Jadwiga Fijalkowska ,&nbsp;Dariusz Jagielak ,&nbsp;Philipp Ruile ,&nbsp;Simon Schoechlin ,&nbsp;Hesham Elzomor ,&nbsp;Piotr Slomka ,&nbsp;Adam Witkowski ,&nbsp;Damini Dey","doi":"10.1016/j.pcad.2025.04.007","DOIUrl":"10.1016/j.pcad.2025.04.007","url":null,"abstract":"<div><div>Prediction of outcomes following transcatheter aortic valve replacement (TAVR) is challenging. Considering that in aortic stenosis outcomes are governed by both valve degeneration and myocardial adverse remodeling, we aimed to evaluate machine-learning leveraging pre-procedural computed tomography (CT) for the prediction of 1-year mortality following TAVR.</div><div>The analysis included data of consecutive patients who underwent TAVR at a high-volume center between January 2017 and January 2022 and was externally validated on unseen data from 3 international sites. Machine learning by extreme gradient boosting was trained and tested using clinical variables, CT-derived volumetric measurements including myocardial mass, and quantitative fibrocalcific aortic valve characteristics measured using standardized software. The EuroScore II and a separate machine learning risk score based exclusively on baseline clinical characteristics served as comparators.</div><div>The derivation cohort included 631 consecutive patients (48 % men, 80 ± 8 years old, EuroSCORE II 6.5 [4.6–10.3] %). Machine learning was externally validated on data of 596 patients (48 % men, 81 ± 8 years old, EuroSCORE II 5.4 [4.7–8.1] %). In external validation, the machine learning prognostic risk score had an area under the receiver operator curve of 0.79 (0.74–0.84) which was superior to the EuroSCORE 0.59 (0.53–0.66), and the machine learning risk based on clinical data alone 0.64 (0.59–0.69), <em>p</em> &lt; 0.001 for difference.</div><div>Machine-learning integrating clinical data and CT-derived imaging characteristics was found to predict 1-year all-cause mortality following TAVR significantly better than clinical variables or clinical risk scores alone; and can help identify patients at higher prognostic risk prior to the procedure.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 119-128"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of recent issues","authors":"","doi":"10.1016/S0033-0620(25)00093-3","DOIUrl":"10.1016/S0033-0620(25)00093-3","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Page A4"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A culture of health promotion in healthcare: Can't pour from an empty cup","authors":"Richard Severin ,&nbsp;Ross Arena","doi":"10.1016/j.pcad.2025.02.007","DOIUrl":"10.1016/j.pcad.2025.02.007","url":null,"abstract":"<div><div>With chronic diseases increasingly prevalent in the United States (U.S.), healthcare providers are in a unique position to promote healthy living behaviors, such as physical activity (PA) and nutrition, to patients. However, many healthcare providers struggle with maintaining their own health, which negatively affects their ability to counsel patients effectively on these behaviors. This paper highlights the barriers healthcare providers face in adopting and promoting healthy behaviors, including individual habits, lack of training, and environmental factors within healthcare institutions. It also examines how these barriers, such as insufficient educational opportunities, inadequate work environments, and systemic obstacles like time constraints and reimbursement issues, hinder effective PA and nutritional counseling. The authors propose that improving the health of healthcare providers will enhance the quality of counseling they provide, ultimately benefiting patient care and population health.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 45-50"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating cardiovascular implementation science research within healthcare systems","authors":"Muhammad Shahzeb Khan ,&nbsp;Ahmed Mustafa Rashid ,&nbsp;Harriette G.C. Van Spall ,&nbsp;Stephen J. Greene ,&nbsp;Ankeet S. Bhatt ,&nbsp;Ambarish Pandey ,&nbsp;Neil Keshvani ,&nbsp;Robert J. Mentz ,&nbsp;Andrew P. Ambrosy ,&nbsp;J. Michael DiMaio ,&nbsp;Javed Butler","doi":"10.1016/j.pcad.2025.04.005","DOIUrl":"10.1016/j.pcad.2025.04.005","url":null,"abstract":"<div><div>Only 1 in 5 evidence-based interventions make it to routine clinical practice and the evidence generated from clinical research may take 17 years to be implemented. This represents a lost opportunity to improve clinical care in healthcare systems. Implementation science refers to the study of methods to promote the adoption and integration of evidence-based practices, interventions, and policies into real-world clinical settings to positively impact population health. Therefore, implementation roadmaps can be crucial for learning healthcare systems (LHS) to bridge the research-to-practice gap, particularly for cardiovascular disease which remains the leading cause of death in the United States. Implementation models exist, all of which require a thorough understanding of the key phases of implementation for effective healthcare system incorporation and optimization (pre-implementation, implementation, monitoring the implementation, evaluation, sustaining, and scaling-up or de-implementation). This review serves as a call-to-action for involvement of large-scale LHS for cardiovascular implementation science, and provides a roadmap by summarizing various implementation science models, highlighting key implementation phases and discussing successful initiatives to improve the process. We also assess challenges associated with implementation science and provide possible solutions to improve translation of evidence in real-world clinical settings.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 97-108"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalizing risk assessment for transcatheter aortic valve replacement: Value of CT imaging and AI","authors":"Andrew Lin ,&nbsp;Thomas A. Treibel ,&nbsp;Marc R. Dweck","doi":"10.1016/j.pcad.2025.05.001","DOIUrl":"10.1016/j.pcad.2025.05.001","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 129-130"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental benefits of combined inhibition of SGLT1 and SGLT2 with sotagliflozin","authors":"Ram D. Bhatt ,&nbsp;Bertram Pitt ,&nbsp;Ph. Gabriel Steg ,&nbsp;Deepak L. Bhatt","doi":"10.1016/j.pcad.2025.04.004","DOIUrl":"10.1016/j.pcad.2025.04.004","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 3-5"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of the right ventricular to left ventricular volume ratio on cardiac magnetic resonance imaging in predicting adverse outcomes for adults with pulmonary hypertension","authors":"Robert S. Zhang ,&nbsp;Lily Jin ,&nbsp;Giorgia Falco ,&nbsp;Rachel Axman ,&nbsp;Pablo Villar-Calle ,&nbsp;Annie Tsay ,&nbsp;Matthew C. Lam ,&nbsp;Udhay Krishnan ,&nbsp;Andre Cheng ,&nbsp;Yuchi Han ,&nbsp;Monica Mukherjee ,&nbsp;Jonathan W. Weinsaft ,&nbsp;Jiwon Kim","doi":"10.1016/j.pcad.2025.04.002","DOIUrl":"10.1016/j.pcad.2025.04.002","url":null,"abstract":"<div><h3>Background</h3><div>Right ventricular (RV) performance impacts clinical outcomes across pulmonary hypertension (PH), yet noninvasive tools for early detection and risk stratification are limited. Cardiac MRI (CMR) derived RV to left ventricular (LV) volume ratio (RV/LV_vol ratio) provides a relative assessment of RV size by normalizing chamber size to the LV. However, its prognostic utility remains underexplored. In the present study, we investigate the association between the RV/LV_vol ratio and outcomes in patients with PH.</div></div><div><h3>Methods</h3><div>This prospective study included patients with PH (pulmonary arterial systolic pressure &gt; 35 mmHg by echocardiography or mean pulmonary artery pressure &gt; 20 mmHg on invasive right heart catheterization), who underwent CMR. Abnormal RV/LV_vol ratio cutoff (≥1.27) was applied and further tested using established gradation thresholds. The primary outcome was a composite of all-cause mortality and heart failure hospitalizations.</div></div><div><h3>Results</h3><div>Of 135 patients, 56 (41.5 %) had an abnormal RV/LV_vol ratio. After a mean follow-up of 1.9 ± 1.3 years, 75 patients experienced the primary outcome. Patients with an abnormal RV/LV_vol ratio had higher rates of the primary outcome (64.3 % vs 50.0 %, <em>p</em> = 0.02). After multivariable analysis adjusting for age and CMR indices, abnormal RV/LV_vol ratio was independently associated with the primary outcome (HR 1.81 [95 % CI 1.06–2.97]; <em>p</em> = 0.003). RV/LV_vol ratio added incremental prognostic value over age and traditional RV indices (global χ2 value increasing from 6.7 to 17.4, <em>p</em> = 0.006).</div></div><div><h3>Conclusions</h3><div>The RV/LV_vol ratio is a simple clinical tool associated with an increased risk of adverse outcomes in PH patients, offering prognostic information beyond traditional RV parameters.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 109-115"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural influences on dietary choices","authors":"Sisitha Jayasinghe ,&nbsp;Nuala M. Byrne ,&nbsp;Andrew P. Hills","doi":"10.1016/j.pcad.2025.02.003","DOIUrl":"10.1016/j.pcad.2025.02.003","url":null,"abstract":"<div><div>Food choices and dietary behaviors are inherently complex and influenced by numerous interconnected factors including individual preferences such as taste, meal timing, and social interactions, alongside external elements like affordability, cultural norms, marketing, and policy environments. The physical contexts of food consumption - homes, schools, workplaces, and neighborhoods- further shape these behaviors, as do societal expectations and generational food literacy. Underpinning these dynamics are food systems, which are influenced by health, ethical, and sustainability considerations throughout the food production and consumption continuum. Cultural influences, encompassing traditions, rituals, and shared beliefs, play a pivotal role in shaping dietary practices. Distinctions between “cultural food” and “food culture” illustrate the deep integration of cuisine within identity and daily life. Historical events, globalization, and modernization have reshaped food traditions, leading to the adoption of new eating patterns and the erosion of others. Religion, socioeconomic status, and social networks also critically impact dietary behaviors, while contemporary challenges such as the nutrition transition and fast-food culture contribute to rising chronic disease burdens. Addressing these issues requires culturally tailored interventions and a focus on food environments, integrating modern tools like social media to promote healthier, community-oriented behaviors while recognizing the social and emotional roles of food.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 22-26"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTA in roadmapping post-CABG evaluation","authors":"Ilana S. Golub ,&nbsp;Angela Misic ,&nbsp;Srikanth Krishnan ,&nbsp;Logan Hubbard ,&nbsp;Dhananjay Chatterjee ,&nbsp;Rosa Lopez ,&nbsp;Travis Benzing ,&nbsp;Sina Kianoush ,&nbsp;Keishi Ichikawa ,&nbsp;Jairo Aldana-Bitar ,&nbsp;Matthew J. Budoff","doi":"10.1016/j.pcad.2025.04.009","DOIUrl":"10.1016/j.pcad.2025.04.009","url":null,"abstract":"<div><div>Although coronary artery bypass grafting (CABG) outcomes are typically highly successful, outpatient evaluation of bypass grafts is an important step. Moreover, the return of myocardial ischemia and acute coronary syndrome (ACS) events after bypass is not uncommon. Whether due to failure of prior bypass grafts or progression of underlying arteriosclerosis in native coronaries, regularly evaluating if a patient requires intervention (and assessing graft patency vs. closure) is essential. Imaging via cardiac computed tomography angiography (CTA) offers a gold standard anatomical map to facilitate efficiency and accuracy in later invasive coronary angiography (ICA) or surgical re-CABG intervention.</div><div>This review discusses the utility of CTA as a safe pre and post CABG evaluation tool, in guiding outpatient evaluation of graft patency and roadmapping subsequent reintervention if needed. We seek to ameliorate clinical uncertainties and synthesize growing amounts of research, to help encourage a homogenous approach to post-CABG evaluation. This comprehensive review paper introduces the indications for bypass grafting surgery and transcatheter PCI approaches, details techniques and strategies for bypass surgery, discusses CTA in evaluating post-CABG graft patency, and consolidates research surrounding pre-reintervention CTA in post-CABG patients. Last, this review explores future directions in standardizing post-CABG evaluation guidelines.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"90 ","pages":"Pages 86-96"},"PeriodicalIF":5.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}