Progress in cardiovascular diseases最新文献

{"title":"Cover 2 (Masthead)","authors":"","doi":"10.1016/S0033-0620(25)00119-7","DOIUrl":"10.1016/S0033-0620(25)00119-7","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Page IFC"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent and ongoing developments in electrophysiology science and treatment","authors":"Daniel P. Morin , Mina K. Chung","doi":"10.1016/j.pcad.2025.08.001","DOIUrl":"10.1016/j.pcad.2025.08.001","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 1-2"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it safe to use class 1C antiarrhythmic drugs in patients with coronary artery disease and/or cardiomyopathy?","authors":"Peter G. Pantlin ,&nbsp;Sahil Bharwani ,&nbsp;Mina K. Chung ,&nbsp;Daniel P. Morin","doi":"10.1016/j.pcad.2025.06.001","DOIUrl":"10.1016/j.pcad.2025.06.001","url":null,"abstract":"<div><div>Class 1C antiarrhythmic drugs<span> (AADs) are a key treatment option for effective rhythm control in several common arrhythmias. Here, we review the relevant background on Class 1C AADs, these drugs' indications and contraindications, and potential safe ways to use them. The safety profile of 1C AADs, and related restrictions on their use, has been largely based on the decades-old CAST trial, but more recent evidence may favor re-evaluating previously excluded populations. This review examines opportunities to reconsider certain patient populations that have previously been excluded from the use of 1C AADs. This reconsideration is made feasible due to advances in cardiac reperfusion, medical therapies for heart failure, and cardiac imaging.</span></div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 28-32"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomics in atrial fibrillation: Predicting recurrence of AF after treatment using genetics","authors":"Samuel Harwood ,&nbsp;M. Benjamin Shoemaker ,&nbsp;John Barnard ,&nbsp;David R. Van Wagoner ,&nbsp;Daniel P. Morin ,&nbsp;Mina K. Chung","doi":"10.1016/j.pcad.2025.06.008","DOIUrl":"10.1016/j.pcad.2025.06.008","url":null,"abstract":"<div><div>With the demonstration that AF is highly hereditable and strongly associated with over 100 genetic loci, one step towards personalized treatment of AF is the potential use of genetic testing to predict response to therapy. Although various clinical models have been developed to predict recurrence, none have shown a consistent ability to predict treatment outcomes. This highlights a need for additional patient information to increase predictive value. Here, we review the use of genetic data for prediction of AF recurrence after interventions such as ablation, cardioversion, or drug therapy. We explore the use of other downstream predictors, such as mRNA and protein, as other possible predictive tools. Finally, we assess how this genetic data can further our mechanistc understanding of AF pathogenesis and recurrence.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 62-66"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden cardiac arrest: Limitations in risk-stratification and treatment, and the potential for digital technologies and artificial intelligence to improve prediction and outcomes","authors":"Sudarshan Srivats ,&nbsp;Fawzi Zghyer ,&nbsp;Zaid Shahrori ,&nbsp;Christine Albert ,&nbsp;Sana M. Al-Khatib ,&nbsp;Sumeet Chugh ,&nbsp;Susan P. Etheridge ,&nbsp;Zachary D. Goldberger ,&nbsp;Rakesh Gopinathannair ,&nbsp;Dhanunjaya Lakkireddy ,&nbsp;Daniel P. Morin ,&nbsp;Marco V. Perez ,&nbsp;Markus Rottmann ,&nbsp;Jacob E. Sunshine ,&nbsp;Paul J. Wang ,&nbsp;Mina K. Chung","doi":"10.1016/j.pcad.2025.06.005","DOIUrl":"10.1016/j.pcad.2025.06.005","url":null,"abstract":"<div><div>Sudden cardiac death (SCD) remains a pervasive public health challenge, accounting for a significant proportion of cardiac and all-cause mortality worldwide. Despite notable advancements in cardiovascular therapies and reductions in overall cardiac mortality, survival following sudden cardiac arrest (SCA) remains dismally low, and prediction strategies remain inadequate. This comprehensive review examines the current landscape of SCD etiologies and the latest guidelines for primary and secondary prevention of SCD with implantable cardioverter defibrillators (ICDs). Particular attention is given to the limitations of left ventricular ejection fraction (LVEF) as the primary tool for risk stratification, given its low sensitivity, specificity, and limited applicability to the broader population in which most SCDs occur. Emerging risk scores and machine learning (ML) driven prediction models have begun to efficiently integrate clinical, electrical, imaging, genetic and laboratory parameters to improve SCD risk stratification. This review highlights examples of such artificial intelligence (AI) prediction models and discusses their potential role in the near-term and long-term prediction of SCD in both in-hospital and out-of-hospital settings, while emphasizing the need for external validation of such models. The review also discusses critical system-level gaps in the chain of survival from cardiac arrest, particularly the need for automated emergency medical services (EMS) activation, community responder engagement, high-quality cardiopulmonary resuscitation (CPR) and improved access to defibrillation. It explores the role of digital technologies such as wearable sensors, smartwatches, smartphone applications and implantable devices in improving real-time SCA detection and enhancing early aspects of the chain of survival from cardiac arrest. Finally, the review calls for a multidisciplinary, multi-sectoral approach including regulatory, technological, and public health stakeholders to bridge gaps in SCD prevention, detection, and response.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 144-166"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability in patients with cardiovascular diseases","authors":"Muhammad Shahzeb Khan ,&nbsp;Syed Sarmad Javaid ,&nbsp;Robert J. Mentz ,&nbsp;JoAnn Lindenfeld ,&nbsp;Hau-Tieng Wu ,&nbsp;Jürgen H. Prochaska ,&nbsp;Jens Brock Johansen ,&nbsp;Philipp S. Wild ,&nbsp;Dominik Linz ,&nbsp;Wilfried Dinh ,&nbsp;Marat Fudim","doi":"10.1016/j.pcad.2025.06.003","DOIUrl":"10.1016/j.pcad.2025.06.003","url":null,"abstract":"<div><div>Heart rate variability (HRV) has been reported to predict overall mortality and the risk of cardiovascular disease events in patients, including those with heart failure. However, inconsistent methods of recording and analyzing HRV parameters, along with a lack of randomized data substantiating its clinical efficacy and potential to guide treatment decisions for improved patient outcomes, have limited its use in clinical settings. With the advancements in technologies such as artificial intelligence and machine learning, and emergence of ablation procedures that can alter autonomic function, this article re-explores HRV assessment methods, their potential for clinical application, the issues encountered in using them in clinical research, and potential approaches to studying HRV in the future (Graphical Abstract).</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 67-79"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioneuroablation: Three different approaches","authors":"Medhat Farwati ,&nbsp;Tolga Aksu ,&nbsp;Enrique I. Pachon ,&nbsp;Tomas Santillana ,&nbsp;Carlos Thiene Pachon ,&nbsp;Pasquale Santangeli ,&nbsp;Jose Carlos Pachon","doi":"10.1016/j.pcad.2025.04.003","DOIUrl":"10.1016/j.pcad.2025.04.003","url":null,"abstract":"<div><div><span><span>Cardioneuroablation (CNA) is an emerging therapy for patients with vasovagal syncope with predominant cardioinhibitory responses. The procedure targets the neuromyocardial connections localized in specific regions of the right and left atrium<span> as well as the adjacent ganglionated plexi (GP) providing parasympathetic innervation to the sinus and </span></span>atrioventricular nodes. The target regions for CNA can be determined with various techniques, which result in heterogenous procedural approaches and endpoints in different centers specialized in this procedure. In this review we summarize the rationale and details of the procedural approach for three different techniques for CNA, namely: CNA controlled by extra-cardiac vagal stimulation, CNA guided by analysis of fractionated </span>electrograms, and an anatomical approach to CNA.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 80-89"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for optimizing efficacy of electrical cardioversion of atrial fibrillation","authors":"Sahil Bharwani ,&nbsp;Mina K. Chung ,&nbsp;Daniel P. Morin","doi":"10.1016/j.pcad.2025.06.009","DOIUrl":"10.1016/j.pcad.2025.06.009","url":null,"abstract":"<div><div><span>Direct current </span>cardioversion<span><span><span> (DCCV) is a cornerstone in the management of atrial fibrillation<span> (AF) and is the quickest way to convert AF to sinus rhythm. Overall, the procedure is effective and safe, but the efficacy of DCCV can be reduced due to modifiable and non-modifiable </span></span>patient characteristics, or procedural factors. Additionally, inadequate preparation, such as a lack of QRS-synchronization or omitting preprocedural imaging of the left atrial appendage (LAA), could lead to significant harm. This manuscript discusses a brief history of electrical cardioversion, the currently available cardioverter settings/configuration with the highest success rate, the common barriers to successful cardioversion, strategies to overcome these barriers, and suggested protocols to ensure a high level of </span>patient safety.</span></div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 18-27"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of contact force and pulsed field ablation parameters on myocardial lesion formation during pulsed field ablation: A systematic review of pre-clinical studies","authors":"Jacopo Marazzato ,&nbsp;Fengwei Zou ,&nbsp;Marco Schiavone ,&nbsp;Vincenzo Mirco La Fazia ,&nbsp;Giovanni Forleo ,&nbsp;Sanghamitra Mohanty ,&nbsp;Aung Lin ,&nbsp;Domingo Ynoa Garcia ,&nbsp;Andrea Natale ,&nbsp;Xiaodong Zhang ,&nbsp;Luigi Di Biase","doi":"10.1016/j.pcad.2025.07.001","DOIUrl":"10.1016/j.pcad.2025.07.001","url":null,"abstract":"<div><div>Pulsed field ablation (PFA) is a novel and minimally thermal energy source that exploits the biophysics of irreversible electroporation (IRE) to cause cell death. Differently from radiofrequency ablation (RFA) where adequate catheter-tissue contact proved paramount in lesion formation, the additional role of contact force (CF) during PFA is under debate due to the inherent myocardial selectivity and the customizable nature of IRE. In fact, it is not clear whether the amount of contact exerted during PFA delivery is as pivotal in achieving optimal lesion size as during RFA. Moreover, the variety of PFA catheters and the myriads of IRE ablation settings available would further potentially limit the role of CF in this scenario. However, beyond CF, specific ablation parameters, such as the PFA dose, number of pulses, catheter tip orientation and specific PFA workflows, proved to act in synergy with CF in achieving wide and deep ablation lesions even during PFA delivery. Therefore, the aim of this systematic review is to provide a better understanding on which ablation parameters – CF included - can help to obtain effective lesion formation during PFA.</div></div>","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Pages 49-61"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of recent issues","authors":"","doi":"10.1016/S0033-0620(25)00121-5","DOIUrl":"10.1016/S0033-0620(25)00121-5","url":null,"abstract":"","PeriodicalId":21156,"journal":{"name":"Progress in cardiovascular diseases","volume":"91 ","pages":"Page A3"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}