Research Journal of Pharmacy and Technology最新文献

{"title":"Formulation and Evaluation of Teneligliptin Nanosuspension","authors":"Sreekala. Mg, C. Reichal, M. S","doi":"10.52711/0974-360x.2024.00015","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00015","url":null,"abstract":"In this present study, the drug Teneligliptin is selected for the management of Type-2 Diabetes mellitus. The drug-excipient compatibility study results showed that there is no chemical change occur between the drug and the excipients and there was no functional group change observed. Teneligliptin is poorly water-soluble drug and it was fabricated as nanosuspension of Nine formulations by using nano precipitation technique. In this method, nano size particle size of Teneligliptin was obtained by using different type of various proportions of stabilizers along with other ingredient at different stirring speed. For the prepared formulation (F1-F9) the particle size, polydispersibility index and zeta potential were done. Among nine formulations, formulation 8(F8) results revealed that the values are desirable and stable. The total drug content of all the formulation ranges from 81% to 99%, The average particle size of F1 to F9 batches was found to be in the range of 0.211 nm to 0.486 nm The scanning electron microspore study stated that the nano size particles were spherical in shape. Among all the formulations (F8) was optimized which showed maximum highest percentage of drug release at 24 hours. The cumulative percentage of drug release of formulation 8 (F8) increase with the optimum concentration of stabilizers and tween 80. The release rate of optimized formulation 8(F8) was fitted with various release kinetic studies and the selected formulation followed zero order kinetics. The results of stability study was confirmed that the prepared Teneligliptin nanosuspension is stable during the stability study. Thus, it can be concluded that the nanosuspension method was commercially feasible and cost effective.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"75 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Modeling Study of Bis-sulfonamide Derivatives Synthesis Targeting Aromatase Enzyme as Anticancer","authors":"Mohamad M, Djamila Bh, Amir B, Mustapha Fc","doi":"10.52711/0974-360x.2024.00008","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00008","url":null,"abstract":"Most studies indicate the important role of estrogen in the mechanism of occurrence and development of breast cancer. The importance of our research is the synthesis of bis-sulfonamide compounds that inhibit the aromatase enzyme, which is the main enzyme in the biosynthesis of estrogen. Molecular modeling of studied compounds was carried out by Molegro Virtual Docker (MVD) targeting aromatase enzyme and binding energy calculated to select the most encouraging compound. The highest binding energy among the studied compounds was -118.52 kcal/mol (compound A5) comparing with the aromatase substrate androstenedione -132.51 kcal/mol and the aromatase inhibitor letrozole -136.52 kcal/mol. Several of these compounds were synthesized in a simple way with good yields by reacting sulfonyl chloride derivatives with amino derivatives in an alkaline aqueous solution, or in a pyridine solution. The physicochemical characteristics and identification of synthesized compounds were determined by various analytical methods such as Mass spectrometry, Infrared spectroscopy and Nuclear Magnetic Resonance.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"428 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking, ADME and Toxicity Study of Dibenzo-α-pyrone derivatives for GABA and NMDA receptors for their antiepileptic activity","authors":"Shalini K. Sawhney, Chaitanya Narayan, Achal Mishra, Monika Singh, Avneet Kaur","doi":"10.52711/0974-360x.2024.00053","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00053","url":null,"abstract":"The twelve most effective dibenzo-α-pyrone derivatives as anticonvulsant chemicals have been chosen from our earlier study, and their 2D structures have been determined. Using Spartan'14 version 1.1.2, the compounds' 3D structures were generated, optimized, and transferred in PDB format. Molecular docking investigations of effective anticonvulsant drugs utilized the Toshiba Satellite, Dual-core CPU, Windows 8 operating system, and the AutoDockVina of PyRx virtual screening program. PyRx was activated with the flexible docking option to dock the GABAAT enzyme, NMDA, and dibenzo-α-pyrone derivatives (Ligands) into the X, Y, and Z coordinate systems. Some Dibenzo- α -pyrone compounds were studied for their antiepileptic efficacy by molecular docking, absorption, distribution, metabolism, and toxicity. Docking analysis revealed that all the compounds have good binding scores, and SS9 derivative has the highest binding score compared to others in both the targets selected. ADME results revealed that most parameters are within limits, and toxicity analysis suggested that the designed compounds are low in toxicity. This research on molecular docking gives a valued insight for medicinal and pharmaceutical chemists to synthesize more derivatives of designed Dibenzo-α-pyrone compounds as lead for antiepileptic drugs, which would be more effective for managing convulsions.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"50 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Observe the patterns of Cutaneous Adverse Drug Reactions in a Tertiary health care teaching hospital in Hyderabad","authors":"Divya Jampani, P. M. Rohini, Bhuvaneshwari Bhuvaneshwari, S.U.M. Raju, E. Shravya","doi":"10.52711/0974-360x.2024.00021","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00021","url":null,"abstract":"Cutaneous adverse drug reactions are very common and seen quite often during clinical practice. It is difficult to get a comprehensive list of the various types of drug reactions and their corresponding drug due to many cases going unreported. There is a possibility of a cutaneous drug reaction every time a new drug is introduced into the market. While most types of drug reactions are trivial and benign, there is always a possibility of the reaction attaining a more malignant nature. The diagnosis of a CADR is more often based on a clinical examination. However, in order to understand the full scope of the reaction it must be reported and studied. The pharmacovigilance programme takes into account the spontaneous nature of the cases and employs alogical approach based on clinical characteristics, chronologic factors, and generation of a focused differential diagnosis. Using study tools like Naranjo scale and Modified Hartwig and Siegel scale, a physician can easily determine the severity and causality of the drug reaction. After compiling the data, one can determine the trend of the morphology of these CADRs, and determine the most likely drug responsible for the reaction. The data obtained in this study is useful for helping the clinician in the proper identification, approach and treatment of a patient suffering from a cutaneous adverse rug reaction.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Phytochemicals present in a Polyherbal Anti-diabetic Formulation using Chemical methods and HPTLC methods","authors":"Chitra Kamath, Swarupa Salvi","doi":"10.52711/0974-360x.2024.00002","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00002","url":null,"abstract":"The important challenge to Herbal products for their worldwide acceptance is developing the standard methods for their quality assurance. Qualitative and quantitative analysis of the phytochemicals present in any herbal product plays very important role in its further standardisation. BSL-150 is an Indian polyherbal, anti-diabetic tablet formulation which majorly contains leaves of Gymnemasylvestre, seeds of Syzygiumcumini, seeds of Phyllanthusemblica and bark of Tinospora cordifolia. The phytochemical analysis of the marketed tablets and in-house formulation by standard chemical methods showed presence of Alkaloids, Flavanoids, Steroids, Triterpenoids, Saponins, Tannins, Phenols, Phytosterols, Proteins, Anthraquinones, Gums and mucilages. The phytochemical analysis using HPTLC methods showed presence of Flavanoids, Steroids, Triterpenoids, Saponins, Tannins, Phenols, sterols, Anthraquinones, Essential oils, Bitter principles and coumarins. On comparison of the chemical method and HPTLC method for phytochemical screening, the chemical methods are less time consuming but they are not plant specific and general. Whereas, HPTLC methods can be plant specific and can be developed further for polyherbal formulation. Also, on the basis of intensity and Rf of a band, the selection of the phytochemicals as chemical marker for standardisation of the polyherbal product becomes easy. Thus Modern instrumental method of phytochemical screening has more advantages over the chemical method.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"429 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic uses of Cannabis in Indian Traditional medicine with attention on Gastrointestinal disorders","authors":"Deepak Kumar Hati, Pratap Kumar Sahu, Saroj Kumar Patro","doi":"10.52711/0974-360x.2024.00036","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00036","url":null,"abstract":"Ayurveda is the world's oldest and most complete spiritual teachings, as well as the \"oldest medicinal system\" known to man. Ayurvedic treatments along with natural substances do not have any usual side effects as contemporary drugs. The cannabis plant has been used as a medicine for thousands of years to treat various illnesses including gastrointestinal disorders. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most well-known and researched phyto cannabinoids, with impressive therapeutic properties for a variety of neurological, gastrointestinal, ophthalmic, and skin problems. Cannabis and cannabinoids are beneficial in healing the sign and symptoms of several gastrointestinal diseases, according to research, in part because they interact with the digestive tracts endogenous cannabinoid receptors. This could help in relaxing pain and cramps, reducing discomfort, and improving motility. Many Indian classical formulations were found cannabis is used processing agent in pharmaceuticals. For the treatment of GI issues, there are some popular cannabis-based ayurveda or herbal formulations on the market. CBD levels are frequently higher in medical marijuana, while THC levels are lower. For certain people, the therapeutic CBD is desirable for medicinal purposes, but the psychoactive THC may be needless and undesired. There are numbers of traditional cannabis formulations on the market that lack standardised quality control parameters and methods of evaluation.So, there is a need to develop a standardization technique with special reference to CBD and THC content to include this system of medicine in the main stream of health science. Standardization of popular Ayurvedic or herbal formulations is essential in order to assess the quality, safety, efficacy of that.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"89 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Emulgel product from Standardized Dengen Steam Bark Extract (Dillenia serrata)","authors":"Santi Sinala, Ismail Ibrahim, Sisilia Teresia Rosmala Dewi, Arisanty Arisanty","doi":"10.52711/0974-360x.2024.00030","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00030","url":null,"abstract":"One of the endemic plants of the island of Sulawesi, Indonesia is the Dengen plant (Dillenia serrata). One part of this plant that is claimed by the public as a treatment for vomiting blood is the bark because the stem bark contains polyphenolic compounds which are efficacious as antioxidants and sunscreens. Based on the results of the study, Dengen stem bark extract (EKBD) has been standardized and in accordance the requirements so that the extract can be formulated in pharmaceutical dosage forms, one of which is a cosmetic preparation in the form of an emulgel. This study aims to see the effect of the addition of EKBD on the physical quality of emulgel preparations and to obtain a stable emulgel product containing standardized EKBD with an accelerated storage process using variations of the gelling agent, namely carbopol 940 and CMC sodium. There are two base variations, namely the Carbopol base with a concentration of 0.25%, 0.5%, 1% with the addition of 1:1 TEA; and CMC sodium base with concentrations of 1%, 2% and 3%. Furthermore, the base and extract are combined until homogeneous. Tests include organoleptic test, pH test, viscosity test, spread ability test, adhesion test and emulsion type test. In organoleptic testing, F1 of both bases showed inhomogeneity and watery texture. In the pH test, both bases F3 did not meet the skin pH requirements. In the viscosity test, F1 on both bases was significantly different before and after storage (p<0.05). In the spread ability test, statistically, all formulas F1, F2 and F3 on both bases showed a value of p>0.05, which means there was no significant difference in the spreadability values before storage and after accelerated storage. In the adhesion test, F3 on the Carbopol base showed a significant difference (p<0.05). In the emulsion type test, both basic formulas had a oil-in-water (O/W) emulsion type. Based on the results of data analysis, the addition of EKBD affected the pH and viscosity of the EKBD emulgel and the formula that met the requirements was formula F2 based on CMC sodium, is a concentration of 2%.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"455 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPTLC Phytochemical Profiling and Simultaneous Quantification of Quercetin and Gallic acid in Neolamarckia cadamba (Roxb.)","authors":"Anant Kumar Srivastav, Shikhar Verma, Himani Awasthi, Santosh Kumar","doi":"10.52711/0974-360x.2024.00042","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00042","url":null,"abstract":"HPTLC analysis of Neolamarckia cadamba (Roxb.) Bosser commonly known as kadamb reveals presence of several bioactive compounds along with percentage of quercetin and gallic acid in the methanolic extract of test samples. Quantification of markers (quercetin and gallic acid) along with phytochemical profiling of Neolamarckia cadamba was done at 254nm and 366nm wavelength through HPTLC CAMAG scanner III. Quantification was done by using peak area and peak height. Chromatograms and tracks obtained reveals that the test samples, sample 1 and sample 2 have quercetin 1.29% and 0.77% respectively. Phytochemical profiling of sample 1 and sample 2 reveals presence of 16 and 10 unknown bioactive compounds respectively denoted by the number of peaks present in chromatograms. As this study acknowledging phytochemical profiling, quantification of quercetin and gallic acid will be accountable for further research towards pharmacognostic and therapeutic value of Neolamarckia cadamba.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"443 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the fear of recurrence in Breast cancer patients","authors":"Dinara Kussainova, Anar Tursynbekova, Gulshara Aimbetova, F. Bagiyarova, D. Kaidarova","doi":"10.52711/0974-360x.2024.00049","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00049","url":null,"abstract":"The fear of cancer recurrence is defined as a mental state of anxiety or concern that cancer may return or spread. It is assumed to be the commonest unpleasant psychological disorder among cancer survivors. Breast cancer is assumed to be one of the commonest cancers in women. Also, the treatment modalities for breast cancer are strongly developed and there is an increase in the cure rate in recent years. However, surviving cancer patients are still feared of recurrence of the neoplasm. The fear of cancer recurrence affected negatively the patients' health and lowered their quality of life. Therefore, we sought to establish effective preventive strategies to improve the psychological health of patients. We searched the literature and reviewed the most recent available data from 2017 to 2023 to clarify the different factors affecting the fear of cancer recurrence in breast cancer patients.We identified different factors that increase the fear of cancer recurrence in breast cancer patients including; anxiety, chemotherapy, avoidance, intrusive thoughts, distress and exhaustion. Also, we identified other factors that decrease the fear of cancer recurrence in breast cancer patients including; younger age patients, having a good quality of time, good social support and good self-efficacy. Regarding preventive measures; our meta-analysis showed that breast cancer patients who underwent Mindfulness-Based Stress Reduction had significant improvements on the Center for Epidemiological Studies-Depression scale (P<0.0001), State-Trait Anxiety Inventory scale (P=0.0002) and perceived stress scale (P=0.0004). Also, we noticed that breast cancer patients who underwent blended cognitive behavior therapy or Smartphone problem-solving therapy had lower fear of cancer recurrence than those who received usual care. Finally, we advocate more research articles applying different modalities to overcome FCR in patients with breast cancer. Also, we recommend the use of different psychological treatments for patients with breast cancer to decrease their fear of cancer recurrence and improve their health.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"432 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efavirenz cocrystals with Ascorbic acid: A Strategy for Polymorphic Modification and improvement of Dissolution properties","authors":"Atul S. Gurav, Ajit S. Kulkarni","doi":"10.52711/0974-360x.2024.00034","DOIUrl":"https://doi.org/10.52711/0974-360x.2024.00034","url":null,"abstract":"The objective of this research was to improve the solubility and dissolution rate of Efavirenz (EFA), a BCS II drug utilized for HIV infection treatment, by cocrystallization with ascorbic acid (AA). An in silico analysis indicated that EFA and AA exhibited physical interaction and compatibility. EFA exists in two polymorphic forms, I and II, with varying crystalline habits, where polymorph II presents better solubility and dissolution rate. Cocrystals were prepared using the solvent evaporation method by varying AA concentration and temperature. FTIR and NMR analysis confirmed the absence of chemical interaction between EFA and AA. Increasing AA concentration and temperature significantly increased the saturation solubility. DSC, XRD and SEM analysis revealed a shift in the endothermic peak of EFA, change in intensity with 2θ values, and modified surface morphology respectively. This also confirmed a polymorphic structure change in the cocrystals due to high heating rates and maximum crystallization rate. The dissolution rate of the cocrystals was enhanced by the optimized batch, which contained an intermediate concentration of AA and was subjected to the highest temperature condition, and the data fitted well with the Higuchi model of kinetics. The stability of the cocrystals was also evaluated by accelerated stability testing to determine the percentage of drug content. Thus, cocrystallization with AA proved to be a suitable approach for enhancing the dissolution characteristics and polymorphic modification of BCS II drugs, such as EFA.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"61 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}