Reproduction最新文献

Effects of maternal exercise intensity during pregnancy on fetal ovarian development in mice. 妊娠期母体运动强度对小鼠胎儿卵巢发育的影响。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-28 DOI: 10.1093/reprod/xaag135

Fan Mo, Lu Chen, Jing Huang, Zhaojun Wang, Mengying Yin, Liaobin Chen, Hui Wang

{"title":"Effects of maternal exercise intensity during pregnancy on fetal ovarian development in mice.","authors":"Fan Mo, Lu Chen, Jing Huang, Zhaojun Wang, Mengying Yin, Liaobin Chen, Hui Wang","doi":"10.1093/reprod/xaag135","DOIUrl":"https://doi.org/10.1093/reprod/xaag135","url":null,"abstract":"Maternal exercise is widely regarded as beneficial for metabolic homeostasis and pregnancy outcomes; however, whether different exercise intensities are associated with distinct patterns of fetal ovarian development remains unclear. Pregnant C57BL/6J mice were assigned to control, limited exercise (LE; cage-space restriction from GD0 to GD17), moderate exercise (ME; 10 m/min treadmill running from GD9 to GD17), excessive exercise (EE; 14 m/min treadmill running from GD9 to GD17), or limited exercise with moderate exercise superimposed from GD9 to GD17 (LE&ME). The litter was used as the biological unit. Fetal ovaries collected on GD18 were assessed for morphology, proliferation and apoptosis, estradiol (E2) content, steroidogenesis-related markers, oocyte-development markers and candidate signalling pathways. Compared with controls, LE had lower ovarian volume, cumulative oocyte-profile counts, proliferative and oocyte-development indices, together with higher apoptosis-related indices, ovarian E2 content and steroidogenesis-related markers. ME increased ovarian volume, cumulative oocyte-profile counts, proliferative activity, E2 content, and several oocyte- and steroidogenesis-related markers. EE increased E2 and steroidogenesis-related markers but reduced oocyte-development markers without parallel increases in the measured morphometric or proliferative indices. LE&ME showed lower ovarian E2 content than LE and partially attenuated several LE-associated changes in proliferation, apoptosis and oocyte-development markers. Exploratory analyses identified correlations between Igf1 or Mek1 expression and selected developmental markers. Collectively, different maternal exercise intensities were associated with distinct fetal ovarian developmental profiles, with ME showing a more favourable overall profile.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149288687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early menarche in association with ovarian reserve and biological aging in young adults: a cross-sectional study. 早期月经初潮与卵巢储备和年轻成人的生物衰老有关：一项横断面研究。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-27 DOI: 10.1093/reprod/xaag134

Wenqing Liu, Ying Li, Yue Yu, Ya Wang, Liwei Zou, Deyun Liu, Ying Sun

{"title":"Early menarche in association with ovarian reserve and biological aging in young adults: a cross-sectional study.","authors":"Wenqing Liu, Ying Li, Yue Yu, Ya Wang, Liwei Zou, Deyun Liu, Ying Sun","doi":"10.1093/reprod/xaag134","DOIUrl":"https://doi.org/10.1093/reprod/xaag134","url":null,"abstract":"Age at menarche has declined in many populations, but whether earlier menarche is related to ovarian reserve markers and biological aging in young adulthood remains unclear. In this cross-sectional study, we compared 82 women with early menarche (<12 years) and 92 women with normal menarche (12-13.5 years), all aged 18-25 years, from Anhui Province, China. Serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone and estradiol (E2) were measured; antral follicle count (AFC) and ovarian volume were assessed by transabdominal ultrasound; and biological age was estimated using the Klemera-Doubal method (KDM-BA) and Phenotypic Age (PhenoAge). After adjustment for potential confounders, early menarche was associated with lower AMH (-15.5%, 95% CI: -26.8% to -2.4%) and AFC (-6.2%, 95% CI: -11.4% to -0.8%), higher FSH (22.1%, 95% CI: 5.5% to 41.3%) and E2 (25.7%, 95% CI: 6.5% to 48.3%), and greater KDM-BA acceleration (0.75 years, 95% CI: 0.04 to 1.46), but not with PhenoAge acceleration. These associations were modest: menarche group explained only 1.4%-4.1% of the variance in these outcomes. Early menarche is associated with small differences in ovarian reserve markers and biological age in young women; however, on its own it is unlikely to indicate a clinically meaningful reduction in reproductive potential.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149272826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term sildenafil attenuates age-associated functional and reproductive decline in male rats. 长期服用西地那非可减轻雄性大鼠与年龄相关的功能和生殖衰退。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-27 DOI: 10.1093/reprod/xaag136

Srdjan Sokanovic, Isidora Keselj, Marija Medar, Aleksandar Baburski, Silvana A Andric, Tatjana S Kostic

{"title":"Long-term sildenafil attenuates age-associated functional and reproductive decline in male rats.","authors":"Srdjan Sokanovic, Isidora Keselj, Marija Medar, Aleksandar Baburski, Silvana A Andric, Tatjana S Kostic","doi":"10.1093/reprod/xaag136","DOIUrl":"https://doi.org/10.1093/reprod/xaag136","url":null,"abstract":"Aging in males is accompanied by a progressive decline in physical activity, androgen status, and reproductive function. We investigated whether long-term treatment with the phosphodiesterase type 5 inhibitor sildenafil attenuates these changes and is accompanied by remodeling of mitochondrial homeostasis in the testis. Male rats were treated with low-dose sildenafil from 12 to 18 months of age, with age-matched untreated rats serving as controls and young adult rats providing a reference for the age-associated phenotype. Aging markedly reduced voluntary locomotor activity, circulating testosterone, and sperm production, while increasing circulating corticosterone. Long-term sildenafil treatment increased locomotor activity, testosterone, and sperm number, while corticosterone tended to decrease. Sildenafil-associated body weight changes were observed in animals with access to voluntary running. Treatment was also accompanied by pronounced changes in mitochondrial homeostasis-related gene expression in Leydig cells and spermatozoa. These transcriptional responses differed between cell types, particularly for genes regulating mitochondrial dynamics and quality control. Expression of mitochondrial homeostasis-related genes was more closely associated with circulating testosterone than with corticosterone and showed distinct testosterone-associated patterns in Leydig cells and spermatozoa. Recovery toward young levels differed among parameters, being more pronounced for reproductive and endocrine measures than for locomotor activity. These findings indicate that long-term low-dose sildenafil attenuates age-associated functional and reproductive decline and promotes a partial shift toward a younger male phenotype, accompanied by cell-specific mitochondrial transcriptional remodeling.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149272782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progesterone feedback effects on LH pulse and surge secretion in ovariectomized Bos taurus, Bos indicus and crossbred heifers. 黄体酮反馈对去卵巢牛牛、籼牛和杂交母牛黄体生成素脉冲和激素分泌的影响。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-22 DOI: 10.1093/reprod/xaag133

Sarah West, Lucas O E Silva, Viviana Garza, Jessica Sustaita-Monroe, Leslie King, Sarah Bynum, Emily Ecord, George Perry, Roberto Sartori, Rodolfo C Cardoso

{"title":"Progesterone feedback effects on LH pulse and surge secretion in ovariectomized Bos taurus, Bos indicus and crossbred heifers.","authors":"Sarah West, Lucas O E Silva, Viviana Garza, Jessica Sustaita-Monroe, Leslie King, Sarah Bynum, Emily Ecord, George Perry, Roberto Sartori, Rodolfo C Cardoso","doi":"10.1093/reprod/xaag133","DOIUrl":"https://doi.org/10.1093/reprod/xaag133","url":null,"abstract":"This study evaluated the effects of progesterone (P4) on LH pulse and surge secretion, and hypothalamic neuroendocrine differences between Bos indicus, Bos taurus, and crossbred heifers. Ovariectomized Brahman (n = 8), Hereford (n = 6), and Braford (F1; n = 7) heifers received estradiol (E2) implants to maintain low E2 concentrations. On d - 5, each heifer from the three genetic groups (Gen) was exposed to high P4 (HP4; two CIDRs for 5d), decreasing P4 (DP4; sequential CIDR removal from d - 1.5), and no P4 (NoP4) environments, creating a 3 × 3 crossover factorial design. Serial blood samples were collected for 8h on d - 0.5 (Pulse period) and for 6.5h on d0 (Surge period) following a GnRH challenge (100µg gonadorelin-acetate i.m.) to evaluate LH secretion. Subsequently, hypothalamic tissue was collected for dual-label immunofluorescence of kisspeptin and dynorphin in the arcuate nucleus. Circulating P4 differed among environments (P<0.01) but was not affected by Gen (P = 0.98), with no interaction. LH pulse frequency was reduced under HP4 and increased under DP4 compared to NoP4 (2.7±0.4, 6.7±0.5, and 5.0±0.6 pulses/8h; P<0.01), with no Gen effect (P=0.48). However, Bos indicus heifers exhibited lower LH pulse amplitude and peak than Bos taurus and crossbred (P<0.01). P4 environment did not affect GnRH-induced LH surge (P=0.96), but Bos taurus had greater surge than crossbred and Bos indicus (P<0.01). Additionally, Bos indicus had fewer kisspeptin- and dynorphin-immunopositive neurons in the arcuate nucleus. In conclusion, P4 suppressed LH pulse frequency without altering surge magnitude. Regardless of P4 environment, Bos indicus heifers exhibited reduced LH secretion and fewer kisspeptin/dynorphin neurons than Bos taurus.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149246350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective depletion of AMH-expressing granulosa cells in vivo impairs follicular development and fertility in female mice. 体内选择性消耗表达amh的颗粒细胞会损害雌性小鼠的卵泡发育和生育能力。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-19 DOI: 10.1093/reprod/xaag131

Tsutomu Endo, Mayu Tamemasa, Kana Hayakawa, Fuka Okada, Natsumi Oyama, Kyoko Watanabe, Tianfu Lai, Yuki Nakano, Yoshifumi Fujioka, Motohito Goto, Riichi Takahashi, Ayako Tomita, Koji Sugiura, Yoshikazu Hirate, Naoaki Mizuno, Yoshiakira Kanai, Masami Kanai-Azuma

{"title":"Selective depletion of AMH-expressing granulosa cells in vivo impairs follicular development and fertility in female mice.","authors":"Tsutomu Endo, Mayu Tamemasa, Kana Hayakawa, Fuka Okada, Natsumi Oyama, Kyoko Watanabe, Tianfu Lai, Yuki Nakano, Yoshifumi Fujioka, Motohito Goto, Riichi Takahashi, Ayako Tomita, Koji Sugiura, Yoshikazu Hirate, Naoaki Mizuno, Yoshiakira Kanai, Masami Kanai-Azuma","doi":"10.1093/reprod/xaag131","DOIUrl":"https://doi.org/10.1093/reprod/xaag131","url":null,"abstract":"In mammals, ovarian follicle development is a highly coordinated process that underlies female fertility. Granulosa cells expressing anti-Müllerian hormone (AMH) are widely used as a marker of growing follicles. However, the in vivo roles of granulosa cells in follicular development and female fertility remain unclear. Here, we analyzed AMH-toxin receptor-mediated cell knockout (AMH-TRECK) transgenic (Tg) mice on a NOG background, in which AMH-expressing granulosa cells are specifically depleted by diphtheria toxin (DT). We first found that, after a single DT injection into postnatal AMH-TRECK Tg females, AMH-expressing granulosa cells in primary and secondary follicles exhibited cleaved caspase-3 signals 1 day later and were depleted 4 days later. Second, after repeated DT injections weekly from 1 to 7 weeks of age in AMH-TRECK Tg females, antral follicles and corpora lutea were rarely observed, and the numbers of primordial, primary, and secondary follicles were decreased. Following PMSG and hCG stimulation, repeated DT-injected Tg females exhibited a reduced number of ovulated oocytes with a low proportion of mature oocytes, resulting in reduced IVF rates and fertility. Further, after a cessation of repeated DT treatment, ovarian weight and follicular development recovered: the numbers of primary, secondary, and antral follicles were recovered, whereas the primordial follicle pool remains reduced. We conclude that selective depletion of AMH-expressing granulosa cells in vivo impairs follicular development and fertility. Our model enables assessment of the in vivo effects of granulosa cell depletion and may provide a useful platform for future transplantation-based studies to understand complex follicular dynamics.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Fertility Preservation for Women Undergoing Cancer Treatment: From Cryopreservation to Novel Therapies. 癌症治疗女性生育能力保存的进展：从冷冻保存到新疗法。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-14 DOI: 10.1093/reprod/xaag123

R Antolín, M Gargallo-Alonso, A Lacueva-Aparicio, E E Telfer, I Ochoa, C Malo

引用次数: 0

Metabolic remodelling and dynamic integration of ATP supply from spermatogenesis to mature sperm function. 从精子发生到成熟精子功能的ATP供应的代谢重塑和动态整合。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-12 DOI: 10.1093/reprod/xaag130

Yasuyuki Kurihara

{"title":"Metabolic remodelling and dynamic integration of ATP supply from spermatogenesis to mature sperm function.","authors":"Yasuyuki Kurihara","doi":"10.1093/reprod/xaag130","DOIUrl":"https://doi.org/10.1093/reprod/xaag130","url":null,"abstract":"Male germ cell development begins with spermatogonial stem cell self-renewal and proceeds through meiosis and spermiogenesis, followed by epididymal maturation to generate mature sperm capable of motility and fertilisation. During this process, ATP demands and the physiological environment of germ cells change progressively. Therefore, ATP supply strategies are shaped by adaptation to stage-specific physiological constraints rather than by selection of pathways with the highest energetic efficiency. In the testes, metabolic pathways are remodelled in a stage-dependent manner in response to requirements for stemness and genome stability, changes in substrate availability associated with passage across the blood-testis barrier, energetic demands of meiosis, and extensive cellular reorganisation during spermiogenesis. Although sperm have limited transcriptional and translational capacities in the epididymis, their membrane properties, signalling systems, and metabolic functions mature through exposure to region-specific luminal environments and molecular transfer from the epididymal epithelium. In mature sperm, glycolysis and oxidative phosphorylation are spatially compartmentalised yet functionally coordinated, with their relative contributions adjusted in response to substrate availability, oxygen tension, and functional demand. Additional processes, including carbon recycling potentially mediated by gluconeogenesis-like reactions, may support ATP homeostasis under specific conditions. This review re-evaluates these findings within a unified framework in which physiological constraints define the metabolic pathways available at each developmental stage, thereby reshaping ATP supply strategies. Metabolic remodelling in the testes, maturation in the epididymis, and integration in mature sperm thus represent successive and interconnected processes that establish adaptive ATP supply throughout male germ cell development.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotinamide mononucleotide supports the development of bovine embryo through enhancement of mitochondrial function in morula. 烟酰胺单核苷酸通过增强桑葚胚线粒体功能支持牛胚胎发育。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-12 DOI: 10.1093/reprod/xaag128

Shuting Ye, Shu Hashimoto, Masaya Yamanaka, Sanath Udayanga Kankanam Gamage, Yuki Inoue, Hisataka Iwata, Yoshiharu Morimoto, Daisuke Tachibana

引用次数: 0

Identification of Immune-Related Hub Genes as Candidate Biomarkers for Preeclampsia: Integrative Transcriptomic and Machine Learning Approaches. 鉴定作为子痫前期候选生物标志物的免疫相关中心基因：整合转录组学和机器学习方法。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-10 DOI: 10.1093/reprod/xaag129

Xianyang Hu, Lu Liu, Tingxuan Yin, Xixi Huang, Hailin Yu, Yang Yan, Tianyu Zhong, Meirong Du, Fuju Zhao

{"title":"Identification of Immune-Related Hub Genes as Candidate Biomarkers for Preeclampsia: Integrative Transcriptomic and Machine Learning Approaches.","authors":"Xianyang Hu, Lu Liu, Tingxuan Yin, Xixi Huang, Hailin Yu, Yang Yan, Tianyu Zhong, Meirong Du, Fuju Zhao","doi":"10.1093/reprod/xaag129","DOIUrl":"https://doi.org/10.1093/reprod/xaag129","url":null,"abstract":"Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and is increasingly recognized as a disorder involving immune dysregulation. However, reliable candidate biomarkers and key molecular alterations associated with PE remain unclear. We integrated multiple public placental transcriptomic datasets from patients with PE and normotensive controls. Weighted gene co-expression network analysis and eight machine-learning algorithms were used to identify stable immune-related candidate genes, followed by immune infiltration analysis, single-cell analysis, SHAP interpretation, and in silico gene knockout analysis. A six-gene logistic regression model was evaluated in the same merged placental dataset used for feature selection and explored in a small independent peripheral-blood cohort. Frequency-based integration across the eight algorithms identified a six-gene signature comprising ACSS3, F13A1, MCTP1, PTGFR, SLC16A10, and TNFRSF11A. The model showed apparent discrimination in the merged placental dataset (AUC = 0.869, 95% CI: 0.820-0.919) and exploratory cross-tissue discrimination in the peripheral-blood cohort (AUC = 0.860, 95% CI: 0.691-1.000). Immunohistochemical analysis of placental tissues from five women with PE and five normotensive controls showed lower protein abundance of all six candidates in PE, consistent with the bulk transcriptomic findings. Single-cell analysis indicated heterogeneous cell-type-dependent expression patterns, while in silico knockout analysis suggested potential macrophage-associated regulatory effects. Collectively, these exploratory findings identify a six-gene immune-related candidate signature associated with PE that requires validation in larger, prospectively collected cohorts before clinical application.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contribution of circadian, sleep and hormonal rhythms to pregnancy outcomes: an opportunity for improved management of women during pregnancy. 昼夜节律、睡眠和荷尔蒙节律对妊娠结局的贡献：改善妊娠期妇女管理的机会。

IF 3.4 3区生物学

Reproduction Pub Date : 2026-10-08 DOI: 10.1093/reprod/xaag127

Thu Van-Quynh Duong, Rene Cortese, Hanne M Hoffmann

{"title":"The contribution of circadian, sleep and hormonal rhythms to pregnancy outcomes: an opportunity for improved management of women during pregnancy.","authors":"Thu Van-Quynh Duong, Rene Cortese, Hanne M Hoffmann","doi":"10.1093/reprod/xaag127","DOIUrl":"https://doi.org/10.1093/reprod/xaag127","url":null,"abstract":"Circadian rhythms are fundamental regulators of physiology and play a critical role in reproductive success. During pregnancy, precise temporal coordination of endocrine, metabolic, and immune processes is required to support maternal adaptation, placental function, and foetal development. Disruption of circadian rhythms through environmental factors such as light at night, shift work, or sleep disorders has emerged as a significant risk factor for adverse pregnancy outcomes, including preterm birth, gestational diabetes, and preeclampsia. In this review, we synthesize current evidence linking circadian and sleep disruption to pregnancy complications, with a particular focus on the temporal regulation of key hormones, including progesterone, oestrogen, cortisol, oxytocin, and melatonin. We discuss how altered rhythmicity of hormone production and tissue responsiveness may impair target tissue function, maternal cardiovascular adaptation, and the development of gestational diabetes. We highlight emerging mechanistic insights into molecular clock regulation across reproductive tissues and its interaction with environmental cues. Finally, we outline opportunities for clinical translation, including chronobiology-informed diagnostics and chronotherapeutic strategies, to improve pregnancy management and reduce the burden of adverse outcomes.","PeriodicalId":21127,"journal":{"name":"Reproduction","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0