Reviews in Clinical Medicine最新文献_第3页

The Prevalence of Zinc Deficiency in Six to Sixty Months Old Children with Febrile Seizure 6 ~ 60月龄热性惊厥患儿缺锌的发生率

Reviews in Clinical Medicine Pub Date : 2021-01-30 DOI: 10.22038/RCM.2021.54723.1348

A. Alami, H. Kianifar, F. Nabavi, S. Shayan, S. Babaniamansour, Derafshi Raheleh

{"title":"The Prevalence of Zinc Deficiency in Six to Sixty Months Old Children with Febrile Seizure","authors":"A. Alami, H. Kianifar, F. Nabavi, S. Shayan, S. Babaniamansour, Derafshi Raheleh","doi":"10.22038/RCM.2021.54723.1348","DOIUrl":"https://doi.org/10.22038/RCM.2021.54723.1348","url":null,"abstract":"Background: Bleeding during ENT surgeries may contribute to impaired view. The less blood in surgical filed, the better quality and more surgeon's satisfaction is expected. Deliberate hypotension is a technique to achieve this goal. Current study aimed to evaluate effects of Labetalol andNitroglycerinein deliberate hypotension.Methods: It is a double blind RCT,conducted on 68 septo-rhinoplastypatients in ENT ward, Imam Reza Hospital, Mashhad, during 2017 after obtaining written consent. Patients were assigned to receive Nitroglycerine (n=32) or Labetalol (n=36) randomly. Mean arterial pressure and HR monitored. Total blood loss was estimated and recorded at a Boezaart Surgical Field Grading Scale. Surgeon's satisfaction with surgical field condition was measured after the procedures using a questionnaire at a 5-point Likert scale.Results: Two studied groups were similar in demographic characteristics. Heart rate was lower in Labetalol group (P <0.001) significantly, but there was no significant difference between two groups regarding mean arterial pressure variations (P = 0.12). Surgeon's satisfaction with the operation condition was not significantly different (P= 0.28). According to Boezaart scale, no statistically significant difference was found between groups with regard to bleeding volume (P= 0.75). Patients in Labetalol group received less additive drugs to maintain hypotension than another group (P=0.025). Conclusion: Although Labetalol and Nitoglycerine are not much different in reducing blood loss or providing a better view of surgical field but Labetalol is superior in maintaining heart rate and hypotension and noneed toadditive drug.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44649496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Factor Predicting Severity of COVID-19: Narrative Review 预测COVID-19严重程度的预后因素:叙述性综述

Reviews in Clinical Medicine Pub Date : 2021-01-16 DOI: 10.22038/RCM.2021.53865.1344

Nasrin Milani, M. R. R. Zahmatkesh, S. Soleimanpour, Z. Mirfeizi

{"title":"Prognostic Factor Predicting Severity of COVID-19: Narrative Review","authors":"Nasrin Milani, M. R. R. Zahmatkesh, S. Soleimanpour, Z. Mirfeizi","doi":"10.22038/RCM.2021.53865.1344","DOIUrl":"https://doi.org/10.22038/RCM.2021.53865.1344","url":null,"abstract":"The coronavirus disease 2019 (COVID-19), which has spread to many countries, is so severe that it progresses rapidly to acute respiratory failure. Therefore, in our paper, we aimed to describe and evaluate the most practical laboratory pro-inflammatory factors to predict the course of severe COVID-19 cases.Given the physiopathology of COVID-19 and the consequent immune system hyperactivity, we started to investigate the background pathology of these occurrences aiming to find the prognostic laboratory factors in COVID-19 cases. All reviews focused on the potential cellular and molecular mechanisms causing the cytokine storm in viral diseases, and several studies approved applicable laboratory parameters for COVID-19 patients. Based on our data, increased CRP level, LDH, serum ferritin, creatine kinase (CK), higher D-dimer and FDP levels, IL-6, cardiac troponin I and longer PT can be potential markers for predicting the course of infection; particularly, D-dimer, which was elevated to five times the original count in severe cases. Apart from that, the severe cases showed lymphopenia, neutrophilia, thrombocytopenia, and prolonged PTT. However, there was contradictory evidence about AST, ALT, BUN, and serum creatinine.The major cause of COVID-19 in critical patients was a cytokine storm; therefore, prognostic factors in the cytokine storm can also predict the prognosis of COVID-19. Thus, severe cases can be solved by early detection of these laboratory parameters.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45834322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physician Burnout: a Brief Review of Its Definition, Causes, and Consequences 医师职业倦怠:对其定义、原因和后果的简要回顾

Reviews in Clinical Medicine Pub Date : 2020-12-01 DOI: 10.22038/RCM.2020.51483.1335

M. H. Daloee, M. AkbariRad, Sahar Rajabzadeh Karizi, Mehrdad Sarabi

{"title":"Physician Burnout: a Brief Review of Its Definition, Causes, and Consequences","authors":"M. H. Daloee, M. AkbariRad, Sahar Rajabzadeh Karizi, Mehrdad Sarabi","doi":"10.22038/RCM.2020.51483.1335","DOIUrl":"https://doi.org/10.22038/RCM.2020.51483.1335","url":null,"abstract":"Burnout among physicians is a potential warning to the health system and one of the prime occupational hazards of recent years. Burnout is characterized by emotional, mental, and physical fatigue. Numerous studies have shown that burnout has a high prevalence among physicians, such that about one-third of them are affected at some point in their career. A recent study from the United States reported that 45.8% of physicians present at least one symptom of burnout. Statistics indicating one suicide per day among physicians show the urgency of the matter and the need for improvement. It has been reported that this syndrome may even start from the beginning of medical studies such that medical students and r=is review article, we describe the main cause and consequences of physician burnout. To investigate the issue, the two keywords of “burnout” and “physician” were searched in PubMed, Medline, Sciences Direct, and Google Scholar. We did a comprehensive literature review to extract any recent related content about the cause and consequences of physician burnout. Drawing from the studied literature, it is concluded that to address the issue, first, the elements of physicians’ wellness and satisfaction should precisely be determined, then necessary interventions should be adopted to improve the situation.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48164674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Labetalol and Nitroglycerine,s Effects on Deliberate Hypotension in Septo-Rhinoplasty Ssurgery, a Randomized Clinical Trial 拉贝洛尔和硝化甘油对鼻中隔成形术中故意低血压影响的随机临床试验比较

Reviews in Clinical Medicine Pub Date : 2020-12-01 DOI: 10.22038/RCM.2021.47435.1313

Majid Rrazavi, Mohsen Najafi, M. Ahmadi, I. Kashani

{"title":"Comparison of Labetalol and Nitroglycerine,s Effects on Deliberate Hypotension in Septo-Rhinoplasty Ssurgery, a Randomized Clinical Trial","authors":"Majid Rrazavi, Mohsen Najafi, M. Ahmadi, I. Kashani","doi":"10.22038/RCM.2021.47435.1313","DOIUrl":"https://doi.org/10.22038/RCM.2021.47435.1313","url":null,"abstract":"Introduction:Bleeding during ENT surgeries may contribute to impaired view. The less blood in surgical filed, the better quality and more surgeon’s satisfaction is expected. Deliberate hypotension is a technique to achieve this goal. Current study aimed to evaluate effects of Labetalol andNitroglycerinein deliberate hypotension. \u0000Methods: It is a double blind RCT,conducted on 68 septo-rhinoplastypatients in ENT ward, Imam Reza Hospital, Mashhad, during 2017 after obtaining written consent. Patients were assigned to receive Nitroglycerine (n=32) or Labetalol (n=36) randomly. Mean arterial pressure and HR monitored. Total blood loss was estimated and recorded at a Boezaart Surgical Field Grading Scale. Surgeon’s satisfaction with surgical field condition was measured after the procedures using a questionnaire at a 5-point Likert scale. \u0000Results: Two studied groups were similar in demographic characteristics. Heart rate was lower in Labetalol group (P <0.001) significantly, but there was no significant difference between two groups regarding mean arterial pressure variations (P = 0.12). Surgeon’s satisfaction with the operation condition was not significantly different (P= 0.28). According to Boezaart scale, no statistically significant difference was found between groups with regard to bleeding volume (P= 0.75). Patients in Labetalol group received less additive drugs to maintain hypotension than another group (P=0.025). \u0000Conclusion: Although Labetalol and Nitoglycerine are not much different in reducing blood loss or providing a better view of surgical field but Labetalol is superior in maintaining heart rate and hypotension and noneed toadditive drug.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48621480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to Antiretroviral Therapy and Its Determinants in HIV Patients in Mashhad, IRAN, 2018: a Prospective Study 2018年伊朗马什哈德HIV患者抗逆转录病毒治疗依从性及其决定因素:一项前瞻性研究

Reviews in Clinical Medicine Pub Date : 2020-12-01 DOI: 10.22038/RCM.2020.52601.1339

Amin Bojdy, Mahnaz Arian, M. Najafi, Mahdi Mottaghi

{"title":"Adherence to Antiretroviral Therapy and Its Determinants in HIV Patients in Mashhad, IRAN, 2018: a Prospective Study","authors":"Amin Bojdy, Mahnaz Arian, M. Najafi, Mahdi Mottaghi","doi":"10.22038/RCM.2020.52601.1339","DOIUrl":"https://doi.org/10.22038/RCM.2020.52601.1339","url":null,"abstract":"Introduction:Proper adherence to antiretroviral therapy (ART) provides good viral load suppression, while poor adherence can give rise to resistant strains and failure of the treatment. Methods: We performed a prospective cohort study from December 2017 to March 2018. Of 245 patients, 103 of them were compliant with ART. Patient adherence is determined through the self-report method and pill-count method. Pill-count failed, and only self-reports of adherence were used for analysis. In each visit, we gave each patient medication needed for one month’s treatment and asked them to bring back drug-pockets in the next visit. We also ask the number of tablets they did consume in this period. Mean adherence in three months is considered final adherence. Pearson chi-square model was used for analysis.Results: Mean age ± SD was 40 ± 1.36 years. 44.7% were female. 84.5% of patients are considered adherent (≥ 95% of doses were consumed). Married patients had better adherence (p = 0.04). Age, sex, addiction, imprisonment history, intravenous drug usage were not associated with adherence (p > 0.05). We also extracted previews history of treatment cessation and regimen changes. Efavirenz containing regimens had a higher rate of failure (p = 0.001).Conclusion: Although the adherence level was acceptable, the lack of a self-report control method might overestimate adherence.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43766630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Epidemiological and Socio-Demographic Characteristics of Children with Acute Poisoning in Northeast of Iran. 伊朗东北部儿童急性中毒的流行病学和社会人口学特征

Reviews in Clinical Medicine Pub Date : 2020-12-01 DOI: 10.22038/RCM.2020.53996.1345

A. Alami, Maryam Aghaei, Sepideh Shayan Karkon, Raheleh ِDerafshi

{"title":"Epidemiological and Socio-Demographic Characteristics of Children with Acute Poisoning in Northeast of Iran.","authors":"A. Alami, Maryam Aghaei, Sepideh Shayan Karkon, Raheleh ِDerafshi","doi":"10.22038/RCM.2020.53996.1345","DOIUrl":"https://doi.org/10.22038/RCM.2020.53996.1345","url":null,"abstract":"Introduction:Acute Poisoning in the developed countries include about 2% of all childhood deaths and more than 5% cause of death in the developing countries. Poisoning usually is defined as taking a substance which can cause an organism becoming injured. The purpose of this study was to identify sociological factors that are important in improving prevention, prognosis, and management of poisoning. Methods: This retrospective evaluated 1200 children in the pediatric ward of the 22 Bahman hospital, Gonabad, Iran, from March 2015 to July 2018. The information about Children was recorded by individual examination of the files in standardized forms including epidemiological and demographic features for statistical analysis and data were analyzed by using the U Test Chi square, Pearson correlation analysis and variance analysis in SPSS Version 21.0. Results: Acute poisoning included 2.3% of referring causes with mean age 3.7 ± 1.3 years. The mean age of poisoned children was significantly lower than other children (p value = 0/002). The majority of cases were accidental poisonings with opium (ICD-10 T40.0X1) and methadone (ICD-10 T40.3X1). Most common symptoms were neurological disorders, vomiting, tachypnea and tachycardia.Common clinical symptoms in children diagnosed with poisoning include: Neurological symptoms including seizures, hallucinations, drowsiness, decreased level of consciousness and confusion (50%), nausea and vomiting (25%), tachypnea and tachycardia (7.1%). Respiratory depression, meiotic pupil, shortness of breath, cough, tears and hallucinations (3.6%) due to referring severe toxic patients to more equipped center no death was recorded in our center. Conclusion: Acute poisoning is one of the most abudant emergencies in children. This study with identifying epidemiological and demographic factors of acute poisoning in children would help to improve prevention, and management of future programs.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43232803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Perioral Skin Rejuvenation with Platelet – Rich Plasma 富含血小板的血浆对口周皮肤再生的评价

Reviews in Clinical Medicine Pub Date : 2020-12-01 DOI: 10.22038/RCM.2021.49093.1321

Suha N. Aloosi, Bahjat Taha Ahmed

{"title":"Evaluation of Perioral Skin Rejuvenation with Platelet – Rich Plasma","authors":"Suha N. Aloosi, Bahjat Taha Ahmed","doi":"10.22038/RCM.2021.49093.1321","DOIUrl":"https://doi.org/10.22038/RCM.2021.49093.1321","url":null,"abstract":"Introduction:Using Platelet- Rich Plasma (PRP )in aesthetic dermatology has been recently considered and its safety and effectiveness have been widely reported. We conducted this study to evaluate the technique and degree of benefit. Methods: Fifteen (15) patients with different ages, sexes, and facial perioral wrinkles have participated in the current research and received a session of monthly PRP injections (three courses), targeting line and wrinkles in the perioral area. In this study, we have prepared the PRP by using a special test tube and then centrifuge it with relative centrifugal force (RCF) of 1700G for 5 minutes, followed by two minutes of soft centrifugation at room temperature. Results: Mean age ± SD was 40 ± 1.36 years. 44.7% were female. 84.5% of patients are considered adherent (≥ 95% of doses were consumed). Married patients had better adherence (p = 0.04). Age, sex, addiction, imprisonment history, intravenous drug usage were not associated with adherence (p> 0.05). We also extracted previews history of treatment cessation and regimen changes. Efavirenz containing regimens had a higher rate of failure (p =0.001). Conclusion: Wrinkles in perioral area management by PRP injection is an easy technique, with high- quality result and high patient satisfaction, no serious side effects, high patient toleration, and short downtime. Platelet- Rich Plasma can be a competitive substitute for other fillers and revitalization methods in lips and perioral rejuvenation.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49494244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery Rate of Hyperthyrotropinemia and Its Associated Factors: A Prospective Observational Study 高甲状腺球蛋白血症的恢复率及其相关因素:一项前瞻性观察研究

Reviews in Clinical Medicine Pub Date : 2020-12-01 DOI: 10.22038/RCM.2021.54973.1351

S. Babaniamansour, Nazanin Ershadinia, Ehsan Aliniagerdroudbari, Amirmohammad Babaniamansour, Atieh Masali, A. Entezari

{"title":"Recovery Rate of Hyperthyrotropinemia and Its Associated Factors: A Prospective Observational Study","authors":"S. Babaniamansour, Nazanin Ershadinia, Ehsan Aliniagerdroudbari, Amirmohammad Babaniamansour, Atieh Masali, A. Entezari","doi":"10.22038/RCM.2021.54973.1351","DOIUrl":"https://doi.org/10.22038/RCM.2021.54973.1351","url":null,"abstract":"Introduction:Hyperthyrotropinemia (HT) can be transient or permanent. There is no specific protocol in confirmatory tests to discriminate between transient and permanent forms. The aim of this study was to investigate the prevalence of transient HT and the factors that help to discriminate transient from permanent HT. Methods:This was an observational prospective study in all neonates diagnosed with HT referred to the pediatric clinic of Boali Hospital, affiliated to Islamic Azad University Tehran Faculty of Medicine, Tehran, Iran during September 2017 and January 2019. The recovery rate was investigated during a three-month follow-up while withholding medical treatment. Data were analyzed with SPSS Version 22.0.Results: Totally, 80 neonates (65% girls) were enrolled in this study. Among them, 62 participants (77.5%) recovered without any treatment during the three months of follow-up. The recovery rate was significantly higher in term newborns (p < 0.01). The mean weight of recovered neonates (2767.7 ± 440.2 gr) was significantly higher than that of the neonates who did not recover (2141.7 ± 755.2) (p < 0.01). The mean level of thyroid-stimulating hormone (TSH) of the recovered neonates (9.4 ± 3.0 mIU/L) was significantly lower than in the neonates who did not recover (22 ± 6.5 mIU/L) (p < 0.01). Conclusion: The outcome of HT became mostly permanent in patients with a higher level of TSH. The prematurity and low birth weight were the influential factors on TSH level, which could indirectly increase the risk of HT permanence.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42856174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A look at the Current Situation of Iranian Molecular Diagnostic Methods and the Implementation of Required Future Policy: A Review Article. 伊朗分子诊断方法的现状和未来政策的实施：一篇综述文章。

Reviews in Clinical Medicine Pub Date : 2020-11-15 DOI: 10.22038/RCM.2020.41731.1282

M. Hajia

引用次数: 0

Effect of N-Acetylcysteine on Positive and Negative Syndrome Scale associated with Schizophrenia: A Meta-Analysis N-乙酰半胱氨酸对精神分裂症阳性和阴性综合征量表的影响：Meta分析

Reviews in Clinical Medicine Pub Date : 2020-09-01 DOI: 10.22038/RCM.2020.50482.1329

A. Ghaderi, A. Bussu, C. Tsang, S. Jafarnejad

{"title":"Effect of N-Acetylcysteine on Positive and Negative Syndrome Scale associated with Schizophrenia: A Meta-Analysis","authors":"A. Ghaderi, A. Bussu, C. Tsang, S. Jafarnejad","doi":"10.22038/RCM.2020.50482.1329","DOIUrl":"https://doi.org/10.22038/RCM.2020.50482.1329","url":null,"abstract":"Background and objective: N-acetylcysteine (NAC), a precursor of L-cysteine with antioxidant, anti-inﬂammatory and neurotropic effects, is a promising agent in alleviating symptoms associated with schizophrenia. However, the role of NAC on parameters of Positive and Negative Syndrome Scale (PANSS) remain uncertain. This systematic review and meta-analysis explored the effect of NAC on parameters of PANSS in patients with chronic schizophrenia. \u0000Methods: We searchedPubmed/MEDLINE™, PsycNET™, PsycLIT™, Scopus™ and Google Scholar™ for studies on the effect of NAC on PANSS in patients with schizophrenia from inception to March 2019. We adopted medical and non-medical subjects headings (MeSH, non-MeSH) and several keywords, including “NAC”, “N-acetylcysteine”, “N-acetyl cysteine”, “Acetylcysteine”, “N-Acetyl-L-cysteine”, “schizophrenia”, “psychotic disorder”, “psychosis”, “schizoaffective” and “dementia praecox”. \u0000Results: We identified seven trials with274 patients meeting the inclusion criteria, with follow up between 8-52 weeks, and NAC supplementation between 1200-3600 mg/day. Significant improvements in PANSS were identified following NAC for total (SMD=-0.61, 95% CI = -0.91, -0.31 ; P<0.001), general (SMD = -0.58; 95% CI = -0.90, -0.26; P=0.0004); and negative (SMD = -0.56; 95% CI = -0.92, -0.21; P = 0.001) scores, respectively. No significant heterogeneity was found among studies. Significant reductions were observed following sub-group analysis in trials ≤ 24 weeks duration, with appreciable effect size for total (SMD= -0.83), general (SMD= -0.67) and negative (SMD=-1.09) scores. \u0000Conclusion: Supplementation of NAC was effective in alleviating PANSS symptoms associated with schizophrenia in trials ≤ 24 weeks duration. The use of NAC as an adjunct seems promising and further investigation is warranted to determine its precise role.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43224034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0