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Effects of Exercise on Testosterone Level, Heat Shock Protein, and Fertility Potential 运动对睾酮水平、热休克蛋白和生育潜力的影响
Reviews in Clinical Medicine Pub Date : 2018-12-01 DOI: 10.22038/RCM.2018.31772.1232
Sedigheh Abdollahzadeh Soreshjani, M. Ashrafizadeh
{"title":"Effects of Exercise on Testosterone Level, Heat Shock Protein, and Fertility Potential","authors":"Sedigheh Abdollahzadeh Soreshjani, M. Ashrafizadeh","doi":"10.22038/RCM.2018.31772.1232","DOIUrl":"https://doi.org/10.22038/RCM.2018.31772.1232","url":null,"abstract":"In recent years, professional exercise has been significantly expanded among the individuals, especially young ones. According to high-intensity exercise courses, which are necessary for professional exercise, we decided to investigate the effects of high-intensity exercise  on testosterone levels, heat shock proteins, and fertility potentials. Findings have shown that the levels of testosterone increase in moderate exercise; however, there are findings about the decrease of testosterone in the athletes who exercise with high intensity. In addition, because the high-intensity training is considered as a stressful condition, the heat shock proteins are activated, and their expression levels are increased that shows the vital role of these essential proteins in eliminating or weakening of that stress. Besides, the parameters, such as sperm quantity, sperm motility, and morphology determine the fertility potential of a person, and studies have shown that high-intensity exercise has harmful effects on these parameters.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43598606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
A Review on Serum Level of Vitamin D in Atopic March 特应性三月血清维生素D水平的研究进展
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.32450.1238
Z. Amirian, F. Behmanesh, E. Heidari
{"title":"A Review on Serum Level of Vitamin D in Atopic March","authors":"Z. Amirian, F. Behmanesh, E. Heidari","doi":"10.22038/RCM.2018.32450.1238","DOIUrl":"https://doi.org/10.22038/RCM.2018.32450.1238","url":null,"abstract":"Recent studies have reported a relationship between vitamin D and atopic diseases such as asthma, allergic rhinitis, and atopic dermatitis, which is due to the recently discovered vitamin D receptors on many immune system cells. Among all atopic diseases, asthma has been studied the most in this regard. However, the role of vitamin D in other atopic diseases such as allergic rhinitis and atopic dermatitis is a matter of controversy. In this paper, we review the literature on the association between atopic diseases and vitamin D level with a focus on the childhood period. As of today, the role of vitamin D in atopic march is not clear and studies show controversial results. Therefore, further studies with adequate sample sizes and correction for perplexing factors are needed since this could be an innovative treatment in atopic children. It is also advisable to examine high-risk groups of children for vitamin D deficiency. According to the extracted data, vitamin D has a protecting effect against atopic diseases. At the same time, no evidence was found for such an association in some studies, thus, further studies are needed to clarify this issue.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41471068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Primary Central Nervous System Lymphoma Presenting with Peripheral Neuropathy; A Rare Case of Coincident PCNSL and Mononeuritis Multiplex 原发性中枢神经系统淋巴瘤表现为周围神经病变罕见的PCNSL合并多发性单神经炎1例
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.33480.1241
Z. Baghestani, R. Boostani
{"title":"Primary Central Nervous System Lymphoma Presenting with Peripheral Neuropathy; A Rare Case of Coincident PCNSL and Mononeuritis Multiplex","authors":"Z. Baghestani, R. Boostani","doi":"10.22038/RCM.2018.33480.1241","DOIUrl":"https://doi.org/10.22038/RCM.2018.33480.1241","url":null,"abstract":"A 43-year-old male presented with diplopia and right sixth-nerve palsy. Brain magnetic resonance imaging (MRI) demonstrated a lesion in the right periventricular area. High-dose corticosteroid pulse therapy did not resolve the symptom. After one month, his diplopia progressed and he developed weakness of the left lower limb. Detailed examination revealed left sixth-nerve palsy, dropped foot, waddling gait, atrophy of the gluteal muscles and mild atrophy and weakness of the right upper limb. Neurological examination supported evidence of multiple cranial nerve palsies along with asymmetrical peripheral neuropathy. Electrodiagnostic studies were compatible with a mononeuritis multiplex. Rheumatologic evaluations were normal. Malignancy work-up were normal, except for some insignificant lymph nodes. Bone marrow aspiration and biopsy were normal. The second brain MRI detected multiple homogenous enhancing lesions in the right periventricular area.The result of stereotactic biopsy and immunohistochemistry staining demonstrated primary B-cell CNS lymphoma (PCNSL). Mononeuritis multiplex has not been reported as a paraneoplastic manifestation of PCNSL yet. In other words, it is not clear whether involvement of the peripheral nervous system in our patient is a paraneoplastic manifestation of PCNSL or a coincidence of PCNSL and hematologic lymphoma presenting with peripheral vasculitic neuropathy. It is recommendedthat future studies focus more on symptoms associated with PCNSL to recognize the exact relationship between PCNSL and peripheral neuropathy.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42676768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Human Herpes virus 8 (HHV8-) and Plasma Cell Myeloma: a Systematic Review 人类疱疹病毒8型（HHV8-）与浆细胞性骨髓瘤相关性的系统评价
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.32149.1235
M. Sadeghian, Zahra Rezaei Dezaki, S. Shams, Sepideh Shakeri
{"title":"Correlation between Human Herpes virus 8 (HHV8-) and Plasma Cell Myeloma: a Systematic Review","authors":"M. Sadeghian, Zahra Rezaei Dezaki, S. Shams, Sepideh Shakeri","doi":"10.22038/RCM.2018.32149.1235","DOIUrl":"https://doi.org/10.22038/RCM.2018.32149.1235","url":null,"abstract":"Introduction: Plasma cell myeloma is the distortion of differentiated B lymphocytes which is associated with uncontrolled proliferation of plasma cells in bone marrow. Some studies propound a role for HHV-8 virus in pathogenesis of plasma cell myeloma. Yet the findings are inconsistent. In this article we reviewed the literatures to determine the HHV-8 virus role in plasma cell myeloma pathogenesis.Methods: In this systematic review, scientific databanks including PubMed, Scopus, Embase, ISI, and Google scholar were searched. The search was based on the subsequent keywords and medical terms in title; different combinations of keywords were used, they were compatible with MeSH terms.Result: Four articles declared that there is no link between the HHV-8 and the pathogenesis of plasma cell myeloma; while five reported a connection between the virus and myeloma, arguing that virus infection will lead to disease progression.Conclusion: There are differences between the results of the studies. It is required to do further researches about the association of HHV-8 and plasma cell myeloma.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43386742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Intractable Epilepsy in Children 儿童顽固性癫痫
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.31192.1230
M. B. Toosi, F. Ebrahimzadeh
{"title":"Intractable Epilepsy in Children","authors":"M. B. Toosi, F. Ebrahimzadeh","doi":"10.22038/RCM.2018.31192.1230","DOIUrl":"https://doi.org/10.22038/RCM.2018.31192.1230","url":null,"abstract":"A seizure is defined as a paroxysmal and transient occurrence of signs or symptoms resulting from abnormal synchronous or excessive neuronal activity in the brain. About 15 to 40 percent of children who have any type of seizure are resistant to standard anti-seizure drugs, so called intractable epilepsy. Before documenting the seizure attacks as refractory, the selected drugs using for the type of seizure and dose of them should be checked. There are several factors that predict development of refractory seizures. These include age <1 year, multiple seizures before starting the treatment, myoclonic seizures, neurologic defects, neonatal and daily seizures, male gender, and first abnormal electroencephalogram and brain imaging (including computerized tomography scan and / or MRI). Options for the management of refractory epilepsy, after prescribing routine anti-seizure drugs are: Second line drugs (IVIG treatment, Ketogenic diet, Prednisolone treatment or Herbal treatment), Surgery and Stem cell therapy. Because none of these methods can stop all the drug-resistant epilepsies, researches are going on.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68371722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Convulsion Associated with Gastroenteritis 与肠胃炎有关的抽搐
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.11719
M. Khalesi, F. Heydarian, S. J. Sayedi, Shima Badzai, E. Heidari
{"title":"Convulsion Associated with Gastroenteritis","authors":"M. Khalesi, F. Heydarian, S. J. Sayedi, Shima Badzai, E. Heidari","doi":"10.22038/RCM.2018.11719","DOIUrl":"https://doi.org/10.22038/RCM.2018.11719","url":null,"abstract":"Convulsion with mild gastroenteritis is an afebrile seizure associated with viral gastroenteritis in a healthy child without fever, dehydration, electrolyte imbalance, meningitis, or encephalitis. Convulsion with mild gastroenteritis is more common in children aged 1 to 2 years. Usually, Convulsions are brief generalized tonic colonic type. Most convulsions occur within first 24 hours of illness onset. Rotaviral gastroenteritis is known as the most common type of gastroenteritis associated with Convulsion. Laboratory investigations are normal. Also EEG and neuroimaging are usually normal. Long term antiepileptic treatment is not necessary. It is usually a benign condition with good prognosis and no risk for developing epilepsy in future. Considering this etiology of seizure could prevent supernumerary evaluations and long-term antiepileptic treatment.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45542939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Acute Subclavian Artery Thrombosis Secondary to Oral Contraceptive Agent Consumption: A Case Report 口服避孕药继发急性锁骨下动脉血栓形成1例报告
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.28505.1225
M. Ghiasian, Sajjad Daneshyar, M. Olfat
{"title":"Acute Subclavian Artery Thrombosis Secondary to Oral Contraceptive Agent Consumption: A Case Report","authors":"M. Ghiasian, Sajjad Daneshyar, M. Olfat","doi":"10.22038/RCM.2018.28505.1225","DOIUrl":"https://doi.org/10.22038/RCM.2018.28505.1225","url":null,"abstract":"Subclavian artery thrombosis is an uncommon cause of limb ischemia in females without a history of vasculopathy. This condition usually occurs secondary to atherosclerotic changes and hypercoagulable states, which are generally asymptomatic. However, it can manifest with such symptoms as coldness, pain, and pulselessness in the upper extremity. Herein, we presented a 40-year-old female admitted to our hospital with three days history of right-side hemiparesis and complaints of imbalance and vertigo. The patient had a history of 2-month consumption of high-dose oral contraceptive (OCP) agents for birth control purposes. Cervical magnetic resonance angiography showed a significant occlusion in the proximal part of the left subclavian artery, leading to the diagnosis of subclavian artery thrombosis secondary to the use of long-term high-dose OCP. Our diagnosis was confirmed with the Doppler color sonography. This case demonstrated the importance of a full assessment regardless of the patient’s chief complaints. This kind of assessment allows for a faster and more effective management, thereby reducing the associated costs. Therefore, any suggestive signs or symptoms of arterial thrombosis should be followed up even in low-risk patients. Accordingly, in case the achievement of confirmatory findings regarding the diagnosis of arterial thrombosis, the patient should be immediately subjected to proper medical and surgical interventions.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44672561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venlafaxine-induced Thyroiditis: A Case Report 文拉法辛致甲状腺炎1例报告
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.32213.1237
Ideh Ghafour, F. Elyasi
{"title":"Venlafaxine-induced Thyroiditis: A Case Report","authors":"Ideh Ghafour, F. Elyasi","doi":"10.22038/RCM.2018.32213.1237","DOIUrl":"https://doi.org/10.22038/RCM.2018.32213.1237","url":null,"abstract":"Thyroiditis is the most common inflammatory disorder that affects thyroid gland.The diagnosis is mainly based on clinical findings, in particular the degree of pain and tenderness of thyroid. Confirmatory laboratory test includes presence of thyroid specific autoantibodies. Treatment is based on the severity of symptoms (pain and redness) and aims to restore the normal function of thyroid. Drug-induced thyroiditis has been described previously in the literature. Venlafaxine is an antidepressant agent with an efficacy similar to that of selective serotonin reuptake inhibitors. The dose of this medicine can be adjusted up to 150 mg/day one year after initiation. However, usage of venlafaxine may be limited due to the dose-dependent side effects. Here we describe a patient diagnosed with generalized anxiety disorder and migraine headache who developed venlafaxine-induced thyroiditis following dose adjustment to the maximum of 150 mg/day. The diagnosis was made based on the clinical symptoms and confirmatory laboratory tests according to the Naranjo Adverse Drug Reaction Probability Scale. Thyroiditis symptoms subsided after reducing venlafaxine dose and initiating prednisolone therapy. It should be noted that thyroid function was fully restored to normal only after cessation of venlafaxine administration.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45051886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review 扁平苔藓和额纤维性脱发的治疗进展：系统综述
Reviews in Clinical Medicine Pub Date : 2018-09-01 DOI: 10.22038/RCM.2018.30338.1228
Behnoush Bakhshoudeh, M. Salehi, R. Sadeghi, Alireza Omranzadeh, T. Sahranavard, S. Arekhi, Ali Jafarzadeh Esfehani, Naghmeh Zabolinejad
{"title":"Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review","authors":"Behnoush Bakhshoudeh, M. Salehi, R. Sadeghi, Alireza Omranzadeh, T. Sahranavard, S. Arekhi, Ali Jafarzadeh Esfehani, Naghmeh Zabolinejad","doi":"10.22038/RCM.2018.30338.1228","DOIUrl":"https://doi.org/10.22038/RCM.2018.30338.1228","url":null,"abstract":"Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47829682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review 股骨头坏死的细胞治疗：文献综述
Reviews in Clinical Medicine Pub Date : 2018-06-01 DOI: 10.22038/RCM.2018.24046.1203
A. Parsa, M. H. Moghaddam, F. Bagheri, Mohammad Hassani
{"title":"Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review","authors":"A. Parsa, M. H. Moghaddam, F. Bagheri, Mohammad Hassani","doi":"10.22038/RCM.2018.24046.1203","DOIUrl":"https://doi.org/10.22038/RCM.2018.24046.1203","url":null,"abstract":"The preferred desire of orthopedic surgeons is to preserve the femoral head in the early stages of femoral head osteonecrosis; however, hip arthroplasty is needed in most cases. The outcomes of traditional surgical treatments alone are not favorable. Thus, femoral head osteonecrosis frequently follows an unpredictable course resulting in significant hip arthritis. Through the years, it has been identified that decreased proliferation capacity and content of bone marrow stem cells (BMSCs) in the femoral head region play a key role in the pathogenesis of osteonecrosis of femoral head (ONFH). In the past two decades, researchers have focused on cell-based therapies for ONFH treatment. The regenerative potential of damaged cartilage and bone tissue with stem cells has become a new treatment approach in the field of orthopedics. Ongoing basic science and clinical studies are progressing toward efficient standard treatment options for this extremely challenging condition. In this article, we reviewed the recently developed methods of cell therapy for these types of musculoskeletal conditions.","PeriodicalId":21081,"journal":{"name":"Reviews in Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45930952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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