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Recent advances in studies on cardiac structure and metabolism最新文献

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Substitution of phosphate for oxalate in the study of calcium accumulation and release by cardiac microsomal fractions. 用磷酸盐代替草酸盐在心脏微粒体部分钙积累和释放的研究中。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
J Dunnett, W G Nayler
{"title":"Substitution of phosphate for oxalate in the study of calcium accumulation and release by cardiac microsomal fractions.","authors":"J Dunnett,&nbsp;W G Nayler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Phosphate-supported calcium uptake by guinea pig cardiac sarcoplasmic reticulum has been shown to exhibit a pattern different from that of oxalate-supported calcium uptake. Ionophore-induced calcium release has been demonstrated following phosphate-supported calcium uptake. Rat cardiac sarcoplasmic reticulum has been shown to differ from the guinea pig in its sensitivity to ionophore.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"213-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11988972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of ATP or oxygen plus substrate on occurrence of the calcium paradox. ATP或氧加底物对钙悖论发生的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
T J Ruigrok, A B Boink, A N Zimmerman
{"title":"Influence of ATP or oxygen plus substrate on occurrence of the calcium paradox.","authors":"T J Ruigrok,&nbsp;A B Boink,&nbsp;A N Zimmerman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Reperfusion of Ca2+-deprived rat hearts with Ca2+-containing medium results in irreversible cell damage (calcium paradox). In this study this type of cell damage was studied in the anoxic rat heart, in the presence and absence of glucose. Creatine kinase (CK) release was used to define cell damage. Hearts were perfused successively with Ca2+-containing medium (30 min), Ca2+-free medium (5 min), and Ca2+-containing medium (5 min). In the presence of glucose, myocardial ATP was maintained at a fairly high concentration. Reperfusion with Ca2+ resulted in an immediate and massive release of CK. In the absence of glucose, the ATP concentration was almost zero after 30 min. Reperfusion with Ca2+ did not result in release of CK. Massive release occurred as soon as these hearts were reoxygenated. It is concluded that this type of calcium-induced cell damage only occurs in the presence of ATP, or oxygen plus substrate. Mitochondria most likely play a major role in the occurrence of the calcium paradox because of their ability to accumulate huge amounts of Ca2+ under these conditions.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"565-9"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energy liberation in abnormal cardiac muscle. 异常心肌的能量释放。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
T Ishiyama, Y Morita
{"title":"Energy liberation in abnormal cardiac muscle.","authors":"T Ishiyama,&nbsp;Y Morita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Uncoupling of oxidative phosphorylation was suggested in experiments using the infarcted myocardium, even in dogs with 15-min ligation. The same type of disturbance in mitochondrial respiration was observed in dogs with reperfusion after 45-min ligation, whereas the disturbance was recovered in dogs with reperfusion after 15-min ligation.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"583-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fine structure of the sinoatrial node of rabbit heart. 兔心脏窦房结精细结构。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
H Irisawa
{"title":"Fine structure of the sinoatrial node of rabbit heart.","authors":"H Irisawa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"77-80"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lowering of blood acetaldehyde levels-a possible approach to prevention of alcoholic cardiomyopathy. 降低血液中乙醛水平——预防酒精性心肌病的一种可能方法
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
C S Alexander, H T Nagasawa, E G Demaster, D J Goon
{"title":"Lowering of blood acetaldehyde levels-a possible approach to prevention of alcoholic cardiomyopathy.","authors":"C S Alexander,&nbsp;H T Nagasawa,&nbsp;E G Demaster,&nbsp;D J Goon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Based on the assumption that circulating acetaldehyde (AcH) is cardiotoxic, D-penicillamine was administered to dogs given alcohol orally, or given AcH intravenously. Paralleling the increase in plamsa norepinephrine (NE) and epinephrine (E) induced by AcH infusion, hemodynamic measurements showed a positive inotropic response with increase in pulse, blood pressure, left ventricular contractility, and cardiac output. Infusion of D-penicillamine abruptly lowered circulating levels of AcH and catecholamines, which was accompanied by an appropriate hemodynamic response.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"345-50"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12216835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relaxation of frog myocardium. 蛙心肌松弛。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
G Vassort, M J Roulet, K Mongo, R Clapier-Ventura
{"title":"Relaxation of frog myocardium.","authors":"G Vassort,&nbsp;M J Roulet,&nbsp;K Mongo,&nbsp;R Clapier-Ventura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tension fall of frog heart contraction was analyzed under voltage-clamp conditions. It appears mostly exponential. The rate of relaxation depends upon the extracellular and intracellular Na concentrations. This suggests that the relaxation is under the control of Na-Ca exchange. The speeding up of relaxation by adrenaline in frog heart is revealed by low Na solution, while it is hidden by the primordial Na-Ca exchange in Ringer's solution.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"143-7"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12267493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membrane calcium current in cardiac excitation: effects of ATP and related substances and sodium pump on bullfrog atrium. 心脏兴奋时膜钙电流:ATP及相关物质和钠泵对牛蛙心房的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M Goto, A Yatani, Y Tsuda
{"title":"Membrane calcium current in cardiac excitation: effects of ATP and related substances and sodium pump on bullfrog atrium.","authors":"M Goto,&nbsp;A Yatani,&nbsp;Y Tsuda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12267494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual effects of fluoride on the action potential, contraction, and membrane currents in frog atrial muscle. 氟对蛙心房肌动作电位、收缩和膜电流的双重影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
Y Abe, M Aomine, M Goto
{"title":"Dual effects of fluoride on the action potential, contraction, and membrane currents in frog atrial muscle.","authors":"Y Abe,&nbsp;M Aomine,&nbsp;M Goto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of NaF (10(-7) - 10(-2) M) on the membrane potential, current, and contractile tension in bullfrog atrial muscle were investigated under voltage-clamped or unclamped conditions. NaF showed two opposite actions, positive and negative inotropic effects, depending on the concentration of the drug. NaF in lower concentrations produced a marked increase in contractility, a moderate prolongation of action potential, an augmentation of calcium response, and an increase of ICa-dependent tension. Contrarily, NaF in higher concentrations produced an inhibition of contractile tension associated with a shortening of action potential, an increase in potassium conductance, and an inhibition of calcium response. These results indicate that NaF affects the contractile response by dual mechanisms.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12268308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcium transport and release by the sarcoplasmic reticulum. 钙通过肌浆网运输和释放。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
A M Katz, M Shigekawa, D I Repke, W Hasselbach
{"title":"Calcium transport and release by the sarcoplasmic reticulum.","authors":"A M Katz,&nbsp;M Shigekawa,&nbsp;D I Repke,&nbsp;W Hasselbach","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The slow rate of calcium transport by cardiac sarcoplasmic reticulum vesicles, compared to those prepared from skeletal muscle, is due mainly to a lesser density of transport sites and a lower Ca2+ affinity. Because the turnover rate of the cardiac sarcoplasmic reticulum calcium pump is similar to that of comparable skeletal muscle preparations, the cardiac sarcoplasmic reticulum seems able to effect the slower relaxation of the heart. Calcium permeability of skeletal sarcoplasmic reticulum vesicles is increased when the Ca2+ concentration outside the vesicles is increased, or when that inside the vesicle is decreased.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"205-12"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11246433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of physical fitness on myocardial damage and circulation after myocardial necrosis. 健身对心肌坏死后心肌损伤及循环的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M Ahmad, M Tajuddin, M Tariq
{"title":"Effect of physical fitness on myocardial damage and circulation after myocardial necrosis.","authors":"M Ahmad,&nbsp;M Tajuddin,&nbsp;M Tariq","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of physical training (conditioning) on myocardial circulation and myocardial damage has been evaluated in experimental myocardial necrosis in albino rats. Conditioning was done by making the animals swim in a tank of water, thermostatically controlled at 32 degrees +/- 1 degrees C, 60 minutes daily, six days a week, for eight weeks. Myocardial necrosis was produced by subcutaneous injection of isoproterenol, 85 mg/kg body weight, on two consecutive days. Investigations included ECG (lead II), SGOT, SGPT, SLDH, SCPK, histopathology of the heart, and myocardial Rubidium 84 uptake. It was observed that, in conditioned animals, elevation of serum enzymes was less, incidence of cardiac arrhythmia was lower, myocardial damage was less marked, and myocardial circulation was better after myocardial necrosis in comparison to unconditioned animals. Less myocardial damage and lower incidence of cardiac of cardiac arrhythmia are presumably associated with a better prognosis.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"519-24"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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