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Recent advances in studies on cardiac structure and metabolism最新文献

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Substitution of phosphate for oxalate in the study of calcium accumulation and release by cardiac microsomal fractions. 用磷酸盐代替草酸盐在心脏微粒体部分钙积累和释放的研究中。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
J Dunnett, W G Nayler
{"title":"Substitution of phosphate for oxalate in the study of calcium accumulation and release by cardiac microsomal fractions.","authors":"J Dunnett,&nbsp;W G Nayler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Phosphate-supported calcium uptake by guinea pig cardiac sarcoplasmic reticulum has been shown to exhibit a pattern different from that of oxalate-supported calcium uptake. Ionophore-induced calcium release has been demonstrated following phosphate-supported calcium uptake. Rat cardiac sarcoplasmic reticulum has been shown to differ from the guinea pig in its sensitivity to ionophore.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"213-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11988972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fine structure of the sinoatrial node of rabbit heart. 兔心脏窦房结精细结构。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
H Irisawa
{"title":"Fine structure of the sinoatrial node of rabbit heart.","authors":"H Irisawa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"77-80"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of coronary artery ligation on transmural high-energy phosphates following 20 minutes of blood reflow. 冠状动脉结扎术对20分钟血流后跨壁高能磷酸盐的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
C A Ramey, J W Holsinger
{"title":"The effects of coronary artery ligation on transmural high-energy phosphates following 20 minutes of blood reflow.","authors":"C A Ramey,&nbsp;J W Holsinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Normal or elevated levels of ATP and phosphocreatine (PCr) were observed from the subepicardium to the subendocardium of the canine left ventricle after five and 20 minutes of left circumflex artery occlusion followed by 20 minutes of blood reflow. However, after two or four hours of occlusion, followed by reflow, ATP and PCr levels were markedly depressed, and a significant decreasing decreasing subepicardial to subendocardial gradient appeared, suggestive of inhibition of oxidative metabolism during extended periods of ischemia but not during short periods of ischemia.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"573-7"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue specificity of myocardial glycopeptides synthesized during early embryonic development. 早期胚胎发育过程中心肌糖肽合成的组织特异性。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
F J Manasek, J W Lacktis
{"title":"Tissue specificity of myocardial glycopeptides synthesized during early embryonic development.","authors":"F J Manasek,&nbsp;J W Lacktis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>[3H] Glucosamine-labeled glycopeptides synthesized by hearts from stage 14-16 chick embryos were separated on DE-52 by ion-exchange chromatography and compared to those synthesized in other parts of the embryo at the same stage. Relatively few molecular species were present in all tissues, and they appeared closely homologous. There were no glycopeptides unique to any embryonic region examined, suggesting that tissue specificity may result from quantitative rather than qualitative differences in glycopeptides.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12217025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membrane calcium current in cardiac excitation: effects of ATP and related substances and sodium pump on bullfrog atrium. 心脏兴奋时膜钙电流:ATP及相关物质和钠泵对牛蛙心房的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M Goto, A Yatani, Y Tsuda
{"title":"Membrane calcium current in cardiac excitation: effects of ATP and related substances and sodium pump on bullfrog atrium.","authors":"M Goto,&nbsp;A Yatani,&nbsp;Y Tsuda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12267494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual effects of fluoride on the action potential, contraction, and membrane currents in frog atrial muscle. 氟对蛙心房肌动作电位、收缩和膜电流的双重影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
Y Abe, M Aomine, M Goto
{"title":"Dual effects of fluoride on the action potential, contraction, and membrane currents in frog atrial muscle.","authors":"Y Abe,&nbsp;M Aomine,&nbsp;M Goto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of NaF (10(-7) - 10(-2) M) on the membrane potential, current, and contractile tension in bullfrog atrial muscle were investigated under voltage-clamped or unclamped conditions. NaF showed two opposite actions, positive and negative inotropic effects, depending on the concentration of the drug. NaF in lower concentrations produced a marked increase in contractility, a moderate prolongation of action potential, an augmentation of calcium response, and an increase of ICa-dependent tension. Contrarily, NaF in higher concentrations produced an inhibition of contractile tension associated with a shortening of action potential, an increase in potassium conductance, and an inhibition of calcium response. These results indicate that NaF affects the contractile response by dual mechanisms.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12268308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcium transport and release by the sarcoplasmic reticulum. 钙通过肌浆网运输和释放。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
A M Katz, M Shigekawa, D I Repke, W Hasselbach
{"title":"Calcium transport and release by the sarcoplasmic reticulum.","authors":"A M Katz,&nbsp;M Shigekawa,&nbsp;D I Repke,&nbsp;W Hasselbach","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The slow rate of calcium transport by cardiac sarcoplasmic reticulum vesicles, compared to those prepared from skeletal muscle, is due mainly to a lesser density of transport sites and a lower Ca2+ affinity. Because the turnover rate of the cardiac sarcoplasmic reticulum calcium pump is similar to that of comparable skeletal muscle preparations, the cardiac sarcoplasmic reticulum seems able to effect the slower relaxation of the heart. Calcium permeability of skeletal sarcoplasmic reticulum vesicles is increased when the Ca2+ concentration outside the vesicles is increased, or when that inside the vesicle is decreased.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"205-12"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11246433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of energy production in cardiac muscle: effects of ischemia in acidosis. 心肌能量产生的控制:缺血对酸中毒的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
J R Williamson, C Steenbergen, G Deleeuw, C Barlow
{"title":"Control of energy production in cardiac muscle: effects of ischemia in acidosis.","authors":"J R Williamson,&nbsp;C Steenbergen,&nbsp;G Deleeuw,&nbsp;C Barlow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Evidence is summarized indicating that mitochondrial respiration and citric acid cycle activity in the intact heart are controlled by the cytosolic phosphate potential and mitochondrial NAD oxidation-reduction state. Data are presented showing that the effect of respiratory acidosis is greater than that of metabolic acidosis in inhibiting left ventricular pressure development in the perfused rat heart, because of a greater fall of intracellular pH under the former conditions. Respiratory acidosis is shown to be readily associated with tissue hypoxia as a result of an increased vascular resistance and diminished flow rate through the coronary circulation. In nonischemic respiratory acidosis, the rate of ATP production is well balanced by the rate of ATP utilization, and tissue ATP and creatine-P levels remain approximately normal. Partially ischemic respiratory acidosis was associated with low tissue levels of ATP and creatine-P and high tissue levels of lactate and NADH. Ischemic areas with sharp border zones were visualized during and after an abrupt decrease of perfusion fluid pH by directly photographing NADH fluorescence from the surface of perfused hearts. Reversal of the hypodynamic state with partially ischemic respiratory acidosis could not be achieved by augmenting the coronary flow by means of an external pump. The demonstration of the existence of sharp zones of high pyridine nucleotide fluorescence adjacent to normal zones indicates a great heterogeneity of coronary perfusion and the existence of steep oxygen gradients in the intact heart.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"521-31"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11246438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyploidization of heart muscle nuclei as a prerequisite for heart growth and numerical hyperplasia in heart hypertrophy. 心肌细胞核的多倍体化是心脏生长的先决条件和心脏肥大的数值增生。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
W Sandritter, C P Adler
{"title":"Polyploidization of heart muscle nuclei as a prerequisite for heart growth and numerical hyperplasia in heart hypertrophy.","authors":"W Sandritter,&nbsp;C P Adler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"115-27"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11364865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological study of hypertrophied myocardium of known etiologies with special reference to correlation of ECG changes. 病因明确的肥厚心肌的组织病理学研究，特别参考心电图变化的相关性。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
R Okada, K Kitamura
{"title":"Histopathological study of hypertrophied myocardium of known etiologies with special reference to correlation of ECG changes.","authors":"R Okada,&nbsp;K Kitamura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sixty-two autopsied hearts, with left ventricular hypertrophy (LVH) caused by mitral regurgitation (MR), aortic failure (AR), combined valvular disease (CVD), hypertension (HHD), or ischemia (IHD), and 23 control hearts with normal left ventricles were studied morphologically for analysis of modes of hypertrophy and for ECG-pathology correlation. Basic disorders modify the mode of hypertrophy; that is, elongated AR-type LV makes muscle fiber orientation in the outer layer more vertical, and globular MR-type LV makes it more horizontal than normal. High-voltage QRS correlates with hypertrophy of the outer layer which is often associated with that of the inner layer. ST depression and T changes correspond to relative deterioration of the inner and median layers, respectively.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"141-7"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11364867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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