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Recent advances in studies on cardiac structure and metabolism最新文献

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Metabolism of individual fatty acids in heart muscle. 单个脂肪酸在心肌中的代谢。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
K J Kako, S C Vasdev, G Zaror-Behrens
{"title":"Metabolism of individual fatty acids in heart muscle.","authors":"K J Kako,&nbsp;S C Vasdev,&nbsp;G Zaror-Behrens","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have studied the incorporation of various long chain fatty acids into tissue lipids using various heart preparations. We found that individual fatty acids are incorporated into various lipid fractions at unequal rates. In particular, erucic acid was shown to be a poor acyl donor for various acylation reactions. Labeling of triacylglycerol by exogenous fatty acid was found to be extremely rapid in the perfused rat heart and in the in vivo heart.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"369-77"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and phosphorylation of canine cardiac myosin in tissue-culture assessment of hypertrophying factors. 犬心肌肌球蛋白的合成和磷酸化在组织培养肥厚因子评价中的应用。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
J Wilkman-Coffelt, C Fenner, D T Mason
{"title":"Synthesis and phosphorylation of canine cardiac myosin in tissue-culture assessment of hypertrophying factors.","authors":"J Wilkman-Coffelt,&nbsp;C Fenner,&nbsp;D T Mason","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Canine cardiac myosin, which was synthesized in a 14-day tissue culture, based on L-[3H] leucine incorporation, was precipitated with goat gamma G antimyosin (cardiac-specific) and analyzed on dodecylsulfate gels. Incorporation of 32PO4 into myosin chains occurring in culture was the same as that obtained in vivo and appeared to be coupled with translation. Removal of 32PO4 from myosin heavy chains with base treatment indicated the presence of phosphoserine and phosphothreonine in canine cardiac myosin heavy chains. Further acid hydrolysis confirmed the data. The system described here, i.e., analyses of 32PO4 and L[3H] leucine incorporation into myosin heavy chains, could be used as a system for assaying hypertrophying factors.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"677-82"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contraction duration and diastolic stiffness in aged canine left ventricle. 老年犬左心室收缩持续时间和舒张刚度。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
G H Templeton, J T Willerson, M R Platt, M Weisfeldt
{"title":"Contraction duration and diastolic stiffness in aged canine left ventricle.","authors":"G H Templeton,&nbsp;J T Willerson,&nbsp;M R Platt,&nbsp;M Weisfeldt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data obtained from groups of young and old beagles demonstrate that senescent beagle hearts are characterized by lower contractile function as measured by developed pressure and maximal rate of pressure change with time, by longer contraction duration, and by increased dynamic stiffness per given pressure as measured by the sinusoidal forcing technique.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"169-73"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal mouse hearts in organ culture. Studies in cardiac metabolism. 胚胎小鼠心脏器官培养。心脏代谢的研究。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
J S Ingwall, K Wildential
{"title":"Fetal mouse hearts in organ culture. Studies in cardiac metabolism.","authors":"J S Ingwall,&nbsp;K Wildential","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"621-33"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial protection during open-heart surgery: preservation of myocardial metabolism and ultrastructure by cold coronary perfusion. 心内直视手术中的心肌保护:冠状动脉冷灌注对心肌代谢和超微结构的保护。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
A Nonoyama, K Kasahara, M Fukunaka, T Sato, A Masuda, S Kotani, T Kagawa
{"title":"Myocardial protection during open-heart surgery: preservation of myocardial metabolism and ultrastructure by cold coronary perfusion.","authors":"A Nonoyama,&nbsp;K Kasahara,&nbsp;M Fukunaka,&nbsp;T Sato,&nbsp;A Masuda,&nbsp;S Kotani,&nbsp;T Kagawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Myocardial protection by means of selective, continuous coronary perfusion with cold oxygenated blood of low flow rate and of low perfusion pressure is an excellent procedure both clinically and experimentally. This method should be particularly useful in poor-risk patients, for whom a maximal preservation of the myocardium is imperative.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"479-84"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial energy metabolism and protection of heart muscle at low temperatures. 低温下心肌能量代谢与心肌保护。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
T Watanabe, H Murashige, T Naito, S Sassa, S Takahashi, S Asazuma, I Hashimoto
{"title":"Myocardial energy metabolism and protection of heart muscle at low temperatures.","authors":"T Watanabe,&nbsp;H Murashige,&nbsp;T Naito,&nbsp;S Sassa,&nbsp;S Takahashi,&nbsp;S Asazuma,&nbsp;I Hashimoto","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"485-9"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local pulsatile intramyocardial pressure (IMP) as a vector force: simultaneous measurements of IMP and tissue oxygen availability. 局部搏动心内压(IMP)作为矢量力:IMP和组织氧可用性的同时测量。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
T Koyama, T Sasajima, T Yagi, Y Kakiuchi, T Arai
{"title":"Local pulsatile intramyocardial pressure (IMP) as a vector force: simultaneous measurements of IMP and tissue oxygen availability.","authors":"T Koyama,&nbsp;T Sasajima,&nbsp;T Yagi,&nbsp;Y Kakiuchi,&nbsp;T Arai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A directional nonuniformity of the intramyocardial pressure (IMP) was observed in anesthetized open-chest dogs using a piezoelectric pressure sensor implanted in the left ventricular myocardium. The nonuniformity seemed to be attributable to the variation in myocardial fiber orientation. The IMP, which developed in a direction parallel to the base-apex line, was measured in the deep portion of the myocardium, simultaneously with local O2 availability. In some cases, IMP decreased quickly as soon as a decrement in O2 availability had proceeded only slightly as a result of ligation of the anterior descending artery (LAD). In other cases, the once decreased IMP recovered gradually even when O2 availability remained lowered by continuation of the ligation. These observations indicated that IMP had no direct dependency on O2 availability in the case of acute LAD.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"237-43"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Binding of divalent cations by canine cardiac myosin: differences in normal right and left ventricles dependent upon number of light chains. 犬心肌肌球蛋白对二价阳离子的结合:正常左、右心室轻链数量的差异。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
J Wikman-Coffelt, D T Mason
{"title":"Binding of divalent cations by canine cardiac myosin: differences in normal right and left ventricles dependent upon number of light chains.","authors":"J Wikman-Coffelt,&nbsp;D T Mason","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The moles of calcium bound by the left ventricle were 1.5 +/- 0.1, while those of the right ventricle were 2.9 +/- 0.2. The calcium binding constants were the same between myosins of the two cardiac ventricles. The Ca2+ binding constants were approximately 1.1 X 10(5) M-1 for both left and right ventricular myosins. Left ventricular myosin bound 1.3 +/- 0.1 mol of Mn2+, whereas right ventricular myosin bound 2.8 +/- 0.1 mol of Mn2+. The divalent cation Mn2+ only partially competed out Ca2+ (50%). Because of the partial competition, it seemed that Ca2+ and Mn2+ had some sights in common. These studies demonstrate a twofold difference in divalent cation binding (Ca2+, Mn2+) between left and right ventricular myosins. This variation in cation binding between the two ventricles is reflected in similar differences in myosin ATPase activity between the two ventricles.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"103-9"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11364980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of acetaldehyde on functioning of cardiac muscle at the ultrastructural level. 乙醛对心肌超微结构功能的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
W G Nayler, E Fassold
{"title":"Effect of acetaldehyde on functioning of cardiac muscle at the ultrastructural level.","authors":"W G Nayler,&nbsp;E Fassold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of acetaldehyde, the hepatic metabolite of alcohol, on the functioning of cardiac muscle was investigated at the subcellular level. Concentrations of acetaldehyde that occur in plasma failed to alter either the microsomal Ca2+-accumulating and ATPase activity or the Ca2+-accumulating activity of the mitochondria. These same concentrations of acetaldehyde inhibited the Ca2+-dependent myofibrillar ATPase.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"489-94"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11364986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on myocardial mitochondria in failing dog hearts: studies by electron spin resonance (ESR) spectrometry. 衰竭犬心脏心肌线粒体的研究:电子自旋共振(ESR)光谱法研究。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
Y Suzuki, N Yamazaki, K Ogawa, K Mizutani, N Kakizawa
{"title":"Studies on myocardial mitochondria in failing dog hearts: studies by electron spin resonance (ESR) spectrometry.","authors":"Y Suzuki,&nbsp;N Yamazaki,&nbsp;K Ogawa,&nbsp;K Mizutani,&nbsp;N Kakizawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The formation of free radicals, which was represented by the concentration of free radicals in state 4 respiration, and the respiratory control ratio were studied in the myocardial mitochondria isolated from dog hearts that were failing due to aortic constriction. Both formation and respiratory control ratio were lowered, compared to each control value, in acute and chronic heart failure. A positive correlation was recognized between free radicals in state 4 respiration and respiratory control ratio. From these results it was concluded that there was uncoupling of oxidative phosphorylation in the mitochondria isolated from failing dog hearts. Measurement of free radicals in state 4 respiration, as well as respiratory control ratio, is a useful method for evaluation of the function of oxidative phosphorylation.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"599-603"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11418089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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