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Recent advances in studies on cardiac structure and metabolism最新文献

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Modulation of calcium in the heart. 心脏钙的调节。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
A Schwartz, G S Levey, M L Entman, E G Ezrailson, W B Van Winkle, E P Bornet, B J Pitts
{"title":"Modulation of calcium in the heart.","authors":"A Schwartz, G S Levey, M L Entman, E G Ezrailson, W B Van Winkle, E P Bornet, B J Pitts","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"195-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11364983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of rapid cooling on toad and guinea pig cardiac muscles. 快速冷却对蟾蜍和豚鼠心肌的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
S Kurihara, T Sakai
{"title":"Effect of rapid cooling on toad and guinea pig cardiac muscles.","authors":"S Kurihara,&nbsp;T Sakai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>When bathing solution temperature was lowered rapidly to below 5 degrees C, contracture was observed in toad and guinea pig cardiac muscles (Rapid Cooling Contracture, RCC). RCC in toad cardiac muscle was observed even in the presence of TTX and Mn, and enhanced by reducing [Na]o and caffeine. RCC in guinea pig cardiac muscle showed two components; phasic component was dependent on stimulation frequency before cooling, stimulation period, [Ca]o, and [Na]o; tonic component was not dependent on these factors, but was enhanced by reducing [Na]o and in high [K]o solution. From these results, the possible role of Ca ion accumulated at intracellular sequestered sites in cardiac muscle was discussed in relation to excitation-contraction (E-C) coupling.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"181-4"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12014780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible mode of action of nitroglycerin on heart mitochondria. 硝酸甘油对心脏线粒体可能的作用方式。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
L Szekeres, P Vághy, P Bor, K Csete
{"title":"Possible mode of action of nitroglycerin on heart mitochondria.","authors":"L Szekeres,&nbsp;P Vághy,&nbsp;P Bor,&nbsp;K Csete","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nitroglycerin has no effect on the electron transport and oxidative phosphorylation of isolated rabbit heart mitochondria at 5 X 10(-4) M and lower concentrations. However, it diminished the phosphate-induced energy-dependent potassium fluxes through the mitochondrial membrane in both directions; thus it was able to prevent the impairment of the efficiency of oxidative phosphorylation produced by increased ion transport.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"495-500"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12014781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ionic basis of excitation mechanism in cardiac muscle. 心肌兴奋机制的离子基础。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
E Coraboeuf
{"title":"Ionic basis of excitation mechanism in cardiac muscle.","authors":"E Coraboeuf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiac electrical activity is due to passive ionic permeabilities and, partially, to nonneutral (electrogenic) active transport, but extracellular accumulation or depletion of potassium is also of importance. The rapid sodium current responsible for the spike of the action potential and the slow calcium or calcium and sodium inward current responsible for the plateau are governed by activation and inactivation variables, but the range of potential in which the corresponding conductances \"open\" or \"close\" differs markedly. For that reason, partially depolarized fibers exhibit slow action potentials deprived of a rapid ascending phase. The normal sinoatrial and atrioventricular node action potentials are of this type. Several components of of outward (repolarizing) currents, mainly carried by potassium ions (although anions may also carry repolarizing currents), exist, some of them being controlled by intracellular calcium. Repolarization is a much more labile process in Purkinje fibers than in myocardium. Recovery from inactivation of rapid and slow inward currents is important in controlling the shape of the action potential as a function of the previous diastole.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"11-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11989254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiotoxic effects of adriamycin in mammalian cardiac cells in culture. 阿霉素对培养的哺乳动物心脏细胞的心脏毒性作用。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M W Seraydarian, M F Goodman
{"title":"Cardiotoxic effects of adriamycin in mammalian cardiac cells in culture.","authors":"M W Seraydarian,&nbsp;M F Goodman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiotoxicity of unknown etiology may preclude the use of adriamycin, a cancer chemotherapeutic agent. Mammalian cardiac cells in culture were used as a model system in the study of the mechanisms involved. Adriamycin inhibited cell growth, particularly of the fast-dividing nonmuscle cells. This inhibition might be a contributory factor to cardiomyopathy, but it does not explain the cessation of the rhythmic contractions characteristic of myocardial cells in culture. The concentrations of ATP and phosphorylcreatine (PC) were decreased in the adriamycin-treated cells, but the addition of creatine resulted in a several-fold increase of PC. Therefore, the regulation of energy production and the potential to maintain a high, steady-state concentration of PC were not impaired.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"713-9"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Free fatty acid content of myocardial interstitial spaces of dog. 犬心肌间隙游离脂肪酸含量。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
P Julien, G R Dagenais, L Gailis, P E Roy
{"title":"Free fatty acid content of myocardial interstitial spaces of dog.","authors":"P Julien,&nbsp;G R Dagenais,&nbsp;L Gailis,&nbsp;P E Roy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Morphological and biochemical observations from our laboratory have shown the presence of lipids in the cardiac interstitial spaces of the dog. The present study was designed to assess the importance of free fatty acids (FFA) in these lipids using FFA or sucrose tracers in 14 anesthetized fasting open-chest mongrel dogs. Endogenous FFA and labeled tracers were measured in arterial and coronary sinus plasma; they were also determined in lymph collected from cardiac efferent lymphatic trunks. [14C] sucrose was infused at a constant rate in the femoral vein of 5 dogs. The concentration of the tracer in the lymph was 90% of the arterial concentration after 60 min of infusion. On the other hand, when [1-14C] palmitate was infused at the same rate in 7 dogs, the ratio of lymph to arterial tracer concentration was only 20% (60 min) and 25% (120 min), even though the myocardial extraction and oxidation of the tracer were stable. This ratio tended to reach a plateau (greater than or equal to 90%) only 24 hr after a bolus injection of the tracer. This tracer study shows the presence of a pool of myocardial fatty acids with a relatively slow turnover rate that may constitute an important reservoir of FFA.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"385-9"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ouabain-induced arrhythmias of cultured myocardial cells and their improvement by quinidine. 瓦巴因致心肌细胞心律失常及奎尼丁对心律失常的改善作用。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
K Goshima
{"title":"Ouabain-induced arrhythmias of cultured myocardial cells and their improvement by quinidine.","authors":"K Goshima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Single-isolated myocardial cells obtained in vitro from fetal mouse heart developed various types of arrhythmic movements, such as fibrillatory and fluttering movements, in medium containing ouabain. The percentage of isolated myocardial cells that exhibited arrhythmic movements increased as ouabain concentration was increased. The arrhythmic movements induced by relatively low concentrations of ouabain were reduced by addition of quinidine. Cell clusters also developed various types of arrhythmic movements in medium containing ouabain. These arrhythmias became more severe when the ouabain concentration was increased. Under conditions such that approximately 43% of the single-isolated myocardial cells showed arrhythmias, many cells in cell clusters showed fibrillatory movements, but the cell clusters as a whole still maintained rhythmic beating. Under conditions in which about 65% of the single-isolated myocardial cells showed arrhythmias, cell clusters as a whole showed irregular beating. The cell clusters stopped beating under conditions in which about 79% of the single-isolated myocardial cells showed arrhythmias. Relatively mild types of arrhythmias of cell clusters were improved by addition of quinidine. From these observations, the genesis and improvement of arrhythmias of cell clusters were concluded to be essentially a result of the genesis and improvement of arrhythmic movements of the individual component cells in the clusters.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"697-704"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delay in diastolic restitution of full myocardial contractility in guinea pig atrium. 豚鼠心房心肌完全收缩性舒张恢复的延迟。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
H Reichel, K Baumann
{"title":"Delay in diastolic restitution of full myocardial contractility in guinea pig atrium.","authors":"H Reichel,&nbsp;K Baumann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an isolated perfused left atrium of guinea pig, pressure amplitudes were recorded at 37 degrees C and a stimulation rate of 240/min with interposed variable resting pauses. After prolonged intervals the preparation develops maximum pressure, which does not depend on perfusion time or on any positive inotropic intervention. The latter is found to shorten the time needed for restitution of full contractility. Nifedipine (5 X 10(-7)M) exerts its negative inotropic effect mainly by a delay in restitution time; acetylcholine (2 X 10(-7)M), by a concomitant reduction of all pressure amplitudes over the whole range of stimulus intervals. The latter effect is similar to that of lowering [Ca2+]o.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"175-9"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular localization of cardiac adenylate cyclase: sarcolemma or sarcoplasmic reticulum? 心脏腺苷酸环化酶的亚细胞定位:肌膜还是肌浆网?
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
L R Jones, H R Besch, A M Watanabe
{"title":"Subcellular localization of cardiac adenylate cyclase: sarcolemma or sarcoplasmic reticulum?","authors":"L R Jones,&nbsp;H R Besch,&nbsp;A M Watanabe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"227-34"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental studies on myocardial metabolism of carbohydrates and lipids in surface-induced deep hypothermia. 表面深度低温对心肌碳水化合物和脂质代谢的实验研究。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
H Shida, M Morimoto, K Inokawa, J Tsugane
{"title":"Experimental studies on myocardial metabolism of carbohydrates and lipids in surface-induced deep hypothermia.","authors":"H Shida,&nbsp;M Morimoto,&nbsp;K Inokawa,&nbsp;J Tsugane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In surface-induced deep hypothermia, metabolic acidosis resulting from lactacidemia was observed. In the hypothermic heart, the rate of reduction in the coronary arteriovenous (A-V) difference ratio of lactate, pyruvate, and nonesterified fatty acids (NEFA) was proportionately less than that of coronary flow and myocardial oxygen consumption, suggesting that lactate, pyruvate, and NEFA play important roles as energy fuels in the hypothermic heart. Myocardial metabolism of glucose was reduced; exogenous corticosteroids and ATP do not influence the myocardial metabolism of carbohydrates and lipids in the hypothermic heart.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"501-6"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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