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Recent advances in studies on cardiac structure and metabolism最新文献

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Right ventricular hypertrophy in tetralogy of Fallot. 法洛四联症的右心室肥厚。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M Kato, Y Kawashima, T Fujita, T Mori, H Manabe
{"title":"Right ventricular hypertrophy in tetralogy of Fallot.","authors":"M Kato,&nbsp;Y Kawashima,&nbsp;T Fujita,&nbsp;T Mori,&nbsp;H Manabe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Histopathological studies were carried out on right ventricular myocardium in 104 patients with tetralogy of Fallot (T/F). Detailed analysis of the correlation between morphological and clinical data was performed. Right ventricular hypertrophy in T/F was found to initiate immediately after birth, and the diameter of right ventricular muscle fiber (D) increased with age (r = 0.74). There was a correlation between D and the hemoglobin level. There was, however, no correlation between D arterial oxygen saturation (SaO2), and pulmonary trunk/aorta diameter (PA/Ao) ratio. Histopathological alterations were related directly to D and to the age of the patient, and were unrelated to hemoglobin, SaO2, and PA/Ao ratio. Irreversible histopathological alterations were first observed when the D exceeded 15 micron, when most patients were four years old or more. From these findings, it is considered that the optimal age for corrective surgery to prevent irreversible alteration of the right ventricular muscle fibers in patients with T/F is less than three years.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"149-55"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11364870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of insulin on mammalian cardiac muscle. 胰岛素对哺乳动物心肌的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
I Imanaga
{"title":"Effects of insulin on mammalian cardiac muscle.","authors":"I Imanaga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Insulin increases the contractile force of myocardium with hyperpolarization and a faster rate of fall of the action-potential plateau. This phenomenon is augmented inthe reduced-K+ or ouabain solution. It is suggested that the insulin-induced positive inotropism can be explained by facilitation of inward movement of Ca2+, which possibly is associated with an increase in outward movement of K+.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"441-50"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental studies on cardiac arrhythmias with special reference to fibrillation in heart cell culture. 心律失常的实验研究，特别是心脏细胞培养中的纤颤。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
S Yoneda, S Toyama
{"title":"Experimental studies on cardiac arrhythmias with special reference to fibrillation in heart cell culture.","authors":"S Yoneda,&nbsp;S Toyama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fibrillation-like beating of cardiac muscle cells in culture was induced by altering the concentrations of various ions. Fine structural changes of cell membrane and intercellular alteration of cardiac muscle cells appeared to be more prominent in cells with fibrilliation-like beating than in others. From the results of the present study, it may be concluded that fibrillation-like beating may occur in the presence of altered concentrations of certain ions, accompanied by fine structural changes in the cells.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"705-6"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on experimental coronary insufficiency. II. Effects of beta-adrenergic blocking agent (propranolol) on metabolic response to adrenaline and noradrenaline in dogs with coronary constriction. 实验性冠状动脉不全的研究。2-肾上腺素能阻滞剂(心得安)对冠状动脉收缩犬肾上腺素和去甲肾上腺素代谢反应的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
O Iimura, C Wakabayashi, T Kobayashi, T Shoji, S Yoshida, M Miyahara
{"title":"Studies on experimental coronary insufficiency. II. Effects of beta-adrenergic blocking agent (propranolol) on metabolic response to adrenaline and noradrenaline in dogs with coronary constriction.","authors":"O Iimura,&nbsp;C Wakabayashi,&nbsp;T Kobayashi,&nbsp;T Shoji,&nbsp;S Yoshida,&nbsp;M Miyahara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To obtain further information on the mechanism by which catecholamines produce myocardial ischemia, the effects of propranolol on metabolic and mechanical responses to adrenaline or noradrenaline were investigated in coronary-constricted dogs. Propranolol suppressed the myocardial ischemia produced by noradrenaline and adrenaline in dogs with moderate coronary constriction.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"543-7"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural change in myocardium subsequent to ischemic cardioplegia "no-reflow phenomenon". 缺血性心脏骤停后心肌超微结构改变的“无血流现象”。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M Sunamori, R Hatano, T Suzuki, N Yamamoto, T Tsukuura, T Yamada, T Kumazawa, M Nakagawa, T Sunaga
{"title":"Ultrastructural change in myocardium subsequent to ischemic cardioplegia \"no-reflow phenomenon\".","authors":"M Sunamori,&nbsp;R Hatano,&nbsp;T Suzuki,&nbsp;N Yamamoto,&nbsp;T Tsukuura,&nbsp;T Yamada,&nbsp;T Kumazawa,&nbsp;M Nakagawa,&nbsp;T Sunaga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mongrel dogs were subjected to cardiopulmonary bypass with hemodilution and to normothermic anoxic arrest for 30 minutes, to study the subepicardial and the subendocardial myocardial ultructure and the DPTI/TTI ratio. \"No-reflow phenomenon\" was demonstrated in the myocardium after cardiopulmonary bypass, associated with normothermic anoxic arrest. No-reflow phenomenon was a contributing factor to subendocardial ischemia in the normotrophied ventricle after open-heart surgery. Severe hemodilution with hemoglobin less than 5.0 g% resulted in irreversible damage in both myocardial layers.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"597-601"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viability and histopathology of eleven fresh, antibiotic-treated allografts removed three weeks to three years after implantation. 11个新鲜的，抗生素治疗的同种异体移植物在植入后3周至3年的生存能力和组织病理学。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
N Al-Janabi, H E Olson, T Ammerante, D N Ross
{"title":"Viability and histopathology of eleven fresh, antibiotic-treated allografts removed three weeks to three years after implantation.","authors":"N Al-Janabi,&nbsp;H E Olson,&nbsp;T Ammerante,&nbsp;D N Ross","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Changes in metabolic activity of removed heart valve allografts have been measured. The fresh heart valves were sterilized and stored in antibiotic solution before implantation in patients. Viability was determined before insertion and after removal from patients by two methods: 1) tissue culture, and 2) autoradiography, using tritiated thymidine. The length of storage in the Hank's antibiotic or nutrient-antibiotic medium before insertion did not seem to influence the final metabolic activity nor the structural integrity of the allografts when they were removed. Results from the present study show that the most severe degenerative changes occur in valves stored in Hank's solution and then implanted in the mitral position. The viability percentage declined progressively during the time that a valve treated in this manner was functioning in a patient.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"549-56"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transmural gradients in myocardial gas tensions in regionally ischemic canine left ventricle. 局部缺血犬左心室心肌气体张力的跨壁梯度。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
J Flaherty, J O'Riordan, S Khuri, V Gott
{"title":"Transmural gradients in myocardial gas tensions in regionally ischemic canine left ventricle.","authors":"J Flaherty,&nbsp;J O'Riordan,&nbsp;S Khuri,&nbsp;V Gott","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Previous studies from this laboratory have demonstrated the usefulness of myocardial gas tensions as measured by mass spectrometry for the quantitative assessment of regional myocardial ischemia (Khuri et al., 1975a). Progressive increases in myocardial carbon dioxide tensions were noted when progressive reduction in coronary blood flow was created by means of a variable constrictor. The present study was designed to determine if changes in myocardial oxygen and carbon dioxide tension were greater in deep, compared to more superficial, myocardial layers. In eight anesthetized dogs, progressive reduction in circumflex coronary flow was associated with a progressive reduction in myocardial oxygen tension and a progressive increase in myocardial carbon dioxide tension and intramyocardial ST-segment voltage. Evidence of a transmural gradient in the severity of ischemia was present at all degrees of flow reduction. These results confirm the findings of previous metabolic studies, which demonstrated gradients in lactate and high-energy phosphates. Myocardial carbon dioxide tension, which can be monitored continuously by mass spectrometry, would appear to provide a useful means of quantitatively assessing changes in regional myocardial metabolism.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"219-25"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
X-ray microanalysis of mitochondrial calcium. 线粒体钙的x射线微量分析。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
H D Sybers
{"title":"X-ray microanalysis of mitochondrial calcium.","authors":"H D Sybers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>X-ray microanalytical techniques using wavelength dispersive (WDS) and energy dispersive spectrometry (EDS) indicate that Ca2+ is present in intramitochondrial granules which occur in myocardial cells following irreversible ischemic injury. Preliminary results using tissue prepared for routine electron microscopy suggest that the degree of calcium binding that occurs in the mitochondria increases with increased duration of ischemia. Free ions are leached out of the tissue during processing; hence, the role of ion redistribution in producing myocardial necrosis cannot be elicited from a study of this nature. However, with continued progress in the development of techniques of tissue preparation x-ray spectrometry may provide a means of assessing quantitative ion alterations that occur during ischemia.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"279-89"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic consequences of Sephadex-induced reduction of coronary flow in isolated rat heart. 西伐地克斯诱导的离体大鼠心脏冠状动脉血流减少的代谢后果。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
H Stam, J W De Jong, H L Van Der Wiel
{"title":"Metabolic consequences of Sephadex-induced reduction of coronary flow in isolated rat heart.","authors":"H Stam,&nbsp;J W De Jong,&nbsp;H L Van Der Wiel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With a polysaccharide microsphere suspension (Sephadex), coronary flow of isolated perfused rat hearts was reduced by approximately 70%. During this Sephadex-induced ischemia, the energy charge and creatine phosphate content of the myocardial tissue dropped significantly, while total nucleoside and lactate release from the heart increased. During hypoxia (30% O2), changes in high-energy phosphate content and lactate and nucleoside release were similar to the changes induced by ischemia. During hypoxia, coronary flow rate was increased by 47%. Thus, Sephadex-induced reduction of coronary flow could be a useful model in studies of metabolic change during ischemia.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"253-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraventricular conduction disturbance due to delayed recovery from ventricular inactivation in chlorpromazine-treated dogs. 氯丙嗪治疗犬脑室失活后延迟恢复所致的脑室内传导障碍。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M Arita, Y Nagamoto, T Saikawa
{"title":"Intraventricular conduction disturbance due to delayed recovery from ventricular inactivation in chlorpromazine-treated dogs.","authors":"M Arita,&nbsp;Y Nagamoto,&nbsp;T Saikawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In in situ canine hearts, chlorpromazine induced a time (preceding cycle length)-dependent decrease in conduction velocity within the ventricle. Thus, QRS duration of nonpremature beats was lengthened at rapid pacing rates while QRS duration of atrial premature beats was lengthened at short coupling intervals. These slow conductions were not due to reduced take-off potential of ventricular action potentials but to drug-induced slow recovery of the rapid Na+ system. The phenomenon may be responsible for reported QRS prolongation and fatal ventricular arrhythmias encountered in patients receiving phenothiazines.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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