Reviews in cardiovascular medicine最新文献

{"title":"Effect of Interactions Between Endothelial Lipase Gene Polymorphisms and Traditional Cardiovascular Risk Factors on Coronary Heart Disease Susceptibility.","authors":"Chunhui He, Xingming Song, Ting He, Qing Tian, Yuhui Zhang, Halisha Airikenjiang, Dilihumaer Abulaiti, Haitang Qiu, Mengbo Zhu, Juan Yang, Jian Zhang, Ying Gao","doi":"10.31083/RCM37356","DOIUrl":"10.31083/RCM37356","url":null,"abstract":"<p><strong>Background: </strong>Coronary heart disease (CHD) arises from a complex interplay of genetic and environmental factors. This study examines the influence of <i>endothelial lipase</i> gene polymorphisms (<i>rs2000813</i> and <i>rs3813082</i>) and their interactions with traditional cardiovascular risk factors on CHD susceptibility.</p><p><strong>Methods: </strong>This retrospective case-control study enrolled 900 CHD patients and 900 control subjects. We evaluated associations between conventional cardiovascular risk factors and polymorphisms at the <i>rs2000813</i> and <i>rs3813082</i> loci in the <i>endothelial lipase</i> gene. Multifactorial analysis was used to assess interactions between traditional risk factors and these polymorphisms. Additionally, we developed a predictive model integrating genetic variants and clinical variables to estimate CHD risk.</p><p><strong>Results: </strong>No significant differences were observed in the distribution of <i>rs2000813</i> genotypes (<i>CC</i>, <i>CT</i>, <i>TT</i>) and alleles (<i>C</i>, <i>T</i>), or <i>rs3813082</i> genotypes (<i>AA</i>, <i>AC</i>, <i>CC</i>) and alleles (<i>A</i>, <i>C</i>) between CHD and control groups, including among males. However, in females with CHD, the <i>rs2000813CT</i> genotype was significantly more frequent (49.30%) than in controls (37.80%), whereas the <i>CC</i> genotype was less frequent in the CHD group (45.00%) than in controls (55.20%). Multivariate logistic regression identified the <i>rs2000813CT</i> genotype, hypertension, ages ≥60 years, body mass index (BMI) values ≥28 kg/m², total cholesterol (TC) ≥6.2 mmol/L, and apolipoprotein B (ApoB) ≥1.1 g/L as potential risk factors for CHD in women (<i>p</i> < 0.05). Gene-environment interaction analysis revealed that BMI exerted the greatest influence (12.62%). A predictive model incorporating <i>rs2000813</i> genotypes estimated CHD risk in women with an area under the curve (AUC) of 0.804.</p><p><strong>Conclusions: </strong>The <i>rs2000813CT</i> <i>endothelial lipase</i> genotype is potentially associated with an increased CHD risk in females, whereas the <i>CC</i> genotype may confer a protective effect. Integrating <i>endothelial lipase</i> gene variants with traditional cardiovascular risk factors enhances CHD risk prediction in women. Synergistic interaction between <i>endothelial lipase</i> polymorphisms and environmental factors appears to influence CHD occurrence in this population.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"37356"},"PeriodicalIF":1.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does HFpEF Exist? A Comment on \"The Concept of 'Heart Failure with Preserved Ejection Fraction': Time for a Critical Reappraisal\" (Rev Cardiovasc Med. 2023;24(7):202).","authors":"Maria Giulia Bellicini","doi":"10.31083/RCM42408","DOIUrl":"10.31083/RCM42408","url":null,"abstract":"","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"42408"},"PeriodicalIF":1.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trend Analysis of Atrial Fibrillation/Flutter Disease Burden in High-Income Countries Between 1990 and 2021.","authors":"Yuqiao Pang, Hui Li, Yuyao Zhang, Xiaoting Sun, Hong Li, Yi Liang, Xuejing Song, Lizhi Zhao","doi":"10.31083/RCM36427","DOIUrl":"10.31083/RCM36427","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation and atrial flutter (AF/AFL) disease is a common arrhythmia that poses a significant health risk to the older population. With an aging population worldwide, the incidence and mortality rates of AF/AFL show notable gender differences, presenting a challenge to public health systems. This study focused on the AF/AFL disease burden trends in high-income European Union 15+ (EU15+) countries.</p><p><strong>Methods: </strong>Data were sourced from the Global Burden of Disease Study (GBD 2021), using age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) by gender for each year from 1990 to 2021 in EU15+ countries; the mortality-incidence index (MII) was calculated. Analyses were conducted using Joinpoint regression software and age-period-cohort (APC) models to evaluate trends in morbidity, annual changes in morbidity (net drift), annual percentage changes in age-specific morbidity (local drift), and period- and cohort-relative risks by gender, allowing the impact of age, period, and cohort effects on morbidity trends to be assessed.</p><p><strong>Results: </strong>The study found a declining trend in AF/AFL ASIRs and ASMRs in most EU15+ countries, though significant differences were observed between countries. Male ASIRs and ASMRs were generally higher than those of females, though older women often had higher incidence and mortality rates than men. Furthermore, advances in treatment methods, such as updated anticoagulation therapy, radiofrequency ablation, and novel rhythm control drugs, have impacted the changes in disease burden.</p><p><strong>Conclusions: </strong>Although the AF/AFL disease burden has declined in more than half of the high-income EU15+ countries, there are significant differences in trend changes between countries. This decline may be due to advances in treatment, such as newer anticoagulation therapies, radiofrequency ablation techniques, and the use of novel cardioverter drugs. Trend changes with unique characteristics may be related to the healthcare system of each country, socioeconomic factors, and the promotion of health education. This study also identified gender differences, with older women at greater risk of developing AF/AFL, implying that the older female population faces the need for enhanced risk assessment and management.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"36427"},"PeriodicalIF":1.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Dysfunction, Coronary Artery Lesion Complexity, and Adverse Cardiovascular Outcomes in Patients With Acute Coronary Syndrome.","authors":"Qiang Chen, Yike Li, Siqi Yang, Haoming He, Yingying Xie, Wei Wang, Long Wang, Yanxiang Gao, Lin Cai, Shiqiang Xiong, Jingang Zheng","doi":"10.31083/RCM38389","DOIUrl":"10.31083/RCM38389","url":null,"abstract":"<p><strong>Background: </strong>Renal dysfunction is linked to both the complexity of coronary artery lesions and the prognosis of acute coronary syndrome (ACS). However, the nature of this intricate relationship remains unclear. Therefore, this study aimed to investigate the mechanisms through which coronary lesion complexity mediates the association between renal dysfunction and adverse cardiovascular outcomes in patients with ACS.</p><p><strong>Methods: </strong>This analysis included 1400 ACS patients who underwent percutaneous coronary intervention (PCI). Renal function was assessed using the estimated glomerular filtration rate (eGFR), calculated according to the 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, which incorporates both creatinine and cystatin C. Coronary lesion complexity was evaluated using the baseline SYNTAX score (bSS). The associations among eGFR, bSS, and major adverse cardiovascular events (MACEs) were examined using survival analysis, restricted cubic spline (RCS) analysis, and mediation analysis.</p><p><strong>Results: </strong>A total of 229 MACEs (16.4%) occurred over a median follow-up of 31.03 (27.34, 35.06) months, including 99 all-cause deaths (7.0%), 41 myocardial infarctions (2.9%), and 123 unplanned revascularizations (8.9%). After multivariate adjustment, both the eGFR and bSS significantly predicted MACEs across the total population and various subgroups. Mediation analysis showed that bSS mediated 16.49%, 14.76%, 12.87%, and 11.95% of the correlation between eGFR and MACEs in different adjusted models.</p><p><strong>Conclusion: </strong>The relationship between renal dysfunction and MACEs in ACS patients is partially mediated by coronary lesion complexity. This finding underscores the importance of integrating kidney function assessments with coronary anatomical evaluations to develop individualized risk stratification strategies.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"38389"},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neovascularization in Atherosclerotic Plaques: Clinical Implications, Detection, and Prevention Strategies.","authors":"Long Zhang, Chancui Deng, Sha Wang, Bei Shi, Guanxue Xu","doi":"10.31083/RCM36468","DOIUrl":"10.31083/RCM36468","url":null,"abstract":"<p><p>Following the global increase in atherosclerotic cardiovascular diseases, the demand for the effective identification of high-risk factors that lead to atherosclerotic plaque rupture and the search for new therapeutic targets has also increased. Neovascularization within plaques is widely recognized as an important indicator of plaque vulnerability. Thus, the timely detection of neovascularization within plaques and early intervention treatment can help reduce the potential adverse cardiovascular events caused by plaque rupture. This article introduces the formation mechanism, clinical significance, detection techniques, and prevention strategies for neovascularizing atherosclerotic plaques.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"36468"},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation Between Triglyceride-Glucose-Body Mass Index, and the Risk of Silent Myocardial Infarction: Construction of a Predictive Model.","authors":"Rong Feng, Jiahui Lu, Honggen Cui, Yaqin Li","doi":"10.31083/RCM36608","DOIUrl":"10.31083/RCM36608","url":null,"abstract":"<p><strong>Background: </strong>The incidence of silent myocardial infarction (SMI) is increasing. Meanwhile, due to the atypical clinical symptoms and signs associated with SMI, the prognosis for patients is often poor.</p><p><strong>Methods: </strong>This prediction model used the least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression analyses to screen variables. Predictive accuracy was assessed using the area under the receiver operating characteristic (ROC) curve (AUC). The clinical decision curve analysis (DCA), alongside the calibration curve and clinical impact curve (CIC) analyses, were used to assess model validity.</p><p><strong>Results: </strong>This study included 174 patients, 64 (36.8%) of whom experienced SMI; logistic regression analysis identified six variables: gender, age, high-density lipoprotein cholesterol (HDL-C), apolipoprotein B/apolipoprotein A1 (ApoB/A1), uric acid (UA), and triglyceride glucose-body mass index (TyG-BMI). The results identified the TyG-BMI as a predictor of SMI (odds ratios (OR) = 1.02, 95% CI: 1.01-1.03; <i>p</i> = 0.003). The ROC curve of the model demonstrated an AUC of 0.772 (95% CI: 0.699-0.844), which increased to 0.774 (95% CI: 0.707-0.841) following a bootstrap analysis with 1000 repetitions. The calibration curve of the model was in high agreement with the ideal curve. The DCA demonstrated that the prediction probability threshold of the model ranged from 12% to 83%, where the patient achieved a significant net clinical benefit. The CIC showed that the model effectively identified high-risk SMI patients when the threshold probability exceeded 0.7.</p><p><strong>Conclusions: </strong>The TyG-BMI is an independent predictor of SMI. A prediction model based on the TyG-BMI showed good predictive ability for SMI.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"36608"},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Aging.","authors":"Marco Tana, Rachele Piccinini, Livia Moffa, Ettore Porreca, Fernando Tana, Claudio Tana","doi":"10.31083/RCM27437","DOIUrl":"10.31083/RCM27437","url":null,"abstract":"<p><p>Aging is a slow, progressive, and inevitable process that affects multiple organs and tissues, including the cardiovascular system. The most frequent cardiac and vascular alterations that are observed in older adults (especially patients aged ≥80 years) are diastolic and systolic dysfunction, progressive stiffening of the vascular wall and endothelial impairment usually driven by an excess of extracellular matrix (ECM) and profibrotic substances, reduced levels of matrix metalloproteinases (MMPs), or by amyloid and calcium deposits in myocardium and valves (especially in aortic valves). Moreover, deformation of the heart structure and shape, or increased adipose tissue and muscle atrophy, or altered ion homeostasis, chronotropic disability, reduced heart rate, and impaired atrial sinus node (SN) activity are other common findings. Interestingly, aging is often associated with oxidative stress, alterations in the mitochondrial structure and function, and a low-grade proinflammatory state, characterized by high concentrations of cytokines and inflammatory cells, without evidence of infectious pathogens, in a condition known as 'inflammaging'. Aging is a well-recognized independent risk factor for cardiovascular disease and easily leads to high mortality, morbidity, and reduced quality of life. Recently, several efforts have been made to mitigate and delay these alterations, aiming to maintain overall health and longevity. The primary purpose of this review was to provide an accurate description of the underlying mechanisms while also exploring new therapeutic proposals for oxidative stress and inflammaging. Moreover, combining serum biomarkers with appropriate imaging tests can be an effective strategy to stratify and direct the most suitable treatment.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"27437"},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Experiences With Guidewire Application in Chronic Total Occlusion: Technological Advances and Clinical Implications.","authors":"Demin Liu, Yaxin Zhi, Wei Sun, Yanan Ma, Shuoyuan Ji, Guoqiang Gu","doi":"10.31083/RCM33469","DOIUrl":"10.31083/RCM33469","url":null,"abstract":"<p><p>Chronic total occlusion (CTO) poses a significant challenge in cardiovascular interventional therapy, owing to the complexity and difficulty involved, which limit the effectiveness of traditional treatment methods. Thus, innovative designs and application concepts of guidewires have expanded the possibilities for clinical intervention, resulting in significant improvements in treatment strategies for CTO. Recently, numerous studies have detailed the application experiences of various guidewires in CTO interventional therapy, including the performance characteristics, selection strategies, and differences in clinical outcomes. Nevertheless, despite these advancements, limitations remain in CTO treatment, such as low success rates and the risk of complications. Therefore, this article aims to review the current application experience of CTO guidewires. Moreover, by reviewing existing literature and summarizing clinical practices, this paper explores strategies to optimize guidewire selection and usage to enhance the success rate and safety of CTO interventional therapy and provide practical guidance for clinicians.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"33469"},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Atrial Fibrillation in Stroke Prevention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Xueru Yang, Jun Huang, Ziqian Huang, Yumei Xue, Hai Deng, Xi Cao","doi":"10.31083/RCM36262","DOIUrl":"10.31083/RCM36262","url":null,"abstract":"<p><strong>Background: </strong>Evidence is needed to determine the benefits and harms of screening for atrial fibrillation (AF) in stroke prevention. This meta-analysis aimed to evaluate the benefits and issues of AF screening among older adults.</p><p><strong>Methods: </strong>This systematic review and meta-analysis were conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We systematically searched several databases from inception through 28 March 2025, selecting randomized controlled trials (RCTs) comparing AF screening, including systematic and opportunistic screening, versus routine practice or no screening. Two reviewers independently extracted the data and appraised the risks of bias of the studies.</p><p><strong>Results: </strong>Thirteen articles covering 12 RCTs were included in the meta-analysis. For routine screening, systematic screening, rather than opportunistic screening, was more effective in detecting new AF cases (relative risk (RR), 2.07; 95% CI, 1.41 to 3.04; <i>p</i> = 0.0002). However, no difference was observed in the effectiveness of systematic and opportunistic screening in detecting AF (RR, 1.39; 95% CI, 0.59 to 3.30; <i>p</i> = 0.45). Compared with no screening, single-time-point screening did not improve the AF detection rate, whereas intermittent/continuous screening was associated with a greater likelihood of detecting AF (RR, 2.40; 95% CI, 1.59 to 3.64; <i>p</i> < 0.0001). There were no significant differences in the anticoagulation prescription rate between patients who underwent screening and routine care (RR, 1.16; 95% CI, 0.94 to 1.44; <i>p</i> = 0.16). Systematic screening was associated with a lower risk for the composite endpoint (combination of thrombosis-related events and mortality; RR, 0.96; 95% CI, 0.93 to 0.99; <i>p</i> = 0.02) but not for the individual endpoints. Compared with routine care, systematic screening did not increase the risk of major bleeding (RR, 0.88; 95% CI, 0.72 to 1.06; <i>p</i> = 0.18), whereas a positive screening result could promote anxiety.</p><p><strong>Conclusions: </strong>Systematic screening outperformed routine care but was comparable to opportunistic screening in detecting undiagnosed AF. Systematic screening was related to a reduction in the composite endpoints of stroke and all-cause mortality without increasing the risk of bleeding.</p><p><strong>Prospero registration: </strong>This systematic review was prospectively registered in PROSPERO, registration number: CRD42024558614, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024558614.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"36262"},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Nomogram to Predict Ventricular Fibrillation During Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction.","authors":"Ruifeng Liu, Xiangyu Gao, Jihong Fan, Huiqiang Zhao","doi":"10.31083/RCM37301","DOIUrl":"10.31083/RCM37301","url":null,"abstract":"<p><strong>Background: </strong>Ventricular fibrillation (VF) is a life-threatening complication of acute myocardial infarction (AMI), particularly in patients undergoing percutaneous coronary intervention (PCI). Early identification of high-risk patients is crucial for implementing preventive measures and improving outcomes.</p><p><strong>Methods: </strong>This retrospective study analyzed clinical, laboratory, and angiographic data from 155 AMI patients to identify predictors of VF during PCI. Variable selection was performed using least absolute shrinkage and selection operator (LASSO) regression, elastic net regression, and random forest. Independent predictors were identified through multivariable logistic regression, and a nomogram was developed and validated to predict VF risk. Model performance was assessed using receiver operating characteristic (ROC) and calibration curves.</p><p><strong>Results: </strong>Independent predictors of VF included diabetes (OR = 3.676 (1.365-10.668); <i>p</i> = 0.012), neutrophil-to-lymphocyte ratio (NLR) (odds ratio (OR) = 1.149 (1.053-1.265); <i>p</i> = 0.002), right coronary artery (RCA) intervention (OR = 3.185 (1.088-9.804); <i>p</i> = 0.037), Gensini score (OR = 1.020 (1.007-1.033); <i>p</i> = 0.003), and absence of beta blockers (OR = 0.168 (0.054-0.472); <i>p</i> = 0.001). The nomogram, incorporating these predictors, demonstrated a strong discriminative ability with an area under the ROC curve (AUC) of 0.882 (0.825-0.939) and good calibration (Hosmer-Lemeshow test, <i>p</i> = 0.769). The calibration curve showed a strong alignment between predicted probabilities and observed outcomes, with a mean absolute error of 0.033.</p><p><strong>Conclusions: </strong>This study identified diabetes, NLR, RCA intervention, Gensini score, and absence of beta-blocker use as key predictors of VF during PCI in AMI patients. A nomogram incorporating these factors showed strong predictive performance, aiding clinicians in identifying high-risk patients for targeted preventive strategies.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 7","pages":"37301"},"PeriodicalIF":1.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}