Reviews in cardiovascular medicine最新文献

{"title":"Mitral Transcatheter Edge-to-Edge Repair in Acute Ischemic Mitral Regurgitation: Current Evidence and Future Perspectives.","authors":"Marco Frazzetto, Claudio Sanfilippo, Francesco Briguglio, Chiara Giacalone, Claudia Contrafatto, Andrea Munafò, Michela Bonanni, Jacopo Oreglia, Giuliano Costa, Guilherme Attizzani, Davide Capodanno, Carmelo Grasso","doi":"10.31083/RCM33396","DOIUrl":"https://doi.org/10.31083/RCM33396","url":null,"abstract":"<p><p>Acute ischemic mitral regurgitation is a rare but potentially catastrophic complication following acute myocardial infarction (AMI), characterized by severe clinical presentation and high mortality. Meanwhile, advancements in primary percutaneous coronary intervention (PCI) have reduced the incidence of acute mitral regurgitation (AMR). The surgical approach remains the standard treatment but is associated with high rates of complications and in-hospital mortality, particularly in patients with cardiogenic shock or mechanical complications, such as papillary muscle rupture. Mitral transcatheter edge-to-edge repair (M-TEER) has emerged as a minimally invasive treatment. Current evidence demonstrates the feasibility and safety of M-TEER in reducing mitral regurgitation, stabilizing hemodynamics, and improving in-hospital and short-term survival. The procedural success rate is high, with notable symptoms and functional status improvements. Mortality rates remain significant, reflecting the severity of AMR, but are lower compared to medical management alone. Challenges remain regarding the optimal timing of M-TEER, long-term device durability, and patient selection criteria. Ongoing iterations in device technology and procedural techniques are expected to enhance outcomes. This review highlights the role of M-TEER in AMR management, emphasizing the need for multidisciplinary decision-making and further research to refine M-TEER application and improve outcomes in this high-risk AMR population.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"33396"},"PeriodicalIF":1.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research.","authors":"Zhe Jiang, Changlin Zhai, Guanmin Tang","doi":"10.31083/RCM27963","DOIUrl":"https://doi.org/10.31083/RCM27963","url":null,"abstract":"<p><p>An estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases. The role of the renin-angiotensin system (RAS) is widely acknowledged in the development and progression of hypertension. This system comprises angiotensinogen, the renin/(pro)renin/(pro)renin receptor (PRR) axis, the renin/angiotensin-converting enzyme/angiotensin (Ang) II/Ang II type I receptor (AT1R) axis, the renin/angiotensin-converting enzyme (ACE) 2/Ang (1-7)/Mas receptor (MasR) axis, the alamandine/Mas-related G protein-coupled D (MrgD) receptor axis, and the renin/ACE/Ang II/Ang II type II receptor (AT2R) axis. Additionally, brain Ang III plays a vital role in regulating central blood pressure. The current overview presents the latest research findings on the mechanisms through which novel anti-hypertensive medications target the RAS. These include zilebesiran (targeting angiotensinogen), PRO20 (targeting the renin/(pro)renin/PRR axis), sacubitril/valsartan (targeting the renin/ACE/Ang II/AT1R axis), GSK2586881, Ang (1-7) and AVE0991 (targeting the renin/ACE2/Ang (1-7)/MasR axis), alamandine (targeting the alamandine/MrgD receptor axis), C21 and β-Pro7-Ang III (targeting the renin/ACE/Ang II/AT2R axis), EC33, and firibastat and NI956 (targeting brain Ang III).</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"27963"},"PeriodicalIF":1.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Gut Microbiota Derivatives with Coronary Artery Disease Severity and Prognosis.","authors":"Yifeng Bai, Chunrong Jin, Hui Zhang, Yuanyang Jia, Shan Xiao, Yongjiang Yang","doi":"10.31083/RCM26566","DOIUrl":"https://doi.org/10.31083/RCM26566","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Previous research has highlighted a connection between gut microbiota derivatives and atherosclerosis. This study assesses the association between gut microbiota derivatives and coronary artery disease (CAD) to enhance CAD prevention and treatment strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients presenting with suspected CAD were categorized into CAD and non-CAD groups. A propensity score matching analysis was performed to exclude confounding factors. Key differences in general characteristics and gut microbiota derivatives between these groups were also assessed. Additionally, the study explored the correlation between significant differences in the Gensini score and coronary flow reserve. Moreover, the potential of significant indicators to predict the diagnosis of coronary artery disease was analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After propensity score matching, the concentrations of interleukin-6 (IL-6) (47.23 ± 7.45 vs. 39.56 ± 7.37; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), lipopolysaccharide (LPS) (12.79 ± 2.07 vs. 11.71 ± 1.88; &lt;i&gt;p&lt;/i&gt; = 0.031), high-sensitivity C-reactive protein (hs-CRP) (13.58 ± 2.62 vs. 11.57 ± 2.49; &lt;i&gt;p&lt;/i&gt; = 0.002), phenylacetyl glutamine (PAGIn) (619.20 ± 119.33 vs. 555.64 ± 109.29; &lt;i&gt;p&lt;/i&gt; = 0.029), and trimethylamine-N-oxide (TMAO) (13.01 ± 2.19 vs. 11.70 ± 1.78; &lt;i&gt;p&lt;/i&gt; = 0.011) in the CAD group were significantly elevated compared to those in the non-CAD group. Conversely, the serum levels of glucagon-like peptide-1 (GLP-1) (7.74 ± 2.07 vs. 9.06 ± 2.11; &lt;i&gt;p&lt;/i&gt; = 0.012) were notably lower in the CAD group than in the non-CAD group. A positive association was observed between the serum concentrations of IL-6 (r = 0.410; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), hs-CRP (r = 0.317; &lt;i&gt;p&lt;/i&gt; &lt; 0.007), TMAO (r = 0.311; &lt;i&gt;p&lt;/i&gt; &lt; 0.008), and coronary Gensini score. Moreover, IL-6 (b = 1.769, 95% confidence interval (CI): 0.256-3.282; &lt;i&gt;p&lt;/i&gt; = 0.023) and TMAO (b = 10.735, 95% CI: 4.883-16.588; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) had a direct positive impact on the coronary Gensini score. The highest diagnostic value for CAD was observed when the IL-6 cut-off value was 45.17 (sensitivity 69.6%, specificity 73.1%, area under curve 0.770; 95% CI: 0.662-0.879; &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Meanwhile, the highest diagnostic value for CAD was noted when the TMAO cut-off value was 12.44 (sensitivity 65.2%, specificity 76.9%, the area under the curve 0.689; 95% CI: 0.564-0.814; &lt;i&gt;p&lt;/i&gt; = 0.008). Serum TMAO was negatively correlated with coronary flow reserve (CFR) in CAD patients (r = -0.593; &lt;i&gt;p&lt;/i&gt; = 0.009).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;These findings suggest that serum IL-6, LPS, hs-CRP, PAGIn, TMAO, and GLP-1 levels can be used as clinical markers for predicting CAD severity. Among these, IL-6, hs-CRP, and TMAO are identified as independent risk factors influencing the severity of CAD-elevated levels of IL-6 and TMAO exhibit predictive utility for CAD diagnosis. Furthermore, serum TMAO is a potential clinical marker for forecasting a CAD pr","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26566"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Risk of New-Onset Atrial Fibrillation in Patients With Conduction System Pacing Versus Right Ventricular Pacing: A Meta-Analysis.","authors":"Tingwen Gao, Zhaofeng Li, Wei Li, Xue Wang, Xinxing Xie","doi":"10.31083/RCM27921","DOIUrl":"https://doi.org/10.31083/RCM27921","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have established the safety and efficacy of conduction system pacing (CSP) in improving echocardiographic parameters and clinical outcomes. This meta-analysis aimed to investigate whether CSP could reduce the occurrence of new-onset atrial fibrillation (AF) in comparison to traditional right ventricular pacing (RVP) therapy.</p><p><strong>Methods: </strong>A literature search was performed in PubMed, Embase, and the Cochrane Library to identify relevant clinical studies comparing CSP with RVP from January 2000 to June 2024. The study outcome was new-onset AF after pacemaker implantation. Estimated risk ratios (RR), odds ratio (OR) with 95% confidence intervals (CI) were evaluated.</p><p><strong>Results: </strong>Our analysis included 8 observational studies comprising a total of 2033 patients. The results indicated that 20% (406/2033) of study patients experienced new-onset AF, and CSP was associated with a significantly lower risk of new-onset AF when compared with RVP (RR: 0.44, 95% CI: 0.36-0.54, <i>p</i> < 0.00001, I² = 11%; OR: 0.34, 95% CI: 0.27-0.44, <i>p</i> < 0.0001, I² = 0). In the subgroup analysis, patients with atrioventricular block (AVB) tended to benefit more from CSP than those with sinus node dysfunction (SND) or AVB (<i>p</i> = 0.06 for RR; <i>p</i> = 0.12 for OR). Publication bias was observed and confirmed by the Egger's test (<i>p</i> = 0.0125 for RR and 0.0345 for OR). Trim and fill analysis was performed, and the overall summary effect size (RR: 0.51, 95% CI: 0.40-0.64; OR: 0.40, 95% CI: 0.31-0.52) remained significant after adjusting for publication bias.</p><p><strong>Conclusion: </strong>CSP could reduce the occurrence of new-onset AF compared with RVP, and this benefit appeared to be more pronounced in patients with AVB than those with SND or AVB. However, large scale randomized controlled trials are needed to validate our findings.</p><p><strong>The prospero registration: </strong>Registration number: CRD42024569052; registration date: July 25, 2024; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024569052.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"27921"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Helicobacter pylori</i> and Atrial Fibrillation: Insights into Their Inter-Relationship.","authors":"Weiting Feng, Qiming Liu, Shenghua Zhou, Mingxian Chen, Yichao Xiao","doi":"10.31083/RCM26911","DOIUrl":"https://doi.org/10.31083/RCM26911","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and atrial fibrillation (AF) are prevalent global health concerns that significantly impact societal and economic well-being. This study explored the potential associations between <i>H. pylori</i> infection and the incidence and progression of AF. Emerging research suggests that <i>H. pylori</i> may influence AF through various pathways, including systemic inflammation, metabolic disturbances, immune responses, and changes in the gut microbiota. These pathways provide a novel perspective on the etiology of AF, suggesting that chronic <i>H. pylori</i> infection could exacerbate or even initiate the arrhythmic events typical of AF. Current evidence, while preliminary, points to significant correlations, particularly through changes in markers such as C-reactive protein (CRP) and lipid metabolism, which are heightened in individuals with active <i>H. pylori</i> infection. However, the exact mechanisms and causal nature of this relationship remain elusive, with studies showing conflicting results. This inconsistency underscores the need for more comprehensive and rigorously designed clinical and experimental research to elucidate fully the interactions between <i>H. pylori</i> infection and AF. Understanding these connections is crucial for developing innovative treatments and management strategies targeting microbial influences in AF patients. Future research should focus on defining the role of <i>H. pylori</i> eradication in the clinical management of AF assessing its impact on disease progression and patient outcomes.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26911"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of the White Blood Cells Count for the Prognosis of Hospitalized Patients with Acute Aortic Dissection.","authors":"Yuzhen Suolang, Yizhu Gao, Changli Sun, Shu Zhang","doi":"10.31083/RCM26347","DOIUrl":"https://doi.org/10.31083/RCM26347","url":null,"abstract":"<p><strong>Objective: </strong>Our study evaluated the prognostic significance of white blood cells (WBC) count and WBC subsets in relation to the risk of mortality in acute aortic dissection (AAD) patients during their hospital stay.</p><p><strong>Methods: </strong>We included 833 patients with AAD in this retrospective study. The primary outcome was in-hospital mortality. Cox regression analysis was employed to determine the independent risk factors for mortality in patients with AAD. Amidst the low- and high-WBC groups, we use Kaplan‒Meier survival analysis to compare the cumulative survival rates of patients with AAD.</p><p><strong>Results: </strong>Within 342 patients with type A AAD, patients belonging to the high-WBC group exhibited a notably higher mortality rate compared to patients in the low-WBC group. Kaplan-Meier analysis exhibited that the patients in high-WBC patients had a significantly higher mortality rate. Multivariable Cox regression analysis demonstrated that an elevated WBC was an independent impact factor of in-hospital mortality of patients with type A AAD (hazard ratio, 2.01; 95% confidence interval (CI): 1.24 to 3.27; <i>p</i> = 0.005). Corresponding outcomes were witnessed in 491 patients with type B AAD.</p><p><strong>Conclusions: </strong>An elevated WBC count was strongly correlated with an elevated risk of mortality in hospitalized patients afflicted with either type A or type B AAD.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26347"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Interval Time after Subintimal Plaque Modification on the Success Rate of Future Recanalization for Chronic Total Occlusion Percutaneous Coronary Interventions.","authors":"Ze Zheng, Xiaowen Bo, Songyuan He, Hongyu Peng, Ping Wang, Shujuan Cheng, Qian Fan, Jinghua Liu","doi":"10.31083/RCM26991","DOIUrl":"https://doi.org/10.31083/RCM26991","url":null,"abstract":"<p><strong>Background: </strong>Chronic total occlusion (CTO) is a complex and difficult type of coronary lesion for which elective secondary intervention after subintimal plaque modification (SPM) can improve the success rate. This study sought to determine the most appropriate timing for secondary interval interventions to maximize the benefit to the patient.</p><p><strong>Methods: </strong>This study retrospectively included patients who failed their first CTO percutaneous coronary intervention (PCI) at Beijing Anzhen Hospital Department of Cardiology from January 2019 to December 2022. We reviewed the clinical characteristics, procedural features, and outcomes of patients who underwent SPM and returned to our institution for a second CTO-PCI.</p><p><strong>Results: </strong>Of the 2847 patients who visited our institution between January 2019 and December 2022, 528 underwent SPM and returned to our institution on an elective basis for a secondary procedure. Of these, 236 procedures were performed within 30 days (Group I), and 292 were performed between 30 and 90 days (Group II). After the intervention, the occluded segment was successfully opened in 170 (72.0%) Group I and 248 (84.9%) Group II participants. When analyzing the factors for operational failure, we found that different intervals, diabetes mellitus, hyperlipidemia, and a history of previous PCI or percutaneous coronary angioplasty (PTCA) were the reasons for the secondary intervention failure. When analyzing the safety of the procedure, we found that pericardial effusion was the most common complication after the procedure, with an incidence of 7.4%. There was no notable variation in the incidence of pericardial effusion between the two groups, 8.9% vs. 6.2% (<i>p</i> = 0.232).</p><p><strong>Conclusions: </strong>Higher success rates were observed when secondary procedures were performed between 30 and 90 days instead of within 30 days after the initial CTO-PCI SPM, with no significant difference in safety noted between the two groups.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26991"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Burden of Cardiovascular Diseases Associated with Particulate Matter Pollution: A Systematic Analysis of Deaths and Disability-Adjusted Life Years with Projections to 2030.","authors":"Yi He, Qiongyue Zhang, Ting Zhou, Ying Lan","doi":"10.31083/RCM27056","DOIUrl":"https://doi.org/10.31083/RCM27056","url":null,"abstract":"<p><strong>Background: </strong>This research assesses how fine particulate matter (PM2.5) pollution influences cardiovascular diseases (CVDs) globally.</p><p><strong>Methods: </strong>Utilizing data from the 2021 Global Burden of Disease (GBD) study, we assessed the impact of PM2.5 pollution on CVDs in individuals aged 25 and older. The health burden was quantified using measures such as disability-adjusted life years (DALYs), age-standardized rates (ASRs), and the effective annual percentage change (EAPC). Joinpoint regression models were used to describe the temporal trends of CVD burdens, while the Bayesian age-period-cohort (BAPC) models were employed to project the CVD burdens through 2030. Frontier analysis was conducted to identify potential areas for improvement and gaps between the development statuses of different countries. Decomposition analysis was applied to assess the impact of population growth, aging, and epidemiological changes on the burden of CVDs.</p><p><strong>Results: </strong>Despite a decline in ASRs for both sexes, males continued to bear a disproportionate burden of CVDs. While substantial reductions in ASRs have been noted in Western Europe and High-income North America, smaller decreases in the EAPC have been seen in South Asia, Oceania, and Western Sub-Saharan Africa; however, Oceania faces the highest mortality burden. An inverse relationship between the sociodemographic index (SDI) and ASRs is evident nationally. Meanwhile, Afghanistan and Egypt reported elevated ASRs, and Iceland recorded the lowest rate. Projections suggest a potential reversal in ASRs by 2021. A decomposition analysis revealed that intracerebral hemorrhage poses the greatest burden in middle SDI regions, while ischemic heart disease is notably burdensome in high SDI and high-middle SDI regions.</p><p><strong>Conclusions: </strong>This study highlights the disproportionate burden of CVDs associated with PM2.5 pollution, particularly in males and lower SDI regions, with significant regional disparities and projections indicating potential reversals in trends.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"27056"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocarditis in Hypertrophic Cardiomyopathy: Incidence and Contribution to Disease Progression and Outcome.","authors":"Yulia Lutokhina, Nasiba Seifatova, Polina Chernova, Natalia Kireeva, Roman Komarov, Marina Vukolova, Sergey Pirozhkov, Ekaterina Yantikova, Nargiza Babakulova, Boris Tlisov, Andrey Dzyundzya, Beatrice Volel","doi":"10.31083/RCM28234","DOIUrl":"https://doi.org/10.31083/RCM28234","url":null,"abstract":"<p><strong>Background: </strong>Myocardial diseases such as myocarditis and cardiomyopathies are clinically important and can cause complications such as heart failure and arrhythmias, which increase the risk of death. The combination of myocarditis with cardiomyopathy is difficult to diagnose because their manifestations often overlap, and multiple myocardial diseases are usually not included in the diagnostic search. Hypertrophic cardiomyopathy (HCM) is the most common cardiomyopathy; however, few studies have examined the combination of myocarditis and HCM, thereby highlighting the importance of this problem. This article aimed to analyze the influence of myocarditis on clinical features and outcomes in patients with HCM.</p><p><strong>Methods: </strong>A literature search was performed using PubMed and the Scientific Electronic Library eLIBRARY.ru databases. Relevant studies, published until November 2023, were analyzed in detail. Studies were selected in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards.</p><p><strong>Results: </strong>Twelve studies (three original articles and nine clinical cases) were isolated from a total cohort of 1504 publications and were included in the study. The prevalence of myocarditis in HCM ranged from 23.5% to 46.7%. The presence of concomitant myocarditis in patients with HCM was associated with heart failure progression, worsening of ventricular arrhythmias, and an increased risk of sudden cardiac death.</p><p><strong>Conclusions: </strong>The incidence of myocarditis in HCM is high. Early detection and treatment of myocarditis in patients with HCM can slow the progression of heart failure rhythm disturbances and improve the disease prognosis.</p><p><strong>The prospero registration: </strong>The systematic review was registered in the International Prospective Register of Systematic Reviews PROSPERO (CRD42024499672, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024499672).</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"28234"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Three-Dimensional Assessment of Maternal Left Ventricular Systolic Function on Pregnancy Outcomes.","authors":"Aleksandra Ilić, Snežana Tadić, Maja Stefanović, Djordje Ilić, Milovan Petrović, Aleksandra Milovančev, Marija Bjelobrk, Tatjana Miljković, Dragana Dabović, Snežana Stojšić, Muamer Bačevac, Anastazija Stojšić-Milosavljević","doi":"10.31083/RCM27639","DOIUrl":"https://doi.org/10.31083/RCM27639","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive disorders in pregnancy (HDP) are associated with adverse pregnancy outcomes. Three-dimensional (3D) echocardiography provides greater accuracy for assessing cardiac geometry and function during pregnancy. The aim was to assess the impact of the 3D left ventricle (LV) systolic function in HDP on pregnancy outcomes.</p><p><strong>Methods: </strong>The prospective cohort study included primiparous with singleton pregnancies, without previous comorbidities who underwent medical history assessment, laboratory tests, ambulatory blood pressure monitoring (ABPM), and transthoracic echocardiography at baseline and six weeks after delivery. Participants were divided into a HDP group and a control group. Pregnancy outcomes (intrauterine growth restriction (IUGR), preterm delivery, and birth weight) were recorded and analyzed.</p><p><strong>Results: </strong>The study involved 174 HDPs and 64 controls, with a median gestational age of 34 weeks (31; 36). Compared to controls HDP exhibited significantly impaired values in both two-dimensional (2D) and 3D parameters for the systolic and diastolic function of the LV. They had higher LV mass index values and lower absolute values for 2D global longitudinal strain and 3D LV strain in all directions (<i>p</i> < 0.001). Multivariable regression analysis revealed that body mass index (BMI) with odds ratio (OR) of 0.751 (95% confidence interval (CI): 0.666-0.847, <i>p</i> < 0.001) and 3D LV global area strain (GAS) with OR of 0.234 (95% CI: 0.155-0.352, <i>p</i> < 0.001) were the strongest predictors of IUGR, while BMI with OR of 0.832 (95% CI: 0.758-0.914), nighttime systolic blood pressure (SBP) with OR of 1.055 (95% CI: 1.032-1.079, <i>p</i> < 0.01) and 3D LV ejection fraction (EF) with OR of 0.780 (95% CI: 0.687-0.885) were the strongest predictors of preterm delivery. The receiver operating characteristic (ROC) curve showed that the model with BMI and 3D LV GAS can be a good predictor for IUGR with an area under the curve (AUC) 0.951 (0.925-0.976) with 89.5% sensitivity and 86.4% specificity, <i>p</i> < 0.001, while the model with BMI, nighttime SBP and 3D LV EF is a predictor for preterm delivery with AUC of 0.835 (0.776-0.893) with 79.1% sensitivity and 73.7% specificity, <i>p</i> < 0.001. Person correlation showed a significant positive correlation between birth weight and 3D GAS, r = 0.485; <i>p</i> < 0.001.</p><p><strong>Conclusions: </strong>LV GAS is significantly associated with IUGR and birth weight, while 3D LV EF strongly predicts preterm delivery.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"27639"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}