Reviews in cardiovascular medicine最新文献

{"title":"Structural Heart Interventions in Patients with Left Ventricular Assist Devices.","authors":"Puvi Seshiah, Eugene Chung, Santiago Garcia, Joseph Choo, Robert Dowling, Geoffrey Answini, Dean Kereiakes, Gregory Egnaczyk","doi":"10.31083/RCM27964","DOIUrl":"https://doi.org/10.31083/RCM27964","url":null,"abstract":"<p><p>Left ventricular assist devices (LVADs) have changed the landscape for patients with advanced heart failure (HF). With advances in pump design and management, patients with LVADs are living longer with improved quality of life despite having more comorbidities and complex structural heart disease. As such, HF cardiologists and surgeons collaborate more frequently with structural heart interventionalists to address the complex problems of patients with LVADs who present at different points of failure in their circuits. Unlike heart transplants and total artificial heart recipients, the native heart and its components must function to maintain successful circulatory support from these assist devices. Multiple points of potential failure of the native heart and the LVAD circuit exist that can result in significant morbidity and mortality. These include regurgitant valve lesions, interatrial shunts, outflow cannula obstruction, and pump thrombosis. Transcatheter interventions can be applied and tailored specifically to the anatomy of the individual in these situations to improve the lives and outcomes of our LVAD patients. This review provides a comprehensive approach for diagnosing and treating structural heart disease associated with patients who have LVADs, focusing on multidisciplinary collaboration and individualized interventional strategies.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"27964"},"PeriodicalIF":1.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Stroke History and Clinical Events in Atrial Fibrillation Patients after Valve Replacement.","authors":"Xinsheng Yan, Shuwen Lian, Dong Wang, Bao Yan, Litao Zhang, Zhenlu Zhang","doi":"10.31083/RCM26992","DOIUrl":"https://doi.org/10.31083/RCM26992","url":null,"abstract":"<p><strong>Background: </strong>The association between stroke history and clinical events after valve replacement in patients with atrial fibrillation (AF) combined with valvular heart disease (VHD) is unclear. Thus, we sought to investigate the relationship between stroke history and clinical events in patients with AF after valve replacement.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled 746 patients with AF who underwent valve replacement between January 2018 and December 2019 at the Wuhan Asia Heart Hospital. Patient information was collected from the hospital's electronic medical record system. Patients were categorized based on their stroke history and followed through outpatient visits or by telephone until the occurrence of an endpoint event; the maximum follow-up period was 24 months. Endpoint events included thrombotic events, bleeding, and all-cause mortality. The frequency of thrombotic, hemorrhagic, and fatal events during the follow-up period was compared between the two groups. Independent risk factors for endpoint events were analyzed using multifactorial Cox regression.</p><p><strong>Results: </strong>The analysis included 746 patients. Over a 24-month follow-up period, there were more total adverse events (hazard ratio (HR) = 2.08, 95% confidence interval (CI) 1.06-4.08, <i>p</i> = 0.018), thrombotic events (HR = 10.28, 95% CI 2.85-37.11, <i>p</i> < 0.001), and increased all-cause mortality (HR = 5.74, 95% CI 1.84-17.93, <i>p</i> < 0.001) in the stroke history group than in the non-stroke history group. Fewer bleeding events were observed in the group with a history of stroke (HR = 0.87, 95% CI 0.37-2.04, <i>p</i> = 0.757). A multifactorial Cox regression analysis revealed that a personal history of stroke was an independent risk factor for total adverse events, thrombotic events, and all-cause mortality.</p><p><strong>Conclusions: </strong>Previous stroke history is significantly associated with adverse events in AF patients following valve replacement.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26992"},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Evaluations in Electrophysiology in the Last 15 Years: A Systematic Review of the Literature.","authors":"Davide Antonio Mei, Jacopo Francesco Imberti, Marco Vitolo, Niccolò Bonini, Edoardo Casali, Lucia Osoro, Ruben Casado-Arroyo, Giuseppe Boriani","doi":"10.31083/RCM36206","DOIUrl":"https://doi.org/10.31083/RCM36206","url":null,"abstract":"<p><strong>Background: </strong>Electrophysiology (EP) procedures, including cardiac implantable electronic devices (CIEDs) and ablations, are widely used to manage arrhythmias and heart failure. These interventions, though effective, require substantial resources, prompting the need for systematic economic evaluations to inform healthcare decision-making.</p><p><strong>Methods: </strong>A systematic review of studies from 2007 to 2024 was conducted in two phases. Phase one assessed trends in economic evaluations of EP procedures, analyzing 129 studies across regions and timeframes. Phase two focused on cost-effectiveness analyses of implantable cardioverter defibrillators (ICDs), cardiac resynchronization therapy defibrillators (CRT-Ds), and atrial fibrillation (AF) ablation, examining outcomes like quality-adjusted life years (QALYs) and incremental cost-effectiveness ratios (ICERs), while identifying factors influencing economic results.</p><p><strong>Results: </strong>EP procedures generally demonstrated favorable cost-effectiveness, particularly in high-income regions. Studies on ICDs and CRT-Ds consistently supported their economic value for patients with arrhythmias or heart failure, while AF ablation showed potential for long-term benefits, particularly when compared to medical therapies. However, results varied by region, reflecting differences in healthcare systems, costs, and patient populations.</p><p><strong>Conclusions: </strong>The review highlights the overall cost-effectiveness of EP procedures in many settings but underscores the need for tailored economic evaluations in low- and middle-income countries. Simplified methodologies and greater attention to regional contexts are recommended to guide resource allocation and policy development globally.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"36206"},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Methods and Devices for Atrial Fibrillation.","authors":"Yalu Yu, Qin Jiang","doi":"10.31083/RCM26841","DOIUrl":"https://doi.org/10.31083/RCM26841","url":null,"abstract":"<p><p>As technology advances, surgical approaches for atrial fibrillation have diversified. Surgical treatments include Cox-Maze surgery, left atrial appendage occlusion, or closure using a clip. Cox-Maze surgery removes excessive cardiac electrical conduction pathways, ensures electrical signals propagate exclusively through the predetermined maze channel and restores normal heart rhythm. Left atrial appendage closure reduces the risk of long-term disability or death caused by left atrial appendage thromboembolism in patients with atrial fibrillation. These devices are constantly being refined, including bipolar radiofrequency clamps (monopolar or bipolar radiofrequency), left atrial appendage closure devices (external excision using staplers, internal ligation with biomatrix patch occlusion, external device placement with the AtriClip and Endoloop ligature). In addition to surgical interventions, surgical biomaterial materials with biocompatibility and electrical conductivity have emerged in the basic research phase of atrial fibrillation treatment. This review delineates the primary surgical techniques, emphasizing their safety and efficacy in treating atrial fibrillation. An introduction to commonly used surgical equipment is provided as a reference for the clinical management of atrial fibrillation.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26841"},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Computed Tomography-based Technique for Predicting Atrial Fibrillation Recurrence Following Ablation Using an Adjusted Skeletal Muscle Index.","authors":"Pingchuan Ma, Zhicheng Gao, Jiaqi Bao, Yilan Hu, Pengfei Sun, Qiqi Yan, Lifang Ye, Lihong Wang","doi":"10.31083/RCM26933","DOIUrl":"https://doi.org/10.31083/RCM26933","url":null,"abstract":"<p><strong>Background: </strong>This research focuses on the unresolved question of how low muscle mass influences the likelihood of atrial fibrillation (AF) recurrence after ablation treatment. Despite the growing body of evidence highlighting the importance of muscle mass in cardiovascular health, the specific impact of low muscle mass on the recurrence of AF following ablation has yet to be well-established. Thus, this study evaluated the relationship between a low computed tomography (CT)-based skeletal muscle index (SMI) of muscle sites at the fourth thoracic level (T4-SMI) and AF recurrence post-radiofrequency ablation. Furthermore, this study aimed to determine whether the T4-SMI is a predictive marker for AF recurrence.</p><p><strong>Methods: </strong>This study included 641 patients with AF who underwent radiofrequency ablation. T4 muscle sites were determined using SliceOmatic software. Height- and body mass index (BMI)-corrected SMIs were calculated.</p><p><strong>Results: </strong>The lowest quartile in the T4-SMI group was defined for each sex as the \"low SMI\" group. The height-adjusted T4-SMI thresholds were 69.7 cm²/m² for males and 55.91 cm²/m² for females. The BMI-adjusted thresholds were 8.10 cm²/kg/m² for males and 5.78 cm²/kg/m² for females. After potential confounder adjustment, low T4-SMI was associated with a higher risk of AF recurrence. The correlation between T4-SMI (height) and AF recurrence was fully validated by constructing multiple models, and adjusting for different covariates barely altered the results. Fully adjusted models suggested that compared with the fourth T4-SMI (height) quartile, the risk odds ratio (OR) with a 95% confidence interval (CI) of the \"low SMI\" group was 1.57 (0.76-3.22). Finally, subgroup analysis and interaction according to gender, age, overweight/obesity, hypertension, or diabetes indicate that the differences between different layers are not significant.</p><p><strong>Conclusions: </strong>Low CT-based BMI- or height-adjusted T4-SMIs were risk factors for AF recurrence post-radiofrequency ablation. A lower T4-SMI (height) significantly correlated with AF recurrence post-ablation, regardless of gender, age, or overweight/obesity. The height adjustment performed better than the BMI adjustment in that regard.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26933"},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced Pluripotent Stem Cells in Congenital Long QT Syndrome: Research Progress and Clinical Applications.","authors":"Qing Li, Yi-Fei Wang, Bin Wang, Ting-Ting Lv, Ping Zhang","doi":"10.31083/RCM28251","DOIUrl":"https://doi.org/10.31083/RCM28251","url":null,"abstract":"<p><p>Congenital long QT syndrome (LQTS) is a potentially life-threatening hereditary arrhythmia characterized by a prolonged QT interval on electrocardiogram (ECG) due to delayed ventricular repolarization. This condition predisposes individuals to severe arrhythmic events, including ventricular tachycardia and sudden cardiac death. Traditional approaches to LQTS research and treatment are limited by an incomplete understanding of its gene-specific pathophysiology, variable clinical presentation, and the challenges associated with developing effective, personalized therapies. Recent advances in human induced pluripotent stem cell (iPSC) technology have opened new avenues for elucidating LQTS mechanisms and testing therapeutic strategies. By generating cardiomyocytes from patient-specific iPSCs (iPSC-CMs), it is now possible to recreate the patient's genetic context and study LQTS in a controlled environment. This comprehensive review describes how iPSC technology deepens our understanding of LQTS and accelerates the development of tailored treatments, as well as ongoing challenges such as incomplete cell maturation and cellular heterogeneity.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"28251"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, Risk Factors, and Stroke Prevention During Transcatheter Aortic Valve Implantation.","authors":"Sannidhya Misra, Arif A Khokhar, Carla Lucarelli, Saud Khawaja, Ghada W Mikhail","doi":"10.31083/RCM26867","DOIUrl":"https://doi.org/10.31083/RCM26867","url":null,"abstract":"<p><p>Stroke remains a significant, potentially life-threatening complication following transcatheter aortic valve implantation (TAVI). Moreover, the rate of strokes, particularly disabling strokes, has not diminished over time despite improvements in pre-procedural planning and implantation techniques. The mechanisms of stroke in TAVI patients are complex, and identifying consistent risk factors is challenging due to evolving patient profiles, varied study cohorts, and continuous device modifications. Multiple pharmacological and mechanical treatment strategies have been developed to mitigate the risk of stroke, particularly as TAVI expands toward younger populations. This review article discusses the pertinent factors in the evolution of stroke post-TAVI, appraises the latest evidence and techniques designed to reduce the risk of stroke, and highlights future strategies and technologies to address this unmet need.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26867"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neglected Internodal Tract-A Cardiac Conduction System Structure Homologous to the Development and Regulation of the Sinoatrial Node.","authors":"Yuanqin Zhao, Juyi Wan, Bin Liao, Man Qi","doi":"10.31083/RCM27882","DOIUrl":"https://doi.org/10.31083/RCM27882","url":null,"abstract":"<p><p>The existence of internodal tracts (ITs) is controversial. Indeed, ITs in the cardiac conduction system (CCS), connected to the sinoatrial node (SAN), transmit electrical signals quickly to the left atrium and the atrioventricular node (AVN). Interestingly, research has suggested that the ITs and the tail of the SAN may share developmental homology. Additionally, many studies indicate that ITs blockage can lead to atrial conduction block and is associated with atrial fibrillation (AF). However, few studies have been reported on the morphogenesis, development, and function of ITs. Therefore, this paper aims to review the morphogenesis, development, and function of ITs, focusing on the regulatory mechanisms of transcription factors (TFs), such as NK2 homeobox 5 (NKX2.5), SHOX homeobox 2 (SHOX2), hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), and T-box transcription factor 3 (TBX3) in the development and morphogenesis of ITs. This review also explores the causes of arrhythmias, especially atrial block, in order to provide new insights into the pathogenesis of CCS disorders.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"27882"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure.","authors":"Yipin Yu, Qiong Yi, Chenglong Yang, Xudong Song, Duoting Tan, Qinghua Peng, Xiang Sun, Hao Liang","doi":"10.31083/RCM27001","DOIUrl":"https://doi.org/10.31083/RCM27001","url":null,"abstract":"<p><strong>Background: </strong>Diuretic resistance (DR) is characterized by insufficient fluid and sodium excretion enhancement despite maximum loop diuretic doses, indicating a phenotype of refractory heart failure (HF). Recently, metabolomics has emerged as a crucial tool for diagnosing and understanding the pathogenesis of various diseases. This study aimed to differentiate diuretic-resistant patients from non-resistant HF to identify biomarkers linked to the emergence of DR.</p><p><strong>Methods: </strong>Serum samples from HF patients, both with and without DR, were subjected to non-targeted metabolomic analysis using liquid chromatography-tandem mass spectrometry. Metabolite variations between groups were identified using principal component analysis and orthogonal partial least-square discriminant analysis. Metabolic pathways were assessed through the Kyoto Encyclopedia of Genes and Genomes database enrichment analysis, and potential biomarkers were determined using receiver operating characteristic curves (ROCs).</p><p><strong>Results: </strong>In total, 192 metabolites exhibited significant differences across the two sample groups. Among these, up-regulation was observed in 164 metabolites, while 28 metabolites were down-regulated. A total of 28 pathways involving neuroactive ligand-receptor interaction and amino acid biosynthesis were affected. The top five metabolites identified by ROC analysis as potential DR biomarkers were hydroxykynurenine, perillic acid, adrenic acid, 5-acetamidovalerate, and adipic acid.</p><p><strong>Conclusions: </strong>Significant differences in metabolite profiles were observed between the diuretic-resistant and non-diuretic-resistant groups among patients with HF. The top five differentially expressed endogenous metabolites were hydroxykynurenine, perillic acid, adrenic acid, 5-acetamidovalerate, and adipic acid. The metabolic primary pathways implicated in DR were noted as amino acid, energy, and nucleotide metabolism.</p><p><strong>Clinical trial registration: </strong>This study was registered with the China Clinical Trials Registry (https://www.chictr.org.cn/hvshowproject.html?id=197183&v=1.7, ChiCTR2100053587).</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"27001"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Novel Nomogram Risk Prediction Model for In-Hospital Death Following Extended Aortic Arch Repair for Acute Type A Aortic Dissection.","authors":"Qiyi Chen, Yulin Wang, Yixiao Zhang, Fangyu Liu, Kejie Shao, Hao Lai, Chunsheng Wang, Qiang Ji","doi":"10.31083/RCM26943","DOIUrl":"https://doi.org/10.31083/RCM26943","url":null,"abstract":"<p><strong>Background: </strong>Extended aortic arch repair (EAR) is increasingly adopted for treating acute type A aortic dissection (ATAAD). However, existing prediction models may not be suitable for assessing the in-hospital death risk in ATAAD patients undergoing EAR. This study aims to develop a comprehensive risk prediction model for in-hospital death following EAR based on patient's preoperative status and surgical data, which may contribute to identification of high-risk individuals and improve outcomes following EAR.</p><p><strong>Methods: </strong>We reviewed clinical records of consecutive adult ATAAD patients undergoing EAR at our institute between January 2015 and December 2022. Utilizing data from 925 ATAAD patients undergoing EAR, we employed multivariable logistic regression and machine learning techniques, respectively, to develop nomograms for in-hospital mortality. Employed machine learning techniques included simple decision tree, random forest (RF), eXtreme Gradient Boosting (XGBoost), and support vector machine (SVM).</p><p><strong>Results: </strong>The nomogram based on SVM outperformed others, achieving a mean area under the receiver operating characteristic (ROC) curve (AUC) of 0.842 on training dataset and a mean AUC of 0.782 on testing dataset, accompanied by a Brier score of 0.058. Key risk factors included cerebral malperfusion, mesenteric malperfusion, preoperative critical station, Marfan syndrome, platelet count, D-dimer, coronary artery bypass grafting, and cardiopulmonary bypass time. A web-based application was developed for clinical use.</p><p><strong>Conclusions: </strong>We develop a novel nomogram risk prediction model based on SVM algorithm for in-hospital death following extended aortic arch repair for ATAAD with good discrimination and accuracy.</p><p><strong>Clinical trial registration: </strong>Registration number ChiCTR2200066414, https://www.chictr.org.cn/showproj.html?proj=187074.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 4","pages":"26943"},"PeriodicalIF":1.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}