Rejuvenation research最新文献

{"title":"Dietary Restriction Attenuates Inflammation and Protects Mouse Skin from High-Dose Ultraviolet B Irradiation.","authors":"Duozhuang Tang, Jianying Wu, Yiting Wang, Hui Cui, Zhendong Tao, Lang Lei, Zhuangfa Zhou, Si Tao","doi":"10.1089/rej.2021.0022","DOIUrl":"10.1089/rej.2021.0022","url":null,"abstract":"<p><p>Ultraviolet B (UVB) radiation may influence the occurrence or even worsen cutaneous disorders from inflammatory to neoplastic disorders. Dietary restriction (DR) is a well-known regimen that can retard aging-associated pathologies, and is shown by us and others that it can significantly inhibit inflammation under various conditions, including in both undisturbed and stressed settings. It is unknown whether DR could act as a nonpharmacological factor to protect skin against UVB-induced damage. In this study, we performed 30% DR to mice 1 week before UVB irradiation (798.6 mJ/cm²). Remarkably, continuous DR significantly ameliorated UVB-induced skin damage and histological changes, associated with a great reduction in the inflammatory responses in the skin. Intriguingly, refed DR mice with <i>ad libitum</i> diet even 24 hours postirradiation reinflamed the inflammatory responses and induced significantly strong damage to the skin. Together, this study provides the first experimental evidence that DR greatly protects mouse skin from high dose of UVB irradiation, which if translatable could have great implications in human beings.</p>","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":"25 3","pages":"149-157"},"PeriodicalIF":2.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247678/pdf/rej.2021.0022.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9555196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"June 2022 Editorial.","authors":"I. Conboy","doi":"10.1089/rej.2022.0035","DOIUrl":"https://doi.org/10.1089/rej.2022.0035","url":null,"abstract":"na.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48028133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF PROGRESSIVE RESISTANCE TRAINING ON FUNCTIONALITY AND HANDGRIP STRENGTH IN THE OLDER INDIVIDUALS OF A COMMUNITY: A QUASI-EXPERIMENTAL STUDY.","authors":"L. S. Silva Neto, C. D. Dos Santos, Andrea Travassos, A. Figueiredo, D. P. Nunes, T. Rosa, Fabrício Cavalcante Frauzino, Wesquisley Vidal de Santana, L. F. Sesti, Genildo Ferreira Nunes, Emerson Moura Ribeiro, N. B. Osório","doi":"10.1089/rej.2021.0029","DOIUrl":"https://doi.org/10.1089/rej.2021.0029","url":null,"abstract":"BACKGROUND\u0000Muscle weakness is associated with negative outcomes, in addition to being related to the pathogenesis of frailty and functional disability in the older individuals. Muscle strength and functionality are considered biomarkers of aging. Progressive resistance training (PRT) is a type of training that has been the subject of studies as it presents itself as a therapeutic option to fight the reduction of muscle strength and functionality in older individuals. However, few studies have assessed the clinically-relevant gains in the levels of muscle strength and functionality of older individuals after PRT, in addition to the need of testing new PRT approaches, including individualization and periodization in training programs. Therefore, this article aims to assess the effect of a individual and periodized PRT protocol on handgrip strength and functionality in older individuals. Thus, the study sample included 69 older individuals, divided into two groups: case (n = 41) and control (n = 28). The case group participated in a progressive resistance training protocol for 12 weeks, with two weekly sessions. When compared to the control group, which received only health education, the individuals in the case group had a greater magnitude of improvement in all variables related to the assessed functionality (Timed up and go test, gait speed, and handgrip strength), proving the applicability of the assessed protocol to improve strength and functionality in the older individuals people of a community.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42881698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Condition and Risk of Hospitalization and Polypharmacy in Older Adults.","authors":"Ana Fernández-Araque, Laura García-de-Diego, María Martínez-Ferrán, I. Diez-Vega, T. Yvert, T. Mingo, C. Santiago, H. Pareja-Galeano, Z. Verde","doi":"10.1089/rej.2021.0030","DOIUrl":"https://doi.org/10.1089/rej.2021.0030","url":null,"abstract":"Hospitalization in older population leads to a decline in physical function, physical condition and independency. However, a scarce number of studies has addressed the effect of being in good physical condition on the risk of hospitalization and polypharmacy in older people. Therefore, this study aims to examine the relationship between physical condition and other health factors, and the incidence of hospitalization and polypharmacy in Spanish older persons. For this cross-sectional study 102 community-dwelling persons aged 80 years or older who were being treated at three primary care centers. The data collected were number of hospitalizations and medications, dietary habits, nutrition status, quality of life, independence in activities of daily life, physical performance and associated genotype data. Scoring higher in the tests Chair stand and 8-Foot Up-and-go was found associated with reduced risks of hospitalization [OR = .45 (95% CI = .2, .99); OR .32 (95% CI = .12, .86)] and polypharmacy [OR = .36 (95% CI = .16, .8); OR= .28 (95% CI = .1, .78)]. The number of medications was also lower in individuals with a greater aerobic capacity and activities of daily life independence [OR = .28 (95% CI = .1, .78); OR = .37 (95% CI = .16, .82)]. No associations were found with the remaining physical performance tests or other factors assessed. Our findings point to benefits of greater strength, balance and aerobic capacity in terms of reducing the risk of hospitalization and polypharmacy.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48184097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma proteomic signature of cellular senescence and markers of biological aging among postmenopausal women.","authors":"Ji-Won Shin, Eunil Lee, Seungbong Han, Seungyong Choi, Ok-hee Jeon","doi":"10.1089/rej.2022.0024","DOIUrl":"https://doi.org/10.1089/rej.2022.0024","url":null,"abstract":"We aimed to investigate the association of circulatory senescence-associated secretory phenotypes (SASP) produced by senescent cells with chronological and menopausal age in women aged 45 years or more. The proteomic profiles for 32 SASP factors of plasma samples were measured in 76 healthy postmenopausal women aged 46-82 years from the Korean Genome and Epidemiology Study Cardiovascular Disease Association Study (KoGES-CAVAS). We assessed the association between the SASP factors and aging indicators (chronological age, menopausal age, and years since menopause) using single- and multi-protein models. First, we composed a profile of proteins associated with chronological age, menopausal age, and years since menopause. In a single-protein model, three proteins (growth differentiation factor 15 (GDF15), insulin-like growth factor binding protein-2 (IGFBP-2), and tumor necrosis factor-α (TNF-α)) are positively associated with chronological age. Menopausal age and years since menopause are interrelated with Interlukin-8 (IL-8). The direction of association between menopausal age and monocyte chemoattractant protein-1 (MCP-1) was only negative, and IGFBP-2 and TNF-α were significant in all three aging factors. We also constructed parsimonious multi-protein models to confirm the association of the proteomic signature for aging after adjusting for covariates and the combination of proteomic signature of 13 proteins (GDF15, IFN-γ, IGFBP-2, IGFBP-7, IL-15, IL-1β, IL-17A, IL-8, MCP-1, TIMP-2, TNF-α, VEGF-A, and IP-10) appear to be associated with chronological age and menopausal state of individuals. Thus, by observing association between the selected SASPs and age-related markers among healthy postmenopausal women, we examine how menopause in women relates to proteomic indicators of aging and highlight the potential use of SASP factors as a marker to reflect the state of biological aging attributed by ovarian senescence.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48415447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covid-19 as a paradigmatic model of the heterogeneous disease presentation in older people: data from the GeroCovid Observational study.","authors":"C. Trevisan, Francesca Remelli, S. Fumagalli, E. Mossello, C. Okoye, G. Bellelli, A. Coin, A. Malara, P. Gareri, F. Monzani, S. Del Signore, G. Zia, R. Antonelli Incalzi, S. Volpato","doi":"10.1089/rej.2021.0063","DOIUrl":"https://doi.org/10.1089/rej.2021.0063","url":null,"abstract":"Covid-19 may have a heterogeneous onset, especially in older age. However, whether and how Covid-19 signs and symptoms may present and aggregate together according to sociodemographic and health factors is unclear, as well as their prognostic value. This work included 981 Covid-19 inpatients who participated in the GeroCovid Observational study. Signs/symptoms at disease onset, sociodemographic, health, cognitive status, and mobility were systematically recorded. Clusters of signs/symptoms were identified through agglomerative hierarchical clustering. The associations of single signs/symptoms and symptom clusters with longer hospitalization (≥16 days) and in-hospital mortality were explored through logistic and Cox regressions. The signs/symptoms most reported in our sample (age 78.3±9.39 years; 49.4% women) were fever (62.5%), cough (45.5%), and dyspnoea (62.7%). Atypical were reported by up to one-third of patients, and delirium by 9.1%. Atypical symptoms were more frequent with advancing age and with lower pre-Covid-19 cognitive and mobility levels. Older men more likely reported respiratory symptoms than women. Dyspnoea (HR=1.47, 95%CI:1.02-2.12), tachypnea (HR=1.53, 95%CI:1.14-2.07), low oxygen saturation (HR=1.95, 95%CI:1.32-2.88) and delirium (HR=1.60, 95%CI:1.13-2.28) were associated with higher in-hospital mortality. Four symptom clusters were identified. Compared with the mild respiratory symptoms cluster, the severe clinical impairment cluster was associated with higher mortality (HR=2.57, 95%CI:1.58-4.18). The severe clinical impairment and aspecific symptoms clusters were associated with longer hospitalization (OR=2.38, 95%CI:1.56-3.63, and OR=1.75, 95%CI:1.08-2.83, respectively). Multiple health aspects influence Covid-19 clinical presentation. A symptom clusters approach may help predict adverse health outcomes in older patients. In addition to respiratory symptoms, delirium is independently associated with mortality risk.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":"24 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41248887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormetic effect of 3-Bromopyruvate on age-induced alterations in erythrocyte membrane transporters and oxidative biomarkers in rats.","authors":"J. Arya, Raushan Kumar, Shambhoo Sharan Tripathi, S. Rizvi","doi":"10.1089/rej.2021.0060","DOIUrl":"https://doi.org/10.1089/rej.2021.0060","url":null,"abstract":"3-bromopyruvate (3-BP) is a glycolytic inhibitor and a potential calorie restriction mimic that shows a variety of beneficial effects in several aging model systems. A chronic low dose of 3-BP was given to male Wistar rats for four weeks. The effect of 3-BP on age-dependent alteration on the activities of various transporters/exchangers and redox biomarkers (protein carbonyl (PC), sialic acid (SA), sulfhydryl group (-SH), intracellular calcium ion [Ca2+]i, and osmotic fragility) was studied. In aged rats, 3-BP treatment increases the membrane-bound activities of Na+/K+-ATPase (NKA) and Ca2+-ATPase (PMCA), along with levels of -SH and SA. It also exerts a concomitant decrease in Na+/H+ exchanger (NHE) activity and the levels of [Ca2+]i, PC, and osmotic fragility in aged groups. 3-BP can be considered as a potential anti-aging agent that induces a hormetic effect leading to amelioration of age-dependent impairment of membrane-bound ATPases and alterations in the redox biomarker level.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46254395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Political Action Matters for the Longevity Biotechnology Industry.","authors":"Dylan V Livingston","doi":"10.1089/rej.2022.0018","DOIUrl":"https://doi.org/10.1089/rej.2022.0018","url":null,"abstract":"The hallmark sign of a mature industry is representation in politics and government. Advocates encourage elected officials to pass beneficial laws for an industry and maybe more importantly, they defend the industry's reputation if things go awry. Technology centered around extending healthy human lifespan is set to explode over the next decade and the industry must have a unified presence in Washington to help guide the development and distribution of these society-altering therapeutics aimed to defeat the aging process.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":" ","pages":"116-117"},"PeriodicalIF":2.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40318955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Minimization of False Discovery of Metabolic Bioorthogonal Noncanonical Amino Acid Proteomics.","authors":"Chao Liu,&nbsp;Nathan Wong,&nbsp;Etsuko Watanabe,&nbsp;William Hou,&nbsp;Leonardo Biral,&nbsp;Jonalyn DeCastro,&nbsp;Melod Mehdipour,&nbsp;Kiana Aran,&nbsp;Michael J Conboy,&nbsp;Irina M Conboy","doi":"10.1089/rej.2022.0019","DOIUrl":"https://doi.org/10.1089/rej.2022.0019","url":null,"abstract":"<p><p>Metabolic proteomics has been widely used to characterize dynamic protein networks in many areas of biomedicine, including in the arena of tissue aging and rejuvenation. Bioorthogonal noncanonical amino acid tagging (BONCAT) is based on mutant methionine-tRNA synthases (MetRS) that incorporates metabolic tags, for example, azidonorleucine [ANL], into newly synthesized proteins. BONCAT revolutionizes metabolic proteomics, because mutant MetRS transgene allows one to identify cell type-specific proteomes in mixed biological environments. This is not possible with other methods, such as stable isotope labeling with amino acids in cell culture, isobaric tags for relative and absolute quantitation and tandem mass tags. At the same time, an inherent weakness of BONCAT is that after click chemistry-based enrichment, all identified proteins are assumed to have been metabolically tagged, but there is no confirmation in mass spectrometry data that only tagged proteins are detected. As we show here, such assumption is incorrect and accurate negative controls uncover a surprisingly high degree of false positives in BONCAT proteomics. We show not only how to reveal the false discovery and thus improve the accuracy of the analyses and conclusions but also approaches for avoiding it through minimizing nonspecific detection of biotin, biotin-independent direct detection of metabolic tags, and improvement of signal to noise ratio through machine learning algorithms.</p>","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":"25 2","pages":"95-109"},"PeriodicalIF":2.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063144/pdf/rej.2022.0019.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9220010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Correction to:</i> Persistence of Long-Term Memory in Vitrified and Revived Caenorhabditis elegans, by Vita-More, et al. Rejuvenation Res.2015;18(5):458-463; doi:10.1089/rej.2014.1636.","authors":"","doi":"10.1089/rej.2014.1636.correx","DOIUrl":"https://doi.org/10.1089/rej.2014.1636.correx","url":null,"abstract":"","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":"25 2","pages":"118-119"},"PeriodicalIF":2.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063216/pdf/rej.2014.1636.correx.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}