Ana Fernández-Araque, Laura García-de-Diego, María Martínez-Ferrán, I. Diez-Vega, T. Yvert, T. Mingo, C. Santiago, H. Pareja-Galeano, Z. Verde
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Physical Condition and Risk of Hospitalization and Polypharmacy in Older Adults.
Hospitalization in older population leads to a decline in physical function, physical condition and independency. However, a scarce number of studies has addressed the effect of being in good physical condition on the risk of hospitalization and polypharmacy in older people. Therefore, this study aims to examine the relationship between physical condition and other health factors, and the incidence of hospitalization and polypharmacy in Spanish older persons. For this cross-sectional study 102 community-dwelling persons aged 80 years or older who were being treated at three primary care centers. The data collected were number of hospitalizations and medications, dietary habits, nutrition status, quality of life, independence in activities of daily life, physical performance and associated genotype data. Scoring higher in the tests Chair stand and 8-Foot Up-and-go was found associated with reduced risks of hospitalization [OR = .45 (95% CI = .2, .99); OR .32 (95% CI = .12, .86)] and polypharmacy [OR = .36 (95% CI = .16, .8); OR= .28 (95% CI = .1, .78)]. The number of medications was also lower in individuals with a greater aerobic capacity and activities of daily life independence [OR = .28 (95% CI = .1, .78); OR = .37 (95% CI = .16, .82)]. No associations were found with the remaining physical performance tests or other factors assessed. Our findings point to benefits of greater strength, balance and aerobic capacity in terms of reducing the risk of hospitalization and polypharmacy.
期刊介绍:
Rejuvenation Research publishes cutting-edge, peer-reviewed research on rejuvenation therapies in the laboratory and the clinic. The Journal focuses on key explorations and advances that may ultimately contribute to slowing or reversing the aging process, and covers topics such as cardiovascular aging, DNA damage and repair, cloning, and cell immortalization and senescence.
Rejuvenation Research coverage includes:
Cell immortalization and senescence
Pluripotent stem cells
DNA damage/repair
Gene targeting, gene therapy, and genomics
Growth factors and nutrient supply/sensing
Immunosenescence
Comparative biology of aging
Tissue engineering
Late-life pathologies (cardiovascular, neurodegenerative and others)
Public policy and social context.