Research Journal of Pharmaceutical Dosage Forms and Technology最新文献_第10页

Formulation and Evaluation of Transdermal Patches of Decongestant Drug 减充血药透皮贴剂的研制与评价

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00031

Vaseeha Banu T.S, Jaiswal Vikas Awdesh, Mohammad Sameer Ansari

引用次数: 2

Global demand, Regulatory aspect and Current research and Future prospect of Nutraceutical: A Review 全球需求、监管方面以及营养保健品的研究现状和未来展望

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00041

Shaikh Habeeba

引用次数: 1

An Updated Review on Novel Drug Delivery System 新型给药系统研究进展

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00034

Wajid Ahmad, Rihan Jawed

{"title":"An Updated Review on Novel Drug Delivery System","authors":"Wajid Ahmad, Rihan Jawed","doi":"10.52711/0975-4377.2022.00034","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00034","url":null,"abstract":"Novel drug delivery systems are the method for delivering of the medications to patients in such a manner which increases concentration of medications inside various body parts. The drug delivery widely found over nanomedicines that plan for employing nano particles mediated drugs delivery for combating downfall for the conventional drug delivery. The nano particles that loaded along with drug and target for the specific part of body where it must solely diseased tissues, hence by avoiding interactions along with the healthy tissues. The aim of targeted drugs delivery system is for the prolonged, localizing, and targeting and has the protected drugs interactions along with diseased tissues. The conventional drugs delivery systems are absorption of drugs around the biological membrane, the targeted releases systems release the drugs in the form of dosage. The pharmaceuticals innovation such as newer drugs delivery system presents the health professional along with wider range of the arsenal for treating disease with better efficacy, precision and the safety. In the future, it is hopeful that along with the more researches endeavor that focused in the arena in the coming future, a larger portion of conventional dosages form be replaced by the betterment of the health care delivery that expected to change over. The pharmacovigilance will provide the cost-efficient health care that helped for extending the better health care for underprivileged.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76576574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Detailed Review on Fast Dissolving Niosomal Films for Sublingual Drug Delivery 舌下给药快速溶膜的研究进展

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-04-30 DOI: 10.52711/0975-4377.2022.00026

N. Sharma, T. Kumar Sharma, A. Chaudhary, V. Pandit, M. Ashawat

{"title":"A Detailed Review on Fast Dissolving Niosomal Films for Sublingual Drug Delivery","authors":"N. Sharma, T. Kumar Sharma, A. Chaudhary, V. Pandit, M. Ashawat","doi":"10.52711/0975-4377.2022.00026","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00026","url":null,"abstract":"Fast dissolving or Quick-dissolving dosage forms have great importance in the pharmaceutical field due to their special properties and advantages. Fast-dissolving dosage forms breakdown immediately in the salivary fluids of the oral cavity within a minute, where they release the active pharmaceutical ingredient. Sublingual drug delivery system is a novel route of drug administration in which the drug substance is placed under the tongue and is directly absorbed via the blood vessels and produces the immediate onset of action. Noisome are closed bilayer vesicles formed by self-assembly of nonionic surfactant in an aqueous medium. Noisome is similar to liposome but has the ability to increase the stability of the drug. Formulated niosomes are added into the film-forming polymers to obtain sublingual niosomal films. Fast dissolving niosomal film is suitable for the drugs which show high first-pass metabolism or hepatic metabolism, low bioavailability drugs, and have a short half-life drugs. Fast Dissolving Niosomal Films used to improve the oral bioavailability and reduce the dose and dosing frequency, which reduce systemic side effects and as well as cost-effective. Niosomes allow the prolonged release of the drug and film was used to increase the bioavailability of drugs via the sublingual route of drug administration. Fast dissolving niosomal films have great importance during emergency conditions like allergy, short-term spasm, and asthma whenever an immediate onset of action is required. Fast dissolving films are also suitable for pediatric, geriatric, and dysphasic patients or patients with fear of choking.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80719452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Review on Orodispersible Tablet: Recent Trends of Manufacturing of Orodispersible Tablet 孔分散片的研究进展:孔分散片的最新发展趋势

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-04-30 DOI: 10.52711/0975-4377.2022.00028

P. Deore, Avish D. Maru, Yashpal M. More

{"title":"Review on Orodispersible Tablet: Recent Trends of Manufacturing of Orodispersible Tablet","authors":"P. Deore, Avish D. Maru, Yashpal M. More","doi":"10.52711/0975-4377.2022.00028","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00028","url":null,"abstract":"The article mainly focuses on several aspects of orodispersible tablets (ODTs). These types of tablets are those when placed in the mouth cavity disperse the drug in very rapid manner i.e. instantaneously releasing the drug which dissolve in saliva. ODTs are alternative dosage forms for the patients who are suffering from dysphasia i.e. difficulty in swallowing. The oral administration of the drug is most important method for administrating the drugs for systemic effects. Except that the parenteral route is not used routinely for self-administration e.g. insulin. The topical route is only applicable to deliver the drugs into the body for the systemic effect. The administration of the drug by the parenteral route is only beneficial for treating medical emergencies in which the subject is comatose or can’t swallow. Never the less it is probable that at least 90% of all drugs used to provide systemic effects are administered by the oral route. ODTs are different from traditional tablets in that they are designed to be dispersed on the tongue rather than swallowed whole. ODTs dissolve or disintegrate in the oral cavity without the need of water or chewing. And also it is mainly used for rapid action, to enhance the bioavailability, accurate dosing, enhance palatability, ease of administration, accurate dosing, having good patient compliance because most of the people are familiar with this route. Drugs present in ODTs do not suffer from the first-pass metabolism. This type of drug administration or delivery is becoming popular day by day due to its numerous advantages.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78217587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Study the effect of Cross linking of Sodium Alginate on the Rate of Drug Release 目的:研究海藻酸钠交联对药物释放速度的影响

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-04-30 DOI: 10.52711/0975-4377.2022.00020

Aachal Kolhe, Akshda Chauhan, Aishwarya Dongre

{"title":"To Study the effect of Cross linking of Sodium Alginate on the Rate of Drug Release","authors":"Aachal Kolhe, Akshda Chauhan, Aishwarya Dongre","doi":"10.52711/0975-4377.2022.00020","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00020","url":null,"abstract":"Verapamil hydrochloride (VH) is a calcium channel blocking agent used in the treatment of hypertension, cardiac arrhythmia and angina pectoris. The short half life and high frequency of administration of VH makes it a suitable candidate for designing sustained drug delivery system. The aim of the present investigation was to develop a sustained release matrix tablet of verapamil hydrochloride (VH) using sodium alginate and cross linked sodium alginate and to evaluate the drug release kinetics. In order to achieve the required sustained release profile, the tablets were prepared by a wet granulation method. The formulated tablets were characterized for pre-compression and post-compression parameters and they were in the acceptable limits. The drug release data obtained after an in vitro dissolution study was fitted to various release kinetic models in order to evaluate the release mechanism and kinetics. The criterion for selecting the best fit model was linearity (coefficient of correlation). Drug release mechanism was found to follow a complex mixture of diffusion, swelling and erosion. The dosage form holds the potential to control the release rate of drug and extend the duration of action of a drug.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89002182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Glance at the Literature review on Buccal films 口腔电影的文献综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-04-30 DOI: 10.52711/0975-4377.2022.00030

Yarragunta Roja, Hindustan Abdul Ahad, Haranath Chinthaginjala, Maninjeri Soumya, Sana Muskan, Nagaraju gari Kavyasree

{"title":"A Glance at the Literature review on Buccal films","authors":"Yarragunta Roja, Hindustan Abdul Ahad, Haranath Chinthaginjala, Maninjeri Soumya, Sana Muskan, Nagaraju gari Kavyasree","doi":"10.52711/0975-4377.2022.00030","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00030","url":null,"abstract":"The present article concentrates on the Buccal film. It is a buccoadhesive drug delivery system that enhances the safety, efficacy, and stability of active pharmaceutical ingredients. The buccal film is a novel technology due to its better option to optimize therapeutic efficacy. This drug delivery system is suitable for drugs that pass through high first-pass metabolism and are used for enhancing bioavailability. The buccal film can be formulated as a solvent casting, semi-solid casting, hot-melt extrusion, solid dispersion, or rolling method. Among them, the solvent casting method is mostly adopted. The buccal films are evaluated for mechanical properties viz., Organoleptic assessment, thickness, dryness, tack test, tensile strength, percent elongation, folding endurance, swelling assets, surface pH, contact angle, transparency, uniformity in drug content, disintegration, and in-vitro dissolution tests. The article gave a handful of literature on past work done on buccal films. This article helps with quick references to the earlier attempts so far made on buccal films.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86636354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Herbal extracts in Novel Drug Delivery System: A Magical Combo: A Brief Review 草药提取物在新型药物传递系统中的作用:一个神奇的组合:简要综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-04-30 DOI: 10.52711/0975-4377.2022.00024

Sheetal Sharma, Jigar Vyas, U. Upadhyay

{"title":"Herbal extracts in Novel Drug Delivery System: A Magical Combo: A Brief Review","authors":"Sheetal Sharma, Jigar Vyas, U. Upadhyay","doi":"10.52711/0975-4377.2022.00024","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00024","url":null,"abstract":"Novel drug delivery system is a system which overcomes out the limitation of the herbal or traditional drug delivery system. The novel drug delivery technology used in the herbal plant based medicine boost up the efficacy and decreasing the side effect of herbal drugs. Drug delivery system of herbal medicine is an ancient technique used by our ancestors for curing and recovering. Due to the introduction of new allopathic and homeopathic medicine herbal system become out-of-date resulting in reducing efficacy of the drug. Herbal medicines improved by novel drug delivery system become able to combat more serious disease easily. Due to lack of scientific justification and research development of herbal drug Novel formulation growth was Because of improper standardization, extraction, identification of individual drug, complex Polyherbal system etc. This problem becomes can be solved by the application of the Modern phyto-pharmaceutical research which can also help for improved pharmacokinetics of the herbal medicines and better understanding of mechanism of action. The incorporation of NDDS such as nanoparticles, microemulsions, matrix systems, liposomes, solid lipid nanoparticle, solid dispersions, etc. can also be useful for site specific drug delivery.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87154073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride 盐酸佐米曲坦咀嚼口服液的研制及评价

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-04-30 DOI: 10.52711/0975-4377.2022.00022

Wajid Ahmad, Rihan Jawed

{"title":"Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride","authors":"Wajid Ahmad, Rihan Jawed","doi":"10.52711/0975-4377.2022.00022","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00022","url":null,"abstract":"The present study aimed to develop an immediate release of Zolmitriptan hydrochloride oral jellies for the treatment of severe migraine. The jellies were prepared by using chitosan hydrochloride with different concentration as a polymer and propylene glycol as a co-polymer. The prepared jellies were evaluated for its various physio-chemical parameters such as pH, appearance, viscosity, in vitro drug release and drug content. The pH of the prepared formulations was found to be in the range of 7.5-8.1. The appearance of the prepared formulations was transparent to opaque. The viscosity of the prepared jellies was found to be in the range of 273600 - 542335 CPS. The drug content of the prepared jellies was found to be more than 97%. The in vitro drug release immediate release with increased concentration of Chitosan Hydrochloride, and the drug release were found to be more than 60% in 15 minutes. This present studies concluded that Zolmitriptan hydrochloride oral jellies can be a better alternative for oral dispersible tablets and it could produce improved bioavailability as compared to other fast releasing dosage form. From the above studies of various parameters, it was concluded that the FJ5 formulation was found to be optimized formulation.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90305759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation and Evaluation of Yohimbine Hydrochloride Agglomerates by Crystallo Co-Agglomeration technique 结晶共团聚法制备盐酸育亨宾团聚物及评价

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-04-30 DOI: 10.52711/0975-4377.2022.00016

Pallavi Wadaskar, Pallavi Kharkar, Pallavi Ispade

{"title":"Preparation and Evaluation of Yohimbine Hydrochloride Agglomerates by Crystallo Co-Agglomeration technique","authors":"Pallavi Wadaskar, Pallavi Kharkar, Pallavi Ispade","doi":"10.52711/0975-4377.2022.00016","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00016","url":null,"abstract":"Crystallo-co-agglomeration (CCA) is an innovative technique developed with the intention to produce the drugs with good micromeritic and mechanical characteristics. Yohimbine Hydrochlorideis an anti-retroviral drug with poor dissolution and poor flow properties. Hence the aim of the study is to prepare the crystallo co-agglomerates of Yohimbine Hydrochloridewhich may improve the properties of Yohimbine Hydrochloride.The present study was carried out in order to develop pharmaceutically equivalent, stable, and quality improved agglomerates of Yohimbine Hydrochloridewith enhanced solubility wettability, dissolution rate, flow properties and mechanical properties using hydrophilic polymers and to characterize the physico-chemical properties of prepared crystallo-co-agglomeration.The present work was carried out using PVA and PEG 6000 as the polymers in different ratios by crystallo-co agglomeration method. The various evaluations of prepared agglomerates like micromeritics of the agglomerates such as flowability, packability and compatibility were dramatically improved. The dissolution and disintegration rate of agglomerate was increased in presence of PEG 6000 than compared with PVA.TheYohimbine Hydrochloridepolymer agglomerates were successfully prepared by crystallo-co-agglomeration technique and it was concluded that crystallo-co-agglomeration technique can be successfully employed as an alternative to conventional wet agglomeration.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74256277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2