Research Journal of Pharmaceutical Dosage Forms and Technology最新文献_第9页

Analytical Methods of Antidiabetic Drugs – Sitagliptin, Saxagliptin, Linagliptin, Alogliptin, Gemifibrozil, Troglitazone, Pioglitazone and Rosiglitazone: A Review 抗糖尿病药物西格列汀、沙格列汀、利格列汀、阿格列汀、吉米菲齐、曲格列酮、吡格列酮和罗格列酮的分析方法综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-11-12 DOI: 10.52711/0975-4377.2022.00053

D. S. Varma., Devidas D Dighe

{"title":"Analytical Methods of Antidiabetic Drugs – Sitagliptin, Saxagliptin, Linagliptin, Alogliptin, Gemifibrozil, Troglitazone, Pioglitazone and Rosiglitazone: A Review","authors":"D. S. Varma., Devidas D Dighe","doi":"10.52711/0975-4377.2022.00053","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00053","url":null,"abstract":"Analytical techniques used to determine chemical or physical property of analyte, chemical substance, chemical element or mixture. There are different types of analytical techniques used in pharmaceutical field for qualitative and quantitative estimation of drugs in biological fluids such as human plasma, human serum, human urine etc. and its formulations such as tablet, capsule, bulk drugs etc. This review work aims to provide most of existing analytical methods for analysis of Dipeptidyl peptidase-4 (DPP4) inhibitor and Peroxisome proliferator activated (PPAR) agonist. Estimation of Sitagliptin, Saxagliptin, Alogliptin, Gemifibrozil, Troglitazone, Pioglitazone, Linagliptin, and Rosiglitazone in active pharmaceutical ingredients, biological fluids and in various formulations which is reported in various research articles are reviewed. The analytical techniques which are utilised for the estimation of these drugs involves RP-HPLC, HPTLC, UPLC-MS/MS, LC-MS/MS, MALDI-TOF mass spectrometry, Raman spectroscopy, Liquid chromatography and Tandem mass spectrometry, TLC-densitometry with fluorescent detector, LC-ESI-MS-MS etc. are involved. The review assist in appropriate selection of analytical technique, mobile phase, column and detector based on available analytical instruments and chemicals by referring tabulated extensive condition. DPP4 inhibitor used in treatment of type 2 diabetes, hypoglycemia, weight loss etc. PPAR agonist also used in treatement of type 2 diabetes, in metabolic syndrome mainly for lowering triglycerides and blood sugar etc.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90457167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Berberine on Skin Diseases: A Review 小檗碱在皮肤病中的应用综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-11-12 DOI: 10.52711/0975-4377.2022.00050

Keshav Dhiman, Anshul Sharma, Kamya Goyal, V. Pandit, M. Ashawat, Shammy Jindal

引用次数: 0

Microballoons: An Advanced Avenue for Gastro Retentive Drug Delivery System 微气球:胃保留性药物输送系统的先进途径

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00038

Pratibha. B. Wakchaure, Maya. Y. Gaikwad

{"title":"Microballoons: An Advanced Avenue for Gastro Retentive Drug Delivery System","authors":"Pratibha. B. Wakchaure, Maya. Y. Gaikwad","doi":"10.52711/0975-4377.2022.00038","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00038","url":null,"abstract":"The motivation of writing this review on micro balloons is a Gastro retentive drug delivery system are micro balloons (hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug delivery system is novel drug delivery on the foundation of non- effervescent system that containing empty particles of spherical shape without core ideally having a size less than 200 micrometers which is designed to be retained in the stomach for a prolonged period of time and release their active ingredients and thereby enable sustained and prolonged input of the drug in the upper part of the gastrointestinal (GI) tract. They are gastro retentive drug-delivery systems, which provide controlled release properties for a drug. Recently gastro retentive drug delivery system (GRDDS) are gaining wide acceptance for drugs with narrow absorption windows, decreased stability at high alkaline pH, and increased solubility at low pH. The design of this article is to compose the various gastro retentive arrive. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling retention i.e. high density, floating, bio-or that adheres to a mucous membrane (adjective), extensile, attractor etc. In addition of central element controlling gastro retention, superiority and finally future potential are discussed.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77817803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An updated review on Immunoglobulin 免疫球蛋白最新综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00036

Rahul Jodh, M. Tawar, Prashant J. Burange, Pradyumna Keche

{"title":"An updated review on Immunoglobulin","authors":"Rahul Jodh, M. Tawar, Prashant J. Burange, Pradyumna Keche","doi":"10.52711/0975-4377.2022.00036","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00036","url":null,"abstract":"Immunoglobulin’s are heterodimeric proteins composed of two heavy (H) and two light (L) chains. They can be separated functionally into variable (V) domains that binds antigens and constant (C) domains that specify effectors functions such as activation of complement or binding to Fc receptors. The variable domains are created by means of a complex series of gene rearrangement events, and can then be subjected to somatic hypermutation after exposure to antigen to allow affinity maturation. Immunoglobulin is the antibodies and glycoprotein’s molecules produced by plasma cells or white blood cells, a signal production occur due the reaction with B cells. In 20th century the science of immunoglobulin was considered as an important science, centrifugation, Immuno adsorption such novel techniques was discovered for dissection of human blood components such as antibodies, so the naming of antibodies was necessary, Latin terms was used at that time for the purpose of naming. But the various in vitro studies shows that the pepsin and acidic condition shows a degradative effect on immunoglobulin neutralizing titer. To overcome this the IgY antibodies are encapsulated. For the protection of mucosal membrane of the IgA plays an essential role, the immune response of the secretory IgA is short lived due to this the genetically engineered antibodies are used for passive immunotherapy.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82957438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Recent attempt made on Fast Disintegrating Tablets: A Precise Review 快速崩解片的最新尝试:精确评价

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00037

Hindustan Abdul Ahad, Haranath Chinthaginjala, Nagarajugari Kavyasree, Jyothi Vinay Krishna, Sushma Papireddypalli, Kotlo Saijyoshna

{"title":"A Recent attempt made on Fast Disintegrating Tablets: A Precise Review","authors":"Hindustan Abdul Ahad, Haranath Chinthaginjala, Nagarajugari Kavyasree, Jyothi Vinay Krishna, Sushma Papireddypalli, Kotlo Saijyoshna","doi":"10.52711/0975-4377.2022.00037","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00037","url":null,"abstract":"The purpose of this study was to investigate previous research on fast-acting pills. Fast dissolving tablets (FDTs) have become a rapidly emerging field in the pharmaceutical business over the last ten years. For the administration of many medications, oral drug delivery remains the recommended method. Scientists have developed FDTs with increased patient compliance and convenience during insertion into the mouth because of recent technological advances. For simple administration of active pharmaceutical substances, these tablets crumble or dissolve in the mouth without the use of water. Because of the formulation's popularity and use, several FDT technologies have been developed. FDTs are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without the use of water or chewing. FDT shines in areas where pediatrics and geriatrics have trouble swallowing traditional tablets and capsules. FDT is a new drug delivery system that is intended for rapid dissolution and action, as well as treating acute illnesses with greater patient compliance. The authors gathered enough data from previous FDT trials. This review article can be used by researchers to quickly obtain latest literature on FDT.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89895434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approaches to Creating and Past Successful Attempts on Microspheres: A Primer for Aspiring Researchers 在微球上创造和过去成功尝试的方法:有抱负的研究人员的入门

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00040

Kappala Sailaja, Hindustan Abdul Ahad, Haranath Chinthaginjala, Renuka Gudisipalli, Sugali Indravath Rajyalakshmi, Yamuna Vagganagari

{"title":"Approaches to Creating and Past Successful Attempts on Microspheres: A Primer for Aspiring Researchers","authors":"Kappala Sailaja, Hindustan Abdul Ahad, Haranath Chinthaginjala, Renuka Gudisipalli, Sugali Indravath Rajyalakshmi, Yamuna Vagganagari","doi":"10.52711/0975-4377.2022.00040","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00040","url":null,"abstract":"The work was aimed at the gathering and projection of literature on microspheres. A targeted drug delivery system is intended to increase the concentration of medication in the areas of interest while reducing its concentration in the rest of the body. Thus, the drug is localized at the target site. It does not affect the surrounding tissues. Carriers have therefore proven to be a useful approach to drug delivery since the drug is coupled with a carrier particle such as microspheres, nanoparticles, liposomes, niosomes, and so on, that controls the release and absorption of the drug. A microsphere is a free-flowing powder consisting of proteins or synthetic polymers that are biodegradable in nature and, ideally, have a particle size of under 200 m. If it is modified, it is a reliable way to deliver the drug to the target site with high specificity and to maintain the desired concentration without unintended side effects. As a result of their long-term release, microspheres have been receiving a lot of attention, especially for their ability to target anticancer drugs to the tumor. By combining microspheres with a variety of other strategies, microspheres will have a key role in the delivery of pharmaceuticals, especially in diseased cell sorting, diagnostics, gene delivery, and safe, targeted, and effective in vivo delivery. This article will help research to get a quick reference to the past work done on microsphere dosage forms.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76810767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Stability indicating Method development and Validation of Lamivudine, Zidovudine and Nevirapinein Tablet dosage form 拉米夫定、齐多夫定、奈韦拉平片剂型的稳定性指示方法研究与验证

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00039

Shinde G. S., Jadhav R. S., Vikhe D. N.

{"title":"Stability indicating Method development and Validation of Lamivudine, Zidovudine and Nevirapinein Tablet dosage form","authors":"Shinde G. S., Jadhav R. S., Vikhe D. N.","doi":"10.52711/0975-4377.2022.00039","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00039","url":null,"abstract":"The RP-HPLC method for Lamivudine, Zidovudine and Nevirapine was developed using Inertsil ODS 3V C18 column (5µm, 150mm × 4.6mm) as stationary phase and 0.01M 1-octane Sulphonic acid: Methanol (60:40v/v, pH2.6) as mobile phase. The mobile phase was maintained at a flow rate of 1ml/min, run time 15 min and detection was carried out at 270nm.Lamivudine, Zidovudine and Nevirapine were found to be linear in the concentration range of 75-225µg/ml, 150-450µg/ml and 100-300µg/ml respectively. The result of % assay of marketed formulation was found as 101.93±0.1527, 100.86±0.2021and 94.2±0.1527 for Lamivudine, Zidovudine and Nevirapine respectively. Accuracy of the method was determined by performing recovery study and the result were found in the range of 100.9-101.4%, 100.1-100.7% and 99.0-99.9% for Lamivudine, Zidovudine and Nevirapine respectively. Percentage RSD of precision study of these drugs were found less than 2 percent which indicated good precision of the developed method. The proposed method was validated for linearity, accuracy, precision, and robustness. The proposed method is simple, rapid. precise and reproducible hence can be applied for routine quality control analysis of Lamivudine, Zidovudine and Nevirapine in pharmaceutical dosage form.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85516350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transferosome: A Vesicular Transdermal Delivery System for Enhanced Drug Permeation 转移体:一种提高药物渗透的囊性透皮给药系统

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00033

Snehal Arjun Kurhe, Kedar Bavaskar, Ashish Jain

{"title":"Transferosome: A Vesicular Transdermal Delivery System for Enhanced Drug Permeation","authors":"Snehal Arjun Kurhe, Kedar Bavaskar, Ashish Jain","doi":"10.52711/0975-4377.2022.00033","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00033","url":null,"abstract":"The barrier function of the skin limits transdermal medication delivery. Vesicular systems are one of the most contentious mechanisms for delivering active compounds transdermally. The discovery of elastic vesicles such transferosomes, ethosomes, cubosomes, phytosomes, and others reignited interest in creating transdermal delivery systems. Vesicular drug delivery systems are highly organised assemblies made up of one or more concentric bilayers that form when amphiphilic building units self-assemble in water. Because of their potential to localise drug activity at the site or organ of action while reducing its concentration at other places in the body, vesicular drug delivery systems are particularly significant for targeted drug delivery. The vesicular drug delivery system keeps drug activity at a specified rate, keeps drug levels in the body reasonably constant (zero order kinetics), and reduces unwanted side effects at the same time. It can also target medication delivery utilizing carriers or chemical derivatization to localise drug action in the affected tissue or organ. Vesicular drug delivery systems have been used to improve The therapeutic index, solubility, stability, and rapid degradation of a pharmacological molecule are all important factors to consider. As a result, a number of innovative vesicular drug delivery systems that allow drug targeting and prolonged or regulated drug release have been produced. This review will focus on diverse lipoidal and non-lipoidal vesicles, with a special emphasis on pharmaceutical targeting.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91309629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Herbal mouthwash: A Review 草药漱口水:综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00035

Shraddha Jethawa, Onkar Gopale, Suvarna J. Shelke

{"title":"Herbal mouthwash: A Review","authors":"Shraddha Jethawa, Onkar Gopale, Suvarna J. Shelke","doi":"10.52711/0975-4377.2022.00035","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00035","url":null,"abstract":"Oral health is important as overall health. Now-a-days people may faces more oral problems like periodontal disease, sore throat, gingivitis, plaque and so on. For maintaining good oral health various formulations are formulated. A mouthwash is recommended for controlling plaque, bad breath, toothache and bacteria. Herbal mouthwash are preferred over chemical mouthwash as it shows less side effects and is non-irritant, less toxic, and do not contain alcohol. Medicinal plants, because of their antiviral and antibacterial action against human microorganisms, have a major role in healing and preventing illnesses. Herbal mouthwash consists of extracts of crude drugs which has no or less side effects as compared to synthetic mouthwash. Herbal mouthwashes are prepared from various plant extracts. The herbs described in this article are cinnamon, neem, guava, pomegranate, tulsi, wintergreen, tulsi, peppermint, miswak and clove that are useful in dentistry. Mouthwashes that may be readily produced and used safely by people at home using natural materials could enhance the population's overall oral health. The major goal of this review is to preserve dental health by using natural mouthwash.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75274281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Characterization of Sustained Released Alginate Beads of Meclizine Hydrochloride 盐酸美甲嗪海藻酸盐缓释微球的设计与表征

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2022-07-16 DOI: 10.52711/0975-4377.2022.00032

Wajid Ahmad, Rihan Jawed

引用次数: 2