Design and Characterization of Sustained Released Alginate Beads of Meclizine Hydrochloride

Abstract

The objective of present study was to prepare alginate beads of antihistamine meclizine hydrochloride for sustain release action. The alginate beads were prepared by employing sodium alginate as a polymer with sodium carboxymethyl cellulose and chitosan hydrochloride as release retardant. The method of preparation employed was ionotropic gelation. The prepared beads were seen having the drug release rate of 98.34% of A4 batch and 99.02% of B4 batch in the time period of 12hrs. The maximum percent drug content of 94.72±0.06% was found in A4 batch. From the results it can be seen that A4 batch was found to be optimum as it was having maximum drug content and maximum amount of drug release in the predicted time period of 12hrs. The microbeads of meclizine hydrochloride by using ionotropic gelation method were prepared successfully employing various polymers in different concentrations. The prepared microbeads can be a better alternative than various other sustained release dosages forms.