Reproductive and Developmental Medicine最新文献

{"title":"<i>Atp6v0d2</i> deficiency partially restores defects in <i>Mcoln1</i>-deficient mouse corpus luteum.","authors":"Yuehuan Li, Ahmed E El Zowalaty, Jonathan Matthew Hancock, Zidao Wang, Taylor Elijah Martin, Tingjie Zhan, Yingzheng Wang, Christian Lee Andersen, Suvitha Viswanathan, Jaymie Bromfield, Venkata Abhigna Atluri, Karly Rae Kallish, Hope Nicole Grismer, Shuo Xiao, Xiaoqin Ye","doi":"10.1097/RD9.0000000000000116","DOIUrl":"10.1097/RD9.0000000000000116","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;ATP6V0d2 is a subunit of the vacuolar-type H&lt;sup&gt;+&lt;/sup&gt;-ATPase (V-ATPase) that pumps H&lt;sup&gt;+&lt;/sup&gt; ions into lysosomes. TRPML1 (&lt;i&gt;MCOLN1&lt;/i&gt;/&lt;i&gt;Mcoln1&lt;/i&gt;) transports cations out of lysosomes. &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt; mice recapitulate the lysosomal storage disorder mucolipidosis type IV (MLIV) phenotype. We previously demonstrated that &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt; female mice quickly became infertile at 5 months old (5M) with degenerating corpora lutea (CL) and progesterone (P4) deficiency. We tested our hypothesis that &lt;i&gt;Atp6v0d2&lt;/i&gt; deficiency could partially compensate for &lt;i&gt;Mcoln1&lt;/i&gt; deficiency to restore CL functions in &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; mice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Control and &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; female mice underwent fertility test from 2M to 7M. A subset of them was dissected at 5M on day 3.5 post-coitum (D3.5). The D3.5 ovaries from 5M control, &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt;, and &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; mice were evaluated for CL morphology, lipid droplet staining, and markers of mitochondria and P4 steroidogenesis in the luteal cells.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The fertility test of &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; female mice (2M-7M) revealed normal mating activity but reduced fertility compared with the control; yet ~25% of them remained fertile at 5M to 7M but with dystocia. We analyzed a subset of 11 &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; mice (5M) in the fertility test on D3.5: three (27.3%) had normal P4 levels and all examined CL parameters, indicating full restoration of CL function compared with &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt;, whereas eight had P4 deficiency, with two (18.2%) infertile and six (54.5%) once fertile. In contrast to &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt; CLs, which had extensive amorphous cellular debris, indicating cell degeneration, &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; CLs had reduced amorphous cellular debris regardless of P4 levels. However, similar to &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-/-&lt;/sup&gt; CLs, P4-deficient &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; CLs showed impaired differentiation, enlarged lipid droplets, disorganized expression of endothelial basal lamina marker collagen IV, and reduced expression of mitochondrial marker heat shock protein 60 (HSP60) and steroidogenesis rate-limiting protein StAR, indicating that additional &lt;i&gt;Atp6v0d2&lt;/i&gt; deficiency compensates for &lt;i&gt;Mcoln1&lt;/i&gt; deficiency-induced cell degeneration, but is insufficient to restore luteal cell differentiation and P4 steroidogenesis in P4-deficient &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; &lt;i&gt;Mcoln1&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/i&gt;-&lt;/sup&gt; CLs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study shows that &lt;i&gt;Atp6v0d2&lt;/i&gt; &lt;sup&gt;-&lt;i&gt;/&lt;/","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"9 1","pages":"11-21"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization evidence for lung function mediates the association between childhood allergies (age <16 years) and essential hypertension.","authors":"Yu-Hang Long, Jun-Sen She, Fei Guo, Bo-Kang Zhou, Chen Fang, Yi-Zhi Hu, Ling Gao, He-Feng Huang","doi":"10.1097/RD9.0000000000000121","DOIUrl":"10.1097/RD9.0000000000000121","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the influence of lung function on the relationship between allergies and hypertension, thereby elucidating significant potential mechanisms from a genetic standpoint. We investigated the causal relationship between childhood allergies (age <16 years) and essential hypertension and identified and quantified the role of lung function (forced vital capacity [FVC] and forced expiratory volume in the first second/forced vital capacity [FEV1/FVC]) as potential mediators.</p><p><strong>Methods: </strong>Using data from a genome-wide association study and the Fenn Genn consortium, a two-sample Mendelian randomization (MR) analysis of genetically predicted childhood allergies (7128 cases and 211,703 controls) and essential hypertension (116,714 cases and 1,032,659 controls) was performed. Furthermore, we used two-step MR to quantify the effect of lung function-mediated childhood allergies on essential hypertension. The FVC and FEV1/FV sample size was 371,898.</p><p><strong>Results: </strong>Childhood allergies were associated with increased odds of developing essential hypertension (odds ratio [<i>OR</i>] = 1.0900, 95% confidence interval [<i>CI</i>] = <b><i> </i></b> 1.0034-1.1842, <i>P</i> = 0.0414). No strong evidence that genetically predicted essential hypertension affected childhood allergy risk was identified (<i>OR</i> = 1.0631, 95% <i>CI</i> = 0.9829-1.1498, <i>P</i> = 0.1264). The proportion of genetically predicted childhood allergies mediated only by FVC was 5.67% (95% <i>CI</i>, 5.13%-5.73%).</p><p><strong>Conclusion: </strong>A causal relationship between childhood allergies and essential hypertension was identified, with a proportion of the effect mediated by FVC. Therefore, implementing early interventions in children with allergies is imperative to mitigate the long-term risk of developing hypertension. Further research is required to identify additional risk factors as potential mediators.</p>","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"9 1","pages":"48-56"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous estrogen partially rescues progesterone deficiency and autophagosome enlargement in <i>Mcoln1</i> ^-/- mouse model with lysosomal storage disorder.","authors":"Zidao Wang, Yuehuan Li, Christian L Andersen, Ahmed E El Zowalaty, Jonathan M Hancock, Taylor E Martin, Elizabeth W Howerth, Suvitha Viswanathan, Haeyeun Byun, Xiaoqin Ye","doi":"10.1097/RD9.0000000000000109","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000109","url":null,"abstract":"<p><strong>Objective: </strong>Female <i>Mcoln1</i> ^-/- mice exhibit progressive progesterone (P4) deficiency, luteal cell degeneration, and premature embryo implantation failure at 5 months old. We attempted to rescue embryo implantation in non-virgin <i>Mcoln1</i> ^-/- mice (5-6 months old) with exogenous P4 treatment on days 1.5 post-coitum (D1.5), D2.5, and D3.5, and observed partially restored luteal cell morphology on D4.5, but unexpectedly found 17β-estradiol (E₂) contamination in the P4 working solution. In this study, we aim to investigate exogenous P4 and/or E₂ for the partial recovery of luteal cell morphology in infertile <i>Mcoln1</i> ^<i>-/-</i> mice.</p><p><strong>Methods: </strong>Control and non-virgin <i>Mcoln1</i> ^-/- mice (5-6 months old) were treated with newly ordered vehicle, P4, E₂, or P4 + E₂ on D1.5 and D2.5 and dissected on D3.5 for P4 and E₂ measurements, ovary histology, immunofluorescence, lipid droplet staining, and transmission electron microscopy.</p><p><strong>Results: </strong>E₂ treatment significantly increased serum P4 levels in D3.5 <i>Mcoln1</i> ^-/- mice. E₂ and P4 + E₂ treatments, but not P4 treatment alone, largely improved the morphology of D3.5 <i>Mcoln1</i> ^-/- corpora lutea, indicated by a more contiguous web-like collagen IV expression pattern, increased heat shock protein 60 expression, and reduced accumulation of large lipid droplets. Transmission electron microscopy revealed extremely enlarged autophagosomes and lipid droplets, lysosomes with lamellar structures, and mitochondria with reduced cristae in vehicle-treated D3.5 <i>Mcoln1</i> ^-/- luteal cells, while in E₂-treated D3.5 <i>Mcoln1</i> ^-/- luteal cells, extremely enlarged autophagosomes and lipid droplets were reduced, indicating improved luteal cell ultrastructure.</p><p><strong>Conclusion: </strong>These findings reveal protective effects of high levels of exogenous E₂ on P4 production and lysosomal function in <i>Mcoln1</i> ^-/- luteal cells.</p>","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"8 4","pages":"197-205"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the influence of the biochemical composition of the human native ejaculate on the preservation of the male gametes’ activity after the application of cryopreservation technology","authors":"Aidana Begaidarova, S. Baikoshkarova, Botakoz Mutaliyeva","doi":"10.1097/rd9.0000000000000083","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000083","url":null,"abstract":"\u0000 \u0000 The purpose of this study is to investigate the influence of the biochemical composition of human native ejaculate on the preservation of male gamete activity after the application of cryopreservation technology, and to evaluate the potential practical application of these findings in future fertilization processes.\u0000 \u0000 \u0000 \u0000 The methodology employed in this study involves a systematic analysis of the technological aspects of cryopreserving human semen, coupled with an analytical examination of how the biochemical composition of semen affects the preservation of male gamete activity.\u0000 \u0000 \u0000 \u0000 The results of the study demonstrate a clear relationship between the activity of male gametes and changes in the biochemical composition of semen following cryopreservation.\u0000 \u0000 \u0000 \u0000 This study addresses the issue of male infertility in Kazakhstan and underscores the importance of research in embryology and reproductive medicine to effectively address this problem.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61786366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Microbiota on Female Fertility and Gynecological problems","authors":"Manish Kumar, Luhan Jiang, Hoi-Lam Lai, Cheuk-Lun Lee, E. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000082","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000082","url":null,"abstract":"The uterus was previously considered a sterile environment for embryo implantation and fetal growth; however, evidence showed that different microorganisms in the female reproductive tract may regulate human fertility. The Lactobacillus family is among the most prevalent bacteria in the vagina and uterus of the female reproductive system. Interestingly, a Lactobacillus-dominated (LD) uterine environment is associated with better pregnancy outcomes. Nevertheless, the mechanism by which an LD environment improves pregnancy outcomes is unknown. In the uterus, many commensal bacteria (e.g., Bifidobacterium, Prevotella, Enterobacter, Streptococcus, and Staphylococcus) produce short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate. SCFAs are crucial in modulating cytokine production (e.g., IL-6 and IL-10) and immune cell populations (e.g., T cells and macrophages) during embryo implantation and gynecological diseases. This minireview provides an overview of the roles of Lactobacilli and SCFAs in female fertility and related diseases.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46226047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study","authors":"L. Jia, Pei-Gen Chen, Lin Chen, C. Fang, Jing Zhang, Panyu Chen","doi":"10.1097/rd9.0000000000000080","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000080","url":null,"abstract":"\u0000 \u0000 To develop a clinically applicable tool for predicting clinical pregnancy, providing individualized patient counseling, and helping couples with nonobstructive azoospermia (NOA) decide whether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction (mTESE).\u0000 \u0000 \u0000 \u0000 A total of 240 couples with NOA who underwent mTESE-ICSI were divided into two groups based on the type of spermatozoa used for intracytoplasmic sperm injection (ICSI): the fresh and cryopreserved groups. After evaluating several machine learning algorithms, logistic regression was selected. Using LASSO regression and 10-fold cross-validation, the factors associated with clinical pregnancy were analyzed.\u0000 \u0000 \u0000 \u0000 The area under the curves (AUCs) for the fresh and cryopreserved groups in the Logistic Regression-based prediction model were 0.977 and 0.759, respectively. Compared with various modeling algorithms, Logistic Regression outperformed machine learning in both groups, with an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved group.\u0000 \u0000 \u0000 \u0000 The model accurately predicted clinical pregnancies in NOA couples.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42135755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Text mining and data analysis identifies potential drugs and pathways for polycystic ovary syndrome treatment","authors":"Xiaoyin Yuan, Y. Wang, Haiyan Yang, Bin Zhao","doi":"10.1097/rd9.0000000000000081","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000081","url":null,"abstract":"\u0000 \u0000 Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. This study aimed to use text mining and microarray data analysis to identify drugs that target genes and potential pathways associated with PCOS.\u0000 \u0000 \u0000 \u0000 We extracted a common set of genes associated with PCOS using text mining and the microarray dataset GSE48301. Next, we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of these genes, as well as protein-protein interaction (PPI) network analysis. Additionally, we used MCODE and cytoHubba to cluster significant common genes in the PPI network and performed gene-drug interaction analyses to identify potential drugs for further investigation. Finally, we annotated pathways associated with the genes identified.\u0000 \u0000 \u0000 \u0000 Text mining and microarray analysis yielded 696 text mining genes (TMGs) and 2,804 differentially expressed genes (DEGs). Among these, a set of 77 genes was found in both TMGs and DEGs. Interestingly, 67 of these genes participated in constructing the PPI network. Seven common hub genes were selected using the MCODE and CytoHubba methods. Finally, five out of seven genes were targeted by 15 existing drugs.\u0000 \u0000 \u0000 \u0000 Four genes (FASLG, IL13, IL17A, and IL2RA), which are mainly related to the cytokine-cytokine receptor interaction pathway, could be prioritized as targets for PCOS.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49187380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Glucose Metabolism and Signaling Pathways at Different Stages of Ovarian Folliculogenesis","authors":"Dan Mo, Zhonghong Zeng, Xin Sui, Rong Li, Yi-Hua Yang","doi":"10.1097/rd9.0000000000000079","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000079","url":null,"abstract":"The female ovaries are critical for follicle growth and development in the process known as “folliculogenesis”. This complex process is regulated by various factors, among which the microenvironment around follicles appears to be crucial. According to previous studies, folliculogenesis is an energy-demanding process. In fact, well-balanced follicular energy metabolism is associated with ovarian function and female fertility. Consequently, glucose metabolism has been widely described as the main source of energy during folliculogenesis. Generally, the follicular glucose metabolism profiles change dynamically during follicular development. Metabolic abnormalities during folliculogenesis are associated with aging, primary ovarian insufficiency, and polycystic ovary syndrome, thereby leading to subfertility and infertility in females. The signaling pathways in follicles appear to form a link between glucose metabolism and folliculogenesis. Therefore, a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental competence. This review aimed to describe variations in glucose metabolism at different stages of folliculogenesis, provide new insights into glucose metabolic disorder-related diseases, and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis: phosphatidylinositol 3-kinase, protein kinase B (PI3K-PKB/AKT) and AMP-activated protein kinase (AMPK) signaling pathways.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49164682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of the emergency management of cardiac conditions during pregnancy in an Egyptian tertiary unit: Newness in paradigms","authors":"M. Mahmoud, Abd Elhalim, M. Ellaban, M. Saleh, Hamdi Mohamed Ali, Khaled M Abdalla, M. Eldeib, Ahmed Ali Faheem, A. Almarghany, M. Samy, Al Hussein Zahran, A. Ali, Medhat Ali","doi":"10.1097/rd9.0000000000000077","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000077","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42049115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics approaches to uncover endometrial receptivity in embryo implantation: A mini-review","authors":"S. Fernando, Yang Yan, Manish Kumar, Hoi-Lam Lai, Yin-Lau Lee, E. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000078","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000078","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43728651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}