Reproductive and Developmental Medicine最新文献

{"title":"Exploring the Mechanisms of Yuanhu Zhitong Oral Liquid for Primary Dysmenorrhea through Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation","authors":"Cheng-Rui Zhang, Dai-yan Zhang, Jin Gao, Zhi-Ming Cao, Yuan-Jia Hu","doi":"10.1097/rd9.0000000000000097","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000097","url":null,"abstract":"\u0000 \u0000 Primary dysmenorrhea (PD) is a prevalent gynecological disorder. Yuanhu Zhitong oral liquid (YHZT) presents a promising alternative treatment for PD. However, the mechanisms underlying its efficacy remain unclear. This study aims to investigate the potential targets and mechanisms of action of YHZT in treating PD using network pharmacology, molecular docking, and molecular dynamics simulations.\u0000 \u0000 \u0000 \u0000 Potential compounds from YHZT were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the Traditional Chinese Medicine Information Database (TCMID). The relevant targets of these compounds were identified using the similarity ensemble approach (SEA) and the Swiss Target Prediction database. PD-related targets were retrieved from the Genecards, DrugBank, and Disgenet databases. ClusterProfiler was utilized for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The compound-target-pathway (CTP) network was constructed to facilitate the identification of key compounds, core targets, and signaling pathways. Finally, molecular docking and molecular dynamics simulations were performed to evaluate the interactions between the targets and compounds.\u0000 \u0000 \u0000 \u0000 A total of 153 putative compounds and 129 targets of YHZT were identified. Network topology analysis revealed eight core targets and six key compounds. The effects of YHZT were mediated by genes associated with hormone and steroid metabolism, as well as pathways involved in steroid hormone biosynthesis and cytochrome P450 enzymes. Docking results showed free-binding energies ranging from -6.06 to -10.85 kcal/mol, indicating strong binding affinity between the compounds and targets. Molecular dynamics simulation results further confirmed the stability of these interactions.\u0000 \u0000 \u0000 \u0000 This study demonstrates that YHZT treats PD by suppressing inflammatory reactions and modulating hormone and cytochrome P450 concentrations. Key compounds such as ferulic acid, (R)-canadine, (S)-canadine, canadine, and asristolone are implicated in this process. These findings offer insights into the mechanisms underlying the action of YHZT and provide a foundation for further research in this area.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the influence of the biochemical composition of the human native ejaculate on the preservation of the male gametes’ activity after the application of cryopreservation technology","authors":"Aidana Begaidarova, S. Baikoshkarova, Botakoz Mutaliyeva","doi":"10.1097/rd9.0000000000000083","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000083","url":null,"abstract":"\u0000 \u0000 The purpose of this study is to investigate the influence of the biochemical composition of human native ejaculate on the preservation of male gamete activity after the application of cryopreservation technology, and to evaluate the potential practical application of these findings in future fertilization processes.\u0000 \u0000 \u0000 \u0000 The methodology employed in this study involves a systematic analysis of the technological aspects of cryopreserving human semen, coupled with an analytical examination of how the biochemical composition of semen affects the preservation of male gamete activity.\u0000 \u0000 \u0000 \u0000 The results of the study demonstrate a clear relationship between the activity of male gametes and changes in the biochemical composition of semen following cryopreservation.\u0000 \u0000 \u0000 \u0000 This study addresses the issue of male infertility in Kazakhstan and underscores the importance of research in embryology and reproductive medicine to effectively address this problem.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61786366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Microbiota on Female Fertility and Gynecological problems","authors":"Manish Kumar, Luhan Jiang, Hoi-Lam Lai, Cheuk-Lun Lee, E. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000082","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000082","url":null,"abstract":"The uterus was previously considered a sterile environment for embryo implantation and fetal growth; however, evidence showed that different microorganisms in the female reproductive tract may regulate human fertility. The Lactobacillus family is among the most prevalent bacteria in the vagina and uterus of the female reproductive system. Interestingly, a Lactobacillus-dominated (LD) uterine environment is associated with better pregnancy outcomes. Nevertheless, the mechanism by which an LD environment improves pregnancy outcomes is unknown. In the uterus, many commensal bacteria (e.g., Bifidobacterium, Prevotella, Enterobacter, Streptococcus, and Staphylococcus) produce short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate. SCFAs are crucial in modulating cytokine production (e.g., IL-6 and IL-10) and immune cell populations (e.g., T cells and macrophages) during embryo implantation and gynecological diseases. This minireview provides an overview of the roles of Lactobacilli and SCFAs in female fertility and related diseases.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46226047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study","authors":"L. Jia, Pei-Gen Chen, Lin Chen, C. Fang, Jing Zhang, Panyu Chen","doi":"10.1097/rd9.0000000000000080","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000080","url":null,"abstract":"\u0000 \u0000 To develop a clinically applicable tool for predicting clinical pregnancy, providing individualized patient counseling, and helping couples with nonobstructive azoospermia (NOA) decide whether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction (mTESE).\u0000 \u0000 \u0000 \u0000 A total of 240 couples with NOA who underwent mTESE-ICSI were divided into two groups based on the type of spermatozoa used for intracytoplasmic sperm injection (ICSI): the fresh and cryopreserved groups. After evaluating several machine learning algorithms, logistic regression was selected. Using LASSO regression and 10-fold cross-validation, the factors associated with clinical pregnancy were analyzed.\u0000 \u0000 \u0000 \u0000 The area under the curves (AUCs) for the fresh and cryopreserved groups in the Logistic Regression-based prediction model were 0.977 and 0.759, respectively. Compared with various modeling algorithms, Logistic Regression outperformed machine learning in both groups, with an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved group.\u0000 \u0000 \u0000 \u0000 The model accurately predicted clinical pregnancies in NOA couples.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42135755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Text mining and data analysis identifies potential drugs and pathways for polycystic ovary syndrome treatment","authors":"Xiaoyin Yuan, Y. Wang, Haiyan Yang, Bin Zhao","doi":"10.1097/rd9.0000000000000081","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000081","url":null,"abstract":"\u0000 \u0000 Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. This study aimed to use text mining and microarray data analysis to identify drugs that target genes and potential pathways associated with PCOS.\u0000 \u0000 \u0000 \u0000 We extracted a common set of genes associated with PCOS using text mining and the microarray dataset GSE48301. Next, we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of these genes, as well as protein-protein interaction (PPI) network analysis. Additionally, we used MCODE and cytoHubba to cluster significant common genes in the PPI network and performed gene-drug interaction analyses to identify potential drugs for further investigation. Finally, we annotated pathways associated with the genes identified.\u0000 \u0000 \u0000 \u0000 Text mining and microarray analysis yielded 696 text mining genes (TMGs) and 2,804 differentially expressed genes (DEGs). Among these, a set of 77 genes was found in both TMGs and DEGs. Interestingly, 67 of these genes participated in constructing the PPI network. Seven common hub genes were selected using the MCODE and CytoHubba methods. Finally, five out of seven genes were targeted by 15 existing drugs.\u0000 \u0000 \u0000 \u0000 Four genes (FASLG, IL13, IL17A, and IL2RA), which are mainly related to the cytokine-cytokine receptor interaction pathway, could be prioritized as targets for PCOS.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49187380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Glucose Metabolism and Signaling Pathways at Different Stages of Ovarian Folliculogenesis","authors":"Dan Mo, Zhonghong Zeng, Xin Sui, Rong Li, Yi-Hua Yang","doi":"10.1097/rd9.0000000000000079","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000079","url":null,"abstract":"The female ovaries are critical for follicle growth and development in the process known as “folliculogenesis”. This complex process is regulated by various factors, among which the microenvironment around follicles appears to be crucial. According to previous studies, folliculogenesis is an energy-demanding process. In fact, well-balanced follicular energy metabolism is associated with ovarian function and female fertility. Consequently, glucose metabolism has been widely described as the main source of energy during folliculogenesis. Generally, the follicular glucose metabolism profiles change dynamically during follicular development. Metabolic abnormalities during folliculogenesis are associated with aging, primary ovarian insufficiency, and polycystic ovary syndrome, thereby leading to subfertility and infertility in females. The signaling pathways in follicles appear to form a link between glucose metabolism and folliculogenesis. Therefore, a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental competence. This review aimed to describe variations in glucose metabolism at different stages of folliculogenesis, provide new insights into glucose metabolic disorder-related diseases, and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis: phosphatidylinositol 3-kinase, protein kinase B (PI3K-PKB/AKT) and AMP-activated protein kinase (AMPK) signaling pathways.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49164682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of the emergency management of cardiac conditions during pregnancy in an Egyptian tertiary unit: Newness in paradigms","authors":"M. Mahmoud, Abd Elhalim, M. Ellaban, M. Saleh, Hamdi Mohamed Ali, Khaled M Abdalla, M. Eldeib, Ahmed Ali Faheem, A. Almarghany, M. Samy, Al Hussein Zahran, A. Ali, Medhat Ali","doi":"10.1097/rd9.0000000000000077","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000077","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42049115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics approaches to uncover endometrial receptivity in embryo implantation: A mini-review","authors":"S. Fernando, Yang Yan, Manish Kumar, Hoi-Lam Lai, Yin-Lau Lee, E. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000078","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000078","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43728651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic analysis of granulosa cells in patients with endometriosis-related infertility: identification of potential molecular mechanisms","authors":"Jian Zhang, Yu Zhang, Jiaxiu Luo, Lin Yu, Minzhi Gao, Zhaogui Sun","doi":"10.1097/rd9.0000000000000075","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000075","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46639208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Update on Hormonal Regulation of Early Embryo-Fallopian Tube Interactions: Insights for Improvements of Assisted Reproduction Technology Outcomes","authors":"S. Kodithuwakku, E. Y. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000074","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000074","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43283689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}